A Study of Pre-Operative Treatment of Newly-Diagnosed, Surgically-Resectable Osteosarcoma With Doxorubicin, Ifosfamide, Etoposide, and Cisplatin With Early Metabolic Assessment of Response
Terminated
This is a pilot study that will allow investigators to collect data related to early and potentially more accurate response assessments using a chemotherapy protocol that eliminates methotrexate to maximize the dose intensity of doxorubicin. The pilot data will be used to seek funding to more fully address the hypotheses in a multi-institutional, Phase II or Phase III trial. The primary and secondary objectives are as follows: Primary: 1. To evaluate the feasibility and potential usefulness of... Read More
Gender:
ALL
Ages:
Between 2 years and 35 years
Trial Updated:
12/09/2013
Locations: University of Chicago Department of Pediatrics Hematology/Oncology, Chicago, Illinois
Conditions: Osteosarcoma, Lung Metastases
Amifostine to Prevent Side Effects in Patients Who Are Receiving Chemotherapy and Radiation Therapy for Limited-Stage Small Cell Lung Cancer
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Drugs such as amifostine may protect normal cells from the side effects of chemotherapy and radiation therapy. PURPOSE: Phase II trial to study the effectiveness of amifostine to prevent side effects in patients who are receiving chemotherapy and radiation therapy for limited-stage small cell lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2013
Locations: University of Florida - Gainesville, Gainesville, Florida
Conditions: Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Radiation Toxicity
Docetaxel, Cisplatin, and Amifostine in Treating Patients With Advanced Non-small Cell Lung Cancer
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs such as amifostine may protect normal cells from the side effects of chemotherapy. PURPOSE: Phase I/II trial to study the effectiveness of combining docetaxel, cisplatin, and amifostine in treating patients who have advanced non-small cell lung cancer that cannot be surgically removed.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2013
Locations: University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin
Conditions: Drug/Agent Toxicity by Tissue/Organ, Lung Cancer
Amifostine Plus Chemotherapy and Radiation Therapy in Treating Patients With Advanced, Unresectable Head and Neck Cancer
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses x-rays to damage tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy and radiation therapy. PURPOSE: Phase I/II trial to study the effectiveness of amifostine plus cisplatin, paclitaxel, and radiation therapy in treating patients who have advanced unresectable head and neck cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2013
Locations: University of Illinois at Chicago Health Sciences Center, Chicago, Illinois
Conditions: Drug/Agent Toxicity by Tissue/Organ, Head and Neck Cancer, Radiation Toxicity
Cisplatin and Gemcitabine in Treating Patients With Advanced Squamous Cell Cancer of the Head and Neck
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of cisplatin and gemcitabine in treating patients with advanced squamous cell cancer of the head and neck that cannot be surgically removed.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2013
Locations: Bethany Medical Center, Kansas City, Kansas +1 locations
Conditions: Head and Neck Cancer
Phase Ib Study of Gemcitabine Plus Cisplatin or Carboplatin Plus Dovitinib in Patients With Advanced Solid Tumors
Terminated
This is a phase Ib dose escalation study of dovitinib given in combination with either gemcitabine plus cisplatin or carboplatin in patients with advanced solid tumors. Patients with advanced solid tumors, for whom treatment with gemcitabine plus cisplatin or carboplatin would otherwise be warranted, will be enrolled. The dose of dovitinib will be escalated in successive cohorts using standard "3+3" dose escalation rules. Patients will continue treatment, in the absence of prohibitive toxicity,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2013
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Solid Tumors, Bladder Cancer
Chemotherapy Plus Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Surgically Removed
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of chemotherapy plus radiation therapy in treating patients who have stage III non-small cell lung cancer that cannot be surgically removed.
Gender:
ALL
Ages:
All
Trial Updated:
11/25/2013
Locations: University of Alabama Comprehensive Cancer Center, Birmingham, Alabama
Conditions: Lung Cancer
Pharmacogenomic Study of Docetaxel and Cisplatin, Followed by Docetaxel, Cisplatin and Irradiation.
Terminated
The purpose of this research study is to find out the effectiveness of the experimental combination of Docetaxel, Cisplatin, and radiation therapy administered prior to the surgical removal of your esophageal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2013
Locations: H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida
Conditions: Esophageal Adenocarcinomas, Adenocarcinomas of the Gastroesophageal Junction
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Cancer of the Esophagus
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not known whether high-dose radiation therapy is more effective than standard dose radiation therapy in treating cancer of the esophagus. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy plus high- or standard-dose radiation therapy in treating patients with cance... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2013
Locations: CCOP - Scottsdale Oncology Program, Scottsdale, Arizona +17 locations
Conditions: Esophageal Cancer
Radiation Therapy Plus Celecoxib, Fluorouracil, and Cisplatin in Patients With Locally Advanced Cervical Cancer
Completed
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving radiation therapy in different ways and combining it with chemotherapy may kill more tumor cells. Celecoxib may slow the growth of cervical cancer by stopping blood flow to the tumor. PURPOSE: Phase I/II trial to study the effectiveness of radiation therapy plus celecoxib, fluorouracil, and cisplatin in tr... Read More
Gender:
FEMALE
Ages:
Between 18 years and 85 years
Trial Updated:
11/18/2013
Locations: Mobile Infirmary Medical Center, Mobile, Alabama +35 locations
Conditions: Cervical Cancer
The Synergistic Metastases Annihilation With Radiotherapy and Docetaxel (Taxotere) [SMART] Trial for Non-Small Cell Lung Cancer (NSCLC)
Terminated
Primary goal of the study is to assess the overall survival of the addition of hypofractionated image guided radiotherapy concurrently with Docetaxel and cisplatin. Survival will be assessed at 1 year from the date of study enrollment to date of death.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2013
Locations: The University of Chicago, Chicago, Illinois
Conditions: Non-small Cell Lung Cancer
Radiation Therapy Plus Combination Chemotherapy in Treating Patients With Small Cell Lung Cancer
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of radiation therapy plus combination chemotherapy in treating patients with limited-stage small cell lung cancer.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/31/2013
Locations: University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama +261 locations
Conditions: Lung Cancer