To Evaluate the Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis (LIMBER-313)
Recruiting
The purpose of the study is to compare the efficacy of parsaclisib when combined with ruxolitinb versus placebo combined with ruxolitinib in participants with myelofibrosis.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/24/2021
Locations: Avera Cancer Institute, Sioux Falls, South Dakota
Conditions: Myelofibrosis, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis
Vitamin D and Human Sperm DNA Fragmentation
Recruiting
The purpose of this study will be to investigate if there is a correlation between Vitamin D levels and Sperm DNA Fragmentation. This is a prospective, cohort study. In this study male participants presenting with their partners because of inability to conceive will be recruited for this study. Participants will have a blood sample drawn which will be tested for Vitamin D level. The investigators will then compare sperm DNA fragmentation between normal Vitamin D levels, Vitamin D insufficiency,... Read More
Gender:
Male
Ages:
Between 21 years and 56 years
Trial Updated:
10/08/2020
Locations: Sanford Health Fertility and Reproductive Medicine, Sioux Falls, South Dakota
Conditions: Infertility,Male, Vitamin D Deficiency
Binocular Custom Vision Utilizing The Light Adjustable Lens (LAL)
Recruiting
The objective of this investigator initiated study (IIT-001) is to obtain data on clinical methods which can be used during the examination of patients desiring binocular custom vision with the Light Adjustable Lens (LAL). An analysis of the collected data will be performed to determine whether these clinical assessments can be used by doctors to enhance their patient's clinical outcome.
Gender:
All
Ages:
Between 18 years and 110 years
Trial Updated:
10/05/2020
Locations: Vance Thompson Vision, Sioux Falls, South Dakota
Conditions: Cataract, Pseudophakia
Effect of Negative Pressure on Pattern Electroretinography Readings
Recruiting
Glaucoma is a leading cause of blindness worldwide. Intraocular pressure (IOP) remains the only modifiable risk factor for glaucoma. Without sufficient IOP lowering therapy, glaucoma induces retinal ganglion cell death and visual field loss. Pattern electroretinography (pERG) measurements directly correlate with retinal ganglion cell (RGC) signaling, providing an objective, repeatable, and non-invasive assessment of RGC function. The purpose of the study is to investigate the pERG changes associ... Read More
Gender:
All
Ages:
22 years and above
Trial Updated:
09/30/2020
Locations: Vance Thompson Vision, Sioux Falls, South Dakota
Conditions: Glaucoma, Open Angle, Low Risk, Ocular Hypertension, Glaucoma Suspect