Cyclophosphamide Treatment Options

A collection of 2185 research studies where Cyclophosphamide is the interventional treatment. These studies are located in the United States . Cyclophosphamide is used for conditions such as Breast Cancer, Lymphoma and Leukemia.

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Featured Trial

Healthy Participants Needed (Colonoscopy + Cancer Screening)

Recruiting

Earn $325 - $475 in electronic payment card compensation for your time and effort by participating in a clinical study to develop a blood test that may one day help screen for colon cancer. Take a quick quiz to see if you qualify.

Conditions:

Healthy

Healthy Volunteers

Healthy Subjects

Healthy Volunteer

Healthy Participants

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Featured Trial

Buy Retatrutide Online Through Celia

Recruiting

Retatrutide (formerly M25) is an investigational peptide being studied for its potential in supporting weight management and metabolic health. It acts on GLP-1, GIP, and glucagon receptors to influence appetite, energy regulation, and fat metabolism.

Conditions:

Healthy

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Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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Featured Trial

Birth Control Clinical Research Study

Recruiting

Living with obesity and looking for a birth control option that is right for you? Clinical trials are now enrolling women with a body mass index (BMI) of 30 or more in the area to help study a potential new progestin-only contraceptive patch. Participating in research studies can help advance birth control options. Don’t let financial stress hold you back. All study-related assessments, care, and study patch are available at no cost. You may also be reimbursed for study-related travel.

Conditions:

Obesity

Overweight

Overweight and Obesity

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Liver Transplantation With Tregs at MGH

NCT03577431

Active Not Recruiting

This is a single-center, prospective, open-label, non-randomized clinical trial exploring cellular therapy to facilitate immunosuppression withdrawal in liver transplant recipients.

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

01/10/2025

Locations: Massachusetts General Hospital: Transplantation, Boston, Massachusetts

Conditions: Liver Transplant

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TGF-beta Resistant Cytotoxic T-lymphocytes in Treatment of EBV-positive Nasopharyngeal Carcinoma / RESIST-NPC

NCT02065362

Active Not Recruiting

Patients have nasopharyngeal carcinoma (NPC). This study is a gene transfer research study using special immune cells. Most patients with NPC show evidence of infection with the virus that causes infectious mononucleosis Epstein Barr virus (EBV) before or at the time of their diagnosis. EBV is found in the cancer cells of almost all patients with advanced stage NPC, suggesting that it may play a role in causing the disease. The cancer cells infected by EBV are able to hide from the body's immune system and escape destruction. We want to see if special white blood cells, called T cells, that have been trained to recognize and kill special parts of EBV infected cells can survive in patient's blood and affect the tumor. We already have given EBV-specific cytotoxic T cells to 30 patients with active NPC and have seen anti-tumor activity in 14 of 30 patients. We are now trying to find out if we can improve this treatment. First, we want to give T cells where more of the cells recognize at least two of the four EBV proteins expressed on NPC cells. We call these cells NPC-specific cytotoxic T cells. Second, we found that T cells work better if we add a receptor to the T cells called DNR (Dominant Negative Receptor). DNR makes T cells resistant to TGFbeta, a factor secreted by cancer cells that helps them escape being killed by the immune system. In this study we will therefore place the DNR gene into NPC-specific T cells (DNR.NPC-specific T cells). In other clinical studies using T cells, some investigators found that giving chemotherapy before the T cell infusion can improve the amount of time the T cells stay in the body and therefore the effect the T cells can have. Giving chemotherapy before a T cell infusion is called lymphodepletion since the chemotherapy is specifically chosen to decrease the number of lymphocytes in the body. Decreasing the number of patient's lymphocytes first should allow the T cells we infuse to expand and stay longer in their body, and potentially kill cancer cells more effectively. The chemotherapy we will use for lymphodepletion is a combination of cyclophosphamide and fludarabine. Cyclophosphamide and fludarabine are the chemotherapy agents most commonly used for lymphodepletion in immunotherapy clinical trials. Read Less

Gender:

ALL

Ages:

All

Trial Updated:

01/08/2025

Locations: Texas Children's Hospital, Houston, Texas

Conditions: EBV-positive Nasopharyngeal Carcinoma

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Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-522/KEYNOTE-522)

NCT03036488

Active Not Recruiting

The purpose of this study is to evaluate the efficacy and safety of pembrolizumab (MK-3475) plus chemotherapy vs placebo plus chemotherapy as neoadjuvant therapy and pembrolizumab vs placebo as adjuvant therapy in participants who have triple negative breast cancer (TNBC). After a screening phase of approximately 28 days, each participant will receive neoadjuvant study treatment (Pembrolizumab + Chemotherapy OR Placebo + Chemotherapy) based on the randomization schedule for approximately 24 wee... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/08/2025

Locations: Virginia G. Piper Cancer Center Pharmacy - Scottsdale Healthcare ( Site 0089), Scottsdale, Arizona +192 locations

Virginia G. Piper Cancer Center Pharmacy - Scottsdale Healthcare ( Site 0089), Scottsdale, Arizona

Arizona Oncology Associates PC- HOPE ( Site 8001), Tucson, Arizona

Cedars Sinai Medical Center ( Site 0091), Los Angeles, California

Pacific Cancer Care ( Site 0069), Monterey, California

ICRI ( Site 0072), Whittier, California

University of Colorado Cancer Center ( Site 0021), Aurora, Colorado

Yale University School of Medicine ( Site 0054), New Haven, Connecticut

Christiana Hospital ( Site 0029), Newark, Delaware

Univ of Miami-Sylvester Comprehensive Cancer Center- Kendall satellite ( Site 0079), Miami, Florida

The University of Chicago Medical Center ( Site 0047), Chicago, Illinois

North Shore University Health System ( Site 0081), Evanston, Illinois

Orchard Healthcare Research Inc. ( Site 0049), Skokie, Illinois

Goshen Center for Cancer Care ( Site 0010), Goshen, Indiana

University of Iowa Hospital and Clinics ( Site 0038), Iowa City, Iowa

New England Cancer Specialists ( Site 0005), Scarborough, Maine

Henry Ford Hospital ( Site 0003), Detroit, Michigan

Minnesota Oncology Hematology, PA ( Site 8013), Minneapolis, Minnesota

Rutgers Cancer Institute of New Jersey ( Site 0073), New Brunswick, New Jersey

Broome Oncology, LLC ( Site 8002), Johnson City, New York

Nyack Hospital Infusion Center ( Site 0059), Nyack, New York

TriHealth Cancer Institute-Good Samaritan Hospital ( Site 0044), Cincinnati, Ohio

Oncology Hematology Care, Inc. ( Site 8011), Cincinnati, Ohio

Providence Portland Medical Center ( Site 0052), Portland, Oregon

Northwest Cancer Specialists, P.C. ( Site 8008), Portland, Oregon

Magee - Women's Hospital ( Site 0011), Pittsburgh, Pennsylvania

Rhode Island Hospital ( Site 0060), Providence, Rhode Island

The West Clinic, P.C. ( Site 0078), Germantown, Tennessee

Texas Oncology-Austin Central ( Site 8005), Austin, Texas

Parkland Health and Hospital System ( Site 0093), Dallas, Texas

Texas Oncology-Baylor Charles A. Sammons Cancer Center ( Site 8006), Dallas, Texas

Simmons Cancer Center ( Site 0094), Dallas, Texas

UT Southwestern Medical Center ( Site 0030), Dallas, Texas

Moncrief Cancer Institute ( Site 0092), Fort Worth, Texas

Texas Oncology-Memorial City ( Site 8003), Houston, Texas

Houston Methodist Cancer Center ( Site 0013), Houston, Texas

Texas Oncology- Plano East ( Site 8010), Plano, Texas

Texas Oncology-San Antonio Northeast ( Site 8012), San Antonio, Texas

Texas Oncology-Tyler ( Site 8007), Tyler, Texas

University of Virginia ( Site 0022), Charlottesville, Virginia

Virginia Cancer Specialists, PC ( Site 8009), Fairfax, Virginia

Bon Secours Cancer Institute Medical Oncology at St. Mary's ( Site 0033), Midlothian, Virginia

Peninsula Cancer Institute, LLC ( Site 0041), Newport News, Virginia

Virginia Oncology Associates ( Site 8000), Norfolk, Virginia

Kadlec Clinic Hematology and Oncology ( Site 0087), Kennewick, Washington

Seattle Cancer Care Alliance ( Site 0068), Seattle, Washington

Medical Oncology Associates (Summit Cancer Centers) ( Site 0014), Spokane, Washington

YVMH dba Vrigina Mason Memorial/North Star Lodge Cancer Center ( Site 8004), Yakima, Washington

Royal North Shore Hospital ( Site 2000), Sydney, New South Wales

Westmead Hospital ( Site 2002), Sydney, New South Wales

Royal Adelaide Hospital ( Site 2008), Adelaide, South Australia

Cabrini Health ( Site 2009), East Malvern, Victoria

Frankston Hospital ( Site 2010), Franskton, Not set

Royal Brisbane and Women s Hospital ( Site 2003), Herston, Not set

St John of God Subiaco Hospital ( Site 2006), Perth, Not set

Hospital Nossa Senhora da Conceicao ( Site 0203), Porto Alegre, Rio Grande Do Sul

UOPECCAN - Uniao Oeste Paranaense de Estudos e Combate ao Cancer ( Site 0206), Cascavel, Not set

Universidade de Caxias do Sul ( Site 0201), Caxias do Sul, Not set

Hospital Erasto Gaertner ( Site 0207), Curitiba, Not set

Instituto do Cancer do Ceara ( Site 0205), Fortaleza, Not set

Hospital Araujo Jorge ( Site 0204), Goiania, Not set

Hospital Sao Lucas da PUCRS ( Site 0200), Porto Alegre, Not set

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0208), Sao Jose do Rio Preto, Not set

Instituto do Cancer de Sao Paulo - ICESP ( Site 0211), Sao Paulo, Not set

Tom Baker Cancer Centre ( Site 0105), Calgary, Alberta

The Ottawa Hospital - Cancer Care ( Site 0100), Ottawa, Ontario

Princess Margaret Cancer Centre ( Site 0103), Toronto, Ontario

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0106), Montreal, Quebec

Jewish General Hospital ( Site 0101), Montreal, Quebec

CIUSSS de l'Estrie-CHUS ( Site 0102), Sherbrooke, Quebec

CHU de Quebec Universite Laval - Hopital du Saint-Sacrement ( Site 0104), Quebec, Not set

Oncomedica S.A. ( Site 0404), Monteria, Cordoba

Oncologos del Occidente S.A. ( Site 0405), Pereira, Risaralda

Hospital Universitario San Ignacio ( Site 0401), Bogota, Not set

Instituto Nacional de Cancerologia [Bogota-Colombia] ( Site 0403), Bogota, Not set

Hemato Oncologos S.A. ( Site 0400), Cali, Not set

Instituto De Cancerologia S.A. ( Site 0406), Medellin, Not set

CHU Jean Minjoz ( Site 0917), Besancon, Not set

Polyclinique Bordeaux Nord Aquitaine ( Site 0911), Bordeaux, Not set

Centre Francois Baclesse ( Site 0907), Caen, Not set

Centre Jean Perrin ( Site 0903), Clermont-Ferrand Cedex 01, Not set

Clinique Victor Hugo ( Site 0901), Le Mans, Not set

Hopital prive du Confluent ( Site 0902), Nantes, Not set

Institut Curie ( Site 0909), Paris, Not set

Hopital Saint Louis ( Site 0908), Paris, Not set

Hopital Diaconesses Croix Saint Simon ( Site 0905), Paris, Not set

CHU de la Miletrie Poitiers ( Site 0913), Poitiers, Not set

Institut Claudius Regaud IUCT Oncopole ( Site 0914), Toulouse Cedex 9, Not set

HELIOS Klinikum Berlin-Buch ( Site 1005), Berlin, Not set

Gynaekologisches Zentrum ( Site 1004), Bonn, Not set

Universitaetsklinikum Erlangen ( Site 1001), Erlangen, Not set

Kliniken Essen Mitte ( Site 1012), Essen, Not set

Universitaetsklinik und Poliklinik Halle/Saale ( Site 1008), Halle, Not set

Universitaetsklinikum Hamburg-Eppendorf ( Site 1007), Hamburg, Not set

Klinikum der Universit. Muenchen ( Site 1002), Muenchen, Not set

Caritasklinik St. Theresia ( Site 1011), Saarbruecken, Not set

Universitaets-Frauenklinik Tuebingen ( Site 1003), Tubingen, Not set

Bon Secours Hospital ( Site 1551), Cork, Not set

St Vincents University Hospital ( Site 1550), Dublin, Not set

Oncology institute ( Site 1601), Beer Sheva, Not set

Assaf Harofeh MC ( Site 1605), Beer Yaakov-Zerifin, Not set

Hadassah Ein Karem - Sharett Institute of Oncology ( Site 1600), Jerusalem, Not set

Rabin-Medical Center ( Site 1604), Petah Tikva, Not set

Sheba Medical Center ( Site 1602), Ramat-Gan, Not set

Sourasky Medical Center ( Site 1603), Tel Aviv, Not set

Istituto Scientifico Romagnolo per Studio e Cura Tumori IRST ( Site 1101), Meldola, FC

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 1103), Brescia, Not set

Ospedale San Luca, AZIENDA USL2 TOSCANA NORD OVEST ( Site 1105), Lucca, Not set

Ospedale Civile di Macerata ( Site 1104), Macerata, Not set

Istituto Europeo di Oncologia ( Site 1106), Milano, Not set

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1102), Napoli, Not set

Aichi Cancer Center Hospital ( Site 2502), Nagoya, Aichi

National Cancer Center Hospital East ( Site 2518), Kashiwa, Chiba

National Hospital Organization Hokkaido Cancer Center ( Site 2512), Sapporo, Hokkaido

Hyogo College of Medicine Hospital ( Site 2506), Nishinomiya, Hyogo

Tokai University Hospital ( Site 2517), Isehara, Kanagawa

St. Marianna University School of Medicine Hospital ( Site 2516), Kawasaki, Kanagawa

Kindai University Hospital ( Site 2507), Osakasayama, Osaka

Saitama Medical University International Medical Center ( Site 2513), Hidaka, Saitama

Saitama Cancer Center ( Site 2510), Kitaadachi-gun, Saitama

Shizuoka Cancer Center Hospital and Research Institute ( Site 2514), Sunto-gun, Shizuoka

Chiba Cancer Center ( Site 2519), Chiba, Not set

Hiroshima City Hiroshima Citizens Hospital ( Site 2501), Hiroshima, Not set

Social medical corporation Hakuaikai Sagara Hospital ( Site 2508), Kagoshima, Not set

Kumamoto University Hospital ( Site 2515), Kumamoto, Not set

National Hospital Organization Osaka National Hospital ( Site 2505), Osaka, Not set

National Cancer Center Hospital ( Site 2500), Tokyo, Not set

St.Luke's International Hospital ( Site 2511), Tokyo, Not set

Toranomon Hospital ( Site 2503), Tokyo, Not set

The Cancer Institute Hospital of JFCR ( Site 2509), Tokyo, Not set

Seoul National University Hospital ( Site 2101), Seoul, Not set

Severance Hospital Yonsei University Health System ( Site 2100), Seoul, Not set

Asan Medical Center ( Site 2102), Seoul, Not set

Samsung Medical Center ( Site 2103), Seoul, Not set

Mazowiecki Szpital Onkologiczny ( Site 1713), Wieliszew, Mazowieckie

Centrum Onkologii Instytut im. Marii Skłodowskiej Curie ( Site 1717), Gliwice, Slaskie

Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1708), Bydgoszcz, Not set

Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1712), Bydgoszcz, Not set

Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1701), Gdynia, Not set

Centrum Onkologii Instytut im. Marii Sklodowskiej Curie ( Site 1719), Krakow, Not set

Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli ( Site 1700), Lublin, Not set

Dolnoslaskie Centrum Onkologii. ( Site 1702), Wroclaw, Not set

Fundacao Champalimaud ( Site 2444), Lisboa, Not set

Hospital de Santa Maria, E.P.E. ( Site 2445), Lisboa, Not set

Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2446), Porto, Not set

Arkhangelsk Clinical Oncological Dispensary ( Site 1810), Arkhangelsk, Not set

Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1805), Chelyabinsk, Not set

Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1806), Kazan, Not set

Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1801), Moscow, Not set

GBU RO Regional Clinical Oncological Dispensary ( Site 1808), Ryazan, Not set

Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1803), Saint Petersburg, Not set

Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1804), Ufa, Not set

National Cancer Centre Singapore ( Site 2600), Singapore, Not set

ICO L Hospitalet ( Site 1305), Hospitalet de Llobregat, Barcelona

Hospital Quiron de Madrid ( Site 1303), Pozuelo de Alarcon, Madrid

Hospital del Mar ( Site 1306), Barcelona, Not set

Instituto Oncologico Baselga.Hospital Quiron. ( Site 1312), Barcelona, Not set

Hospital General Universitari Vall d Hebron ( Site 1301), Barcelona, Not set

Hospital Universitario Reina Sofia ( Site 1304), Cordoba, Not set

Hospital Universitario Ramon y Cajal ( Site 1300), Madrid, Not set

Complejo Hospitalario Universitario de Santiago ( Site 1308), Santiago de Compostela, Not set

Hospital Universitario Virgen del Rocio ( Site 1314), Sevilla, Not set

Hospital Clinico Univ de Valencia ( Site 1313), Valencia, Not set

Linkopings Universitetssjukhus ( Site 1402), Linkoping, Not set

Karolinska Universitetssjukhuset Solna ( Site 1404), Solna, Not set

Norrlands Universitetssjukhus ( Site 1401), Umea, Not set

Akademiska Sjukhuset ( Site 1403), Uppsala, Not set

Taipei Veterans General Hospital ( Site 2302), Taipei, Beitou

National Cheng Kung University Hospital ( Site 2305), Tainan, Not set

National Taiwan University Hospital ( Site 2301), Taipei, Not set

MacKay Memorial Hospital ( Site 2303), Taipei, Not set

Koo Foundation Sun Yat-Sen Cancer Center ( Site 2304), Taipei, Not set

Linkou Chang Gung Memorial Hospital ( Site 2300), Taoyuan, Not set

Samsun Ondokuz Mayıs Universitesi Tıp Fakultesi Hastanesi ( Site 1910), Samsun, Atakum

Adana Acıbadem Hospital Department of Medical Oncology ( Site 1906), Adana, Not set

Baskent Unıversity Adana Kısla Hospital ( Site 1903), Adana, Not set

Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1912), Ankara, Not set

Abdurrahman Yurtaslan Oncology Training and Research Hospital ( Site 1909), Ankara, Not set

Ozel Medicana International Ankara Hastanesi ( Site 1915), Ankara, Not set

Antalya Memorial Hospital Department of Medical Oncology ( Site 1908), Antalya, Not set

Trakya University Medical Faculty Balkan Oncology Hospital ( Site 1901), Edirne, Not set

Acibadem Altunizade Hastanesi ( Site 1900), Istambul, Not set

İstanbul University Cerrahpaşa Medical Faculty ( Site 1904), Istanbul, Not set

Amerikan Hospital Medical ( Site 1902), Istanbul, Not set

Memorial Sisli Hastanesi ( Site 1913), Istanbul, Not set

Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 1905), Izmir, Not set

Izmir Medical Park Hospital Department of Medical Oncology ( Site 1907), Izmir, Not set

Colchester General Hospital ( Site 1508), Colchester, Essex

Barts Cancer Institute ( Site 1500), London, Not set

St George s Hospital ( Site 1516), London, Not set

Maidstone Hospital ( Site 1511), Maidstone, Not set

The James Cook University Hospital ( Site 1515), Middlesbrough, Not set

Nottingham University Hospitals NHS Trust ( Site 1505), Nottingham, Not set

Royal Cornwall Hospitals NHS Trust ( Site 1504), Truro, Not set

Conditions: Triple Negative Breast Neoplasms

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Autologous Stem Cell Transplantation for Crohn's Disease

NCT00692939

Recruiting

The objective of this study is to evaluate the safety and effectiveness of administering high-dose chemotherapy followed by infusion of autologous CD34-selected peripheral blood stem cells (PBSC) in pediatric and adult patients with severe Crohn's disease.

Gender:

ALL

Ages:

Between 10 years and 60 years

Trial Updated:

01/07/2025

Locations: UPMC Prebyterian- Adult Gastroenterology, Pittsburgh, Pennsylvania +1 locations

Conditions: Crohn's Disease

Learn More ›

Cyclophosphamide and Dexamethasone for the Treatment of Metastatic Castration Resistant Prostate Cancer

NCT05479578

Active Not Recruiting

This phase I trial tests the safety and side effects of cyclophosphamide given together with dexamethasone in treating patients with castration resistant prostate cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving low doses of cyclophosphamide daily may reduce side effects. Dex... Read More

Gender:

MALE

Ages:

18 years and above

Trial Updated:

01/06/2025

Locations: University of California Davis Comprehensive Cancer Center, Sacramento, California

Conditions: Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma, Stage IVB Prostate Cancer American Joint Committee on Cancer (AJCC) v8

Learn More ›

Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation

NCT01746849

Active Not Recruiting

The purpose of this study is to help determine if palifermin and leuprolide acetate can help the immune system recover faster following a stem cell transplant. Blood stem cells are very young blood cells that grow in the body to become red or white blood cells or platelets. The transplant uses stem cells in the blood from another person. The donor can be a family member or a volunteer donor. This is called an allogeneic stem cell transplant. The investigators want to see if palifermin and leupr... Read More

Gender:

ALL

Ages:

Between 18 years and 60 years

Trial Updated:

01/06/2025

Locations: Memorial Sloan Kettering Cancer Center, New York, New York

Conditions: Leukemia, Multiple Myeloma, Myelodysplastic Syndrome, Non-Hodgkin's Lymphoma

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A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma

NCT03758989

Recruiting

The overarching goals of this study are to measure levels of circulating tumor DNA (ctDNA) in patients with early stage diffuse large B cell lymphoma (DLBCL), to assess the change in ctDNA during treatment in order to prospectively identify markers of treatment failure, and to use ctDNA as a future tool for response adapted therapy.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/06/2025

Locations: University of Rochester, Rochester, New York

Conditions: DLBCL

Learn More ›

Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma

NCT00554788

Completed

This phase III trial is studying the side effects and how well giving combination chemotherapy together with autologous stem cell transplant and/or radiation therapy works in treating young patients with extraocular retinoblastoma. Giving chemotherapy before an autologous stem cell transplant stops the growth of tumor cells by stopping them from dividing or killing them. After treatment, stem cells are collected from the patient's blood and/or bone marrow and stored. More chemotherapy is given t... Read More

Gender:

ALL

Ages:

10 years and below

Trial Updated:

01/03/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +72 locations

Children's Hospital of Alabama, Birmingham, Alabama

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

Phoenix Childrens Hospital, Phoenix, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

University of Arkansas for Medical Sciences, Little Rock, Arkansas

Kaiser Permanente Downey Medical Center, Downey, California

Children's Hospital Los Angeles, Los Angeles, California

Lucile Packard Children's Hospital Stanford University, Palo Alto, California

UCSF Medical Center-Parnassus, San Francisco, California

UCSF Medical Center-Mission Bay, San Francisco, California

Children's Hospital Colorado, Aurora, Colorado

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado

Connecticut Children's Medical Center, Hartford, Connecticut

Alfred I duPont Hospital for Children, Wilmington, Delaware

Children's National Medical Center, Washington, District of Columbia

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

Nemours Children's Clinic - Orlando, Orlando, Florida

Nemours Children's Hospital, Orlando, Florida

Nemours Children's Clinic - Pensacola, Pensacola, Florida

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia

Lurie Children's Hospital-Chicago, Chicago, Illinois

University of Illinois, Chicago, Illinois

Riley Hospital for Children, Indianapolis, Indiana

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Walter Reed National Military Medical Center, Bethesda, Maryland

Massachusetts General Hospital Cancer Center, Boston, Massachusetts

Dana-Farber Cancer Institute, Boston, Massachusetts

University of Mississippi Medical Center, Jackson, Mississippi

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Sunrise Hospital and Medical Center, Las Vegas, Nevada

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada

Summerlin Hospital Medical Center, Las Vegas, Nevada

Nevada Cancer Research Foundation NCORP, Las Vegas, Nevada

Morristown Medical Center, Morristown, New Jersey

Memorial Sloan Kettering Cancer Center, New York, New York

New York Medical College, Valhalla, New York

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina

Novant Health Presbyterian Medical Center, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

Children's Hospital Medical Center of Akron, Akron, Ohio

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Dayton Children's Hospital, Dayton, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Penn State Children's Hospital, Hershey, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Children's Oncology Group, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Saint Jude Children's Research Hospital, Memphis, Tennessee

Medical City Dallas Hospital, Dallas, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

M D Anderson Cancer Center, Houston, Texas

Children's Hospital of San Antonio, San Antonio, Texas

Methodist Children's Hospital of South Texas, San Antonio, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Hospital de Pediatria Juan P Garrahan, Buenos Aires, Not set

The Children's Hospital at Westmead, Westmead, New South Wales

Princess Margaret Hospital for Children, Perth, Western Australia

Instituto De Oncologia Pediatrica, Sao Paulo, Not set

IWK Health Centre, Halifax, Nova Scotia

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Children's Cancer Hospital, El Saida Zenab, Cairo

Conditions: Extraocular Retinoblastoma

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Anakinra for the Reduction of CAR-T Toxicity in Patients With Relapsed or Refractory Large B-cell Lymphoma

NCT04432506

Completed

This phase II trial studies the side effects and best dose of anakinra and to see how well it works in reducing side effects (toxicity) associated with a CAR-T cell treatment called axicabtagene ciloleucel in patients with large B-cell lymphoma that has come back (relapsed) or has not responded to treatment (refractory). Anakinra is a drug typically used to treat rheumatoid arthritis but may also help in reducing CAR-T cell therapy toxicity. Giving anakinra in combination with axicabtagene cilol... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/03/2025

Locations: M D Anderson Cancer Center, Houston, Texas

Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Recurrent Diffuse Large B-Cell Lymphoma, Recurrent High Grade B-Cell Lymphoma, Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma, Refractory High Grade B-Cell Lymphoma, Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma, Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma, Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma

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Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma

NCT00085735

Completed

This randomized phase III trial is studying how well standard-dose radiation therapy works compared to reduced-dose radiation therapy in children 3-7 years of age AND how well standard volume boost radiation therapy works compared to smaller volume boost radiation therapy when given together with chemotherapy in treating young patients who have undergone surgery for newly diagnosed standard-risk medulloblastoma. Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemo... Read More

Gender:

ALL

Ages:

Between 3 years and 21 years

Trial Updated:

01/03/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +196 locations

Children's Hospital of Alabama, Birmingham, Alabama

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

Phoenix Childrens Hospital, Phoenix, Arizona

Banner University Medical Center - Tucson, Tucson, Arizona

Kaiser Permanente Downey Medical Center, Downey, California

Loma Linda University Medical Center, Loma Linda, California

Miller Children's and Women's Hospital Long Beach, Long Beach, California

Children's Hospital Los Angeles, Los Angeles, California

Cedars Sinai Medical Center, Los Angeles, California

Valley Children's Hospital, Madera, California

UCSF Benioff Children's Hospital Oakland, Oakland, California

Kaiser Permanente-Oakland, Oakland, California

Children's Hospital of Orange County, Orange, California

Lucile Packard Children's Hospital Stanford University, Palo Alto, California

Sutter Medical Center Sacramento, Sacramento, California

University of California Davis Comprehensive Cancer Center, Sacramento, California

Rady Children's Hospital - San Diego, San Diego, California

UCSF Medical Center-Parnassus, San Francisco, California

UCSF Medical Center-Mission Bay, San Francisco, California

Santa Barbara Cottage Hospital, Santa Barbara, California

Children's Hospital Colorado, Aurora, Colorado

Connecticut Children's Medical Center, Hartford, Connecticut

Yale University, New Haven, Connecticut

Alfred I duPont Hospital for Children, Wilmington, Delaware

MedStar Georgetown University Hospital, Washington, District of Columbia

Children's National Medical Center, Washington, District of Columbia

Broward Health Medical Center, Fort Lauderdale, Florida

Lee Memorial Health System, Fort Myers, Florida

Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida

University of Florida Health Science Center - Gainesville, Gainesville, Florida

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

Nicklaus Children's Hospital, Miami, Florida

AdventHealth Orlando, Orlando, Florida

Arnold Palmer Hospital for Children, Orlando, Florida

Nemours Children's Clinic - Orlando, Orlando, Florida

Orlando Health Cancer Institute, Orlando, Florida

Nemours Children's Hospital, Orlando, Florida

Nemours Children's Clinic - Pensacola, Pensacola, Florida

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida

Saint Mary's Hospital, West Palm Beach, Florida

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia

Augusta University Medical Center, Augusta, Georgia

Memorial Health University Medical Center, Savannah, Georgia

University of Hawaii Cancer Center, Honolulu, Hawaii

Kapiolani Medical Center for Women and Children, Honolulu, Hawaii

Tripler Army Medical Center, Honolulu, Hawaii

Saint Luke's Cancer Institute - Boise, Boise, Idaho

Lurie Children's Hospital-Chicago, Chicago, Illinois

University of Illinois, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Loyola University Medical Center, Maywood, Illinois

Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois

Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois

Advocate Lutheran General Hospital, Park Ridge, Illinois

Saint Jude Midwest Affiliate, Peoria, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Riley Hospital for Children, Indianapolis, Indiana

Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana

Blank Children's Hospital, Des Moines, Iowa

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Norton Children's Hospital, Louisville, Kentucky

Tulane University School of Medicine, New Orleans, Louisiana

Children's Hospital New Orleans, New Orleans, Louisiana

Eastern Maine Medical Center, Bangor, Maine

Maine Children's Cancer Program, Scarborough, Maine

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Walter Reed National Military Medical Center, Bethesda, Maryland

Tufts Children's Hospital, Boston, Massachusetts

Massachusetts General Hospital Cancer Center, Boston, Massachusetts

Dana-Farber Cancer Institute, Boston, Massachusetts

C S Mott Children's Hospital, Ann Arbor, Michigan

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan

Henry Ford Health Saint John Hospital, Detroit, Michigan

Michigan State University Clinical Center, East Lansing, Michigan

Hurley Medical Center, Flint, Michigan

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan

Bronson Methodist Hospital, Kalamazoo, Michigan

Kalamazoo Center for Medical Studies, Kalamazoo, Michigan

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota

University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota

Mayo Clinic in Rochester, Rochester, Minnesota

Children's Hospital and Clinic-Saint Paul, Saint Paul, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Cardinal Glennon Children's Medical Center, Saint Louis, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Children's Hospital and Medical Center of Omaha, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada

Nevada Cancer Research Foundation NCORP, Las Vegas, Nevada

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire

Hackensack University Medical Center, Hackensack, New Jersey

Morristown Medical Center, Morristown, New Jersey

Saint Peter's University Hospital, New Brunswick, New Jersey

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

Saint Joseph's Regional Medical Center, Paterson, New Jersey

Overlook Hospital, Summit, New Jersey

University of New Mexico Cancer Center, Albuquerque, New Mexico

Albany Medical Center, Albany, New York

Montefiore Medical Center - Moses Campus, Bronx, New York

Roswell Park Cancer Institute, Buffalo, New York

NYU Langone Hospital - Long Island, Mineola, New York

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

University of Rochester, Rochester, New York

State University of New York Upstate Medical University, Syracuse, New York

New York Medical College, Valhalla, New York

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina

Novant Health Presbyterian Medical Center, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

East Carolina University, Greenville, North Carolina

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Sanford Broadway Medical Center, Fargo, North Dakota

Children's Hospital Medical Center of Akron, Akron, Ohio

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Dayton Children's Hospital, Dayton, Ohio

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio

Mercy Children's Hospital, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Legacy Emanuel Children's Hospital, Portland, Oregon

Legacy Emanuel Hospital and Health Center, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania

Geisinger Medical Center, Danville, Pennsylvania

Penn State Children's Hospital, Hershey, Pennsylvania

Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Medical University of South Carolina, Charleston, South Carolina

Prisma Health Richland Hospital, Columbia, South Carolina

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

Greenville Cancer Treatment Center, Greenville, South Carolina

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

T C Thompson Children's Hospital, Chattanooga, Tennessee

East Tennessee Childrens Hospital, Knoxville, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas

Dell Children's Medical Center of Central Texas, Austin, Texas

Driscoll Children's Hospital, Corpus Christi, Texas

Medical City Dallas Hospital, Dallas, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Brooke Army Medical Center, Fort Sam Houston, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

M D Anderson Cancer Center, Houston, Texas

Covenant Children's Hospital, Lubbock, Texas

Methodist Children's Hospital of South Texas, San Antonio, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Scott and White Memorial Hospital, Temple, Texas

Primary Children's Hospital, Salt Lake City, Utah

University of Vermont and State Agricultural College, Burlington, Vermont

Inova Fairfax Hospital, Falls Church, Virginia

Children's Hospital of The King's Daughters, Norfolk, Virginia

Naval Medical Center - Portsmouth, Portsmouth, Virginia

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia

Carilion Children's, Roanoke, Virginia

Seattle Children's Hospital, Seattle, Washington

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington

Madigan Army Medical Center, Tacoma, Washington

West Virginia University Charleston Division, Charleston, West Virginia

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Women's and Children's Hospital-Adelaide, North Adelaide, South Australia

Princess Margaret Hospital for Children, Perth, Western Australia

University of Alberta Hospital, Edmonton, Alberta

British Columbia Children's Hospital, Vancouver, British Columbia

CancerCare Manitoba, Winnipeg, Manitoba

Janeway Child Health Centre, Saint John's, Newfoundland and Labrador

IWK Health Centre, Halifax, Nova Scotia

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario

Kingston Health Sciences Centre, Kingston, Ontario

Children's Hospital, London, Ontario

Children's Hospital of Eastern Ontario, Ottawa, Ontario

Hospital for Sick Children, Toronto, Ontario

The Montreal Children's Hospital of the MUHC, Montreal, Quebec

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Saskatoon Cancer Centre, Saskatoon, Saskatchewan

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set

Dutch Childhood Oncology Group, Utrecht, Not set

Starship Children's Hospital, Grafton, Auckland

Christchurch Hospital, Christchurch, Not set

San Jorge Children's Hospital, San Juan, Not set

Swiss Pediatric Oncology Group - Bern, Bern, Not set

Swiss Pediatric Oncology Group - Geneva, Geneva, Not set

Swiss Pediatric Oncology Group - Lausanne, Lausanne, Not set

Conditions: Medulloblastoma

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A Phase 2 Multicenter Study of Axicabtagene Ciloleucel in Subjects With Relapsed/Refractory Indolent Non-Hodgkin Lymphoma

NCT03105336

Completed

This study will enroll approximately 160 adult participants who have relapsed or refractory (r/r) iNHL to be infused with the study treatment, axicabtagene ciloleucel, to see if their disease responds to this experimental product and if this product is safe. Axicabtagene ciloleucel is made from the participants own white blood cells which are genetically modified and grown to fight cancer. An objective response rate of 70% is targeted.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/03/2025

Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +18 locations

Conditions: Follicular Lymphoma, Marginal Zone Lymphoma, Indolent Non-Hodgkin Lymphoma

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AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Non Hodgkin Lymphoma

NCT03434769

Active Not Recruiting

The purpose of this study is to determine if it is possible to treat your cancer with a new type of T cell-based immunotherapy (therapy that uses your immune system to treat the cancer). T cells are a type of white blood cell that helps the body fight infections. This treatment uses T cells already present within your body that have been modified outside of the body and returned to target your cancer. This type of treatment is sometimes referred to as adoptive cell transfer (ACT). In this study... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/03/2025

Locations: Washington University School of Medicine, St. Louis, Missouri +1 locations

Conditions: Non-Hodgkin Lymphoma

Learn More ›