Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma
NCT00000801
Completed
To estimate the response rate, overall and disease-free survival, toxicities, factors associated with outcome, and effect on quality of life in patients with AIDS-related primary CNS lymphoma treated with CHOD (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) plus filgrastim (granulocyte-colony stimulating factor; G-CSF) and external beam irradiation. To determine other clinical markers present in this patient population. Combined modality therapy may prove of benefit for patients... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
10/31/2012
Locations: Beth Israel Deaconess - West Campus, Boston, Massachusetts +1 locations
Conditions: Lymphoma, Non-Hodgkin, HIV Infections
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Intravenous And Oral Casopitant (GW679769) For The Prevention Of Chemotherapy Induced Nausea And Vomiting
NCT00366834
Completed
This is a Phase III trial designed to demonstrate that casopitant (GW679769) plus dexamethasone and ondansetron is more effective in the prevention of vomiting than dexamethasone and ondansetron alone following the administration of moderately emetogenic chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/06/2012
Locations: GSK Investigational Site, Pittsfield, Massachusetts +1 locations
Conditions: Vomiting, Nausea, Nausea and Vomiting, Chemotherapy-Induced
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Study of the Effects of Ciclesonide Hydrofluoroalkane (HFA) Nasal Aerosol on Hypothalamic-Pituitary-Adrenal (HPA) Axis
NCT01033825
Completed
To demonstrate the effects of ciclesonide applied as a nasal aerosol and ciclesonide aqueous (AQ) nasal spray on hypothalamic-pituitary-adrenal axis.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/17/2012
Locations: Northeast Medical Research Associates, North Dartmouth, Massachusetts
Conditions: Perennial Allergic Rhinitis
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A Study to Evaluate the Clinical Efficacy and Safety of Tobradex® ST Compared to Azasite® in the Treatment of Subjects With Moderate to Severe Chronic Blepharitis
NCT01102244
Completed
The purpose of this study is to evaluate the clinical efficacy and safety of Tobradex ST compared to AzaSite in the treatment of moderate to severe chronic blepharitis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/07/2012
Locations: Ora, Andover, Massachusetts
Conditions: Blepharitis
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Corticosteroid Injection for Common Upper Extremity Problems
NCT00438672
Completed
The purpose of the study is to compare the effectiveness of a steroid injection to a placebo (inactive substance) in the treatment of lateral elbow pain, deQuervain's tendonitis, or base of the thumb carpometacarpal (CMC) arthritis. We are also trying to identify which personality factors and mindsets influence perceptions of elbow, wrist and hand pain. We hope to enroll 213 subjects in this study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2012
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lateral Elbow Pain
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Safety and Efficacy Study of EGP-437 (Dexamethasone Phosphate Formulated for Ocular Iontophoresis) to Treat Dry Eye
NCT01129856
Completed
The purpose of this study is to assess the safety and efficacy of EGP-437 (dexamethasone phosphate formulated for ocular iontophoresis) using the EyeGate® II Iontophoresis system in patients with dry eye.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
04/25/2011
Locations: Andover Eye Associates, Andover, Massachusetts
Conditions: Dry Eye
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Dexamethasone Treatment of Congenital Adrenal Hyperplasia
NCT00621985
Completed
The purpose of this study is to determine if dexamethasone given at night is a more effective treatment for congenital adrenal hyperplasia in young children than standard three times per day hydrocortisone. Our hypothesis is that nocturnal dexamethasone will lead to more efficient suppression of the hypothalamic-pituitary-adrenal axis. We performed a cross-over trial comparing hormonal control during two 24-hour hospitalizations, one on hydrocortisone and one on nocturnal dexamethasone.
Gender:
ALL
Ages:
Between 2 years and 9 years
Trial Updated:
01/26/2011
Locations: Children's Hospital Boston, Boston, Massachusetts
Conditions: Adrenal Hyperplasia, Congenital
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Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis
NCT00694135
Completed
The purpose of this study is to define a safe and effective dose of iontophoretic delivery of dexamethasone phosphate ophthalmic solution using the EyeGate® II Drug Delivery System in patients with non-infectious anterior segment uveitis.
Gender:
ALL
Ages:
Between 12 years and 85 years
Trial Updated:
08/27/2010
Locations: Ophthalmic Consultants of Boston, Boston, Massachusetts +1 locations
Conditions: Uveitis, Anterior
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Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Dry Eye
NCT00765804
Completed
The purpose of this study is to assess the safety and efficacy of iontophoretic delivery of dexamethasone phosphate ophthalmic solution using the EyeGate® II Drug Delivery System in patients with dry eye.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
08/27/2010
Locations: Ophthalmic Research Associates, Andover, Massachusetts +1 locations
Conditions: Dry Eye Syndrome
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Expanded Access Program:Lenalidomide With or Without Dexamethasone In Previously Treated Subjects With Multiple Myeloma
NCT00179647
Completed
Subjects who qualify for participation will receive lenalidomide with or without dexamethasone in 4 week cycles until disease progression is documented or lenalidomide becomes commercially available for the indication of multiple myeloma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2010
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Multiple Myeloma
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