Cyclophosphamide Treatment Options

A collection of 2183 research studies where Cyclophosphamide is the interventional treatment. These studies are located in the United States . Cyclophosphamide is used for conditions such as Breast Cancer, Lymphoma and Leukemia.

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Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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Chronic Cough Research Study

Recruiting

Are you tired of living with chronic cough? Our research study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough.
You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you!

Conditions:

Chronic Cough

Refractory or Unexplained Chronic Cough

Cough

Asthma

Sinusitis

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Recruiting

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Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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Featured Trial

Depressive disorder Clinical Study

Recruiting

A clinical study for people that suffer with Depressive disorder

Conditions:

Depressive disorder

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Stem Cell Transplantation in Patients With High-Risk and Recurrent Pediatric Sarcomas

NCT00043979

Completed

This study will examine the safety and effectiveness of stem cell transplantation for treating patients with sarcomas (tumors of the bone, nerves, or soft tissue). Stem cells are immature cells in the bone marrow and blood stream that develop into blood cells. Stem cells transplanted from a healthy donor travel to the patient's bone marrow and begin producing normal cells. In patients with certain cancers, such as leukemia and lymphoma, the donor's immune cells attack the patient's cancer cells in what is called a "graft-versus-tumor" effect, contributing to cure of the disease. This study will determine whether this treatment can be used successfully to treat patients with sarcomas. Patients between 4 and 35 years of age with a sarcoma that has spread from the primary site or cannot be removed surgically, and for whom effective treatment is not available, may be eligible for this study. Candidates must have been diagnosed by the age of 30 at the time of enrollment. They must have a matched donor (usually a sibling). Participants undergo the following procedures: Donors: Stem cells are collected from the donor. To do this, the hormone granulocyte colony stimulating factor (G-CSF) is injected under the skin for several days to move stem cells out of the bone marrow into the bloodstream. Then, the cells are collected by apheresis. In this procedure the blood is drawn through a needle placed in one arm and pumped into a machine where the stem cells are separated out and removed. The rest of the blood is returned to the donor through a needle in the other arm. Patients: For patients who do not already have a central venous catheter (plastic tube), one is placed into a major vein. This tube can stay in the body the entire treatment period for giving medications, transfusing blood, , withdrawing blood samples, and delivering the donated stem cells. Before the transplant procedure, patients receive from one to three cycles of "induction" chemotherapy, with each cycle consisting of 5 days of fludarabine, cyclophosphamide, etoposide, doxorubicin, vincristine, and prednisone followed by at least a 17-day rest period. All the drugs are infused through the catheter except prednisone, which is taken by mouth. After the induction therapy, the patient is admitted to the hospital for 5 days of chemotherapy with high doses of cyclophosphamide, melphalan, and fludarabine. Two days later, the stem cells are infused. The anticipated hospital stay is about 3 weeks, but may be longer if complications arise. Patients are discharged when their white cell count is near normal, they have no fever or infection, they can take sufficient food and fluids by mouth, and they have no signs of serious graft-versus-host disease (GVHD)-a condition in which the donor's cells "see" the patient's cells as foreign and mount an immune response against them. After hospital discharge, patients are followed in the clinic at least once or twice weekly for a medical history, physical exam, and blood tests for 100 days. They receive medications to prevent infection and GVHD and, if needed, blood transfusions. If GVHD has not developed by about 120 days post transplant, patients receive additional white cells to boost the immune response. After 100 days, follow-up visits may be less frequent. Follow-up continues for at least 5 years. During the course of the study, patients undergo repeated medical evaluations, including blood tests and radiology studies, to check on the cancer and on any treatment side effects. On four occasions, white blood cells may be collected through apheresis to see if immune responses can be generated against the sarcomas treated in this study. Positron emission tomography (PET) scans may be done on five occasions. This test uses a radioactive material to produce images useful in detecting primary tumors and cancer that has spread. Read Less

Gender:

ALL

Ages:

Between 5 years and 35 years

Trial Updated:

04/11/2017

Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland

Conditions: Sarcoma

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Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia

NCT01193283

Completed

Background: * Severe aplastic anemia (SAA) can lead to problems with bone marrow health and result in low blood cell counts, which require frequent transfusions. Standard treatment for SAA involves injections of antithymocyte globulin (ATG) plus cyclosporine (CsA). This regimen has been shown to improve the blood counts in about two-thirds of patients. However, the ATG/CsA regimen has the following limitations: (a) the disease can come back (relapse) in about one-third of patients who improve i... Read More

Gender:

ALL

Ages:

2 years and above

Trial Updated:

04/11/2017

Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland

Conditions: Aplastic Anemia, Neutropenia, Pancytopenia, Severe Aplastic Anemia

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Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer

NCT00049504

Completed

This phase II trial studies how well giving fludarabine phosphate, cyclophosphamide, tacrolimus, mycophenolate mofetil and total-body irradiation together with a donor bone marrow transplant works in treating patients with high-risk hematologic cancer. Giving low doses of chemotherapy, such as fludarabine phosphate and cyclophosphamide, and total-body irradiation before a donor bone marrow transplant helps stop the growth of cancer cells by stopping them from dividing or killing them. Giving cyc... Read More

Gender:

ALL

Ages:

All

Trial Updated:

04/10/2017

Locations: Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington

Conditions: Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Acute Myeloid Leukemia With t(8;21)(q22;q22), Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission, Childhood Burkitt Lymphoma, Childhood Chronic Myelogenous Leukemia, Childhood Myelodysplastic Syndromes, Childhood Nasal Type Extranodal NK/T-cell Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma, de Novo Myelodysplastic Syndromes, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Hematopoietic/Lymphoid Cancer, Hepatosplenic T-cell Lymphoma, Intraocular Lymphoma, Nodal Marginal Zone B-cell Lymphoma, Peripheral T-cell Lymphoma, Post-transplant Lymphoproliferative Disorder, Previously Treated Myelodysplastic Syndromes, Recurrent Adult Burkitt Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Diffuse Mixed Cell Lymphoma, Recurrent Adult Diffuse Small Cleaved Cell Lymphoma, Recurrent Adult Grade III Lymphomatoid Granulomatosis, Recurrent Adult Hodgkin Lymphoma, Recurrent Adult Immunoblastic Large Cell Lymphoma, Recurrent Adult Lymphoblastic Lymphoma, Recurrent Adult T-cell Leukemia/Lymphoma, Recurrent Childhood Anaplastic Large Cell Lymphoma, Recurrent Childhood Grade III Lymphomatoid Granulomatosis, Recurrent Childhood Large Cell Lymphoma, Recurrent Childhood Lymphoblastic Lymphoma, Recurrent Childhood Small Noncleaved Cell Lymphoma, Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma, Recurrent Marginal Zone Lymphoma, Recurrent Mycosis Fungoides/Sezary Syndrome, Recurrent Small Lymphocytic Lymphoma, Recurrent/Refractory Childhood Hodgkin Lymphoma, Refractory Chronic Lymphocytic Leukemia, Refractory Multiple Myeloma, Relapsing Chronic Myelogenous Leukemia, Secondary Myelodysplastic Syndromes, Small Intestine Lymphoma, Splenic Marginal Zone Lymphoma, Stage II Multiple Myeloma, Stage III Adult Burkitt Lymphoma, Stage III Adult Diffuse Large Cell Lymphoma, Stage III Adult Diffuse Mixed Cell Lymphoma, Stage III Adult Diffuse Small Cleaved Cell Lymphoma, Stage III Adult Hodgkin Lymphoma, Stage III Adult Immunoblastic Large Cell Lymphoma, Stage III Adult Lymphoblastic Lymphoma, Stage III Adult T-cell Leukemia/Lymphoma, Stage III Childhood Hodgkin Lymphoma, Stage III Chronic Lymphocytic Leukemia, Stage III Cutaneous T-cell Non-Hodgkin Lymphoma, Stage III Grade 1 Follicular Lymphoma, Stage III Grade 2 Follicular Lymphoma, Stage III Grade 3 Follicular Lymphoma, Stage III Mantle Cell Lymphoma, Stage III Marginal Zone Lymphoma, Stage III Multiple Myeloma, Stage III Mycosis Fungoides/Sezary Syndrome, Stage III Small Lymphocytic Lymphoma, Stage IV Adult Burkitt Lymphoma, Stage IV Adult Diffuse Large Cell Lymphoma, Stage IV Adult Diffuse Mixed Cell Lymphoma, Stage IV Adult Diffuse Small Cleaved Cell Lymphoma, Stage IV Adult Hodgkin Lymphoma, Stage IV Adult Immunoblastic Large Cell Lymphoma, Stage IV Adult Lymphoblastic Lymphoma, Stage IV Adult T-cell Leukemia/Lymphoma, Stage IV Childhood Hodgkin Lymphoma, Stage IV Chronic Lymphocytic Leukemia, Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma, Stage IV Grade 1 Follicular Lymphoma, Stage IV Grade 2 Follicular Lymphoma, Stage IV Grade 3 Follicular Lymphoma, Stage IV Mantle Cell Lymphoma, Stage IV Marginal Zone Lymphoma, Stage IV Mycosis Fungoides/Sezary Syndrome, Stage IV Small Lymphocytic Lymphoma, Testicular Lymphoma, Waldenström Macroglobulinemia

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Doxorubicin and Cyclophosphamide Followed by Paclitaxel, Trastuzumab, and Lapatinib in Treating Patients With HER2/Neu-Overexpressed Breast Cancer

NCT00482391

Completed

The purpose of this study is to study a new treatment for HER-2/neu (+) breast cancer.

Gender:

ALL

Ages:

Between 18 years and 120 years

Trial Updated:

04/06/2017

Locations: Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston, Massachusetts +1 locations

Conditions: Breast Cancer

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Bone Marrow Transplantation With Specially Treated Bone Marrow in Treating Patients With Hematologic Cancer That Have Not Responded to Previous Therapy

NCT00005988

Completed

RATIONALE: Bone marrow transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells. Sometimes the transplanted cells can make an immune response against the body's normal tissues. Treatment of the donor bone marrow with the patient's white blood cells and a monoclonal antibody may prevent this from happening. PURPOSE: Phase I trial to study the effectiveness of bone marrow transplantation with specially treated bone marro... Read More

Gender:

ALL

Ages:

40 years and below

Trial Updated:

03/30/2017

Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +1 locations

Conditions: Graft Versus Host Disease, Leukemia, Lymphoma, Myelodysplastic Syndromes, Myeloma

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Study of Neoadjuvant Chemotherapy With Nanoparticle Albumin Bound Paclitaxel, Doxorubicin and Cyclophosphamide (NAC) in Patients With Stages II-III Breast Cancer

NCT01090128

Terminated

The purpose of this clinical trial is to test whether treatment of patients with breast cancer with the combination of Abraxane (nab-paclitaxel), Adriamycin (doxorubicin), and Cyclophosphamide prior to surgery is safe and results in good tumor response. Up to 24 patients may be enrolled in this study at the Mitchell Cancer Institute. All patients enrolling in this study will receive treatment with the combination of Abraxane, Adriamycin, and Cyclophosphamide.

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

03/29/2017

Locations: University of Utah Huntsman Cancer Institute, Salt Lake City, Utah

Conditions: Stages II-III Breast Cancer

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Vinorelbine Tartrate and Cyclophosphamide in Combination With Bevacizumab or Temsirolimus in Treating Patients With Recurrent or Refractory Rhabdomyosarcoma

NCT01222715

Completed

This randomized phase II trial studies how well vinorelbine tartrate and cyclophosphamide work in combination with bevacizumab or temsirolimus in treating patients with recurrent or refractory rhabdomyosarcoma. Drugs used in chemotherapy, such as vinorelbine tartrate and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Som... Read More

Gender:

ALL

Ages:

29 years and below

Trial Updated:

03/24/2017

Locations: Children's Hospital of Alabama, Birmingham, Alabama +183 locations

Children's Hospital of Alabama, Birmingham, Alabama

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

Phoenix Childrens Hospital, Phoenix, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

University of Arkansas for Medical Sciences, Little Rock, Arkansas

Southern California Permanente Medical Group, Downey, California

City of Hope Comprehensive Cancer Center, Duarte, California

Loma Linda University Medical Center, Loma Linda, California

Miller Children's and Women's Hospital Long Beach, Long Beach, California

Children's Hospital Los Angeles, Los Angeles, California

Cedars-Sinai Medical Center, Los Angeles, California

Children's Hospital Central California, Madera, California

Children's Hospital and Research Center at Oakland, Oakland, California

Children's Hospital of Orange County, Orange, California

Lucile Packard Children's Hospital Stanford University, Palo Alto, California

University of California Davis Comprehensive Cancer Center, Sacramento, California

Rady Children's Hospital - San Diego, San Diego, California

UCSF Medical Center-Parnassus, San Francisco, California

Children's Hospital Colorado, Aurora, Colorado

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado

Connecticut Children's Medical Center, Hartford, Connecticut

Yale University, New Haven, Connecticut

Alfred I duPont Hospital for Children, Wilmington, Delaware

Children's National Medical Center, Washington, District of Columbia

Lee Memorial Health System, Fort Myers, Florida

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

Florida Hospital Orlando, Orlando, Florida

Nemours Children's Clinic - Orlando, Orlando, Florida

UF Cancer Center at Orlando Health, Orlando, Florida

Nemours Children's Clinic - Pensacola, Pensacola, Florida

All Children's Hospital, Saint Petersburg, Florida

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida

Saint Mary's Hospital, West Palm Beach, Florida

Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia

Memorial University Medical Center, Savannah, Georgia

University of Hawaii Cancer Center, Honolulu, Hawaii

Saint Luke's Mountain States Tumor Institute, Boise, Idaho

Lurie Children's Hospital-Chicago, Chicago, Illinois

University of Illinois, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Loyola University Medical Center, Maywood, Illinois

Saint Jude Midwest Affiliate, Peoria, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana

Riley Hospital for Children, Indianapolis, Indiana

Saint Vincent Hospital and Health Care Center, Indianapolis, Indiana

Blank Children's Hospital, Des Moines, Iowa

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Kosair Children's Hospital, Louisville, Kentucky

Tulane University Health Sciences Center, New Orleans, Louisiana

Children's Hospital New Orleans, New Orleans, Louisiana

Ochsner Medical Center Jefferson, New Orleans, Louisiana

Eastern Maine Medical Center, Bangor, Maine

Maine Children's Cancer Program, Scarborough, Maine

Sinai Hospital of Baltimore, Baltimore, Maryland

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Walter Reed National Military Medical Center, Bethesda, Maryland

Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts

Massachusetts General Hospital Cancer Center, Boston, Massachusetts

Dana-Farber/Harvard Cancer Center, Boston, Massachusetts

C S Mott Children's Hospital, Ann Arbor, Michigan

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan

Saint John Hospital and Medical Center, Detroit, Michigan

Michigan State University Clinical Center, East Lansing, Michigan

Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, Michigan

Bronson Methodist Hospital, Kalamazoo, Michigan

Kalamazoo Center for Medical Studies, Kalamazoo, Michigan

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota

University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota

Mayo Clinic, Rochester, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

University of Missouri - Ellis Fischel, Columbia, Missouri

The Childrens Mercy Hospital, Kansas City, Missouri

Cardinal Glennon Children's Medical Center, Saint Louis, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Mercy Hospital Saint Louis, Saint Louis, Missouri

Children's Hospital and Medical Center of Omaha, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Nevada Cancer Research Foundation CCOP, Las Vegas, Nevada

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Hackensack University Medical Center, Hackensack, New Jersey

Saint Barnabas Medical Center, Livingston, New Jersey

Morristown Medical Center, Morristown, New Jersey

Saint Peter's University Hospital, New Brunswick, New Jersey

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

Saint Joseph's Regional Medical Center, Paterson, New Jersey

Overlook Hospital, Summit, New Jersey

University of New Mexico Cancer Center, Albuquerque, New Mexico

Albany Medical Center, Albany, New York

Montefiore Medical Center - Moses Campus, Bronx, New York

Roswell Park Cancer Institute, Buffalo, New York

Winthrop University Hospital, Mineola, New York

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York

Columbia University/Herbert Irving Cancer Center, New York, New York

Memorial Sloan-Kettering Cancer Center, New York, New York

University of Rochester, Rochester, New York

Stony Brook University Medical Center, Stony Brook, New York

State University of New York Upstate Medical University, Syracuse, New York

New York Medical College, Valhalla, New York

Mission Hospital-Memorial Campus, Asheville, North Carolina

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina

Novant Health Presbyterian Medical Center, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Sanford Medical Center-Fargo, Fargo, North Dakota

Children's Hospital Medical Center of Akron, Akron, Ohio

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Dayton Children's Hospital, Dayton, Ohio

The Toledo Hospital/Toledo Children's Hospital, Toledo, Ohio

Mercy Children's Hospital, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma

Legacy Emanuel Children's Hospital, Portland, Oregon

Legacy Emanuel Hospital and Health Center, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Geisinger Medical Center, Danville, Pennsylvania

Penn State Hershey Children's Hospital, Hershey, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Medical University of South Carolina, Charleston, South Carolina

Palmetto Health Richland, Columbia, South Carolina

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

Greenville Cancer Treatment Center, Greenville, South Carolina

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

T C Thompson Children's Hospital, Chattanooga, Tennessee

East Tennessee Childrens Hospital, Knoxville, Tennessee

St. Jude Children's Research Hospital, Memphis, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Texas Tech University Health Science Center-Amarillo, Amarillo, Texas

Dell Children's Medical Center of Central Texas, Austin, Texas

Driscoll Children's Hospital, Corpus Christi, Texas

Medical City Dallas Hospital, Dallas, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Brooke Army Medical Center, Fort Sam Houston, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

M D Anderson Cancer Center, Houston, Texas

Covenant Children's Hospital, Lubbock, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Scott and White Memorial Hospital, Temple, Texas

Primary Children's Hospital, Salt Lake City, Utah

University of Vermont College of Medicine, Burlington, Vermont

University of Virginia Cancer Center, Charlottesville, Virginia

Inova Fairfax Hospital, Falls Church, Virginia

Childrens Hospital-King's Daughters, Norfolk, Virginia

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia

Seattle Children's Hospital, Seattle, Washington

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington

Mary Bridge Children's Hospital and Health Center, Tacoma, Washington

West Virginia University Charleston, Charleston, West Virginia

Saint Vincent Hospital, Green Bay, Wisconsin

University of Wisconsin Hospital and Clinics, Madison, Wisconsin

Midwest Children's Cancer Center, Milwaukee, Wisconsin

Sydney Children's Hospital, Randwick, New South Wales

The Children's Hospital at Westmead, Westmead, New South Wales

Princess Margaret Hospital for Children, Perth, Western Australia

Alberta Children's Hospital, Calgary, Alberta

University of Alberta Hospital, Edmonton, Alberta

British Columbia Children's Hospital, Vancouver, British Columbia

CancerCare Manitoba, Winnipeg, Manitoba

Janeway Child Health Centre, Saint John's, Newfoundland and Labrador

IWK Health Centre, Halifax, Nova Scotia

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario

Chedoke Hospital at Hamilton Health Sciences, Hamilton, Ontario

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, Ontario

Children's Hospital, London, Ontario

Hospital for Sick Children, Toronto, Ontario

The Montreal Children's Hospital of the MUHC, Montreal, Quebec

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Allan Blair Cancer Centre, Regina, Saskatchewan

Saskatoon Cancer Centre, Saskatoon, Saskatchewan

Centre Hospitalier Universitaire de Quebec, Quebec, Not set

Starship Children's Hospital, Grafton, Auckland

Christchurch Hospital, Christchurch, Not set

Conditions: Adult Rhabdomyosarcoma, Childhood Alveolar Rhabdomyosarcoma, Childhood Pleomorphic Rhabdomyosarcoma, Childhood Rhabdomyosarcoma With Mixed Embryonal and Alveolar Features, Previously Treated Childhood Rhabdomyosarcoma, Recurrent Adult Soft Tissue Sarcoma, Recurrent Childhood Rhabdomyosarcoma

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Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis

NCT00104299

Completed

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis is the most common type of small blood vessel inflammation in adults. ANCA-associated vasculitis includes Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA). Rituximab is a man-made antibody used to treat certain types of cancer. The purpose of this study is to determine the effectiveness of rituximab in treating patients with WG and MPA. Study hypothesis: Rituximab is not inferior to conventional therapy in its ab... Read More

Gender:

ALL

Ages:

15 years and above

Trial Updated:

03/23/2017

Locations: University of Alabama, Birmingham, Alabama +7 locations

Conditions: Vasculitis, Wegener's Granulomatosis, Microscopic Polyangiitis

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Allogeneic Stem Cell Transplantation for Patients With Severe Aplastic Anemia

NCT00578266

Completed

For patients with severe aplastic anemia (SAA) who have failed to respond to immunosuppressive therapy and lack an HLA identical family member, our objectives are to make an initial assessment of the safety and efficacy of allogenic stem cell transplantation from either a matched unrelated donor or a mismatched reacted donor using the conditioning regimen of Cytoxan, reduced total body irradiation (TBI) and Campath IH. The principle measures of safety and efficacy will be : 1. Patient survival... Read More

Gender:

ALL

Ages:

60 years and below

Trial Updated:

03/23/2017

Locations: Mayo Clinic, Rochester, Minnesota

Conditions: Anemia, Aplastic

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Cyclophosphamide and Anti-thymocyte Globulin Followed By Methotrexate and Cyclosporine in Preventing Chronic Graft-Versus-Host Disease in Patients With Severe Aplastic Anemia Undergoing Donor Bone Marrow Transplant

NCT00343785

Completed

This clinical trial is studying how well giving cyclophosphamide together with anti-thymocyte globulin followed by methotrexate and cyclosporine works in preventing chronic graft-vs-host disease (GVHD) in patients with severe aplastic anemia undergoing donor bone marrow transplant. Giving low doses of chemotherapy, such as cyclophosphamide, before a donor bone marrow transplant helps stop the growth of abnormal cells. It also stops the patient's immune system from rejecting the donor's stem cell... Read More

Gender:

ALL

Ages:

65 years and below

Trial Updated:

03/16/2017

Locations: Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah +2 locations

Conditions: Aplastic Anemia

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Phase II ABT-888 With Cyclophosphamide

NCT01306032

Completed

Background: - The experimental cancer treatment drug ABT-888 (Veliparib) works by preventing deoxyribonucleic acid (DNA) repair in tumor cells. Cyclophosphamide is a cancer treatment drug that works by causing DNA damage in cells, including cancer cells, resulting in cell death. However, because cyclophosphamide has strong and unpleasant side effects, researchers are interested in finding drugs that can be given in combination with cyclophosphamide that will allow a lower dose of cyclophosphamide to be given with similar effects. The combination of ABT-88 and cyclophosphamide may be an effective treatment for some types of cancer, such as certain kinds of breast or ovarian cancer and non-Hodgkin's lymphoma that often do not respond to standard therapies. Objectives: - To evaluate the safety and effectiveness of ABT-888 and cyclophosphamide in ovarian and breast cancer and in non-Hodgkin's lymphoma that have not responded to standard treatments. Eligibility: - Individuals at least 18 years of age who have been diagnosed with (1) (Breast cancer 1/2) BRCA1/2 ovarian cancer, primary peritoneal or ovarian high-grade carcinoma, or fallopian tube cancer; (2) triple-negative breast cancer (not responsive to hormone-related therapy); or (3) low grade non-Hodgkin's lymphoma. Design: * Participants will be screened with a full medical history and physical examination, blood and urine tests, and tumor imaging studies. Participants will be divided into two groups with different treatment subgroups. * Group 1: Participants who have BRCA-positive ovarian cancer, primary peritoneal or ovarian high-grade serous carcinoma, or fallopian tube cancer * Participants will receive either the combination of ABT-888 and cyclophosphamide, or cyclophosphamide alone. * Participants will take the study drug by mouth once a day for 21-day cycles of treatment, and will keep a diary to record drug doses and any side effects. * Participants will have clinic visits with blood and urine tests, imaging studies, and other examinations on days 1, 2, 7, and 14 of cycle 1, and on the first day of all other cycles. * Group 2: Participants who have triple-negative breast cancer or non-Hodgkin's lymphoma * Participants will receive either the combination of ABT-888 and cyclophosphamide, or cyclophosphamide alone. * Participants will take the study drug by mouth once a day for 21-day cycles of treatment, and will keep a diary to record drug doses and any side effects. * Participants will have clinic visits with blood and urine tests, imaging studies, and other examinations on days 1, 2, 7, and 14 of cycle 1, and on the first day of all other cycles. * Participants receiving only cyclophosphamide who show signs of disease progression after tumor imaging studies can receive the combination of ABT-888 with cyclophosphamide. * Treatment will continue as long as participants tolerate the drugs and the disease does not progress. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/16/2017

Locations: University of California, Davis, Davis, California +9 locations

Conditions: Ovarian Cancer, Primary Peritoneal Cancer, Serous Carcinoma Cancer, Triple-Negative Breast Cancer, Fallopian Tube Cancer

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Chemotherapy With or Without Additional Chemotherapy and/or Radiation Therapy in Treating Children With Newly Diagnosed Hodgkin's Disease

NCT00025259

Completed

This randomized phase III trial is studying different chemotherapy regimens given with or without radiation therapy to compare how well they work in treating children with newly diagnosed Hodgkin's disease. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving the drugs in different combinations may kill more cancer cells. Radiation therapy uses high-energy x-rays to damage cancer cells. It is not yet known if chemotherapy is more ef... Read More

Gender:

ALL

Ages:

21 years and below

Trial Updated:

03/15/2017

Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +174 locations

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

Phoenix Childrens Hospital, Phoenix, Arizona

University of Arkansas for Medical Sciences, Little Rock, Arkansas

Southern California Permanente Medical Group, Downey, California

City of Hope Comprehensive Cancer Center, Duarte, California

Loma Linda University Medical Center, Loma Linda, California

Children's Hospital Los Angeles, Los Angeles, California

Cedars-Sinai Medical Center, Los Angeles, California

David Geffen School of Medicine at UCLA, Los Angeles, California

Children's Hospital Central California, Madera, California

Kaiser Permanente-Oakland, Oakland, California

Children's Hospital of Orange County, Orange, California

University of California Davis Comprehensive Cancer Center, Sacramento, California

Rady Children's Hospital - San Diego, San Diego, California

Santa Barbara Cottage Hospital, Santa Barbara, California

Children's Hospital Colorado, Aurora, Colorado

Yale University, New Haven, Connecticut

Alfred I duPont Hospital for Children, Wilmington, Delaware

Children's National Medical Center, Washington, District of Columbia

Broward Health Medical Center, Fort Lauderdale, Florida

Lee Memorial Health System, Fort Myers, Florida

University of Florida, Gainesville, Florida

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

Nicklaus Children's Hospital, Miami, Florida

Baptist Hospital of Miami, Miami, Florida

Florida Hospital Orlando, Orlando, Florida

Nemours Children's Clinic - Orlando, Orlando, Florida

All Children's Hospital, Saint Petersburg, Florida

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida

Saint Mary's Hospital, West Palm Beach, Florida

Georgia Regents University Medical Center, Augusta, Georgia

University of Hawaii Cancer Center, Honolulu, Hawaii

Saint Luke's Mountain States Tumor Institute, Boise, Idaho

Lurie Children's Hospital-Chicago, Chicago, Illinois

University of Illinois, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Loyola University Medical Center, Maywood, Illinois

Advocate Lutheran General Hospital, Park Ridge, Illinois

Saint Jude Midwest Affiliate, Peoria, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana

Blank Children's Hospital, Des Moines, Iowa

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Kosair Children's Hospital, Louisville, Kentucky

Tulane University Health Sciences Center, New Orleans, Louisiana

Children's Hospital New Orleans, New Orleans, Louisiana

Eastern Maine Medical Center, Bangor, Maine

Sinai Hospital of Baltimore, Baltimore, Maryland

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Baystate Medical Center, Springfield, Massachusetts

University of Massachusetts Medical School, Worcester, Massachusetts

C S Mott Children's Hospital, Ann Arbor, Michigan

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan

Saint John Hospital and Medical Center, Detroit, Michigan

Michigan State University Clinical Center, East Lansing, Michigan

Hurley Medical Center, Flint, Michigan

Kalamazoo Center for Medical Studies, Kalamazoo, Michigan

William Beaumont Hospital-Royal Oak, Royal Oak, Michigan

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota

University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota

Mayo Clinic, Rochester, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

University of Missouri - Ellis Fischel, Columbia, Missouri

The Childrens Mercy Hospital, Kansas City, Missouri

Cardinal Glennon Children's Medical Center, Saint Louis, Missouri

Washington University School of Medicine, Saint Louis, Missouri

University of Nebraska Medical Center, Omaha, Nebraska

Nevada Cancer Research Foundation CCOP, Las Vegas, Nevada

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Hackensack University Medical Center, Hackensack, New Jersey

Saint Peter's University Hospital, New Brunswick, New Jersey

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

Saint Joseph's Regional Medical Center, Paterson, New Jersey

Overlook Hospital, Summit, New Jersey

University of New Mexico Cancer Center, Albuquerque, New Mexico

Albany Medical Center, Albany, New York

Montefiore Medical Center - Moses Campus, Bronx, New York

Brooklyn Hospital Center, Brooklyn, New York

Roswell Park Cancer Institute, Buffalo, New York

Winthrop University Hospital, Mineola, New York

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York

Mount Sinai Medical Center, New York, New York

Columbia University/Herbert Irving Cancer Center, New York, New York

Weill Medical College of Cornell University, New York, New York

University of Rochester, Rochester, New York

Stony Brook University Medical Center, Stony Brook, New York

State University of New York Upstate Medical University, Syracuse, New York

New York Medical College, Valhalla, New York

Mission Hospital-Memorial Campus, Asheville, North Carolina

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina

Novant Health Presbyterian Medical Center, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

East Carolina University, Greenville, North Carolina

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Sanford Medical Center-Fargo, Fargo, North Dakota

Children's Hospital Medical Center of Akron, Akron, Ohio

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Dayton Children's Hospital, Dayton, Ohio

The Toledo Hospital/Toledo Children's Hospital, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma

Legacy Emanuel Hospital and Health Center, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania

Geisinger Medical Center, Danville, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Medical University of South Carolina, Charleston, South Carolina

Palmetto Health Richland, Columbia, South Carolina

Greenville Cancer Treatment Center, Greenville, South Carolina

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

T C Thompson Children's Hospital, Chattanooga, Tennessee

East Tennessee Childrens Hospital, Knoxville, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Texas Tech University Health Science Center-Amarillo, Amarillo, Texas

Dell Children's Medical Center of Central Texas, Austin, Texas

Driscoll Children's Hospital, Corpus Christi, Texas

Medical City Dallas Hospital, Dallas, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

M D Anderson Cancer Center, Houston, Texas

Covenant Children's Hospital, Lubbock, Texas

Methodist Children's Hospital of South Texas, San Antonio, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Scott and White Memorial Hospital, Temple, Texas

Primary Children's Hospital, Salt Lake City, Utah

University of Vermont College of Medicine, Burlington, Vermont

University of Virginia Cancer Center, Charlottesville, Virginia

Inova Fairfax Hospital, Falls Church, Virginia

Childrens Hospital-King's Daughters, Norfolk, Virginia

Naval Medical Center - Portsmouth, Portsmouth, Virginia

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia

Carilion Clinic Children's Hospital, Roanoke, Virginia

Seattle Children's Hospital, Seattle, Washington

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington

Mary Bridge Children's Hospital and Health Center, Tacoma, Washington

Madigan Army Medical Center, Tacoma, Washington

West Virginia University Charleston, Charleston, West Virginia

Saint Vincent Hospital, Green Bay, Wisconsin

University of Wisconsin Hospital and Clinics, Madison, Wisconsin

Marshfield Clinic, Marshfield, Wisconsin

Midwest Children's Cancer Center, Milwaukee, Wisconsin

Royal Brisbane and Women's Hospital, Herston, Queensland

Women's and Children's Hospital-Adelaide, North Adelaide, South Australia

Princess Margaret Hospital for Children, Perth, Western Australia

Alberta Children's Hospital, Calgary, Alberta

University of Alberta Hospital, Edmonton, Alberta

British Columbia Children's Hospital, Vancouver, British Columbia

CancerCare Manitoba, Winnipeg, Manitoba

Janeway Child Health Centre, Saint John's, Newfoundland and Labrador

IWK Health Centre, Halifax, Nova Scotia

Chedoke Hospital at Hamilton Health Sciences, Hamilton, Ontario

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, Ontario

Children's Hospital of Eastern Ontario, Ottawa, Ontario

Hospital for Sick Children, Toronto, Ontario

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Allan Blair Cancer Centre, Regina, Saskatchewan

Saskatoon Cancer Centre, Saskatoon, Saskatchewan

Centre Hospitalier Universitaire de Quebec, Quebec, Not set

Schneider Children's Medical Center of Israel, Petah Tikua, Not set

Starship Children's Hospital, Grafton, Auckland

Christchurch Hospital, Christchurch, Not set

San Jorge Children's Hospital, San Juan, Not set

Swiss Pediatric Oncology Group - Geneva, Geneva, Not set

Conditions: Childhood Lymphocyte-Depleted Classical Hodgkin Lymphoma, Childhood Mixed Cellularity Classical Hodgkin Lymphoma, Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma, Childhood Nodular Sclerosis Classical Hodgkin Lymphoma, Stage I Childhood Hodgkin Lymphoma, Stage II Childhood Hodgkin Lymphoma, Stage III Childhood Hodgkin Lymphoma, Stage IV Childhood Hodgkin Lymphoma

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