The state of North Carolina currently has 18 active clinical trials seeking participants for Parkinson's Disease research studies. These trials are conducted in various cities, including Durham, Charlotte, Winston-Salem and Chapel Hill.
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease
Recruiting
The objectives of this study are to collect the long-term safety and effectiveness data of performing thalamotomy for tremor dominant Parkinson's Disease (TDPD) using the Exablate Neuro system.
Gender:
ALL
Ages:
Between 30 years and 99 years
Trial Updated:
04/29/2025
Locations: Novant Health Brain & Spine Surgery, Huntsville, North Carolina
Conditions: Tremor Associated With Tremor Dominant Parkinson's Disease
Connectomic Guided DBS for Parkinson's Disease
Recruiting
The objective of this research is to use advanced connectomic imaging models to identify disease-relevant axonal pathway targets for better tremor control in Parkinson's disease patients while avoiding undesirable side effects, with the goal of increasing precision and facilitating the choice of optimal DBS parameters for certain disease phenotypes. The investigators hypothesize that patient centered subthalamic nucleus deep brain stimulation of cerebellothalamic axonal pathways and pallidothala... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/16/2025
Locations: Duke Health Center at Morreene Road, Durham, North Carolina
Conditions: Parkinson Disease, Tremor, Dyskinesias
Retinal Imaging in Neurodegenerative Disease
Recruiting
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Mild Cognitive Impairment, Multiple Sclerosis, Huntington Disease, Neuro-Degenerative Disease, Alzheimer's Disease, Parkinson's Disease, Lewy Body Dementia, Frontotemporal Dementia, Amyotrophic Lateral Sclerosis (ALS), APOE-4 Positive, Traumatic Brain Injury, Concussion, Post-Traumatic Stress Disorder, Down Syndrome, Normal Cognition
Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease
Recruiting
The purpose of this research study is to determine how training to step with a metronome on both a treadmill, as well as overground, will influence the way that people with Parkinson disease walk. Using metronomes is commonly used in clinics, but the investigators will be using a combination of slow and fast frequencies to alter the way that people walk. The use of a slower frequency metronome on the treadmill is intended to help participants take larger steps. The use of a faster frequency metr... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
10/30/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Parkinson Disease
A Study to Assess the Safety of BMS-984923 Compared to Placebo, in People With Parkinson's
Recruiting
A Phase 1, randomized, double-blind, placebo-controlled study of BMS-984923 administered orally twice daily (BID) for 28 days in participants with Parkinson's disease.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
03/15/2024
Locations: Duke Clinical Research Institute, Durham, North Carolina
Conditions: Parkinson Disease
Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation
Recruiting
Individuals experiencing tremors face difficulty performing activities of daily living caused by involuntary oscillation of the muscles in the hands and arms. Current solutions to help suppress tremors include medication, surgery, assistive devices and lifestyle change. However, each of these has a drawback of its own including cost and unwanted side effects. Aside from the solutions listed, it has been shown that functional electrical stimulation(FES) is a possible solution to help suppress tre... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/25/2022
Locations: Engineering Building III, Raleigh, North Carolina
Conditions: Parkinson Disease, Essential Tremor