The Effect of VTC-G15 (a Pentapeptide Cleavage Product og GLP-1) on Whole Body Glucose Metabolism in Man
Unknown
To asses the modulating properties of the cleaved pentapeptide product of GLP-1 amide.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/07/2015
Locations: ICON PLC, San Antonio, Texas
Conditions: Insulin Resistance
Dose-response Study of Exendin-9,39 on Glucose Metabolism
Completed
Multiple studies have examined the effect of endogenous GLP-1 secretions by using a competitive antagonist of GLP-1 - Exendin-9,39 - infused at rates of 300pmol/kg/min. However, the presence of an effect does not necessarily imply that this effect is due to the blockade of the endogenous GLP-1 actions at the receptor. It is possible that the supraphysiologic concentrations of Exendin may have effects of its own. To examine the effect of Exendin on glucose metabolism the investigators propose a d... Read More
Gender:
ALL
Ages:
Between 20 years and 45 years
Trial Updated:
01/18/2013
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Pancreatic Effects of 9,39-Exendin and 9,36-GLP-1
GLP1R Polymorphisms and Response to GLP1
Completed
Glucagon-like Peptide-1 (GLP-1) is an important incretin hormone which acts as a powerful insulin secretagogue. Defects in GLP-1 synthesis and secretion are thought to be part of the pathogenesis of type 2 diabetes. Furthermore GLP-1 based therapy is an important part of the therapeutic armamentarium for the treatment of type 2 diabetes. The GLP-1 receptor (GLP1R) is the principal site of action of GLP-1 and GLP-1 receptor agonists like exenatide and liraglutide. The gene coding for this recepto... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
12/14/2011
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Diabetes