A Study of the mTOR Inhibitor Rapamycin (Rapamune, Sirolimus) in Combination With Abraxane in Advanced Solid Cancers
NCT00337376
Terminated
Rapamycin is a drug that has been approved by the Food and Drug Administration (government) for use in patients receiving a kidney transplant to prevent the patient's body from rejecting the transplanted kidney. It has shown antitumor effects in the laboratory, but has not been approved at this time for the treatment of cancer. Abraxane is a new form of chemotherapy that has been approved by the Food and Drug Administration for the treatment of metastatic breast cancer, and is a promising drug t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2014
Locations: Yale Comprehensive Cancer Center at Yale University School of Medicine, New Haven, Connecticut
Conditions: Advanced Solid Cancers
Register for Updates
Addition of Paclitaxel to High-Dose Combination Chemotherapy in Treating Patients With High-Risk Breast Cancer
NCT00002627
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill tumor cells, allowing higher doses of chemotherapy to be used. PURPOSE: Phase I/II trial to study the effectiveness of paclitaxel when added to high-dose combination chemotherapy followed by peripheral stem cell transplantation in treating women with breast... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
01/09/2014
Locations: St. Louis University Health Sciences Center, Saint Louis, Missouri
Conditions: Breast Cancer
Register for Updates
Addition of Paclitaxel to High-Dose Combination Chemotherapy in Treating Women With Metastatic Breast Cancer
NCT00002628
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill tumor cells, allowing higher doses of chemotherapy to be used. PURPOSE: Phase I/II trial to study the effectiveness of paclitaxel added to a regimen of high-dose chemotherapy with cyclophosphamide and... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
01/09/2014
Locations: Indiana University Cancer Center, Indianapolis, Indiana +2 locations
Conditions: Breast Cancer
Register for Updates
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer
NCT00006378
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells PURPOSE: Randomized phase II trial to compare the effectiveness of three different regimens of combining paclitaxel and carboplatin plus radiation therapy in treating patients who have stage III non-small cell lung cancer that cannot be remov... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2014
Locations: Morristown Memorial Hospital, Morristown, New Jersey +2 locations
Conditions: Lung Cancer
Register for Updates
Abraxane and Avastin as Therapy for Patients With Malignant Melanoma, a Phase II Study
NCT00462423
Completed
The study is an open-label, single arm multicenter Phase II study to evaluate the safety and efficacy of the combination of Abraxane and Avastin as first-line therapy for patients with unresectable metastatic malignant melanoma. The patient sample will be approximately 50 individuals, males and females 18 years of age or older with measurable metastatic melanoma. Patients will be treated with Abraxane administered weekly for 3 weeks via a 30-minute IV infusion at150 mg/m2 followed by 1 week res... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2014
Locations: Northern California Melanoma Center, San Francisco, California +1 locations
Conditions: Metastatic Malignant Melanoma
Register for Updates
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Advanced Cancer of the Mouth, Pharynx, or Larynx
NCT00004094
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy plus radiation therapy in treating patients who have previously untreated advanced cancer of the mouth, pharynx, or larynx.
Gender:
ALL
Ages:
Between 15 years and 80 years
Trial Updated:
01/03/2014
Locations: Monroe Medical Associates, Chicago, Illinois +3 locations
Conditions: Head and Neck Cancer
Register for Updates
Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Persistent Epithelial Ovarian Cancer, Fallopian Tube, or Primary Peritoneal Cancer
NCT00003064
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy and kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of chemotherapy and autologous peripheral stem cell transplantation in treating patients with recurrent or persistent epithelial ovarian cancer, fallopian tube, or primary peri... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/03/2014
Locations: Herbert Irving Comprehensive Cancer Center, New York, New York
Conditions: Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
Register for Updates
Topotecan and Paclitaxel in Treating Patients With Recurrent or Metastatic Cancer of the Cervix
NCT00003065
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of topotecan and paclitaxel in treating patients who have recurrent or metastatic cancer of the cervix.
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
01/03/2014
Locations: Herbert Irving Comprehensive Cancer Center at Columbia University, New York, New York
Conditions: Cervical Cancer
Register for Updates
High-Dose Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Lung Cancer
NCT00003284
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of high-dose combination chemotherapy followed by peripheral stem cell transplantation in treating patients with lung cancer.
Gender:
ALL
Ages:
All
Trial Updated:
01/03/2014
Locations: Herbert Irving Comprehensive Cancer Center, New York, New York
Conditions: Lung Cancer
Register for Updates
Bevacizumab, Doxorubicin, and Cyclophosphamide Followed By Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients Who Have Undergone Surgery for Early-Stage Breast Cancer
NCT00436709
Unknown
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of breast cancer by blocking blood flow to the tumor. Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/03/2014
Locations: Memorial Sloan-Kettering Cancer Center, New York, New York
Conditions: Breast Cancer
Register for Updates
Drug-Drug Interaction - 3 Arm - Carboplatin/Paclitaxel, Dacarbazine
NCT00796991
Completed
The purpose of this clinical research study is to learn the pharmacokinetics of Ipilimumab when combined with Paclitaxel/Carboplatin or Dacarbazine
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/31/2013
Locations: The Angeles Clinic & Research Inst., Los Angeles, California +3 locations
Conditions: Advanced Melanoma
Register for Updates
Evaluation of Drug Resistance in Patients With Metastatic Breast Cancer
NCT00003253
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Some patients may develop a resistance to chemotherapy drugs. PURPOSE: Phase II trial to determine the reliability of a test for measuring drug resistance to paclitaxel in patients with metastatic breast cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2013
Locations: Pacific Coast Hematology/Oncology Medical Group, Fountain Valley, California +8 locations
Conditions: Breast Cancer
Register for Updates