The state of Ohio currently has 51 active clinical trials seeking participants for Diabetes research studies. These trials are conducted in various cities, including Cincinnati, Columbus, Cleveland and Dayton.
Exciflex for Chronic Wound Therapy
Recruiting
Objectives: The study objective is to carry a pilot clinical assessment comparing the exciflex bandage to standard of care (SoC) for ischemic wounds and will involve participants who are Veterans with lower extremity ischemic wounds. Research Plan: The study will employ a randomized repeated measures design to assess the therapeutic effectiveness of exciflex in clinical use. Methodology: All participants with chronic ischemic wounds treated at LSCDVAMC will be potentially eligible for the stud... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio
Conditions: Chronic Wound, Diabetes, Spinal Cord Injury, Ischemic Wound
Mechanisms Underlying Impaired Diabetic Wound Healing
Recruiting
The overall aim of this research is to utilize wound derived inflammatory cells from diabetic versus non diabetic human chronic wounds to understand mechanisms that are responsible for disregulated inflammation in individuals with diabetes. Biology of normal (peripheral blood derived cells) versus wound derived cells will also be studied.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
09/04/2024
Locations: Comprehensive Wound Care Centers, Columbus, Ohio
Conditions: Non-healing Wounds, Diabetes
Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
Recruiting
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D). In a previous study, it was observed in people without diabetes that fasting can be detrimental to the hormonal and hepatic responses to insulin-induced hypoglycemia. In the experiments described herein, the impact fasting has on hypoglycemic counterregulation in people with T1D will be determined.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
08/29/2024
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Hypoglycemia, type1diabetes
Nutrition Outreach and Understanding: Research In Serving Hearts Through Healthy Eating And Tailored Support
Recruiting
This study is a human-centered, three-arm, parallel-group, randomized control, implementation trial (n=75) to compare MTM (Medically Tailored Meals) only (14 meals delivered weekly for 10 weeks) vs. MTM + SMA (Shared Medical Appointments; once weekly sessions for 10 weeks) vs. a wait-list control group (MTM-Later) in patients with hypertension, type 2 diabetes, obesity, and/or metabolic syndrome. All intervention components will be culturally congruent (e.g., MTMs will include food that converge... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Hypertension, Type2diabetes, Metabolic Syndrome, Obesity
RESET System Pivotal Trial (Rev F)
Recruiting
A Randomized, Multi-Center, Pivotal Efficacy and Safety Study Evaluating the RESET System for Glycemic Improvement in Patients with Inadequately Controlled Type 2 Diabetes and Obesity, the STEP-1 Study. A multi-center, double-blinded, randomized, sham-controlled trial to evaluate the safety and effectiveness of the RESET System plus moderate intensity lifestyle and dietary counseling compliant with 2024 ADA Standard of Care as compared to a sham control receiving moderate intensity lifestyle an... Read More
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
07/16/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Diabetes type2, Obesity
Impact of Per Oral Pyloromyotomy (POP) on Glycemic Control in Diabetes
Recruiting
This study will assess changes in glycemic control in 40 patients with diabetes who undergo per-oral pyloromyotomy (POP) for medically refractory gastroparesis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Diabetes Mellitus, Gastroparesis With Diabetes Mellitus, Gastroparesis
Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function
Recruiting
This study is being done to evaluate how a ketone ester (KE) beverage affects heart function and health in people with heart failure compared to a placebo beverage (a beverage made with standard food ingredients that do not contain ketone esters).
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/30/2024
Locations: The Ross Heart Hospital, Columbus, Ohio
Conditions: Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes, Metabolic Syndrome
Self-Management in Young Adults With Type 1 Diabetes 2023
Recruiting
Type 1 diabetes (T1D) affects approximately 2 million Americans, and only 2 in 8 young adults ages 18-31 years achieve glycemic targets (glycated hemoglobin A1C <7.0%). Achieving glycemic targets is associated with reduced risk of micro-and macrovascular complications. Sleep deprivation leads to impaired glucose tolerance and insulin sensitivity in adults without chronic conditions and with T1D. Promoting sleep in laboratory and natural environments contributes to improvements in insulin sensiti... Read More
Gender:
All
Ages:
Between 18 years and 31 years
Trial Updated:
05/15/2024
Locations: University Hospitals of Cleveland Medical Center, Cleveland, Ohio
Conditions: Type1diabetes
Linking Education, Produce Provision, and Community Referrals to Improve Diabetes Care (LINK)
Recruiting
This is a pragmatic randomized controlled trial (pRCT) that aims to test the effect of produce provision, diabetes education, and community referrals on hemoglobin A1c levels in individuals with type 2 diabetes experiencing food insecurity.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Diabetes Mellitus, Type 2, Nutrition Poor, Food Deprivation
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
Recruiting
The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical outcomes in patients with peripheral artery disease (PAD) who are undergoing lower extremity revascularization procedures. We hypothesize that radiotracer imaging of the lower extremities will provide a sensitive non-invasive imaging tool for quantifying regional abnormalities... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Diabetes Mellitus, Peripheral Artery Disease, Chronic Limb-Threatening Ischemia
PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life
Recruiting
This research study is called 'PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life: The PROMISE Study'. The purpose of this study is to find out more about how exposures during pregnancy, such as having an infection, diet and growth may impact later risk of type 1 diabetes (TID) and islet autoimmunity in the child. We are also interested in finding out more about why having a father or sibling with T1D increases risk of autoimmunity in the child more than having a mo... Read More
Gender:
All
Ages:
Between 0 days and 99 years
Trial Updated:
11/15/2023
Locations: Ohio State University, Columbus, Ohio
Conditions: Type 1 Diabetes, Pregnancy in Diabetic
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Recruiting
Lower attainment of cardiovascular health (CVH), indicated by the American Heart Association's Life's Simple 7 (LS7; physical activity, diet, cholesterol, blood pressure, body mass index, smoking, glycemia) and Life's Essential 8 (LE8; LS7+sleep) metrics, is a major contributor to Black men having the shortest life-expectancy of any non-indigenous race/sex group. Unfortunately, a paucity of literature exists on interventions aimed at improving CVH among Black men. The team of clinician scientist... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
09/19/2023
Locations: The Ohio State University, Columbus, Ohio
Conditions: Cardiometabolic Syndrome, Physical Inactivity, Hypertension, Type 2 Diabetes, PreDiabetes, Obesity, Cardiovascular Diseases, Smoking, Sleep, Hyperlipidemias, Diet, Healthy, Blood Pressure