Effects of Short-term Growth Hormone in HIV-infected Patients
NCT00795210
Completed
The purpose of this study is to examine the short-term effects of two different doses of growth hormone, compared to treatment with growth hormone releasing hormone, on the brain's secretion of growth hormone and the body's glucose metabolism. We hypothesize that growth hormone administration will alter the body's endogenous pulsatile growth hormone secretion and that higher dose growth hormone may decrease insulin sensitivity. We hypothesize that growth hormone releasing hormone will augment en... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
12/06/2013
Locations: MGH, Boston, Massachusetts
Conditions: HIV Lipodystrophy
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Cool.Click™ Adolescent Transition Study: Study of Saizen® in Subjects With Childhood-onset Growth Hormone Deficiency
NCT00109733
Completed
The primary objective is to evaluate the efficacy and safety of two different dose regimens of r-hGH (Saizen®) in subjects with childhood-onset growth hormone deficiency (COGHD) during the transition phase from childhood to adulthood.
Gender:
ALL
Ages:
Between 13 years and 25 years
Trial Updated:
08/04/2013
Locations: Children's Hospital of Orange County, Orange, California +8 locations
Conditions: Childhood-onset Growth Hormone Deficiency, Pituitary Dwarfism
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Treatment of Adults With Growth Hormone Deficiency
NCT00294619
Completed
The purpose of this study is to evaluate efficacy and safety profile of a new weekly administered growth hormone preparation compared with placebo in adults with growth hormone deficiency.
Gender:
ALL
Ages:
Between 23 years and 70 years
Trial Updated:
10/04/2012
Locations: Oregon Health Sciences University, Portland, Oregon
Conditions: Pituitary Disorders, Adult Growth Hormone Deficiency
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VRS-317 in Adult Subjects With Growth Hormone Deficiency
NCT01359488
Completed
The purpose of this research study is to determine the safety and tolerability of up to five doses of VRS-317 in Adult Growth Hormone Deficient patients. * Patients will be evaluated for evidence of activity of VRS-317 by measurement of changes from baseline in insulin-like growth factor-1 (IGF-I) and binding protein (IGFBP-3), and bone turnover (bone alkaline phosphatase) * Descriptive pharmacokinetic (PK) and pharmacodynamic (PD) parameters (IGF-I and IGFBP-3) will be determined by standard m... Read More
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
07/19/2012
Locations: Diabetes and Glandular Disease Clinic, San Antonio, Texas
Conditions: Growth Hormone Deficiency
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Low Dose Growth Hormone (GH) on Insulin Sensitivity and Cortisol Production Rates
NCT00517062
Completed
Study hypothesis: Growth hormone (GH), through its generation of free 'bioavailable' insulin-like growth factor (IGF)-I, can improve insulin sensitivity in adults with GH deficiency. Study aims: The purpose of this study is to determine the mechanism of how low dose GH treatment affects the body's sensitivity to insulin actions and whether this low GH dose can affect the body's handling of steroid hormone levels (cortisol clearance) in adults with GH deficiency. Study design: Men and women... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/02/2012
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Growth Hormone Deficiency
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Arimidex Multicenter Trial in Growth Hormone (GH) Deficient Boys
NCT00133354
Completed
The purpose of this study is to see if Arimidex, an aromatase inhibitor, can delay epiphyseal fusion and increase predicted adult height in boys who are growth hormone deficient, in puberty, and who are taking growth hormone. This is a double blind, placebo controlled 3 year trial.
Gender:
MALE
Ages:
Between 11 years and 18 years
Trial Updated:
10/11/2011
Locations: Nemours Children's Clinic, Jacksonville, Florida
Conditions: Hypopituitarism
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Effect of Short Term Growth Hormone Releasing Hormone in Healthy Men
NCT00850564
Completed
The purpose of this trial is to examine the short-term effects of Growth Hormone Releasing Hormone (GHRH, tesamorelin) administration in healthy men. We hypothesize that GHRH will increase GH pulse height and will not affect insulin sensitivity.
Gender:
MALE
Ages:
Between 18 years and 60 years
Trial Updated:
04/15/2011
Locations: MGH, Boston, Massachusetts
Conditions: Healthy Volunteers
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Physiologic Growth Hormone Effects in HIV Lipodystrophy
NCT00100698
Completed
This study will investigate long-term, low-dose growth hormone administration in HIV-infected patients with reduced growth hormone (GH) secretion and increased visceral adiposity. We hypothesize that low-dose growth hormone will reduce visceral fat. Secondary endpoints will include measures of insulin-like growth factor-1 (IGF-1), glucose homeostasis, lipids, blood pressure,bone density, cardiovascular risk and safety parameters.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/22/2010
Locations: MGH, Boston, Massachusetts
Conditions: AIDS, HIV Infections
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Treatment of Children With Insufficient Secretion of Growth Hormone
NCT00271518
Unknown
The purpose of this study is to compare a new weekly administered growth hormone preparation with standard daily treatment in children with insufficient secretion of growth hormone
Gender:
ALL
Ages:
Between 3 years and 11 years
Trial Updated:
03/16/2010
Locations: Division of Endocrinology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Growth Hormone Deficiency (GHD)
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Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing
NCT00324064
Completed
Specific Aim 1 Healthy male and female subjects and growth hormone (GH) deficient subjects display sexually dimorphic GH responses to GHRH administration Specific Aim 2 GH responses to GHRH in both healthy controls and in GH deficient patients correlate with expression and activity of the stimulatory G proteins, G alpha q and G alpha S. G protein levels correlate with gonadal steroid levels. Specific Aim 3 Sexually dimorphic GH responses to GHRH are enhanced in Tanner Stage V compared to Tanne... Read More
Gender:
ALL
Ages:
Between 5 years and 40 years
Trial Updated:
03/03/2010
Locations: Children's Mercy Hospital, Kansas City, Missouri
Conditions: Growth Hormone Deficiency
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Growth Hormone to Increase Immune Function in People With HIV
NCT00071240
Completed
Growth hormone plays an important role in the development of the immune system. Studies suggest that growth hormone may promote growth of the thymus, a gland responsible for the production of important immune cells called T cells. Since these cells are lost during the course of HIV infection, it is possible that growth hormone treatment could help restore the immune system. This study will determine whether the administration of growth hormone can increase the size and function of the thymus and... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2009
Locations: Gladstone Institute of Virology and Immunology, San Francisco, California
Conditions: HIV Infections
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HORMA: Hormonal Regulators of Muscle and Metabolism in Aging
NCT00183040
Completed
The purpose of this study is to determine the relationship of deficiencies in testosterone and growth hormone to loss of muscle mass (sarcopenia) and functional impairment during aging and whether there is an interaction of these two hormone systems in maintaining normal skeletal muscle mass and physical function.
Gender:
MALE
Ages:
Between 65 years and 90 years
Trial Updated:
05/28/2009
Locations: Tufts University, Boston, Massachusetts +1 locations
Conditions: Sarcopenia, Muscle Weakness, Frailty
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