There are currently 256 clinical trials in Sioux Falls, South Dakota looking for participants to engage in research studies. Trials are conducted at various facilities, including Sanford USD Medical Center - Sioux Falls, Avera Cancer Institute, Sanford Cancer Center Oncology Clinic and Sanford Cancer Center at Sanford USD Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Groningen International Study on Sentinel Nodes in Vulvar Cancer-III
NCT05076942
Recruiting
Vulvar cancer patients with SN-metastasis > 2mm will receive chemoradiation instead of an inguinofemoral lymphadenectomy.
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: Avera Cancer Institute, Sioux Falls, South Dakota
Conditions: Vulvar Cancer, Sentinel Lymph Node, Lymph Node Metastases
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A Survey of Physician and Molecular Tumor Board Perspectives on the Clinical Utility and Usability of Cellworks Singula™ and Ventura™ Reports in Facilitating Patient Treatment Decisions for Pan-Cancer Patients
NCT05308784
Recruiting
The purpose of this study is to determine the benefit of Cellworks Singula™ and Ventura™ reports on physician and molecular tumor board treatment recommendations across a large set of pan-cancer indications. Cellworks reports aim to provide NGS-based therapy recommendations to aid the decision-making of patients, physicians, and molecular tumor boards.
Gender:
All
Ages:
All
Trial Updated:
07/18/2023
Locations: Avera McKennan, Sioux Falls, South Dakota
Conditions: Pan-cancer
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Maternal Stress and Blood Sugar Metabolization
NCT05798377
Recruiting
During pregnancy, gestational diabetes increases the risk of complications and adverse outcomes for mother and child, however about 50% of gestational diabetes cases are diagnosed without a known risk factor present. This project uses both a large sample retrospective study, and a prospective study to help us understand the mechanisms by which mental health and stress impact glucose metabolization during pregnancy and delineate their contribution to gestational diabetes and racial disparities. T... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
06/14/2023
Locations: Sanford Health, Sioux Falls, South Dakota
Conditions: Pregnancy
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PTSD, AUD, and Interpersonal Conflict: Within-person Associations
NCT04552782
Recruiting
The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD sy... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/08/2023
Locations: Sioux Falls VA Health Care System, Sioux Falls, South Dakota
Conditions: Stress Disorders, Post-Traumatic, Alcoholism
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KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
NCT03662126
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: Avera Cancer Institute, Sioux Falls, South Dakota
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
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Contoura With Phorcides Compared to Wavefront Optimized LASIK
NCT05486546
Recruiting
Comparing post-operative visual acuity and patient reported satisfaction between Contoura with Phorcides and WaveLight Wavefront Optimized.
Gender:
All
Ages:
Between 21 years and 38 years
Trial Updated:
04/24/2023
Locations: Vance Thompson Vision, Sioux Falls, South Dakota
Conditions: Myopia, Astigmatism
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CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer
NCT05210283
Recruiting
The CORRECT - MRD II study will prospectively enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer. Patients will be followed for a minimum of 3 years and up to 5 years for recurrence.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota
Conditions: Colorectal Cancer
Register for Updates
myCare-102: Clinical Utility and Usability of Cellworks Singula™ and Cellworks Ventura™ Reports
NCT05693831
Recruiting
The purpose of this study is to determine the benefit of Cellworks Singula™ reports on physician and molecular tumor board treatment recommendations across a large set of pan-cancer indications who have already received first-line therapy. The study is also to determine the benefit of Cellworks Ventura™ reports on physician and molecular tumor board treatment recommendations across a large set of relapsed or refractory pan-cancer indications. The primary objective of this study is to survey phy... Read More
Gender:
All
Ages:
All
Trial Updated:
01/20/2023
Locations: Avera Cancer Institute, Sioux Falls, South Dakota
Conditions: Cancer, Relapsed Cancer, Refractory Cancer
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Study of the Safety and Efficacy of STI-6643 in Subjects With Advanced Solid Tumors
NCT04900519
Recruiting
This is a first-in-human, phase 1, open-label, dose-escalation study of STI-6643 administered by intravenous infusion in subjects with a relapsed/refractory advanced solid tumor.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/12/2023
Locations: Sanford Health, Sioux Falls, South Dakota
Conditions: Solid Tumor, Relapsed Solid Neoplasm, Refractory Tumor
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MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
NCT02075775
Recruiting
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiogra... Read More
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
11/07/2022
Locations: Orthopedic Institute, Sioux Falls, South Dakota
Conditions: Other Instability, Shoulder, Dislocations, Subluxations, Recurrent Dislocation of Shoulder Region
Register for Updates
An Observational, Qualitative Study Assessing Eye Drop Administration
NCT05307081
Recruiting
This is a prospective, observational, consecutive, qualitative, multicenter study. Based on the available published evidence that supports patient challenges with eyedrop administration, the purpose of this video-capture study is to evaluate a more real-world population of consenting patients, regardless of age, with or without visual impairment, at routine eyecare visits. To date, no studies have been performed evaluating a real-world population consisting of daily routine eyecare clinic patie... Read More
Gender:
All
Ages:
All
Trial Updated:
09/13/2022
Locations: Vance Thompson Vision, Sioux Falls, South Dakota
Conditions: Ocular Injury
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Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting
NCT04900844
Recruiting
The objective of this pivotal study is to evaluate the safety and efficacy of the CGuard™ Carotid Stent System in the treatment of carotid artery stenosis in symptomatic and asymptomatic patients undergoing carotid artery stenting (CAS) to a performance goal developed from published CAS literature.
Gender:
All
Ages:
Between 19 years and 80 years
Trial Updated:
06/16/2022
Locations: Avera Heart Hospital, Sioux Falls, South Dakota
Conditions: Carotid Artery Stenosis
Register for Updates