S0204 Thalidomide, Chemotherapy, and Peripheral Stem Cell Transplant in Treating Patients With Multiple Myeloma
NCT00040937
Completed
RATIONALE: Thalidomide may stop the growth of cancer cells by stopping blood flow to the cancer. Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Giving thalidomide before and after peripheral stem cell transplant may be effective in treating newly diagnosed multiple myeloma. PURPO... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/26/2016
Locations: McDowell Cancer Center at Akron General Medical Center, Akron, Ohio +26 locations
Conditions: Multiple Myeloma
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A Bioequivalence Study of Two Ciprofloxacin/Dexamethasone Formulations in Patients With Otitis Externa
NCT01910155
Terminated
The objective of this study is to compare the relative efficacy and safety of the test formulation of ciprofloxacin 0.3%/dexamethasone 0.1% sterile otic suspension (Par Pharmaceutical Companies, Inc.) to the already-marketed formulation CIPRODEX® (ciprofloxacin 0.3%/dexamethasone 0.1%) sterile otic suspension (Alcon) in the treatment of acute bacterial otitis externa.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/14/2016
Locations: Julia Mullen, MD, Cincinnati, Ohio
Conditions: Otitis Externa
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Comparison of Docetaxel/Prednisone to Docetaxel/Prednisone in Combination With OGX-011 in Men With Prostate Cancer
NCT01188187
Completed
This Phase 3 study has been designed to confirm that adding custirsen to standard first-line docetaxel/prednisone treatment can slow tumor progression and enhance survival outcomes compared to standard first-line docetaxel/prednisone treatment alone. This will be a randomized, open-label, multicenter, international trial. Treatment will consist of docetaxel/prednisone/custirsen vs. docetaxel/prednisone. A total of at least 1000 patients will be randomized. Patients will be randomly assigned with... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/13/2016
Locations: Teva Investigational Site 107, Cincinnati, Ohio
Conditions: Prostate Cancer
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Chemotherapy and Whole-Brain Radiation Therapy in Treating Patients With Primary Central Nervous System Non- Hodgkin's Lymphoma
NCT00002676
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells and may be an effective treatment for non-Hodgkin's lymphoma. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy and whole-brain radiation therapy in patients with primary central nervous system non-Hodgkin's lymph... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/12/2016
Locations: CCOP - Columbus, Columbus, Ohio +1 locations
Conditions: Lymphoma
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Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer
NCT00002716
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which chemotherapy regimen is more effective for metastatic colorectal cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of intrahepatic floxuridine, leucovorin, and dexamethasone with that of systemic fluorouracil and leucovorin in treating patients who have unresectable liver... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/12/2016
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Colorectal Cancer, Metastatic Cancer
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Gabapentin in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy
NCT00880191
Completed
RATIONALE: Gabapentin may prevent or reduce delayed nausea and vomiting caused by chemotherapy. It is not yet known whether gabapentin is more effective than a placebo in preventing nausea and vomiting. PURPOSE: This randomized phase III trial is studying the side effects of gabapentin and to see how well it works compared with a placebo in preventing nausea and vomiting in patients receiving chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2016
Locations: Mary Rutan Hospital, Bellefontaine, Ohio +47 locations
Conditions: Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific
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The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection
NCT00273377
Completed
The investigators will test the hypotheses that mild hypercapnia and supplemental oxygen reduce wound infection risk in patients undergoing colon resection. The investigators will simultaneously test the hypothesis that low-dose dexamethasone (a common treatment for postoperative nausea and vomiting) does not increase infection risk.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/27/2016
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Surgical Wound Infection, Surgery, Colon
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Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade Glioma That Can Be Removed By Surgery
NCT02031965
Terminated
This phase I trial studies the side effects and the safety of injecting HSV1716 (a new experimental therapy) into or near the tumor resection cavity. The injection will be done at the time of surgery. HSV1716 is a virus that has a gene which has been changed or removed (mutated) in such a way that lets the virus multiply in dividing cells of the tumor and kills the tumor cells.
Gender:
ALL
Ages:
Between 12 years and 21 years
Trial Updated:
05/26/2016
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Recurrent Childhood Anaplastic Astrocytoma, Recurrent Childhood Anaplastic Oligoastrocytoma, Recurrent Childhood Anaplastic Oligodendroglioma, Recurrent Childhood Giant Cell Glioblastoma, Recurrent Childhood Glioblastoma, Recurrent Childhood Gliomatosis Cerebri, Recurrent Childhood Gliosarcoma
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Phase 1 Study of TG02 Citrate in Patients With Advanced Hematological Malignancies
NCT01204164
Completed
This is a multicenter, open-label, dose escalation Phase 1 study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2016
Locations: OSU, Columbus, Ohio
Conditions: AML, ALL, Blast Crisis, MDS, Multiple Myeloma
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Effects of Preoperative Dexamethasone Study on QOL After Vaginal Reconstructive Surgery for POP
NCT02073734
Completed
The investigators hypothesize that preoperative administration of 8 mg IV dexamethasone will benefit patients' perceived quality of recovery after surgery.
Gender:
FEMALE
Ages:
Between 18 years and 81 years
Trial Updated:
04/19/2016
Locations: Triheath, Cincinnati, Ohio
Conditions: Pelvic Organ Prolapse, PONV
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MTD, Safety, and Efficacy of Pomalidomide (CC-4047) Alone or With Low-dose Dexamethasone in Patients With Relapsed and Refractory Multiple Myeloma
NCT00833833
Completed
The purpose of this study is to determine the maximum tolerated dose and effectiveness of the study drug (CC-4047) Alone Or in Combination With Low-dose Dexamethasone as treatment for patients with relapsed and refractory multiple myeloma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2016
Locations: Ohio State University Arthur G. James Cancer Hospital, Columbus, Ohio
Conditions: Multiple Myeloma
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Chemotherapy With or Without Strontium-89 in Treating Patients With Prostate Cancer
NCT00024167
Terminated
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radioactive substances such as strontium-89 may relieve bone pain associated with prostate cancer. It is not yet known whether chemotherapy is more effective with or without strontium-89 in treating bone metastases. PURPOSE: This randomized phase III trial is studying giving chemotherapy together with strontium-89 to see how well it works compared to chemotherapy alone in trea... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/19/2016
Locations: Summa Center for Cancer Care at Akron City Hospital, Akron, Ohio +3 locations
Conditions: Prostate Cancer
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