There are currently 50 active clinical trials seeking participants for Heart Failure research studies. The states with the highest number of trials for Heart Failure participants are .
Lifestyle Behaviours of Women Newly Diagnosed With Heart Failure
NCT05416879
Recruiting
Heart Failure occurs when the heart's ability to pump blood is reduced. Heart failure can lead to symptoms of breathlessness, fatigue and ankle swelling, and result in health complications including damage to other organs (e.g. kidneys), reduced function and quality of life. Although the symptoms of heart failure are similar for men and women, there are sex differences. Lifestyle behaviours such as physical activity are important modifiable risk factor for heart failure. Women continue to be und... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, Not set
Conditions: Heart Failure
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Atrial Fibrillation Ablation Versus Atrioventricular Nodal Ablation with Conduction System Pacing in Heart Failure
NCT06207383
Recruiting
The goal of this clinical trial is to evaluate two treatment strategies in patients with chronic atrial fibrillation and heart failure, who are eligible for atrial fibrillation ablation. Patients will be randomized to either atrial fibrillation ablation or to implantation of a pacemaker with conduction system pacing followed by atrioventricular node ablation. The effect of treatment allocation on total mortality, cardiovascular hospitalization and heart failure hospitalization will be compared.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
12/03/2024
Locations: St Elisabeth sister's Hospital, Graz, Not set +17 locations
Conditions: Atrial Fibrillation, Persistent, Heart Failure
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Observation of Clinical Routine Care for Heart Failure Patients Implanted With BIOTRONIK CRT Devices
NCT03366545
Recruiting
The registry is primarily designed to assess outcome, efficacy and residual safety aspects of CRT based on long-term data from an unselected, real-life clinical set-up. Moreover, the observation of the patient status should help to find possible predictors for HF events and to identify areas of improvement for CRT and for CRT device settings.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Canberra Heart Rhythm Foundation, Canberra, Not set +120 locations
Conditions: Heart Failure
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Physiological Versus Right Ventricular Outcome Trial Evaluated for Bradycardia Treatment Upgrades
NCT06052475
Recruiting
Guidelines for patients having first-time implants advocate that even when heart function is only mildly impaired, modern pacing approaches should be utilised to avoid the potentially damaging effects of RV pacing to preventing symptoms from pacing induced or worsened cardiomyopathy. However, once a traditional (RV) pacemaker is implanted, development of impaired heart function does not prompt a device upgrade. Even at the end of battery life, physicians simply replace it like-for-like. This t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Royal Papworth Hospital, Cambridge, Not set +11 locations
Conditions: Pacing-Induced Cardiomyopathy, Heart Failure
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Therapy to Maintain Remission in Dilated Cardiomyopathy
NCT06091475
Recruiting
One third of patients diagnosed with heart failure demonstrate left ventricular reverse remodelling and recovery of cardiac function following a period of medical therapy. The TRED-HF trial investigated the impact of therapy withdrawal in this cohort and found that 40% of patients relapsed within 6 months of stopping treatment. In this follow-on study, the investigators will investigate the safety of therapy withdrawal of sodium cotransporter 2 inhibitors (SGLT2i) and mineralocorticord receptor... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
09/03/2024
Locations: Royal Brompton Hospital, London, Not set
Conditions: Heart Failure, Cardiomyopathy, Dilated, Cardiomyopathies, Heart Diseases
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Comparison of Cardiac Resynchronisation Therapy (CRT) Response Using High Frequency (HF) - ECG or Q-LV Guided Optimisation for Left Ventricular, Pacing Site.
NCT05829876
Recruiting
The research aims to compare the response of Cardiac Resynchronisation Therapy (CRT) using HF ECG guided or the conventional method of Q-LV measurement guided optimisation for left ventricular, pacing site.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/19/2024
Locations: University Hospitals Birmingham, Birmingham, West Midlands
Conditions: Heart Failure
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IRONHEART: Intravenous Iron in Non-ischaemic Heart Failure
NCT06542822
Recruiting
The aim of this study is to observe the effect of intravenous ferric derisomaltose in participants with non-ischaemic heart failure (LVEF\<40%), iron deficiency (TSATS\<20%) and established on heart failure therapy including Sodium-glucose cotransporter 2 inhibitors (SGLT2i). Participants will undergo baseline laboratory blood tests, cardiac magnetic resonance imaging (cMRI), six-minute walk test, musculoskeletal function test and Kansas City Cardiomyopathy Questionnaire (KCCQ). These investigat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2024
Locations: University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire
Conditions: Heart Failure, Iron Deficiencies
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Safety of AI-Powered Virtual Assistant in Outpatient Management of Heart Failure
NCT06400927
Recruiting
The aim of this pilot randomized study is to examine whether integrating the SIRIO-HF virtual assistant (VA) into the outpatient management of participants recently discharged from hospital with a new diagnosis of heart failure (HF), may reduce the need for regular medical assessment and the healthcare burden, reduce variability in healthcare, and meet with participant satisfaction, without compromising participant safety and overall care quality.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/26/2024
Locations: East and North Hertfordshire NHS Trust, Stevenage, Hertfordshire
Conditions: Heart Failure
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POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium
NCT04899635
Recruiting
To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
06/17/2024
Locations: University Hospitals Coventry and Warwickshire, Coventry, Not set
Conditions: Heart Failure, Fatigue; Muscle, Heart, Myocardial Dysfunction, Exhaustion; Heart
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Rate or Rhythm Control in CRT: the RHYTHMIC Study
NCT04664686
Recruiting
70 patients with heart failure, AF and CRT with BiV\<95% will be randomised to either AF ablation or AV node ablation. Evaluation at 6 months with echocardiography and clinical assessment.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/03/2024
Locations: Guys and St Thomas' NHS Foundation Trust, London, Not set
Conditions: Atrial Fibrillation, Heart Failure
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Correlation of Non-invasive CPM Wearable Device With Measures of Congestion in Heart Failure in Exercise
NCT06393842
Recruiting
Fluid status and congestion can be determined by the CPM wearable device and correlates with non-invasive measures and biochemical markers of congestion and changes in congestion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Glasgow Cardiovascular Research Centre, Glasgow, Scotland
Conditions: Heart Failure
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Role of Cytosorb in Left Ventricular Assist Device Implantation
NCT04596813
Recruiting
Mechanical circulatory support, specifically implantable continuous flow left ventricular assist device (CF-LVAD) therapy has been established as a viable treatment for rapidly deteriorating patients suffering from end stage heart failure either as bridge or alternative to heart transplantation. However, a large proportion of these patients experience severe complications in the early postoperative period including right ventricular failure or multi organ failure leading to increased mortality.... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/17/2024
Locations: Harefield Hospital, Harefield, Not set
Conditions: Heart Failure
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