Phase II Study of Bone Marrow Transplantation Using Related Donors in Patients With Aplastic Anemia
NCT00004323
Completed
OBJECTIVES: I. Evaluate the efficacy of related, HLA-identical bone marrow transplantation following cyclophosphamide (CTX) and antithymocyte globulin in patients with aplastic anemia. II. Evaluate the efficacy of related, HLA-nonidentical bone marrow transplantation following CTX and total-body irradiation/total-lymphoid irradiation in patients with aplastic anemia.
Gender:
ALL
Ages:
Between 0 years and 55 years
Trial Updated:
06/23/2005
Locations: Center for Health Sciences, Los Angeles, California
Conditions: Aplastic Anemia
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Study of Allogeneic Bone Marrow Transplantation Following Cyclophosphamide and Radiotherapy in Patients With Fanconi's Anemia
NCT00005891
Completed
OBJECTIVES: I. Determine the effectiveness of moderate dose cyclophosphamide and total lymphoid radiotherapy in terms of improving the survival and reducing the morbidity following allogeneic bone marrow transplantation in patients with Fanconi's aplastic anemia.
Gender:
ALL
Ages:
Between 0 years and 54 years
Trial Updated:
06/23/2005
Locations: Fairview University Medical Center, Minneapolis, Minnesota
Conditions: Fanconi's Anemia
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Study of Allogeneic Bone Marrow and T-Cell Depleted, CD34+ Peripheral Blood Stem Cell Transplantation in Patients With Aplastic Anemia
NCT00017654
Unknown
OBJECTIVES: I. Determine the effect of supplementation with donor T-cell depleted, CD34+ peripheral blood stem cells on durable engraftment and incidence of graft-versus-host disease in patients with aplastic anemia undergoing allogeneic bone marrow transplantation.
Gender:
ALL
Ages:
Between 15 years and 55 years
Trial Updated:
06/23/2005
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Graft Versus Host Disease, Aplastic Anemia
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Study of Allogeneic Bone Marrow Transplantation Following Cyclophosphamide and Radiotherapy in Patients With Myelodysplastic Syndrome and Acute Leukemia Related to Fanconi's Anemia
NCT00005892
Completed
OBJECTIVES: I. Determine the effectiveness of moderate dose cyclophosphamide and radiotherapy in terms of improving survival and reducing the morbidity following allogeneic bone marrow transplantation in patients with myelodysplastic syndrome and acute leukemia related to Fanconi's anemia.
Gender:
ALL
Ages:
Between 0 years and 54 years
Trial Updated:
06/23/2005
Locations: Fairview University Medical Center, Minneapolis, Minnesota
Conditions: Fanconi's Anemia, Myelodysplastic Syndromes, Leukemia, Nonlymphocytic, Acute, Leukemia, Lymphocytic, Acute
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Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders
NCT00005893
Completed
OBJECTIVES: I. Determine the efficacy of bone marrow transplantation using matched related donors in patients with nonmalignant hematologic disorders. II. Determine the quality of life, absence of adverse effects (e.g., graft versus host disease and B cell lymphoproliferative disease), and completeness of recovery of their underlying condition in these patients with this treatment regimen.
Gender:
ALL
Ages:
0 years and above
Trial Updated:
06/23/2005
Locations: Fairview University Medical Center, Minneapolis, Minnesota
Conditions: Neutropenia, Sickle Cell Anemia, Thalassemia Major, Red-Cell Aplasia, Pure
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Safety and Efficacy Study of Iodine-131 Anti-B1 Antibody Plus CHOP For Untreated Mantle Cell Lymphoma
NCT00022945
Completed
The purpose of this study is to test the safety of Iodine-131 Anti-B1 Antibody followed by CHOP and to see what effects it has on patients with previously untreated mantel cell lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2005
Locations: Rush-Presbyterian-St. Lukes Medical Center, Chicago, Illinois +2 locations
Conditions: Mantle Cell Lymphoma
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Phase I/II Study of Total Body Irradiation, Cyclophosphamide, and Fludarabine Followed by Alternate Donor Hematopoietic Cell Transplantation in Patients With Fanconi's Anemia
NCT00005898
Completed
OBJECTIVES: I. Determine the probability of engraftment with total body irradiation, cyclophosphamide, fludarabine, and anti-thymocyte globulin followed by HLA nongenotypically identical donor, T-cell depleted hematopoietic cell transplantation in patients with Fanconi's anemia. II. Determine the incidence of acute and chronic graft-versus-host disease in these patients after undergoing this treatment regimen. III. Determine the one-year survival rate in these patients after undergoing this tr... Read More
Gender:
ALL
Ages:
Between 0 years and 34 years
Trial Updated:
06/23/2005
Locations: University of Minnesota Cancer Center, Minneapolis, Minnesota
Conditions: Fanconi's Anemia
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Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases
NCT00006055
Unknown
OBJECTIVES: I. Determine whether there is prompt engraftment after autologous peripheral blood stem cell transplantation using filgrastim (G-CSF) mobilization in patients with life threatening autoimmune diseases. II. Determine the kinetics of T- and B-cell immune reconstitution after a combination of timed plasmapheresis, high dose cyclophosphamide and total lymphoid irradiation, and posttransplant immunosuppression with cyclosporine in these patients. III. Determine whether this treatment re... Read More
Gender:
ALL
Ages:
Between 1 year and 55 years
Trial Updated:
06/23/2005
Locations: Fairview University Medical Center, Minneapolis, Minnesota
Conditions: Purpura, Schoenlein-Henoch, Graft Versus Host Disease, Anemia, Hemolytic, Autoimmune, Rheumatoid Arthritis, Churg-Strauss Syndrome, Hypersensitivity Vasculitis, Wegener's Granulomatosis, Systemic Lupus Erythematosus, Giant Cell Arteritis, Pure Red Cell Aplasia, Juvenile Rheumatoid Arthritis, Polyarteritis Nodosa, Autoimmune Thrombocytopenic Purpura, Takayasu Arteritis
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