The state of North Carolina currently has 17 active clinical trials seeking participants for Healthy research studies. These trials are conducted in various cities, including Durham, Winston-Salem, Charlotte and Chapel Hill.
Long-term Effectiveness of the Antiobesity Medication Phentermine
NCT05176626
Recruiting
The purpose of this research study is to understand the long-term effects of the drug phentermine on weight, blood pressure, other health outcomes, and safety. Phentermine has been approved by the US Food and Drug Administration (FDA) for weight management since 1959, but it has not been approved for long-term use (i.e., treatment lasting more than 12 weeks). This trial is designed to learn about the long-term effects of phentermine for up to 2 years because obesity is a chronic disease and expe... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/31/2024
Locations: Atrium Health Wake Forest Baptist Weight Management Center, Winston-Salem, North Carolina
Conditions: Obesity, Obesity; Drug, Lifestyle, Healthy
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The Validation Study of Bioelectronics
NCT05397951
Recruiting
The purpose of this study is to investigate the safe wearability and basic functions of the multi-modality sensors fabricated in the PI lab.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
01/31/2024
Locations: Kenan Laboratories at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Healthy, Health Behavior
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Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin
NCT05929339
Recruiting
The goal of this clinical trial is to learn about oxytocin ( a naturally occurring hormone made in the brain that transmits messages) and the effects it may have on thermal heat pain after intravenous administration. The main question it aims to define is the time course of change in pain score after a 5 minute heating of the skin administered at intervals during and following infusion of intravenous oxytocin in order to create a Pharmacokinetic and a Pharmacodynamic model for oxytocin-induced a... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
08/23/2023
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Acute Pain, Chronic Pain, Healthy Volunteer
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Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype
NCT03876314
Recruiting
Physical activity and Alzheimer's disease (PAAD-2) is a randomized control trial that will assess the effects of exercise on middle-aged (40-65 years) cognitively normal adults who have a heightened risk of Alzheimer's disease (AD) due to family history (FH+). The investigators will also assess the extent to which this effect is moderated by apolipoprotein epsilon-4 (APOE4) carrier status, and will gather critical new experimental evidence on the use of physical activity to improve cognitive per... Read More
Gender:
All
Ages:
Between 40 years and 65 years
Trial Updated:
05/12/2023
Locations: University of North Carolina-Greensboro, Greensboro, North Carolina
Conditions: Healthy, Dementia, Alzheimer Disease, Physical Activity
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A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.
NCT00571389
Recruiting
Primary Objective: This is a study to investigate the feasibility of harvesting, expanding, and selecting T lymphocytes from cancer patients and healthy volunteers. The preliminary objective of this study is aimed at selecting PD-1+ and CTLA4+ T cells and other cellular fractions from peripheral blood of cancer patients and healthy volunteers by using specific conjugated antibodies, evaluating their functional ex vivo anti-tumor cytotoxicity against targeted autologous tumor cells.
Gender:
All
Ages:
5 years and above
Trial Updated:
04/26/2022
Locations: Carolina BioOncology Institute, Huntersville, North Carolina
Conditions: Solid Tumor, Adult, Healthy Donors, COVID-19 Donors
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