The state of North Carolina currently has 16 active clinical trials seeking participants for Epilepsy research studies. These trials are conducted in various cities, including Durham, Charlotte, Winston-Salem and Chapel Hill.
FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
Recruiting
This clinical trial is designed to test whether a single stereotactic intracerebral administration of inhibitory nerve cells into subjects with drug-resistant mesial temporal lobe epilepsy is safe (frequency of adverse events) and effective (seizure frequency).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/11/2024
Locations: Duke University Hospital, Durham, North Carolina +1 locations
Conditions: Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Lacosamide in Neonates With Repeated Electroencephalographic Neonatal Seizures
Recruiting
The purpose of the study is to evaluate the efficacy of lacosamide (LCM) versus an Active Comparator chosen based on standard of care (StOC) in severe and nonsevere seizure burden (defined as total minutes of electroencephalographic neonatal seizures (ENS) per hour) in neonates with seizures that are not adequately controlled with previous anti-epileptic drug (AED) treatment.
Gender:
All
Ages:
28 days and below
Trial Updated:
05/08/2024
Locations: Sp0968 111, Durham, North Carolina
Conditions: Electroencephalographic Neonatal Seizures, Epilepsy
Assessing Comorbidities in Epilepsy Using Eye Movement Recordings
Recruiting
This study wants to make it easier to find kids with a type of epilepsy called childhood absence epilepsy (CAE) who might have problems with ongoing seizures and thinking. Right now, doctors use tests that can be expensive and take a long time. Eysz is developing a system that looks at how kids move their eyes which might help find CAE more quickly and accurately. This study will compare Eysz with the usual tests to see if it can predict seizures and thinking problems in kids with CAE. The goal... Read More
Gender:
All
Ages:
Between 4 years and 12 years
Trial Updated:
05/06/2024
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Childhood Absence Epilepsy, Absence Seizures, Epilepsy Comorbidities
Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
Recruiting
The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of post-neonatal epilepsy among children with acute provoked neonatal seizures. The researchers aim to develop prediction rules to stratify neonates into low, medium, and high risk for post-neonatal epilepsy based on clinical, electroencephalogram (EEG), magnetic resonance... Read More
Gender:
All
Ages:
All
Trial Updated:
03/05/2024
Locations: Duke University, Durham, North Carolina
Conditions: Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhage, Epilepsy, Gene Abnormality