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Carboplatin Treatment Options in United Kingdom
A collection of 302 research studies where Carboplatin is the interventional treatment. These studies are located in the United Kingdom . Carboplatin is used for conditions such as Non-Small Cell Lung Cancer, Ovarian Cancer and Lung Cancer.
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A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
Active Not Recruiting
The purpose of this study is to assess the efficacy of adding lazertinib to amivantamab, carboplatin, and pemetrexed (LACP/ACP-L dosing strategies) and amivantamab, carboplatin and pemetrexed (ACP) compared with carboplatin and pemetrexed (CP) in participants with locally advanced or metastatic epidermal growth factor receptor (EGFR) Exon 19del or Exon 21 L858R substitution non-small cell lung cancer (NSCLC) after osimertinib failure. The purpose of the extension cohort is to further describe th... Read More
The purpose of this study is to assess the efficacy of adding lazertinib to amivantamab, carboplatin, and pemetrexed (LACP/ACP-L dosing strategies) and amivantamab, carboplatin and pemetrexed (ACP) compared with carboplatin and pemetrexed (CP) in participants with locally advanced or metastatic epidermal growth factor receptor (EGFR) Exon 19del or Exon 21 L858R substitution non-small cell lung cancer (NSCLC) after osimertinib failure. The purpose of the extension cohort is to further describe the safety and efficacy for the ACP-L dosing schedule versus ACP with additional data. After completion of the primary analysis, the study may eventually transition to an open-label extension (OLE) or long-term extension (LTE) phase during which participants will have the option to continue their assigned treatment. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2025
Locations: Southern Cancer Center, PC, Mobile, Alabama +246 locations
Southern Cancer Center, PC, Mobile, Alabama
Arizona Oncology Associates, Tucson, Arizona
City of Hope, Duarte, California
Cedars Sinai Medical Center, Los Angeles, California
University of California Irvine, Orange, California
Rocky Mountain Cancer Centers, Colorado Springs, Colorado
Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale, Florida
University Cancer And Blood Center LLC, Athens, Georgia
University of Mississippi Medical Center, Jackson, Mississippi
Nebraska Cancer Specialists, Grand Island, Nebraska
Astera Cancer Care, East Brunswick, New Jersey
TriHealth Network, Cincinnati, Ohio
Providence Portland Medical Center, Portland, Oregon
Kaiser Permanente Northwest, Portland, Oregon
Alliance Cancer Specialists, Horsham, Pennsylvania
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Baptist Cancer Center, Memphis, Tennessee
Texas Oncology-Medical City Dallas, Dallas, Texas
Texas Oncology Baylor Charles A Sammons Cancer Center, Dallas, Texas
Texas Oncology, Grapevine, Texas
Oncology Consultants Texas, Houston, Texas
Texas Oncology - Northeast, Longview, Texas
University of Vermont Medical Center, Burlington, Vermont
University of Virginia, Charlottesville, Virginia
Virginia Cancer Specialists, Fairfax, Virginia
Blue Ridge Cancer Care, Wytheville, Virginia
NorthWest Medical Specialties, PLLC, Puyallup, Washington
Compass Oncology, Vancouver, Washington
CINME Centro de Investigaciones Metabolicas, Caba, Not set
IADT Instituto Argentino de Diagnostico y Tratamiento, Caba, Not set
Centro Medico Fleischer, Caba, Not set
CEMIC (Centro de Educación Médica e Investigaciones Clínicas), Caba, Not set
Hospital Privado Universitario De Cordoba, Cordoba, Not set
Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica, Córdoba, Not set
Hospital Privado de la Comunidad, Mar del Plata, Not set
Clínica Viedma, Viedma, Not set
Grand Hopital De Charleroi Site Les Viviers, Charleroi, Not set
UZA, Edegem, Not set
UZ Gent, Gent, Not set
Jessa Ziekenhuis - Campus Virga Jesse, Hasselt, Not set
UZ Leuven, Leuven, Not set
CHU Sart-Tilman, Liege, Not set
Clinique Saint Pierre, Ottignies, Not set
Cetus Oncologia, Belo Horizonte, Not set
CIONC Centro Integrado de Oncologia de Curitiba, Curitiba, Not set
Ynova Pesquisa Clinica, Florianopolis, Not set
Fundacao Sao Francisco Xavier, Ipatinga, Not set
UPCO Unidade de Pesquisa Clinica em Oncologia, Pelotas, Not set
Associacao Hospitalar Moinhos de Vento, Porto Alegre, Not set
Hospital Ernesto Dornelles, Porto Alegre, Not set
Oncoclinicas Rio de Janeiro S A, Rio de Janeiro, Not set
Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro, Not set
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro, Not set
Nucleo de Oncologia da Bahia, Salvador, Not set
Hospital Sao Rafael, Salvador, Not set
CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia, Santo Andre, Not set
Real e Benemerita Associacao Portuguesa de Beneficencia, Sao Paulo, Not set
Hospital Paulistano, Sao Paulo, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, Not set
Onco Star SP Oncologia Ltda, Sao Paulo, Not set
IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado, Sorocaba, Not set
Hospital Nove de Julho, São Paulo, Not set
COT - Centro Oncologico do Triangulo S.A, Uberlandia, Not set
Multifunctional Hospital for Active Treatment 'Serdika', Sofia, Not set
Multiprofile Hospital for Active Treatment 'Tokuda Hospital Sofia', Sofia, Not set
Specialized Hospital for Active Treatment in Oncology, Sofia, Not set
UMHAT Sofia Med, Sofia, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
British Columbia Cancer Agency, Vancouver, British Columbia
McGill University Health Centre, Montreal, Quebec
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, Not set
Peking University People s Hospital, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
Chinese PLA General Hospital, Beijing, Not set
Beijing Chest hospital, Capital medical university, Beijing, Not set
Hunan Cancer hospital, Changsha, Not set
Sichuan Cancer Hospital, Chengdu, Not set
West China Hospital Sichuan University, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Southwest Hospital, ChongQing, Not set
The First Affiliated Hospital Sun Yat sen University, Guang Zhou, Not set
Sun Yat-Sen Memorial Hospital Sun Yat-sen University, Guangzhou, Not set
Zhejiang Cancer Hospital, Hang Zhou, Not set
Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Not set
The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, Not set
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou, Not set
Harbin medical university cancer hospital, Harbin, Not set
Huizhou Municipal Central Hospital, Huizhou, Not set
Taizhou Hospital of Zhejiang Province, Linhai, Not set
Affiliated Hospital of North Sichuan Medical College, Nanchong, Not set
Ruijin Hospital Shanghai Jiao Tong University, Shanghai, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Shanghai East Hospital, Shanghai, Not set
Shenzhen university General Hospital, Shenzhen, Not set
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
Weifang People's Hospital, Weifang, Not set
The First Affiliated Hospital of Xian Jiaotong University, XI An, Not set
Yantai Yuhuangding Hospital, Yantai, Not set
Daping Hospital Army Characteristic Medical Center, Yuzhong District, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Fakultni nemocnice Olomouc - I.P.Pavlova 6, Olomouc, Not set
Vitkovicka nemocnice a.s., Ostrava- Vitkovice, Not set
Fakultni nemocnice Plzen, Plzen, Not set
Rigshospitalet, Copenhagen, Not set
Institut Sainte Catherine, Avignon Cedex 9, Not set
Hospices Civils de Lyon HCL, Bron, Not set
CHU de Grenoble Hopital Albert Michallon, La Tronche, Not set
Centre Hospitalier du Mans, le Mans, Not set
CHR Hôpital Calmette, Lille, Not set
Hopital Nord, Marseille Cedex 20, Not set
CHU de Montpellier - Arnaud de Villeneuve, Montpellier Cedex 5, Not set
Institut Curie, Paris, Not set
CHU Bordeaux, Pessac, Not set
CHRU Hopital de Pontchaillou, Rennes, Not set
CHU Nantes, Sain-Herblain, Not set
Nouvel Hopital Civil - CHU Strasbourg, Strasbourg cedex, Not set
CHU Bretonneau, Tours, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Asklepios Klinikum Harburg, Hamburg, Not set
Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg, Not set
Onkologische Schwerpunktpraxis, Heilbronn, Not set
POIS Sachsen GmbH iG, Leipzig, Not set
Bethanien Krankenhaus, Moers, Not set
Klinikum der Universitaet Muenchen, München, Not set
Oncologianova GmbH, Recklinghausen, Not set
Universitaetsklinikum Regensburg, Regensburg, Not set
Queen Mary Hospital, Hong Kong, Not set
Health Care Global Enterprises pvt Ltd, Bangalore, Not set
Artemis Hospital, Gurugram, Not set
Tata Medical Center, Kolkata, Not set
Tata Memorial Hospital, Mumbai, Not set
HCG Manavta Cancer Centre, Nasik, Not set
Rajiv Gandhi Cancer Institute and Research Centre, New Delh, Not set
Noble Hospital Pvt Ltd, Pune, Not set
Bhaktivedanta Hospital & Research Institute, Thane, Not set
Soroka University Medical Center, Beersheba, Not set
Rambam Health Corporation, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Rabin Medical Center, Petah Tikva, Not set
Chaim Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel-Aviv, Not set
CRO IRCCS Istituto Nazionale Tumori, Aviano, Not set
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Not set
Istituto Europeo di Oncologia, Milano, Not set
Azienda Ospedaliero-Universitaria Di Parma, Parma, Not set
Ospedale S. Maria Delle Croci, Ravenna, Not set
Istituto Nazionale Tumori Regina Elena, Roma, Not set
Policlinico G.B.Rossi, Verona, Not set
National Hospital Organization Shibukawa Medical Center, Gunma, Not set
Hyogo Cancer Center, Hyogo, Not set
Kanagawa Cancer Center, Kanagawa, Not set
Kobe City Medical Center General Hospital, Kobe City, Not set
Kurume University Hospital, Kurume, Not set
National Hospital Organization Nagoya Medical Center, Nagoya-shi, Not set
Niigata Cancer Center Hospital, Niigata, Not set
Osaka International Cancer Institute, Osaka City, Not set
Shizuoka Cancer Center, Shizuoka, Not set
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Ehime University Hospital, Toon-shi, Not set
Wakayama Medical University Hospital, Wakayama, Not set
National Hospital Organization Iwakuni Clinical Center, Yamaguchi, Not set
National Hospital Organization Yamaguchi Ube Medical Center, Yamaguchi, Not set
National Cancer Center, Gyeonggi-do, Not set
CHA Bundang Medical Center, CHA University, Gyeonggi-do, Not set
Seoul National University Bundang Hospital, Gyeonggi-do, Not set
GyeongSang National University Hospital, Gyeongsangnam-do, Not set
Korea University Anam Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea Seoul St Mary s Hospital, Seoul, Not set
University Malaya Medical Centre, Kuala Lumpur, Not set
Hospital Tengku Ampuan Afzan, Kuantan, Not set
Beacon Hospital Sdn Bhd, Petaling Jaya, Not set
Subang Jaya Medical Centre, Subang Jaya, Not set
Mount Miriam Cancer Hospital, Tanjung Bungah, Not set
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Not set
CIMOVA, Morals Vargas Centro de Investigación SC, Leon, Not set
Health Pharma Professional Research, Mexico, Not set
Instituto Nacional de Cancerologia, Mexico, Not set
Oncologia Integral Satelite, Naucalpan, Not set
VUMC Amsterdam, Amsterdam, Not set
Ziekenhuis St Jansdal, Harderwijk, Not set
Erasmus MC, Rotterdam, Not set
Centrum Onkologii im Prof F Lukaszczyka, Bydgoszcz, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Szpitale Pomorskie Sp z o o, Gdynia, Not set
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie, Olsztyn, Not set
Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow, Poznan, Not set
Private Specialist Hospitals - MedPolonia, Poznan, Not set
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warszawa, Not set
Uls Santa Maria - Hosp. Pulido Valente, Lisboa, Not set
Uls Loures Odivelas - Hosp. Loures, Loures, Not set
Uls Santo Antonio - Hosp. Santo Antonio, Porto, Not set
Instituto Portugues de Oncologia, Porto, Not set
Pan American Center for Oncology Trials LLC, Rio Piedras, Not set
City Clinical Hospital #1, Nalchik, Not set
Llc, Eurocityclinic, Saint Petersburg, Not set
Hosp Univ A Coruna, A Coruña, Not set
Hosp. de La Santa Creu I Sant Pau, Barcelona, Not set
Hosp. Univ. Quiron Dexeus, Barcelona, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp Clinic de Barcelona, Barcelona, Not set
Hosp. Univ. Insular de Gran Canaria, Las Palmas de Gran Canaria, Not set
Hosp. Gral. Univ. Gregorio Maranon, Madrid, Not set
Hosp Univ Fund Jimenez Diaz, Madrid, Not set
Hosp. Univ. 12 de Octubre, Madrid, Not set
Hosp. Univ. La Paz, Madrid, Not set
Hosp Univ Hm Sanchinarro, Madrid, Not set
Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda, Not set
Hosp Regional Univ de Malaga, Málaga, Not set
Clinica Univ. de Navarra, Pamplona, Not set
Hosp. Virgen Del Rocio, Seville, Not set
Hosp. Gral. Univ. Valencia, Valencia, Not set
Hosp. Univ. I Politecni La Fe, Valencia, Not set
Sahlgrenska Universitetssjukhuset, Goteborg, Not set
Linkoping University Hospital, Linkoping, Not set
Skanes universitetssjukhus, Lund, Not set
Norrlands Universitetssjukhus, Umea, Not set
Akademiska Sjukhuset, Uppsala, Not set
Changhua Christian Hospital, Changhua, Not set
Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Not set
Taipei Medical University Shuang Ho Hospital, New Taipei City, Not set
Chung Shan Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Adana City Hospital, Adana, Not set
Memorial Ankara Hastanesi, Ankara, Not set
Gazi University Hospital, Ankara, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Trakya University Medical Faculty, Edirne, Not set
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Not set
Bakirkoy Training and Research Hospital, Istanbul, Not set
Medipol Mega University Hospital, Istanbul, Not set
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi, Istanbul, Not set
Medical Point, Izmir, Not set
Velindre Hospital, Cardiff, Not set
Edinburgh Cancer Centre Western General, Edinburgh, Not set
UCL Cancer Institute, London, Not set
Guys and St Thomas NHS Foundation Trust, London, Not set
The Royal Marsden NHS Trust, London, Not set
The Christie Nhs Foundation Trust, Manchester, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
Not Yet Recruiting
A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy
A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Local Institution - 0154, Orange, California +152 locations
Local Institution - 0154, Orange, California
Local Institution - 0139, Edwards, Colorado
Local Institution - 0085, Gainesville, Florida
Local Institution - 0270, Atlanta, Georgia
Local Institution - 0143, Columbus, Georgia
Local Institution - 0153, Chicago, Illinois
Local Institution - 0067, Boston, Massachusetts
Local Institution - 0091, Saint Louis, Missouri
Local Institution - 0269, Mineola, New York
Local Institution - 0090, New York, New York
Local Institution - 0158, New York, New York
Local Institution - 0186, Rochester, New York
Local Institution - 0087, Cleveland, Ohio
Local Institution - 0038, Portland, Oregon
Local Institution - 0205, Philadelphia, Pennsylvania
Local Institution - 0088, Pittsburgh, Pennsylvania
Local Institution - 0268, Chattanooga, Tennessee
Local Institution - 0093, Nashville, Tennessee
Local Institution - 0025, Houston, Texas
Local Institution - 0173, San Antonio, Texas
Local Institution - 0145, Charlottesville, Virginia
Local Institution - 0138, Richmond, Virginia
Local Institution - 0008, Ciudad Autónoma de Buenos Aires, Buenos Aires
Local Institution - 0004, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0094, Cordoba, Córdoba
Local Institution - 0161, Auderghem, Bruxelles-Capitale, Région De
Local Institution - 0022, Yvoir, Namur
Local Institution - 0023, Gent, Oost-Vlaanderen
Local Institution - 0024, Sint-Niklaas, Oost-Vlaanderen
Local Institution - 0190, Calgary, Alberta
Local Institution - 0183, Toronto, Ontario
Local Institution - 0184, Chicoutimi, Quebec
Local Institution - 0185, Montreal, Quebec
Local Institution - 0006, Santiago, Región Metropolitana De Santiago
Local Institution - 0005, Santiago, Región Metropolitana De Santiago
Local Institution - 0007, Santiago, Región Metropolitana De Santiago
Local Institution - 0244, Beijing, Beijing
Local Institution - 0261, Luoyang, Henan
Local Institution - 0243, Wuhan, Hubei
Local Institution - 0257, Shenyang, Liaoning
Local Institution - 0258, Taiyuan, Shanxi
Local Institution - 0229, Valledupar, Cesar
Local Institution - 0228, Bogotá, Cundinamarca
Local Institution - 0227, Montería, Córdoba
Local Institution - 0226, Cali, Valle Del Cauca
Local Institution - 0014, Strasbourg, Alsace
Local Institution - 0017, Toulouse, Haute-Garonne
Local Institution - 0018, La Tronche, Isère
Local Institution - 0170, Saint Herblain, Loire-Atlantique
Local Institution - 0010, Lille, Nord-Pas-de-Calais
Local Institution - 0162, Bron, Rhône
Local Institution - 0019, Villejuif, Val-de-Marne
Local Institution - 0012, Marseille, Not set
Local Institution - 0011, Paris, Not set
Local Institution - 0015, Paris, Not set
Local Institution - 0207, Esslingen, Baden-Württemberg
Local Institution - 0238, Esslingen, Baden-Württemberg
Local Institution - 0212, Stuttgart, Baden-Württemberg
Local Institution - 0236, Donauwörth, Bayern
Local Institution - 0209, Oldenburg, Niedersachsen
Local Institution - 0213, Köln, Nordrhein-Westfalen
Local Institution - 0208, Chemnitz, Sachsen
Local Institution - 0211, Berlin, Not set
Local Institution - 0215, Gauting, Not set
Local Institution - 0210, Heidelberg, Not set
Local Institution - 0054, Athens, Attikí
Local Institution - 0060, Chaidari, Attikí
Local Institution - 0062, Thessaloniki, Thessaloníki
Local Institution - 0070, New Delhi, Delhi
Local Institution - 0083, Ahmedabad, Gujarat
Local Institution - 0072, Gurugram, Haryana
Local Institution - 0069, Bengaluru, Karnataka
Local Institution - 0077, Mumbai, Maharashtra
Local Institution - 0071, Mumbai, Maharashtra
Local Institution - 0078, Howrah, West Bengal
Local Institution - 0028, Ravenna, Emilia-Romagna
Local Institution - 0036, Aviano, Friuli-Venezia Giulia
Local Institution - 0031, Orbassano, Piemonte
Local Institution - 0137, Avellino, Not set
Local Institution - 0032, Milano, Not set
Local Institution - 0034, Napoli, Not set
Local Institution - 0029, Parma, Not set
Local Institution - 0196, Nagoya, Aichi
Local Institution - 0191, Kashiwa, Chiba
Local Institution - 0203, Toon, Ehime
Local Institution - 0201, Kurume, Fukuoka
Local Institution - 0217, Sapporo, Hokkaido
Local Institution - 0199, Nishinomiya, Hyogo
Local Institution - 0193, Yokohama, Kanagawa
Local Institution - 0192, Sendai, Miyagi
Local Institution - 0200, Kurashiki, Okayama
Local Institution - 0198, Hirakata, Osaka
Local Institution - 0204, Osaka-sayama, Osaka
Local Institution - 0194, Ina-machi, Saitama
Local Institution - 0197, Hamamatsu, Shizuoka
Local Institution - 0195, Nagaizumi-cho,Sunto-gun, Shizuoka
Local Institution - 0202, Koto-ku, Tokyo
Local Institution - 0089, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Local Institution - 0043, Goyang-si, Kyǒnggi-do
Local Institution - 0044, Seongnam, Kyǒnggi-do
Local Institution - 0046, Suwon-si, Kyǒnggi-do
Local Institution - 0095, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0045, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0092, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0042, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0225, Mexico City, Distrito Federal
Local Institution - 0224, Oaxaca de Juarez, Oaxaca
Local Institution - 0222, Chihuahua, Not set
Local Institution - 0223, Mexico City, Not set
Local Institution - 0163, Harderwijk, Gelderland
Local Institution - 0216, Amsterdam, Noord-Holland
Local Institution - 0164, Amsterdam, Noord-Holland
Local Institution - 0103, Drammen, Buskerud
Local Institution - 0106, Bergen, Hordaland
Local Institution - 0105, Oslo, Not set
Local Institution - 0220, Lublin, Lubelskie
Local Institution - 0231, Gdynia, Pomorskie
Local Institution - 0219, Bydgoszcz, Not set
Local Institution - 0120, Bucharest, București
Local Institution - 0123, Bucharest, București
Local Institution - 0132, Florești, Cluj
Local Institution - 0130, Craiova, Dolj
Local Institution - 0115, Bucharest, Not set
Local Institution - 0133, Cluj, Not set
Local Institution - 0124, Iași, Not set
Local Institution - 0119, Iași, Not set
Local Institution - 0263, Singapore, Not set
Local Institution - 0262, Singapore, Not set
Local Institution - 0218, Barcelona, Barcelona [Barcelona]
Local Institution - 0177, Barcelona, Catalunya [Cataluña]
Local Institution - 0175, Madrid, Madrid, Comunidad De
Local Institution - 0206, Madrid, Madrid, Comunidad De
Local Institution - 0176, Madrid, Madrid, Comunidad De
Local Institution - 0181, Majadahonda, Madrid, Comunidad De
Local Institution - 0178, Málaga, Not set
Local Institution - 0182, Sevilla, Not set
Local Institution - 0180, València, Not set
Local Institution - 0179, Zaragoza, Not set
Local Institution - 0188, Baden, Aargau
Local Institution - 0187, st.Gallen, Sankt Gallen
Local Institution - 0189, Bellinzona, Not set
Local Institution - 0053, Kaohsiung, Not set
Local Institution - 0050, Taichung, Not set
Local Institution - 0049, Tainan, Not set
Local Institution - 0048, Taipei, Not set
Local Institution - 0047, Taipei, Not set
Local Institution - 0160, Taipei, Not set
Local Institution - 0265, Bangkok, Krung Thep Maha Nakhon
Local Institution - 0264, Bangkok, Not set
Local Institution - 0266, Songkhla, Not set
Local Institution - 0110, Glasgow, Glasgow City
Local Institution - 0061, London, Kensington And Chelsea
Local Institution - 0140, London, London, City Of
Conditions: Non-Small Cell Lung Cancer
Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2
Recruiting
This study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through the body (ureter, urethra). This study will try to find out if the drugs disitamab vedotin with pembrolizumab works better than platinum-containing chemotherapy to treat patients with UC. This study will also test what side effects happen when participants take these drugs together. A side effect is anything a drug does to the body besides treating th... Read More
This study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through the body (ureter, urethra). This study will try to find out if the drugs disitamab vedotin with pembrolizumab works better than platinum-containing chemotherapy to treat patients with UC. This study will also test what side effects happen when participants take these drugs together. A side effect is anything a drug does to the body besides treating the disease.
Participants in this study will have cancer that has spread through the body (metastatic) or spread near where it started (locally advanced).
In this study, there are 2 different groups. Participants will be assigned to a group randomly. Participants in the disitamab vedotin arm will get the study drug disitamab vedotin once every two weeks and pembrolizumab once every 6 weeks. Participants in the standard of care arm will get gemcitabine once a week for 2 weeks with either cisplatin or carboplatin once every 3 weeks. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Banner Gateway Medical Center, Gilbert, Arizona +328 locations
Banner Gateway Medical Center, Gilbert, Arizona
Banner MD Anderson Cancer Center, Gilbert, Arizona
UCLA Hematology/Oncology - Alhambra, Alhambra, California
Foothill Cardioology, Arcadia, California
Beverly Hills Multi-Specialties Practice, Beverly Hills, California
Providence Saint Joseph Medical Center, Burbank, California
UCLA Burbank Cardiology, Burbank, California
UCLA Hematology/Oncology - Burbank, Burbank, California
UCLA Calabasas Specialty Care, Calabasas, California
UCLA Encino Specialty Care (Radiology), Encino, California
UCLA Hematology/Oncology - Encino, Encino, California
Helios Clinical Research, Glendale, California
Foothill Cardiology Glendora, Glendora, California
Helios Clinical Research, Long Beach, California
UCLA Downtown Los Angeles Primary & Specialty Care, Los Angeles, California
Administrative Address: UCLA Hematology/Oncology, Los Angeles, California
UCLA Cardiovascular Center, Los Angeles, California
UCLA Hematology & Oncology Clinic, Los Angeles, California
UCLA Hematology / Oncology, Los Angeles, California
UCLA Westwood Specialty Care, Los Angeles, California
UCLA Montecito Primary & Specialty Care, Montecito, California
Pacific Cancer Care, Monterey, California
Newport Diagnostics, Newport Beach, California
Foothill Cardiology Pasadena, Pasadena, California
Southern California Heart Specialists, Pasadena, California
UCLA Porter Ranch Primary & Specialty Care, Porter Ranch, California
UCSF Center at China Basin Imaging, San Francisco, California
Helen Diller Family Comprehensive Cancer Center - Imaging Divisadero, San Francisco, California
Helen Diller Family Comprehensive Cancer Center - Imaging Post, San Francisco, California
UCSF Cancer Center MZ Phlebotomy, San Francisco, California
UCSF Mount Zion Phlebotomy, San Francisco, California
Helen Diller Family Comprehensive Cancer Center - Imaging Parnassus, San Francisco, California
UCSF Parnassus Phlebotomy, San Francisco, California
UCSF Parnassus-5 Lab, San Francisco, California
Cardiovascular Care and Prevention Center at Mission Bay, San Francisco, California
UCSF Investigational Drugs Pharmacy, San Francisco, California
UCSF Mission Bay Gateway-2 Lab, San Francisco, California
UCSF Mission Bay PCMB-5 Lab, San Francisco, California
UCSF Mission Bay Pediatric Clinical Research Center, San Francisco, California
UCSF Mission Bay Radiology and Nuclear Medicine, San Francisco, California
University of California San Francisco, San Francisco, California
University of California, San Francisco | HDFCCC - Hematopoietic malignancies, San Francisco, California
Diagnostic Medical Group of Southern California, , San Gabriel, CA, San Gabriel, California
Southern California Heart Centers, San Gabriel, California
UCLA Hematology/Oncology - San Luis Obispo, San Luis Obispo, California
Sierra Vista Regional Medical Center, San Luis Obispo, California
Helios Clinical Research, Santa Ana, California
UCLA Hematology/Oncology - Santa Barbara, Santa Barbara, California
UCLA Hematology/Oncology - Santa Monica, Santa Monica, California
UCLA Simi Valley Alamo Specialty Care, Simi Valley, California
Twin Cities Community Hospital, Templeton, California
UCLA Thousand Oaks Primary & Specialty Care, Thousand Oaks, California
UCLA Hematology/Oncology - Torrance, Torrance, California
UCLA Torrance Lomita Specialty Care, Torrance, California
UCLA Santa Clarita Primary & Specialty Care, Valencia, California
UCLA Ventura Cardiology, Ventura, California
UCLA Hematology/Oncology - Westlake, Westlake Village, California
Helios Clinical Research, Whittier, California
Greater Baltimore Medical Center, Baltimore, Maryland
M Health Fairview Ridges Cancer Clinic, Burnsville, Minnesota
M Health Fairview Cancer Clinic-Edina, Edina, Minnesota
Minnesota Oncology Hematology Pa, Edina, Minnesota
Minnesota Oncology Hematology, PA, Fridley, Minnesota
M Health Fairview Maple Grove Cancer Center, Maple Grove, Minnesota
Allina Health Cancer Institute-United(VPCI), Minneapolis, Minnesota
Hennepin Country Medical Center, Minneapolis, Minnesota
M Health Fairview University of Minnesota Investigational Drug Services, Minneapolis, Minnesota
Metro Minnesota Community Oncology Research Consortium(MMCORC), Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
M Health Fairview Lakes Medical Center, Wyoming, Minnesota
Nebraska Medicine- Bellevue Medical Center, Bellevue, Nebraska
Nebraska Medicine -Nebraska Medical Center, Omaha, Nebraska
Nebraska Medicine-Cancer Center at Village Pointe Health Center, Omaha, Nebraska
The University of Nebraska Medical Center, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Optum Care Cancer Care at Seven Hills, Las Vegas, Nevada
OptumCare Cancer center, Las Vegas, Nevada
OptumCare Cancer Center Care at Fort Apache, Las Vegas, Nevada
Icahn School of Medicine at Mount Sinai, New York, New York
Ship study drug to: Mount Sinai Hospital- Pharmacy Dept, New York, New York
ECU Health Medical Center, Greenville, North Carolina
AHN Saint Vincent Hospital, Erie, Pennsylvania
AHN Jefferson Hospital, Jefferson Hills, Pennsylvania
AHN Forbes Hospital, Monroeville, Pennsylvania
Allegheny Valley Hospital, Natrona Heights, Pennsylvania
AHN Cancer Institute - Allegheny General Hospital, Pittsburgh, Pennsylvania
AHN Cancer Institute Pharmacy, Pittsburgh, Pennsylvania
AHN West Penn Hospital, Pittsburgh, Pennsylvania
UT Southwestern Medical Center - Redbird, Dallas, Texas
University of Texas Southwestern Medical Center - Simmons Cancer Center, Dallas, Texas
University of Texas Southwestern Medical Center-Simmons Cancer Center Pharmacy, Dallas, Texas
University of Texas Southwestern Medical Center, Dallas, Texas
UT Southwestern - Simmons Cancer Center - Fort Worth, Fort Worth, Texas
UT Southwestern - Simmons Cancer Center - Richardson/Plano, Richardson, Texas
Inova Schar Cancer Institue Infusion Pharmacy, Fairfax, Virginia
Inova Schar Cancer Institute, Fairfax, Virginia
Harborview Medical Center, Seattle, Washington
Fred Hutchinson Cancer Center., Seattle, Washington
University of Washington Medical Center, Seattle, Washington
Clinica Viedma, Viedma, RIO Negro
Fundación Dr. Ruben Kowalyszyn, Viedma, RÍO Negro
Comisión Provincial de Evaluación de Proyectos de Investigación en Salud Humana (CEEPISH), Viedma, RÍO Negro
Centro de Oncologia e Investigacion de Buenos Aires (COIBA), Berazategui, Not set
Instituto Médico Especializado Alexander Fleming, Buenos Aires, Not set
Centro Medico Austral, Buenos Aire, Not set
Centro Oncologico Korben, Buenos Aire, Not set
Fundacion Cenit, Caba, Not set
Investigaciones Clinicas Moleculares (ICM), Caba, Not set
CEMAIC - Centro Medico Privado, Cordoba, Not set
Hospital Municipal de Morón. O. B. Lavignolle, Morón, Not set
Centro de Investigacion Pergamino SA, Pergamino, Not set
Comité Provincial de Bioética-Rosario, Rosario, Not set
Sanatorio Parque, Rosario, Not set
Consultorio Dr. Miguel Angel Escudero, Salta, Not set
Oncologia Salta, Salta, Not set
Centro para la Atencion Integral del paciente Oncologico, Tucuman, Not set
Concord Repatriation General Hospital, Concord, New South Wales
Saint Vincents Hospital Sydney - Human Research Ethics Committee, Darlinghurst, New South Wales
St Vincent's Clinic, Darlinghurst, New South Wales
Macquarie University Hospital, Macquarie University, New South Wales
Macquarie University, North Ryde, New South Wales
Prince of Wales Hospital, Randwick, New South Wales
North Shore Private Hospital, St Leonards, New South Wales
Mater Misericordiae - Mater Hospital Brisbane, Brisbane, Queensland
Icon Cancer Centre Chermside, Herston, Queensland
Mater Research, South Bribane, Queensland
Peninsula & South Eastern Hematology and Oncology Group (PASO), Frankston, Victoria
Austin Health, Melbourne, Victoria
South Eastern Sydney Local Health District, Caringbah, Not set
Lyell McEwin Hospital, Elizabeth Vale, Not set
Peninsula And South East Oncology, Frankston, Not set
Cabrini., Malvern, Not set
Mid North Coast Local Health District, NSW, Not set
Port Macquarie Base Hospital, Port Macquarie, Not set
Mater Cancer Care Centre, South Brisbane, Not set
Royal North Shore Hospital, St Leonards, Not set
Algemeen Ziekenhuis Maria Middelares, Gent, Not set
AZ St. Lucas, Ghent, Not set
University Hospital Ghent, Ghent, Not set
CHU de Liege Service Oncologie Medicale, Liege, Not set
CHU UCL Namur-Site de Saint Elisabeth, Namur, Not set
GZA Hospital Sint-Augustinus, Wilrijk, Not set
Centro de Oncologia da Bahia, Salvador, BA
Suporte Nutricional e Quimioterapia - PRONUTRIR, Fortaleza, Ceará
Associacao Mario Penna - Hospital Luxemburgo - NEPI Nucleo de Ensino Pesquisa e Inovacao, Belo Horizonte, MG
Hospital Sao Vicente de Paulo, Passo Fundo, RIO Grande DO SUL
Hospital Mae de Deus, Porto Alegre, RIO Grande DO SUL
Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, RS
Hospital Nossa Senhora da Conceicao / Grupo Hospitalar Conceicao, Porto Alegre, RS
Fundacao Doutor Amaral Carvalho, Jaú, SÃO Paulo
Hospital de Cancer de Barretos - Fundacao Pio XII, Barretos, Not set
Erasto Gaertner Hospital, CuriBba, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta
University of Alberta / Cross Cancer Institute, Edmonton, Alberta
Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC), Oshawa, Ontario
Princess Margaret Cancer Centre - University Health Network, Toronto, Ontario
Centro de Estudios Clínicos SAGA, Santiago, Not set
Centro de Investigaciones Clinicas Vina del Mar, Vina del mar, Not set
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Hradec Králové
Fakultni Nemocnice Olomouc (Fnol) - Onkologicka Klinika, Olomouc, Not set
University Hospital of Besancon, Besancon, Not set
Institut Bergonié Centre de Lutte Contre le Cancer (CLCC), Bordeaux Cedex, Not set
Centre de Lutte contre le Cancer - François Baclesse, Caen Cedex 5, Not set
Institut Paoli Calmettes, Marseille, Not set
Institut régional du Cancer de Montpellier - ICM Val d'Aurelle, MONTPELLIER Cedex 5, Not set
Pharmacy ICM Val d'Aurelle - Bat A - Rez-de-Jardin, MONTPELLIER Cedex 5, Not set
Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne, Nice Cedex 2, Not set
Hopital Europeen Georges Pompidou, Paris, Not set
Hospices Civils de Lyon, Pierre Benite, Not set
Unite de Coordination de la Biologie des Essais Cliniques, Strasbourg, Not set
Institut de Cancerologie Strasbourg Europe, Strasbourg, Not set
Institut Gustave Roussy, Villejuif Cedex, Not set
Athens Medical Center, Maroussi, Attikí
Bioclinic Thessalonikis Private Clinic Single Member S.A., Thessaloniki, Kentrikí Makedonía
Metropolitan General Hospital, Cholargos, Not set
Semmelweis Egyetem Urologiai Klinika, Budapest, Not set
Bacs-Kiskun Varmegyei Oktatokorhaz, Kecskemét, Not set
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Delhi
Nirmal Hospital Pvt Ltd, Surat, Gujarat
Cancer Trials Cork, Cork, Not set
Tallaght University Hospital, Tallaght, Not set
Cork University Hospital, Wilton, Not set
Shaare Zedek Medical Center, Jerusalem, Other
Hadassah Medical Center, Jerusalem, Other
Sheba Medical Center., Ramat Gan, Other
Emek Medical Center, Afula, Not set
Soroka Medical Center, Be'er Sheva, Not set
Rambam Health Care Campus, Hafia, Not set
Meir Medical Center, Kefar Sava, Not set
Rabin Medical Center, Petach Tikva, Not set
Kaplan Medical Center, Rehovot, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
IRCCS Istituto Tumori Giovanni Paolo II, Bari, Apulia
Azienda Ospedaliera Cardinale Giovanni Panico, Tricase, Apulia
Oncologia Medica, Ospedale Civile S. Maria delle Croci, Ravenna, Emilia-romagna
Ospedale Policlinico San Martino, Genova, Liguria
Ospedale San Raffaele, Milano, Lombardy
Istituto Clinico Humanitas-Humanitas Cancer Center, Rozzano (Milano), Lombardy
IRCCS Istituto Clinico Humanitas, Rozzano, Milano
IRCCS - Ospedale San Raffaele, Milano, Milan
Azienda Sanitaria Locale Napoli 2 Nord, Giugliano in Campania, Naples
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Other
P.O. "S. Maria Delle Grazie" - Pozzuoli - ASL Napoli Nord 2, Pozzuoli (NA), Other
ASL-AT, Ospedale Cardinal Massaia di Asti, Asti, Piemonte
SOSD Farmacia Ospedaliera, Aviano, Pordenone
Centro di Riferimento Oncologico Di Aviano, Aviano, Pordenone
AUSL Romagna - Presidio Ospedale "Umberto I" di Lugo, Lugo, Ravenna
AUSL della Romagna - Ospedale degli infermi, Faenza, RA
Azienda Ospedaliero Universitaria Careggi, Firenze, Tuscany
Azienda Ospedaliera S. Maria di Terni, Terni, Umbria
ASL Asti - Ospedale Cardinal Massaia - S.C. Farmacia Ospedaliera, Asti, Not set
ASST Cremona Farmacia Ospedaliera, Cremona, Not set
U.O. Farmacia Ospedaliera a Politiche del Farmaco Az. Osp. Universitaria Careggi, Firenze, Not set
Ospedale Policlinico San Martino Farmacia, Genova, Not set
Istituto Nazionale Tumori IRCCS Fondazione G.Pascale Napoli Pascale, Napoli, Not set
SC Farmacia Ospedaliera C/O Istituto Nazionale Tumori IRCCS Fondazione G.Pascale Napoli Pascale, Napoli, Not set
Istituto Oncologico Veneto - IRCCS, Padova, Not set
Azienda Ospedaliera Universitaria Pisana Ospedale Santa Chiara, Pisa, Not set
Azienda Ospedaliera Universitaria Pisana, U.O. Farmacia Ospedaliera, Pisa, Not set
Policlinico Universitario Agostino Gemelli, Roma, Not set
Centro Ricerche Cliniche Di Verona Srl, Verona, Not set
Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Not set
Hirosaki University Hospital, Hirosaki, Aomori
Ehime University Hospital, Toon, Ehime
National Hospital Organization Kyushu Cancer Center, Fukuoka-shi, Fukuoka
Gunma Prefectural Cancer Center, Ota-Shi, Gunma
Kobe University Hospital, Kobe-shi, Hyogo
University of Tsukuba Hospital, Tsukuba, Ibaraki
Kagawa University Hospital, Kita-gun, Kagawa
Yokohama City University Medical Center, Yokohama, Kanagawa
Kanagawa Cancer Center, Yokohama, Kanagawa
University of Miyazaki Hospital, Miyazaki City, Miyazaki
Nara Medical University Hospital, Kashihara, Nara
Kindai University Hospital, Osakasayama-Shi, Osaka
Osaka University Hopsital, Suita-city, Osaka
Tokushima University Hospital, Tokushima-Shi, Tokushima
Keio University Hospital, Shinjuku-ku, Tokyo
Wakayama Medical University Hospital, Wakayama-shi, Wakayama
Yamaguchi University Hospital, Ube, Yamaguchi
Chiba Cancer Center, Chiba, Not set
National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set
Osaka Prefectural Hospital Organization - Osaka International Cancer Institute, Osaka, Not set
Yamagata University Hospital, Yamagata, Not set
National Cancer Center, Goyang-si, Gyeonggi-do
CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do
The Catholic University of Korea, St. Vincent's Hospital, Suwon-si, Gyeonggi-do
Jeonbuk National University Hospital, Jeonju-si, Jeollabuk-do
Chonnam National University Hwasun Hospital, Hwasun-gun, Jeollanam-do
Wonkwang University Hospital, Iksan-si, Jeonlabuk-do
Inje University Haeundae Paik Hospital, Busan, Not set
Kosin University Gospel Hospital, Busan, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Korea University Anam Hospital, Seoul, Not set
Kangbuk Samsung Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center - Oncology, Seoul, Not set
Amphia Ziekenhuis, Breda, Noord-brabant
Haga Ziekenhuis, Den Haag, Zuid-holland
Antoni van Leeuwenhoek Apotheek,I-2, Amsterdam, Not set
Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, Not set
Rijnstate Hospital, Arnhem, Not set
Maastricht Universitair Medisch Centrum+, Maastricht, Not set
Radboud University Medical Center, Nijmegen, Not set
Akershus universitetssykehus HF, Lørenskog, Akershus
Avdeling for blod og kreft sykdommer. Stavanger universitetssykehus, Stavanger, Not set
Hospital Militar Central Coronel Luis Arias Schreiber, Lima, Not set
Hospital Maria Auxiliadora, Lima, Not set
Hospital de Braga, Sao Victor, Braga
Hospital de Braga, Braga, Not set
Centro Clinico Champalimaud, Lisboa, Not set
Hospital de Santa Maria - Centro Hospitalar Universitario Lisboa Norte, Lisboa, Not set
Champalimaud Clinical Center, Lisbon, Not set
Centro Hospitalar Universitário de São João, Porto, Not set
National University Hospital, Singapore, Not set
National University Cancer Institute, Singapore, Not set
National Cancer Centre Singapore, Singapore, Not set
Raffles Hospital, Singapore, Not set
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, A Coruna
Farmacia Oncologica - Unidad de Ensayos Clinicos, Santiago de Compostela, A Coruna
Hospital Universitario Badajoz, Badajoz, A Coruña [LA Coruña]
Institut Catala d' Oncologia de Badalona - Hospital Universitari Germans Trias i Pujos, Badalona, Barcelona
Institut Catala d'Oncologia Badalona (ICO Badalona) - Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona
Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), L'Hospitalet de Llobregat, Barcelona
Hospital de Cruzes, Barakaldo, Bizkaia
Hospital Universitario Marques de Valdecilla, Santander, Cantabria
Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda, Madrid
Infanta Cristina Hospital, Badajoz, Not set
Hospital Del Mar, Barcelona, Not set
Hospital Universitari Vall D Hebron, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau- Pharmacy, Barcelona, Not set
Hospital de La Santa Creu i Sant Pau, Barcelona, Not set
Unitat d'Assajos Clinics Servei de Farmacia, L'Hospitaler De Llobregat, Not set
Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
MD Anderson Cancer Center Madrid, Madrid, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz: Servicio de Farmacia, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
HM Centro Integral Oncologico Clara Campal, Madrid, Not set
Hospital Universitario HM Sanchinarro, Madrid, Not set
Complejo Hospitalario Universitario de Ourense (CHOU), Ourense, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Consorcio Hospital General Universitario de Valencia (CHGUV), Valencia, Not set
Consorcio Hospital General Universitario de Valencia, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Ryhov Hospital, Jonkoping, Not set
Karolinska University Hospital, Stockholm, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Not set
Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung City, Not set
Kaohsiung Medical University Hospital, Kaohsiung, Not set
China Medical University Hospital - Pharmacy, Taichung, Not set
China Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital Clinical Trials Pharmacy, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
Chi Mei Hospital liouying, Tainan City, Not set
Clinical Trial Pharmacy, Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Not set
National Cheng-Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Investigational Drug Service, Taipei, Not set
National Taiwan University Hospital, Taipei, Not set
NHS Greater Glasgow and Clyde (NHSGGC) - The Beatson West of Scotland Cancer Centre, Glasgow, Other
Barts Health NHS Trust Saint Bartholomews Hospital, London, Not set
Guy's and St Thomas' NHS Foundation Trust, London, Not set
Guy's and St Thomas' NHS Foundation, London, Not set
Conditions: Urothelial Carcinoma
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
Recruiting
This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; MK-2870) in first-line treatment of metastatic squamous non-small cell lung cancer. It is hypothesized that pembrolizumab with maintenance sacituzumab tirumotecan is superior to pembrolizumab without sacituzumab tirumotecan maintenance with respect to overall survival (OS).
This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; MK-2870) in first-line treatment of metastatic squamous non-small cell lung cancer. It is hypothesized that pembrolizumab with maintenance sacituzumab tirumotecan is superior to pembrolizumab without sacituzumab tirumotecan maintenance with respect to overall survival (OS). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: CARTI Cancer Center ( Site 0006), Little Rock, Arkansas +188 locations
CARTI Cancer Center ( Site 0006), Little Rock, Arkansas
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0122), Burbank, California
Exempla Lutheran Medical Center ( Site 0119), Golden, Colorado
Intermountain Health St. Mary's Regional Hospital ( Site 0116), Grand Junction, Colorado
Mid Florida Hematology and Oncology Center ( Site 0109), Orange City, Florida
Centricity Research Columbus Cancer Center ( Site 0111), Columbus, Georgia
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0001), Marietta, Georgia
University of Chicago Medical Center ( Site 0145), Chicago, Illinois
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0146), Minneapolis, Minnesota
New Mexico Oncology Hematology Consultants Ltd. ( Site 0123), Albuquerque, New Mexico
Thomas Jefferson University - Clinical Research Institute ( Site 0147), Philadelphia, Pennsylvania
Oncology Consultants P.A. ( Site 0124), Houston, Texas
Mays Cancer Center ( Site 0132), San Antonio, Texas
Instituto Alexander Fleming ( Site 0203), Ciudad Autónoma de Buenos Aires, Buenos Aires
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0200), Mar del Plata, Buenos Aires
Instituto Médico Río Cuarto ( Site 0204), Rio Cuarto., Cordoba
Fundacion Intecnus ( Site 0205), San Carlos de Bariloche, Rio Negro
Sanatorio Parque ( Site 0201), Rosario, Santa Fe
Hospital Aleman-Oncology ( Site 0202), Buenos Aires, Not set
Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 0720), Linz, Oberosterreich
Klinik Hietzing ( Site 0740), Wien, Not set
Standort Penzing der Klinik Ottakring-Abteilung für Atemwegs-und Lungenkrankheiten ( Site 0730), Wien, Not set
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 0710), Wien, Not set
Hospital do Cancer de Pernambuco ( Site 0312), Recife, Pernambuco
Oncoclínica Oncologistas Associados ( Site 0309), Terezina, Piaui
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0311), Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceição ( Site 0300), Porto Alegre, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 0304), Santa Cruz do Sul, Rio Grande Do Sul
Hospital de Base de São José do Rio Preto ( Site 0310), São José do Rio Preto, Sao Paulo
Hospital Paulistano ( Site 0307), Sao Paulo, Not set
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0100), Kingston, Ontario
Waterloo Regional Health Network (WRHN) ( Site 0153), Kitchener, Ontario
St. Marys Hospital Center ( Site 0105), Montreal, Quebec
McGill University Health Centre ( Site 0103), Montréal, Quebec
Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0106), Trois-Rivières, Quebec
Centro de Investigación del Maule ( Site 0419), Talca, Maule
FALP ( Site 0409), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0402), Santiago, Region M. De Santiago
Bradfordhill-Clinical Area ( Site 0407), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 0400), Viña del Mar, Valparaiso
Bradford Hill Norte ( Site 0420), Antofagasta, Not set
Beijing Cancer Hospital ( Site 2411), Beijing, Beijing
Beijing Cancer hospital-intrathoratic deparmtment II ( Site 2410), Beijing, Beijing
Peking Union Medical College Hospital ( Site 2412), Beijing, Beijing
Army Medical Center of People's Liberation Army-respiratory ( Site 2426), Chongqing, Chongqing
Fujian Provincial Cancer Hospital ( Site 2419), Fuzhou, Fujian
The First Affiliated hospital of Xiamen University-oncology ( Site 2420), Xiamen, Fujian
The First Affiliated Hospital of Guangzhou Medical University ( Site 2417), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 2416), Guangzhou, Guangdong
Harbin Medical University Cancer Hospital-oncology of department ( Site 2415), Harbin, Heilongjiang
Henan Cancer Hospital-Pneumology department ( Site 2423), Zhengzhou, Henan
Tongji Hospital Tongji Medical,Science & Technology ( Site 2424), Wuhan, Hubei
The Second Xiangya Hospital of Central South University-Oncology ( Site 2418), Changsha, Hunan
First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 2402), Huai'an, Jiangsu
Northern Jiangsu People's Hospital-General Surgery Department ( Site 2403), Yangzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University-Oncology Department ( Site 2405), Nanchang, Jiangxi
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 2404), Nanchang, Jiangxi
Jilin Province Tumor Hospital-GCP office ( Site 2413), Changchun, Jilin
The First Hospital of Jilin University-Oncology ( Site 2414), Changchun, Jilin
Shanghai East Hospital ( Site 2428), Shanghai, Shanghai
Shanghai Pulmonary Hospital ( Site 2427), Shanghai, Shanghai
West China Hospital, Sichuan University ( Site 2422), Cheng Du, Sichuan
Sichuan Cancer hospital. ( Site 2421), Chengdu, Sichuan
The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 2425), Urumqi, Xinjiang
The first Affiliated Hospital, Zhejiang University School of Medicine-Respiratory Department ( Site 2406), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 2407), Hangzhou, Zhejiang
Zhejiang Cancer Hospital-Breast Oncology ( Site 2408), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 2430), Taizhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 2409), Wenzhou, Zhejiang
Centro Cancerológico del Caribe (CECAC) ( Site 0509), Barranquilla, Atlantico
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0501), Valledupar, Cesar
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0500), Bogota, Distrito Capital De Bogota
Oncologos del Occidente ( Site 0504), Pereira., Risaralda
Fundación Valle del Lili-Oncology CIC ( Site 0505), Cali, Valle Del Cauca
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0800), Brno, Brno-mesto
Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 0803), Ostrava-Vitkovice, Ostrava Mesto
Fakultni nemocnice Olomouc-Klinika plicnich nemoci a tuberkulozy ( Site 0802), Olomouc, Not set
Clinique Clairval ( Site 0904), Marseille, Bouches-du-Rhone
Hôpital Robert Schuman ( Site 0907), Vantoux, Lorraine
Institut de Cancérologie de l'Ouest ( Site 0908), ANGERS cedex 02, Maine-et-Loire
Sainte Catherine Institut du Cancer Avignon Provence ( Site 0902), Avignon, Vaucluse
CHD Vendee ( Site 0901), La Roche-sur-Yon, Vendee
Hôpital Saint-Louis ( Site 0906), Paris, Not set
GEFOS Gesellschaft f. onkologische Studien ( Site 1005), Dortmund, Nordrhein-Westfalen
Universitätsklinikum Schleswig-Holstein-Pneumologie ( Site 1000), Luebeck, Schleswig-Holstein
SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1006), Gera, Thuringen
Charité Campus Virchow-Klinikum-Department of Infectious Diseases and Pulmonary Medicine ( Site 1003), Berlin, Not set
Bacs-Kiskun Varmegyei Oktatokorhaz ( Site 1100), Kecskemét, Bacs-Kiskun
Petz Aladar Egyetemi Oktato Korhaz ( Site 1101), Gyor, Gyor-Moson-Sopron
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 1103), Szolnok, Jasz-Nagykun-Szolnok
Reformatus Pulmonologiai Centrum ( Site 1102), Torokbalint, Pest
Zala Megyei Szent Rafael Kórház ( Site 1110), Zalaegerszeg, Zala
Országos Korányi Pulmonológiai Intézet ( Site 1104), Budapest, Not set
St. James's Hospital ( Site 1200), Dublin, Not set
Rambam Health Care Campus-Oncology Division ( Site 1302), Haifa, Not set
Shaare Zedek Medical Center ( Site 1300), Jerusalem, Not set
Rabin Medical Center ( Site 1303), Petah Tikva, Not set
Sheba Medical Center ( Site 1301), Ramat Gan, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1401), Napoli, Campania
Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 1409), Roma, Lazio
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1404), Milan, Lombardia
Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 1412), Monza, Lombardia
Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1408), Rozzano, Milano
Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1402), Rome, Roma
Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 1414), Brescia, Not set
Ospedale San Martino ( Site 1407), Genova, Not set
Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 1410), Pavia, Not set
Ospedale di Circolo e Fondazione Macchi Varese-Oncology ( Site 1413), Varese, Not set
Aichi Cancer Center ( Site 2502), Nagoya, Aichi
Nagoya University Hospital ( Site 2519), Nagoya, Aichi
Fujita Health University Hospital ( Site 2515), Toyoake, Aichi
Hirosaki University Hospital ( Site 2514), Hirosaki, Aomori
Ehime University Hospital ( Site 2511), Toon, Ehime
Gunma Prefectural Cancer Center ( Site 2510), Ota, Gunma
Takarazuka City Hospital ( Site 2508), Takarazuka, Hyogo
Kanazawa University Hospital ( Site 2513), Kanazawa, Ishikawa
St. Marianna University Hospital ( Site 2521), Kawasaki, Kanagawa
Kanagawa Cardiovascular and Respiratory Center ( Site 2518), Yokohama, Kanagawa
Kanagawa Cancer Center ( Site 2504), Yokohama, Kanagawa
Matsusaka Municipal Hospital ( Site 2522), Matsusaka, Mie
Sendai Kousei Hospital ( Site 2507), Sendai, Miyagi
Kansai Medical University Hospital ( Site 2503), Hirakata, Osaka
Saitama Prefectural Cancer Center ( Site 2512), Kitaadachi-gun, Saitama
Cancer Institute Hospital of JFCR ( Site 2500), Koto, Tokyo
Toho University Omori Medical Center ( Site 2520), Ota, Tokyo
National Center for Global Health and Medicine ( Site 2516), Shinjuku, Tokyo
National Hospital Organization Yamaguchi Ube Medical Center ( Site 2523), Ube, Yamaguchi
Chiba University Hospital ( Site 2517), Chiba, Not set
National Hospital Organization Kyushu Medical Center ( Site 2509), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 2505), Niigata, Not set
Osaka International Cancer Institute ( Site 2506), Osaka, Not set
The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 2106), Bupyeong-gu, Incheon
Pusan National University Yangsan Hospital ( Site 2104), Yangsan-si, Kyongsangnam-do
Pusan National University Hospital ( Site 2100), Busan, Pusan-Kwangyokshi
Kyungpook National University Chilgok Hospital-Pulmonology ( Site 2102), Deagu, Taegu-Kwangyokshi
Chungnam national university hospital-Department of Internal Medicine ( Site 2107), Daejeon, Taejon-Kwangyokshi
Kyung Hee University Hospital ( Site 2101), Seoul, Not set
Asan Medical Center ( Site 2105), Seoul, Not set
Korea University Guro Hospital-Internal Medicine ( Site 2103), Seoul, Not set
Clínicas AUNA Sede Chiclayo ( Site 0604), Chiclayo, Lambayeque
Oncosalud-Clinical Research ( Site 0600), Lima, Not set
Hospital Militar Central Coronel Luis Arias Schereiber ( Site 0602), Lima, Not set
Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 1510), Poznań, Dolnoslaskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1503), Bydgoszcz, Kujawsko-pomorskie
Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1513), Grudziadz, Kujawsko-pomorskie
Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1507), Gorlice, Malopolskie
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1515), Kraków, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1500), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1501), Przemysl, Podkarpackie
Szpital Wojewódzki w Koszalinie. ( Site 1517), Poland, Zachodniopomorskie
Centrul Medical Medicover Victoria ( Site 2000), Bucharest, Bucuresti
Cardiomed SRL Cluj-Napoca ( Site 2002), Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2001), Florești, Cluj
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2004), Craiova, Dolj
Cabinet Medical Oncomed ( Site 2005), Timisoara, Timis
SC ONCO CARD SRL ( Site 2007), Brasov, Not set
Clinica Polisano ( Site 2008), Sibiu, Not set
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 1703), Santiago de Compostela, Galicia
Hospital Insular de Gran Canaria-Oncology ( Site 1701), Las Palmas de Gran Canaria, Las Palmas
Hospital Quirón Málaga ( Site 1704), Málaga, Malaga
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1700), Barcelona, Not set
Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 1702), Madrid, Not set
Hospital Universitario Virgen de Valme-Departamento de Oncologia ( Site 1705), Sevilla, Not set
National Taiwan University Cancer Center (NTUCC) ( Site 2209), Taipei City, Taipei
Taoyuan General Hospital ( Site 2203), Taoyuan City, Taoyuan
Chang Gung Memorial Hospital at Kaohsiung ( Site 2207), Kaohsiung, Not set
Taichung Veterans General Hospital ( Site 2204), Taichung, Not set
National Cheng Kung University Hospital ( Site 2205), Tainan, Not set
National Taiwan University Hospital-Oncology ( Site 2208), Taipei, Not set
Mackay Memorial Hospital-Chest Medicine ( Site 2201), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 2202), Taoyuan, Not set
Prapokklao Hospital ( Site 2306), Mueang, Chanthaburi
Faculty of Medicine - Khon Kaen University ( Site 2305), Muang, Khon Kaen
Faculty of Medicine Siriraj Hospital ( Site 2301), Bangkok, Krung Thep Maha Nakhon
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 2300), Dusit, Krung Thep Maha Nakhon
Lampang Cancer Hospital ( Site 2304), Mueang Lampang, Lampang
Songklanagarind hospital ( Site 2303), HatYai, Songkhla
Maharaj Nakorn Chiang Mai Hospital ( Site 2302), Chiang Mai, Not set
Medipol Mega Universite Hastanesi-oncology ( Site 1811), Stanbul, Istanbul
Hacettepe Universite Hastaneleri-oncology hospital ( Site 1801), Ankara, Not set
Gazi Universitesi-Oncology ( Site 1804), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1800), Ankara, Not set
Memorial Kayseri Hastanesi ( Site 1805), Kayseri, Not set
Mersin Sehir Eğitim ve Araştırma Hastanesi-Oncology ( Site 1808), Mersin, Not set
Samsun Medical Park Hastanesi-medical oncology ( Site 1806), Samsun, Not set
Burjeel Medical City ( Site 2600), Abu Dhabi, Abu Zaby
Torbay Hospital ( Site 1906), Torquay, Devon
St Bartholomew's Hospital ( Site 1901), London, London, City Of
City Hospital, Nottingham University Hospitals NHS Trust-NCCTT ( Site 1911), Nottingham, Nottinghamshire
Conditions: Non-small Cell Lung Cancer, NSCLC
A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)
Recruiting
Researchers want to know if sacituzumab tirumotecan given alone or with pembrolizumab can treat triple negative breast cancer (TNBC). The main goal of this study is to learn if people treated with sacituzumab tirumotecan alone or with pembrolizumab live longer overall or without the cancer growing or spreading compared to people treated with chemotherapy.
Researchers want to know if sacituzumab tirumotecan given alone or with pembrolizumab can treat triple negative breast cancer (TNBC). The main goal of this study is to learn if people treated with sacituzumab tirumotecan alone or with pembrolizumab live longer overall or without the cancer growing or spreading compared to people treated with chemotherapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Ironwood Cancer & Research Centers ( Site 0036), Chandler, Arizona +93 locations
Ironwood Cancer & Research Centers ( Site 0036), Chandler, Arizona
Yale New Haven Hospital ( Site 0001), New Haven, Connecticut
AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0007), Altamonte Springs, Florida
St. Luke's Cancer Institute: Boise ( Site 0037), Boise, Idaho
MedStar Franklin Square Medical Center ( Site 0031), Baltimore, Maryland
MedStar Good Samaritan Hospital ( Site 0079), Baltimore, Maryland
MedStar Montgomery Medical Center ( Site 0078), Olney, Maryland
Holy Cross Hospital ( Site 0091), Silver Spring, Maryland
Allina Health Cancer Institute ( Site 0069), Minneapolis, Minnesota
Comprehensive Cancer Centers of Nevada ( Site 0015), Las Vegas, Nevada
Renown Regional Medical Center ( Site 0005), Reno, Nevada
New Mexico Oncology Hematology Consultants Ltd. ( Site 0019), Albuquerque, New Mexico
Instituto Alexander Fleming ( Site 2402), Mar De PLata, Buenos Aires
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2401), Mar del Plata, Buenos Aires
Clinica Viedma ( Site 2403), Viedma, Rio Negro
Fundacion Estudios Clinicos ( Site 2405), Rosario, Santa Fe
Hospital Italiano de Cordoba ( Site 2406), Cordoba, Not set
AZ Maria Middelares ( Site 3103), Gent, Oost-Vlaanderen
ZAS Sint Augustinus ( Site 3102), Antwerpen, Vlaams Gewest
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 2301), São Jose do Rio Preto, Sao Paulo
Jewish General Hospital ( Site 0203), Montreal, Quebec
St. Marys Hospital Center ( Site 0201), Montreal, Quebec
Hopital Du Saint-Sacrement ( Site 0210), Québec, Quebec
Biocenter ( Site 2009), Concepcion, Biobio
IC La Serena Research ( Site 2007), La Serena, Coquimbo
FALP ( Site 2000), Santiago., Region M. De Santiago
Clínica UC San Carlos de Apoquindo ( Site 2008), Santiago, Region M. De Santiago
Bradfordhill ( Site 2001), Santiago, Region M. De Santiago
ONCOCENTRO APYS ( Site 2005), Vina del Mar, Valparaiso
The First Afflilated Hospital of Bengbu Medical College ( Site 5022), Bengbu, Anhui
The First Affiliated Hospital of Chongqing Medical University ( Site 5039), Chongqing, Chongqing
Chongqing University Three Gorges Hospital ( Site 5020), Chongqing, Chongqing
Sun Yat-Sen University Cancer Center ( Site 5014), Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital. ( Site 5008), Nanning, Guangxi
Jiangsu Province Hospital ( Site 5009), Nanjing, Jiangsu
Xuzhou Central Hospital ( Site 5036), Xuzhou, Jiangsu
The First Hospital of Jilin University ( Site 5003), Changchun, Jilin
Jinan Central Hospital ( Site 5031), Jinan, Shandong
LinYi Cancer Hospital ( Site 5021), Linyi, Shandong
Sichuan Cancer Hospital. ( Site 5018), Chengdu, Sichuan
Affiliated Tumor Hospital of Xinjiang Medical University ( Site 5006), Urumqi, Xinjiang
Zhejiang Cancer Hospital ( Site 5012), Hangzhou, Zhejiang
The Second Affiliated hospital of Zhejiang University school of medicine ( Site 5024), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 5029), Linhai, Zhejiang
Instituto de Cancerología ( Site 2206), Medellin., Antioquia
Centro Cancerologico del Caribe LTD ( Site 2209), Barranquilla, Atlantico
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 2203), Bogota., Distrito Capital De Bogota
Rambam Health Care Campus ( Site 3700), Haifa, Not set
Shaare Zedek Medical Center ( Site 3704), Jerusalem, Not set
Rabin Medical Center ( Site 3702), Petah Tikva, Not set
Sheba Medical Center ( Site 3701), Ramat Gan, Not set
Sourasky Medical Center ( Site 3703), Tel Aviv, Not set
Nagoya City University Hospital ( Site 5108), Nagoya, Aichi
Hokkaido University Hospital ( Site 5100), Sapporo, Hokkaido
Tokai University Hospital ( Site 5107), Isehara, Kanagawa
Mie University Hospital ( Site 5109), Tsu, Mie
The University of Osaka Hospital ( Site 5111), Suita, Osaka
Saitama Medical University International Medical Center ( Site 5116), Hidaka, Saitama
Showa Medical University Hospital ( Site 5103), Shinagawa, Tokyo
Fukushima Medical University Hospital ( Site 5101), Fukushima, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 5113), Hiroshima, Not set
Social medical corporation Hakuaikai Sagara Hospital ( Site 5114), Kagoshima, Not set
National Cancer Center ( Site 5202), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 5204), Seongnam, Kyonggi-do
Kyungpook National University Chilgok Hospital ( Site 5205), Daegu, Kyongsangbuk-do
Seoul National University Hospital ( Site 5200), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 5201), Seoul, Not set
Samsung Medical Center ( Site 5203), Seoul, Not set
Harbour Cancer & Wellness ( Site 5600), Newmarket, Auckland
Pratia MCM Krakow ( Site 3812), Krakow, Malopolskie
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3801), Siedlce, Mazowieckie
Mazowiecki Szpital Onkologiczny ( Site 3807), Wieliszew, Mazowieckie
Szpitale Pomorskie Sp. z o. o. ( Site 3805), Gdynia, Pomorskie
Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie ( Site 3800), Koszalin, Zachodniopomorskie
Institutul Oncologic Cluj ( Site 4701), Cluj Napoca, Cluj
S.C. Radiotherapy Center Cluj S.R.L ( Site 4705), Comuna Floresti, Cluj
Centrul de Oncologie "Sfântul Nectarie" ( Site 4702), Craiova, Dolj
Centrul Medical Neolife- Baneasa ( Site 4706), Bucuresti, Not set
Hospital Clinico San Carlos ( Site 4100), Madrid, Madrid, Comunidad De
Hospital General Universitario de Valencia ( Site 4102), Valencia, Valenciana, Comunitat
Parc de Salut Mar - Hospital del Mar ( Site 4106), Barcelona, Not set
Hospital Beata María Ana ( Site 4105), Madrid, Not set
Hospital Universitario Ramon y Cajal ( Site 4103), Madrid, Not set
Taichung Veterans General Hospital ( Site 5303), Taichung, Not set
National Cheng Kung University Hospital ( Site 5304), Tainan, Not set
National Taiwan University Hospital ( Site 5300), Taipei, Not set
Mackay Memorial Hospital ( Site 5301), Taipei, Not set
Chang Gung Memorial Hospital ( Site 5302), Taoyuan, Not set
Faculty of Medicine Siriraj Hospital ( Site 5800), Bangkok, Krung Thep Maha Nakhon
Songklanagarind hospital ( Site 5801), HatYai, Songkhla
Faculty of Medicine - Khon Kaen University ( Site 5802), Khon Kaen, Not set
Royal Cornwall Hospital ( Site 4003), Truro, Cornwall
St Bartholomew's Hospital ( Site 4001), London, London, City Of
Nottingham University Hospital NHS Trust ( Site 4009), Nottingham, Nottinghamshire
Conditions: Triple Negative Breast Neoplasms
A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
Not Yet Recruiting
The purpose of this study is to compare the clinical benefit of the combination of BMS-986504 (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with homozygous MTAP deletion
The purpose of this study is to compare the clinical benefit of the combination of BMS-986504 (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with homozygous MTAP deletion Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Local Institution - 0119, Anchorage, Alaska +222 locations
Local Institution - 0119, Anchorage, Alaska
Local Institution - 0388, Phoenix, Arizona
Local Institution - 0120, Tucson, Arizona
Local Institution - 0135, Springdale, Arkansas
Local Institution - 0152, Fort Lauderdale, Florida
Local Institution - 0389, Jacksonville, Florida
Local Institution - 0124, Boise, Idaho
Local Institution - 0333, Lexington, Kentucky
Local Institution - 0125, Lexington, Kentucky
Local Institution - 0127, Scarborough, Maine
Local Institution - 0158, Boston, Massachusetts
Local Institution - 0420, Traverse City, Michigan
Local Institution - 0182, Rochester, Minnesota
Local Institution - 0160, Omaha, Nebraska
Local Institution - 0179, Hawthorne, New York
Local Institution - 0128, Rochester, New York
Local Institution - 0163, Cleveland, Ohio
Local Institution - 0129, Columbus, Ohio
Local Institution - 0164, Portland, Oregon
Local Institution - 0348, Portland, Oregon
Local Institution - 0433, Dallas, Texas
Local Institution - 0374, El Paso, Texas
Local Institution - 0132, Houston, Texas
Local Institution - 0377, The Woodlands, Texas
Local Institution - 0354, Salt Lake City, Utah
Local Institution - 0131, Fairfax, Virginia
Local Institution - 0186, Richmond, Virginia
Local Institution - 0145, Seattle, Washington
Local Institution - 0432, Liverpool, New South Wales
Local Institution - 0382, Birtinya, Queensland
Local Institution - 0381, Elizabeth Vale, South Australia
Local Institution - 0367, Ballarat, Victoria
Local Institution - 0207, Wien, Not set
Local Institution - 0227, Edegem, Antwerpen
Local Institution - 0226, Hasselt, Limburg
Local Institution - 0225, Yvoir, Namur
Local Institution - 0277, Roeselare, West-Vlaanderen
Local Institution - 0342, Brussels, Not set
Local Institution - 0340, Liège, Not set
Local Institution - 0088, Vitória, Espírito Santo
Local Institution - 0079, Natal, Rio Grande Do Norte
Local Institution - 0346, Porto Alegre, Rio Grande Do Sul
Local Institution - 0085, Blumenau, Santa Catarina
Local Institution - 0081, Barretos, São Paulo
Local Institution - 0076, Bauru, São Paulo
Local Institution - 0094, Campinas, São Paulo
Local Institution - 0095, Sao Paulo, São Paulo
Local Institution - 0355, São Caetano do Sul, São Paulo
Local Institution - 0351, São José do Rio Preto, São Paulo
Local Institution - 0091, Rio de Janeiro, Not set
Local Institution - 0078, São Paulo, Not set
Local Institution - 0315, Panagyurishte, Pazardzhik
Local Institution - 0309, Haskovo, Not set
Local Institution - 0308, Ruse, Not set
Local Institution - 0307, Stara Zagora, Not set
Local Institution - 0072, Hefei, Anhui
Local Institution - 0074, Beijing, Beijing
Local Institution - 0049, Beijing, Beijing
Local Institution - 0286, Beijing, Beijing
Local Institution - 0046, Fuzhou, Fujian
Local Institution - 0100, Xiamen, Fujian
Local Institution - 0099, Guangzhou, Guangdong
Local Institution - 0061, Guangzhou, Guangdong
Local Institution - 0281, Shenzhen, Guangdong
Local Institution - 0067, Nanning, Guangxi
Local Institution - 0353, Shijiazhuang, Hebei
Local Institution - 0106, Harbin, Heilongjiang
Local Institution - 0107, Zhengzhou, Henan
Local Institution - 0048, Wuhan, Hubei
Local Institution - 0059, Wuhan, Hubei
Local Institution - 0387, Changsha, Hunan
Local Institution - 0050, Changsha, Hunan
Local Institution - 0352, Nanjing, Jiangsu
Local Institution - 0279, Nanjing, Jiangsu
Local Institution - 0110, Nanchang, Jiangxi
Local Institution - 0284, Shenyang, Liaoning
Local Institution - 0104, Shenyang, Liaoning
Local Institution - 0103, Shenyang, Liaoning
Local Institution - 0060, Xi'an, Shaanxi
Local Institution - 0051, Jinan, Shandong
Local Institution - 0066, Linyi, Shandong
Local Institution - 0278, Shanghai, Shanghai
Local Institution - 0343, Shanghai, Shanghai
Local Institution - 0283, Taiyuan, Shanxi
Local Institution - 0109, Cheng Du, Sichuan
Local Institution - 0102, Chengdu, Sichuan
Local Institution - 0280, Hangzhou, Zhejiang
Local Institution - 0069, Hangzhou, Zhejiang
Local Institution - 0054, Hangzhou, Zhejiang
Local Institution - 0386, Nanjing, Not set
Local Institution - 0047, Zhengzhou, Not set
Local Institution - 0305, Bogotá, Cundinamarca
Local Institution - 0306, Montería, Córdoba
Local Institution - 0251, Hradec Kralove, Hradec Králové
Local Institution - 0250, Olomouc, Not set
Local Institution - 0356, Copenhagen, Hovedstaden
Local Institution - 0219, Pessac, Aquitaine
Local Institution - 0217, Caen, Calvados
Local Institution - 0212, Dijon, Côte-d'Or
Local Institution - 0341, Besançon, Doubs
Local Institution - 0221, Brest, Finistère
Local Institution - 0216, Toulouse, Haute-Garonne
Local Institution - 0220, Montpellier, Hérault
Local Institution - 0222, Rennes, Ille-et-Vilaine
Local Institution - 0215, Saint-Herblain, Loire-Atlantique
Local Institution - 0211, Vandoeuvre lès Nancy, Meurthe-et-Moselle
Local Institution - 0224, Marseille, Provence-Alpes-Côte-d'Azur
Local Institution - 0223, Clermont-Ferrand, Puy-de-Dôme
Local Institution - 0214, Pierre-Bénite, Rhône
Local Institution - 0213, Créteil, Val-de-Marne
Local Institution - 0218, Paris, Not set
Local Institution - 0338, Tours, Not set
Local Institution - 0202, München, Bayern
Local Institution - 0209, Regensburg, Bayern
Local Institution - 0008, Patras, Achaḯa
Local Institution - 0005, Athens, Attikí
Local Institution - 0001, Athens, Attikí
Local Institution - 0009, Athens, Attikí
Local Institution - 0006, Thessaloniki, Kentrikí Makedonía
Local Institution - 0003, Larissa, Thessalía
Local Institution - 0285, Hksar, Not set
Local Institution - 0323, Shatin, Not set
Local Institution - 0290, Gyula, Békés
Local Institution - 0291, Gyöngyös, Heves
Local Institution - 0287, Farkasgyepu, Veszprém
Local Institution - 0288, Budapest, Not set
Local Institution - 0267, New Delhi, Delhi
Local Institution - 0263, Bangalore, Karnataka
Local Institution - 0344, Bengaluru, Karnataka
Local Institution - 0345, Mumbai, Maharashtra
Local Institution - 0266, Mumbai, Maharashtra
Local Institution - 0265, Hyderabad, Telangana
Local Institution - 0264, Varanasi, Uttar Pradesh
Local Institution - 0010, Kfar Saba, HaMerkaz
Local Institution - 0011, Ramat Gan, HaMerkaz
Local Institution - 0016, Afula, HaTsafon
Local Institution - 0014, Haifa, HaTsafon
Local Institution - 0017, Jerusalem, Yerushalayim
Local Institution - 0013, Jerusalem, Yerushalayim
Local Institution - 0105, Napoli, Campania
Local Institution - 0042, Aviano, Friuli-Venezia Giulia
Local Institution - 0037, Orbassano, Torino
Local Institution - 0044, Perugia, Umbria
Local Institution - 0098, Bologna, Not set
Local Institution - 0045, Milano, Not set
Local Institution - 0039, Milan, Not set
Local Institution - 0035, Ravenna, Not set
Local Institution - 0243, Nagoya, Aichi
Local Institution - 0236, Kashiwa, Chiba
Local Institution - 0334, Otashi, Gunma
Local Institution - 0233, Sapporo, Hokkaido
Local Institution - 0336, Himeji, Hyogo
Local Institution - 0247, Kobe, Hyogo
Local Institution - 0335, Shiwa-gun Yahaba-cho, Iwate
Local Institution - 0257, Kawasaki, Kanagawa
Local Institution - 0238, Yokohama, Kanagawa
Local Institution - 0241, Nankoku, Kochi
Local Institution - 0237, Matsusaka City, Mie
Local Institution - 0232, Sendai, Miyagi
Local Institution - 0240, Hirakata, Osaka
Local Institution - 0245, Hidaka, Saitama
Local Institution - 0235, Shimotsuga, Tochigi
Local Institution - 0234, Bunkyo-ku, Tokyo
Local Institution - 0242, Ube, Yamaguchi
Local Institution - 0246, Fukuoka, Not set
Local Institution - 0244, Okayama, Not set
Local Institution - 0239, Osaka, Not set
Local Institution - 0272, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Local Institution - 0271, Goyang-si, Kyǒnggi-do
Local Institution - 0273, Seongnam, Kyǒnggi-do
Local Institution - 0270, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0269, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0268, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0274, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0390, Kuching, Sarawak
Local Institution - 0413, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0293, Mexico City, Distrito Federal
Local Institution - 0294, Mexico City, Distrito Federal
Local Institution - 0296, Guadalajara, Jalisco
Local Institution - 0298, Monterrey, Nuevo León
Local Institution - 0297, Oaxaca de Juarez, Oaxaca
Local Institution - 0327, Chihuahua, Not set
Local Institution - 0230, Arnhem, Not set
Local Institution - 0249, Groningen, Not set
Local Institution - 0261, Warsaw, Mazowieckie
Local Institution - 0259, Kraków, Małopolskie
Local Institution - 0258, Prabuty, Pomorskie
Local Institution - 0262, Poznań, Wielkopolskie
Local Institution - 0260, Bydgoszcz, Not set
Local Institution - 0021, Bucharest, București
Local Institution - 0019, Florești, Cluj
Local Institution - 0025, Craiova, Dolj
Local Institution - 0027, Otopeni, Ilfov
Local Institution - 0030, Ploiești, Prahova
Local Institution - 0020, Bucharest, Not set
Local Institution - 0022, Cluj, Not set
Local Institution - 0023, Cluj, Not set
Local Institution - 0031, Iași, Not set
Local Institution - 0026, Iași, Not set
Local Institution - 0116, Barcelona, Barcelona [Barcelona]
Local Institution - 0248, Hospitalet, Barcelona [Barcelona]
Local Institution - 0253, Barcelona, Catalunya [Cataluña]
Local Institution - 0118, Madrid, Madrid, Comunidad De
Local Institution - 0254, Madrid, Madrid, Comunidad De
Local Institution - 0252, Majadahonda, Madrid, Comunidad De
Local Institution - 0117, Málaga, Not set
Local Institution - 0256, Sevilla, Not set
Local Institution - 0255, València, Not set
Local Institution - 0114, Tainan City, Tainan
Local Institution - 0111, Tainan, Not set
Local Institution - 0113, Taipei, Not set
Local Institution - 0115, Taipei, Not set
Local Institution - 0112, Taoyuan, Not set
Local Institution - 0411, Bangkok, Not set
Local Institution - 0412, Bangkok, Not set
Local Institution - 0349, Izmir, Karsiyaka, İzmir
Local Institution - 0318, Adana, Not set
Local Institution - 0317, Adana, Not set
Local Institution - 0321, Ankara, Not set
Local Institution - 0350, Antalya, Not set
Local Institution - 0320, Bursa, Not set
Local Institution - 0319, Edirne, Not set
Local Institution - 0228, London, London, City Of
Conditions: Metastatic Non-small Cell Lung Cancer With MTAP Deletion
A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
Recruiting
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of divarasib combined with other anti-cancer therapies in participants with previously untreated, advanced or metastatic non-small cell lung cancer (NSCLC).
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of divarasib combined with other anti-cancer therapies in participants with previously untreated, advanced or metastatic non-small cell lung cancer (NSCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: City of Hope National Medical Center, Duarte, California +65 locations
City of Hope National Medical Center, Duarte, California
City of Hope - Seacliff, Huntington Beach, California
City of Hope at Irvine Lennar, Irvine, California
UCSD Moores Cancer Center, La Jolla, California
Yale Cancer Center, New Haven, Connecticut
NYU Langone Hospital - Long Island, Mineola, New York
NYU Cancer Center, New York, New York
Mount SInai Medical Center, New York, New York
MD Anderson Cancer Center, Houston, Texas
Oncology & Hematology Associates of Southwest Virginia, Inc, Blacksburg, Virginia
Virginia Oncology Associates, Norfolk, Virginia
Hospital Britanico, Buenos Aires, Not set
Clinica Adventista Belgrano, Ciudad Autonoma Buenos Aires, Not set
Centro Oncologico Riojano Integral (CORI), La Rioja, Not set
Concord Repatriation General Hospital, Concord, New South Wales
Peter MacCallum Cancer Centre, Melbourne, Victoria
Alfred Health, Melbourne, Victoria
Cliniques Universitaires St-Luc, Bruxelles, Not set
Jessa Zkh (Campus Virga Jesse), Hasselt, Not set
Clinique Ste-Elisabeth, Namur, Not set
AZ Delta (Campus Rumbeke), Roeselare, Not set
Hospital de Cancer de Barretos, Barretos, São Paulo
Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, São Paulo
Ottawa Hospital Regional Cancer Centre, Ottawa, Ontario
Princess Margaret Cancer Center, Toronto, Ontario
Jewish General Hospital, Montreal, Quebec
Hunan Cancer Hospital, Changsha CITY, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Shanghai Pulmonary Hospital, Shanghai, Not set
Rambam Medical Center, Haifa, Not set
Rabin MC, Petach Tikva, Not set
Tel Aviv Sourasky Medical Ctr, Tel Aviv, Not set
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Campania
Policlinico Universitario Agostino Gemelli IRCCS, Roma, Lazio
Irccs Istituto Nazionale Dei Tumori (Int), Milano, Lombardia
A.O. Universitaria S. Luigi Gonzaga, Orbassano, Piemonte
National Cancer Center Hospital East, Chiba, Not set
Kindai University Hospital, Osaka, Not set
National Cancer Center Hospital, Tokyo, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Pusan National University Hospital, Busan, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
NKI The Netherlands Cancer Institute, Amsterdam, Not set
UMC St Radboud, Nijmegen, Not set
Uniwersyteckie Centrum Kliniczne, Gda?sk, Not set
Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II, Kraków, Not set
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie, Olsztyn, Not set
ICO Badalona-H.U. Germans Trias i Pujol, Badalona, Barcelona
Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Sahlgrenska University Hospital, Göteborg, Not set
Universitätsspital Basel, Basel, Not set
Inselspital Bern, Bern, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan Uni Hospital, Taipei, Not set
Chang Gung Medical Foundation - Linkou, Taoyuan, Not set
Beatson West of Scotland Cancer Centre, Glasgow, Not set
Barts & London School of Med, London, Not set
Conditions: Non-Small Cell Lung Cancer
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
Recruiting
The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).
The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Banner MD Anderson Cancer Center ( Site 0181), Gilbert, Arizona +155 locations
Banner MD Anderson Cancer Center ( Site 0181), Gilbert, Arizona
Providence St. Jude Medical Center ( Site 0106), Fullerton, California
UCSF Medical Center at Mission Bay ( Site 0178), San Francisco, California
UCHealth Memorial Hospital Central ( Site 0125), Colorado Springs, Colorado
Banner MD Anderson Cancer Center at North Colorado Medical Center ( Site 0207), Greeley, Colorado
Beacon Cancer Care ( Site 0127), Post Falls, Idaho
The University of Chicago Medical Center ( Site 0118), Chicago, Illinois
Massachusetts General Hospital ( Site 0136), Boston, Massachusetts
Dana Farber Cancer Hospital ( Site 0155), Boston, Massachusetts
Ellis Fischel Cancer Center ( Site 0133), Columbia, Missouri
Lake Regional Hospital-Cancer Center ( Site 0123), Osage Beach, Missouri
Montefiore Medical Center ( Site 0160), Bronx, New York
Roswell Park Cancer Institute ( Site 0184), Buffalo, New York
Hematology-Oncology Associates of CNY ( Site 0164), East Syracuse, New York
Icahn School of Medicine at Mount Sinai ( Site 0116), New York, New York
Memorial Sloan Kettering Cancer Center ( Site 0137), New York, New York
SUNY Upstate Cancer Center ( Site 0140), Syracuse, New York
Westchester Medical Center ( Site 0196), Valhalla, New York
University of Cincinnati Medical Center ( Site 0119), Cincinnati, Ohio
St. Lukes Hospital and Health Network ( Site 0186), Bethlehem, Pennsylvania
Thompson Cancer Survival Center ( Site 0168), Knoxville, Tennessee
MD Anderson Cancer Center ( Site 0150), Houston, Texas
Memorial Hermann Cancer Center ( Site 0172), Houston, Texas
O'Quinn Medical Tower at McNair Campus ( Site 0131), Houston, Texas
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0148), Tyler, Texas
Swedish Cancer Institute ( Site 0143), Seattle, Washington
Virginia Mason Franciscan Health - St. Michael Cancer Center ( Site 0192), Silverdale, Washington
CEMIC ( Site 2454), Caba., Buenos Aires
Fundacion Intecnus ( Site 2456), San Carlos de Bariloche, Rio Negro
Centro Médico IPAM ( Site 2452), Rosario, Santa Fe
Instituto Medico Especializado Alexander Fleming ( Site 2457), Buenos Aires, Not set
Instituto Oncologico de Cordoba -IONC ( Site 2455), Cordoba, Not set
Calvary Mater Newcastle ( Site 2106), Waratah, New South Wales
Tasman Oncology Research ( Site 2104), Southport, Queensland
Princess Alexandra Hospital ( Site 2102), Wooloongabba, Queensland
Grampians Health ( Site 2101), Ballarat, Victoria
One Clinical Research ( Site 2103), Nedlands, Western Australia
Cliniques Universitaires Saint-Luc ( Site 1203), Bruxelles, Bruxelles-Capitale, Region De
Jessa Ziekenhuis ( Site 1204), Hasselt, Limburg
UZ Gent ( Site 1201), Gent, Oost-Vlaanderen
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 2502), Fortaleza, Ceara
Liga Norte Riograndense Contra o Cancer ( Site 2513), Natal, Rio Grande Do Norte
Hospital Tacchini ( Site 2506), Bento Goncalves, Rio Grande Do Sul
Hospital de Clínicas de Passo Fundo ( Site 2504), Passo Fundo, Rio Grande Do Sul
Hospital Moinhos de Vento ( Site 2510), Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora Da Conceicao ( Site 2512), Porto Alegre, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 2507), Santa Cruz do Sul, Rio Grande Do Sul
Hospital de Amor - Barretos ( Site 2511), Barretos, Sao Paulo
Instituto Nacional de Câncer - INCA ( Site 2501), Rio de Janeiro, Not set
MBAL Uni Hospital ( Site 1253), Panagyurishte, Pazardzhik
MHAT - Heart and Brain ( Site 1252), Pleven, Not set
Queen Elizabeth II Health Sciences Centre ( Site 1101), Halifax, Nova Scotia
Hamilton Health Sciences - Juravinski Site ( Site 1104), Hamilton, Ontario
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 1105), Kingston, Ontario
Lakeridge Health ( Site 1107), Oshawa, Ontario
McGill University Health Centre ( Site 1103), Montréal, Quebec
IUCPQ ( Site 1112), Québec, Quebec
FALP ( Site 2551), Santiago., Region M. De Santiago
Orlandi Oncologia ( Site 2555), Santiago, Region M. De Santiago
Clínica RedSalud Vitacura ( Site 2556), Santiago, Region M. De Santiago
Bradfordhill ( Site 2552), Santiago, Region M. De Santiago
ONCOCENTRO APYS ( Site 2554), Viña del Mar, Valparaiso
IMAT S.A.S ( Site 2602), Monteria, Cordoba
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 2603), Bogota, Distrito Capital De Bogota
Hospital Universitario San Ignacio ( Site 2610), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 2604), Bogota, Distrito Capital De Bogota
Oncologos del Occidente ( Site 2608), Pereira, Risaralda
Fundacion Valle del Lili- CIC ( Site 2601), Cali, Valle Del Cauca
Oulun yliopistollinen sairaala ( Site 1301), Oulu, Pohjois-Pohjanmaa
Turku University Hospital ( Site 1303), Turku, Varsinais-Suomi
CHU Besançon ( Site 1358), Besancon, Franche-Comte
Institut De Cancerologie De L Ouest ( Site 1357), Saint Herblain, Loire-Atlantique
CENTRE LEON BERARD ( Site 1351), Lyon CEDEX 08, Rhone
Marienhaus Klinikum Mainz ( Site 1403), Mainz, Rheinland-Pfalz
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 1452), Patras, Achaia
Errikos Dunant Hospital Center ( Site 1457), Athens, Attiki
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1451), Athens, Attiki
Metropolitan Hospital ( Site 1459), Athens, Attiki
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1460), Chaidari, Attiki
University General Hospital of Herakleion ( Site 1458), Herakleion., Irakleio
University General Hospital of Larissa-Oncology Clinic ( Site 1453), Larissa, Thessalia
Papageorgiou General Hospital of Thessaloniki ( Site 1454), Thessaloniki, Not set
Petz Aladár Megyei Oktató Kórház ( Site 1502), Gyor, Gyor-Moson-Sopron
Debreceni Egyetem Altalanos Orvostudomanyi Kar Tudogyogyaszati Tanszek ( Site 1508), Debrecen, Hajdu-Bihar
Mátrai Gyógyintézet ( Site 1504), Mátraháza, Heves
Reformatus Pulmonologiai Centrum-Onkopulmonologiai Jarobeteg Centrum ( Site 1505), Törökbálint, Pest
Somogy Vármegyei Kaposi Mór Oktató Kórház-Oncology center ( Site 1507), Kaposvár, Somogy
Orszagos Koranyi Pulmonologiai Intezet ( Site 1501), Budapest, Not set
Rambam Health Care Campus ( Site 1603), Haifa, Not set
Shaare Zedek Medical Center ( Site 1601), Jerusalem, Not set
Hadassah Medical Center ( Site 1605), Jerusalem, Not set
Sheba Medical Center ( Site 1602), Ramat Gan, Not set
Hospital of the University of Occupational and Environmental Health, Japan ( Site 1166), Kitakyushu, Fukuoka
St. Marianna University Hospital ( Site 1159), Kawasaki, Kanagawa
Kindai University Hospital ( Site 1162), Osakasayama, Osaka
Shizuoka Cancer Center ( Site 1160), Sunto-gun, Shizuoka
National Cancer Center Hospital ( Site 1156), Chuo, Tokyo
Tokyo Medical University Hospital ( Site 1157), Shinjuku, Tokyo
Chiba University Hospital ( Site 1154), Chiba, Not set
National Hospital Organization Kyushu Cancer Center ( Site 1167), Fukuoka, Not set
Fukushima Medical University Hospital ( Site 1151), Fukushima, Not set
Hiroshima University Hospital ( Site 1165), Hiroshima, Not set
Okayama University Hospital ( Site 1164), Okayama, Not set
Wakayama Medical University Hospital ( Site 1163), Wakayama, Not set
National Cancer Center ( Site 2305), Goyang-si, Kyonggi-do
The Catholic University of Korea St. Vincent s Hospital ( Site 2301), Suwonsi, Kyonggi-do
Ajou University Hospital ( Site 2306), Suwon, Kyonggi-do
Seoul National University Hospital ( Site 2303), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 2302), Seoul, Not set
Samsung Medical Center ( Site 2304), Seoul, Not set
Seoul St. Mary's Hospital ( Site 2307), Seoul, Not set
Medisch Centrum Leeuwarden ( Site 1702), Leeuwarden, Fryslan
Radboudumc ( Site 1706), Nijmegen, Gelderland
Dunedin Hospital ( Site 2202), Dunedin, Otago
Aliada ( Site 2753), Lima, Not set
Detecta Clínica ( Site 2751), Lima, Not set
Krakowski Szpital Specjalistyczny im. Jana Pawla II ( Site 1756), Krakow, Malopolskie
Instytut Gruźlicy i Chorób Płuc w Warszawie ( Site 1764), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1759), Przemysl, Podkarpackie
Uniwersyteckie Centrum Kliniczne ( Site 1758), Gdansk, Pomorskie
Swietokrzyskie Centrum Onkologii. ( Site 1754), Kielce, Swietokrzyskie
Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie ( Site 1760), Olsztyn, Warminsko-mazurskie
Wielkopolskie Centrum Pulmonologii i Torakochirurgii ( Site 1763), Poznan, Wielkopolskie
Centrul Medical Medicover Victoria ( Site 1802), Bucharest, Bucuresti
Institutul Regional de Oncologie ( Site 1804), Iasi, Not set
National Cancer Centre Singapore ( Site 2251), Singapore, Central Singapore
Tan Tock Seng Hospital ( Site 2252), Singapore, Central Singapore
Hospital Clinic de Barcelona ( Site 1919), Barcelona, Cataluna
Complejo Hospitalario Universitario A Coruna ( Site 1916), A Coruña, La Coruna
Hospital Universitario Quiron Madrid ( Site 1913), Pozuelo de Alarcon, Madrid
Hospital Universitari Vall D Hebron ( Site 1910), Barcelona, Not set
Hospital Insular de Gran Canaria ( Site 1911), Canarias, Not set
Hospital General Universitario Gregorio Maranon ( Site 1912), Madrid, Not set
Hospital Quiron Malaga ( Site 1914), Malaga, Not set
Karolinska Universitetssjukhuset Solna ( Site 1951), Stockholm, Stockholms Lan
Chung Shan Medical University Hospital ( Site 2351), Taichung, Not set
China Medical University Hospital ( Site 2358), Taichung, Not set
National Cheng Kung University Hospital ( Site 2354), Tainan, Not set
National Taiwan University Cancer Center (NTUCC) ( Site 2360), Taipei, Not set
Mackay Memorial Hospital ( Site 2355), Taipei, Not set
Taipei Medical University Hospital ( Site 2352), Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center ( Site 2359), Taipei, Not set
Taipei Veterans General Hospital ( Site 2357), Taipei, Not set
Chang Gung Memorial Hospital ( Site 2361), Taoyuan, Not set
Hacettepe Universite Hastaneleri ( Site 2001), Sıhhiye, Ankara
Sakarya Universitesi Tip Fakultesi Hastanesi ( Site 2006), Adapazarı, Sakarya
Namık Kemal University Medical Faculty ( Site 2007), Tekirdag, Tekirdas
Ankara Bilkent Sehir Hastanesi ( Site 2002), Ankara, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 2003), Istanbul, Not set
Bristol Haematology and Oncology Centre ( Site 2072), Bristol, Bristol, City Of
St Bartholomews Hospital ( Site 2052), London, London, City Of
Royal Free Hospital ( Site 2074), London, London, City Of
Guys Hospital ( Site 2057), London, London, City Of
Nottingham City Hospital ( Site 2058), Nottingham, Nottinghamshire
St James University Hospital ( Site 2055), Leeds, Not set
The Clatterbridge Cancer Centre ( Site 2069), Wirral, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
Safety and Effectiveness of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
Active Not Recruiting
This is a Phase III, multisite, randomized, double-blinded study to investigate BNT327 combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC).
This is a Phase III, multisite, randomized, double-blinded study to investigate BNT327 combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Clermont Oncology Center, Clermont, Florida +56 locations
Clermont Oncology Center, Clermont, Florida
Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne, Indiana
McFarland Clinic, Ames, Iowa
Helen G. Nassif Community Cancer Center, Cedar Rapids, Iowa
Baptist Cancer Center, Southaven, Mississippi
Nebraska Hematology-Oncology (NHO), Lincoln, Nebraska
University of Tennessee Medical Center, Knoxville, Tennessee
Millennium Research and Clinical Development, LLC, Houston, Texas
Hematology Oncology Associates of Fredericksburg, Inc., Fredericksburg, Virginia
Calvary Mater Newcastle, Waratah, New South Wales
Cancer Care Wollongong Pty Limited, Wollongong, New South Wales
The Queen Elizabeth Hospital, Woodville, South Australia
Olivia Newton-John Cancer Wellness & Research centre, Heidelberg, Victoria
Western Health Sunshine Hospital, St Albans, Victoria
Peninsula & South Eastern Haematology and Oncology Group, Frankston, Not set
Icon Cancer Centre Kurralta Park, Kurralta Park, Not set
Jilin Cancer Hospital, Changchun, Jilin
Korea University Guro Hospital, Seoul, Guro-gu
Ajou University Hospital, Suwon-si, Gyeonggi-do
National Cancer Center, Goyang-si, Gyeonggi
The Catholic University Of Korea, St. Vincent's Hospital, Suwon-si, Gyeonggi
Gyeongsang National University Hospital (GNUH), Jinju-si, Gyeongsangnam-do
Gachon University Gil Medical Center, Incheon, Namdong-gu
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center (AMC), Seoul, Not set
Samsung Medical Center, Seoul, Not set
Acibadem Adana Hospital, Adana, Not set
Seyhan Medical Park Hospital, Adana, Not set
Baskent University Adana Turgut Noyan Application and Research Center, Adana, Not set
Gulhane Training and Research Hospital, Ankara, Not set
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Not set
Hacettepe University Medical Faculty Hospital, Ankara, Not set
Memorial Ankara Hospital, Ankara, Not set
Gazi University, Medical Faculty Hospital, Ankara, Not set
Liv Hospital Ankara, Ankara, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Akdeniz University Hospital, Antalya, Not set
Koc Universitesi Hastanesi (Koc University Hospital), Istanbul, Not set
Medical Park Florya Hospital, Istanbul, Not set
Yeditepe University Kosuyolu Hospital, Istanbul, Not set
Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Not set
Medical Point Izmir Hospital, İzmir, Not set
Kocaeli University Medical Faculty Hospital, Kocaeli, Not set
Sakarya University Training and Research Hospital, Sakarya, Not set
The Christie NHS Foundation Trust, Manchester, Lancashire
Royal Marsden Hospital (RMH) - Royal Marsden NHS Foundation Trust, Chelsea, London
Royal Marsden Hospital (Sutton) - Royal Marsden NHS Foundation Trust, Sutton, London
Huddersfield Royal Infirmary - Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, North Yorkshire
Northern Centre for Cancer Care - The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, Northumberland
Nottingham University Hospitals NHS Trust - Nottingham City Hospital, Nottingham, Nottinghamshire
Churchill Hospital - Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire
Ninewells Hospital and Medical School - Tayside Health Board, Dundee, Scotland
Torbay and South Devon NHS Foundation Trust, Torquay, South Devon
Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, Staffordshire
Velindre NHS Trust, Velindre Cancer Centre, Cardiff, Wales
New Cross Hospital, Wolverhampton, West Midlands
St James's University Hospital - Leeds Teaching Hospitals NHS Trust, Leeds, Not set
Conditions: Extensive-stage Small-cell Lung Cancer
Safety, Effectiveness, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
Recruiting
This is a Phase 2/3, multisite, randomized, open-label study in participants with first-line non-small cell lung cancer (NSCLC).
This study includes two substudies (substudy A and substudy B) that will recruit participants according to histological subtypes due to differences in chemotherapy choice for standard-of-care and type of NSCLC.
This is a Phase 2/3, multisite, randomized, open-label study in participants with first-line non-small cell lung cancer (NSCLC).
This study includes two substudies (substudy A and substudy B) that will recruit participants according to histological subtypes due to differences in chemotherapy choice for standard-of-care and type of NSCLC. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Alaska Oncology and Hematology, LLC, Anchorage, Alaska +98 locations
Alaska Oncology and Hematology, LLC, Anchorage, Alaska
Clermont Oncology Center, Clermont, Florida
Physicians Clinic of Iowa, Cedar Rapids, Iowa
Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Baptist Health, Lexington, Kentucky
SSM Health Cancer Care - St. Clare, Fenton, Missouri
Mary Lanning Healthcare (MLH) - Morrison Cancer Center (MCC), Hastings, Nebraska
Astera Cancer Care, East Brunswick, New Jersey
The Valley Hospital - Valley Health System - The Robert and Audrey Luckow Pavilion, Paramus, New Jersey
White Plains Hospital, White Plains, New York
Fletcher Hospital, Inc. dba AdventHealth Hendersonville, Hendersonville, North Carolina
University of Cincinnati Medical Center, Cincinnati, Ohio
University of Tennessee Medical Center, Knoxville, Tennessee
Baptist Cancer Center, Memphis, Tennessee
Millennium Research and Clinical Development, LLC, Houston, Texas
Royal Adelaide Hospital, Adelaide, Not set
Cairns Hospital, Cairns, Not set
Dubbo Hospital, Dubbo, Not set
Peninsula & South Eastern Haematology and Oncology Group, Frankston, Not set
Icon Cancer Centre Kurralta Park, Kurralta Park, Not set
Western Health Sunshine Hospital, St Albans, Not set
ICON Cancer Care - Townsville, Townsville, Not set
Cancer Care Wollongong Pty Limited, Wollongong, Not set
Universitair Ziekenhuis Leuven, Leuven, Not set
CHU HELORA, Hopital de Mons - Site Kennedy, Mons, Not set
Shandong University - Jinan Central Hospital, Jinan, Not set
Shanghai Chest Hospital, Shanghai, Not set
Cancer Hospital of Shantou University Medical College, Shantou, Not set
Centre Hospitalier Universitaire d'Angers (CHU Angers), Angers, Not set
Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux, Not set
CHU Caen Normandie, Caen, Not set
Centre Francois Baclesse, Caen, Not set
Centre Hospitalier Intercommunal de Creteil (CHIC) - Centre de ressources et de competences pour la mucoviscidose (C.R.C.M.), Créteil, Not set
Institut de Cancerologie de l'Ouest (ICO)- CRLCC Rene Gauducheau, Saint-Herblain, Not set
Centre Hospitalier Intercommunal Toulon La Seyne Sur Mer (C.H.I.T.S) - Hospital Font-Pre, Toulon, Not set
Klinikum Esslingen GmbH, Esslingen, Not set
Asklepios Fachkliniken Muenchen Gauting, Gauting, Not set
Lungenfachklinik Immenhausen - Pneumologische Lehrklinik der Universitaet Goettingen, Immenhausen, Not set
MVZ for oncology and hematology Rhein-Kreis Neuss GmbH, Neuss, Not set
Praxiskooperation Bonn-Euskirchen-Rheinbach-Wesseling, Wesseling, Not set
Azienda Ospedaliera San Giuseppe Moscati, Avellino, Not set
Centro di Riferimento Oncologico, Aviano, Not set
IRCCS Istituto Romagnolo per lo studio dei Tumori Dino Amadori (IRST), Meldola, Not set
Casa Di Cura Polispecialistica Dott Pederzoli, Peschiera del Garda, Not set
Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Not set
Fondazione Ospedale Isola Tiberina - Gemelli Isola, Rome, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
Chungnam National University Hospital (CNUH), Daejeon, Not set
National Cancer Center, Goyang-si, Not set
Gachon University Gil Medical Center, Incheon, Not set
Gyeongsang National University Hospital (GNUH), Jinju-si, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center (AMC), Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
The Catholic University Of Korea, St. Vincent's Hospital, Suwon-si, Not set
Ajou University Hospital, Suwon-si, Not set
NZOZ Medpolonia Sp. Z o.o., Poznan, Not set
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu, Przemyśl, Not set
Instytut MSF Sp. z o.o., Łódź, Not set
Cardiomed, Cluj-Napoca, Not set
S.C. Medisprof S.R.L, Oncologie medicala, Cluj-Napoca, Not set
Radiotherapy Center Cluj, Cluj, Not set
Onco Clinic Consult SA, Craiova, Not set
Centrul de Oncologie Sf. Nectarie S.R.L (Sf Nectarie Oncology Center), Craiova, Not set
Ovidius Clinical Hospital, Ovidiu, Not set
Oncomed, Timisoara, Not set
Hospital Universitario Nuestra Senora De Valme, Sevilla, Not set
Hospital Universitario Virgen del Rocio, Seville, Not set
Adana City Training and Research Hospital, Adana, Not set
Gulhane Training and Research Hospital, Ankara, Not set
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Not set
Hacettepe University Medicine Faculty, Ankara, Not set
Memorial Ankara Hospital, Ankara, Not set
Liv Hospital Ankara, Ankara, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Akdeniz University Hospital, Antalya, Not set
Gaziantep Sanko University Medical Faculty, Gaziantep, Not set
Bezmialem Foundation University Medical Faculty, Istanbul, Not set
Yeditepe University Kosuyolu Hospital, Istanbul, Not set
Medical Point Izmir Hospital, İzmir, Not set
Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Kadıköy, Not set
Kocaeli Universitesi Tip Fakultesi, Kocaeli, Not set
Medical Park Florya Hospital, Kucukcekmece, Not set
Sakarya University - Faculty of Medicine, Sakarya, Not set
Ondokuz Mayis University Health Practice and Research Hospital, Samsun, Not set
Acibadem Adana Hospital, Seyhan, Not set
Medical Park Seyhan Hospital, Seyhan, Not set
Gazi University Faculty of Medicine, Yenimahalle, Not set
Koc Universitesi Hastanesi (Koc University Hospital), Zeytinburnu, Not set
Royal Sussex County Hospital - University Hospitals Sussex NHS Foundation Trust, Brighton, Not set
Velindre NHS Trust, Velindre Cancer Centre, Cardiff, Not set
Hull University Teaching Hospitals NHS Trust, Cottingham, Not set
University College Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Cancer And Haematology Centre-The Churchill Hospital-Oxford University Hospitals, Oxford, Not set
Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust, Preston, Not set
Southampton General Hospital, Southampton, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Non-small Cell Lung Cancer
Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)
Active Not Recruiting
The purpose of this study is to assess the efficacy and safety of pembrolizumab in combination with concurrent chemoradiation therapy followed by either pembrolizumab with olaparib placebo (Arm 1) or with olaparib (Arm 2) compared to concurrent chemoradiation therapy followed by durvalumab (Arm 3) in participants with unresectable, locally advanced NSCLC. Arms 1 and 2 will be studied in a double-blind design and Arm 3 will be open-label. The primary hypotheses are:
1. Pembrolizumab with concurr... Read More
The purpose of this study is to assess the efficacy and safety of pembrolizumab in combination with concurrent chemoradiation therapy followed by either pembrolizumab with olaparib placebo (Arm 1) or with olaparib (Arm 2) compared to concurrent chemoradiation therapy followed by durvalumab (Arm 3) in participants with unresectable, locally advanced NSCLC. Arms 1 and 2 will be studied in a double-blind design and Arm 3 will be open-label. The primary hypotheses are:
1. Pembrolizumab with concurrent chemoradiation therapy followed by pembrolizumab with olaparib is superior to concurrent chemoradiation therapy followed by durvalumab with respect to progression-free survival (PFS) and overall survival (OS)
2. Pembrolizumab with concurrent chemoradiation therapy followed by pembrolizumab is superior to concurrent chemoradiation therapy followed by durvalumab with respect to PFS and OS Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: University of South Alabama, Mitchell Cancer Institute ( Site 0003), Mobile, Alabama +204 locations
University of South Alabama, Mitchell Cancer Institute ( Site 0003), Mobile, Alabama
St. Bernards Medical Center ( Site 0089), Jonesboro, Arkansas
St Joseph Heritage Healthcare-Oncology ( Site 0088), Fullerton, California
Long Beach Memorial Medical Center ( Site 0006), Long Beach, California
UCLA Hematology/Oncology - Santa Monica ( Site 0013), Los Angeles, California
St. Joseph Heritage Healthcare Local Lab ( Site 0011), Santa Rosa, California
Torrance Memorial Physician Network / Cancer Center ( Site 0093), Torrance, California
Memorial Regional Hospital-Memorial Cancer Institute ( Site 0095), Hollywood, Florida
Miami VA Healthcare System ( Site 0024), Miami, Florida
Mid Florida Hematology and Oncology Center ( Site 0022), Orange City, Florida
Orlando Health, UF Health Cancer Center Inc ( Site 0092), Orlando, Florida
Fort Wayne Medical Oncology and Hematology ( Site 0094), Fort Wayne, Indiana
Parkview Research Center ( Site 0032), Fort Wayne, Indiana
Franciscan Health Lafayette East ( Site 0031), Lafayette, Indiana
University of Kentucky ( Site 0096), Lexington, Kentucky
Norton Brownsboro Hospital-Norton Cancer Institute - Brownsboro ( Site 0035), Louisville, Kentucky
Pikeville Medical Center ( Site 0036), Pikeville, Kentucky
Massachusetts General Hospital ( Site 0038), Boston, Massachusetts
Henry Ford Hospital ( Site 0045), Detroit, Michigan
VA St. Louis Health Care System ( Site 0047), Saint Louis, Missouri
Washington University Siteman Cancer Center ( Site 0046), Saint Louis, Missouri
CHI Health St. Francis ( Site 0053), Grand Island, Nebraska
Rutgers Cancer Institute of New Jersey ( Site 0054), New Brunswick, New Jersey
Valley Health Systems - Ridgewood Campus ( Site 0056), Paramus, New Jersey
Montefiore Einstein Center ( Site 0083), Bronx, New York
Novant Health Presbyterian ( Site 0081), Charlotte, North Carolina
Duke University Medical Center ( Site 0050), Durham, North Carolina
Piedmont Hematology-Oncology Associates ( Site 0080), Winston-Salem, North Carolina
The Lindner Center for Research and Education at The Christ Hospital ( Site 0060), Cincinnati, Ohio
Fox Chase Cancer Center ( Site 0063), Philadelphia, Pennsylvania
Sanford Cancer Center Oncology Clinic ( Site 0066), Sioux Falls, South Dakota
Veterans Affairs Puget Sound Health Care System [Seattle, WA] ( Site 0075), Seattle, Washington
Cancer Care Northwest ( Site 0074), Spokane Valley, Washington
Clinica Adventista Belgrano-Oncology ( Site 4002), Caba., Buenos Aires
Instituto Médico Río Cuarto ( Site 4003), Rio Cuarto., Cordoba
Queen Elizabeth II Health Sciences Centre ( Site 0100), Halifax, Nova Scotia
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0102), Montreal, Quebec
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0108), Montreal, Quebec
McGill University Health Center - Research Institute ( Site 0114), Montreal, Quebec
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0110), Quebec, Not set
Centro Investigación del Cáncer James Lind ( Site 0202), Temuco, Araucania
OrlandiOncologia ( Site 0201), Providencia, Region M. De Santiago
Bradfordhill ( Site 0200), Santiago, Region M. De Santiago
Oncocentro ( Site 0203), Vina del Mar, Valparaiso
Bradford Hill Norte ( Site 0204), Antofagasta, Not set
Peking Union Medical College Hospital ( Site 3201), Beijing, Beijing
Cancer Hospital Chinese Academy of Medical Sciences ( Site 3213), Beijing, Beijing
Beijing Cancer Hospital ( Site 3212), Beijing, Beijing
Beijing Cancer Hospital ( Site 3224), Beijing, Beijing
Daping Hospital,Third Military Medical University ( Site 3235), Chongqing, Chongqing
Fujian Provincial Cancer Hospital ( Site 3226), Fuzhou, Fujian
The First Affiliated Hospital of Xiamen University ( Site 3219), Xiamen, Fujian
Peking University Shenzhen Hospital ( Site 3216), Shenzhen, Guangdong
Cancer Hospital Chinese Academy Of Medical Sciences. Shenzhen Center ( Site 3200), Shenzhen, Guangdong
Henan Cancer Hospital ( Site 3205), Zhengzhou, Henan
Wuhan Union Hospital Cancer Center ( Site 3222), Wuhan, Hubei
Hubei Cancer Hospital ( Site 3218), Wuhan, Hubei
Xiangya Hospital of Central South University ( Site 3637), Changsha, Hunan
Second Xiangya Hospital of Central-South University ( Site 3227), Changsha, Hunan
Hunan Cancer Hospital ( Site 3225), Changsha, Hunan
Hunan Cancer Hospital ( Site 3238), Changsha, Hunan
Jiangsu Cancer Hospital ( Site 3234), Nanjing, Jiangsu
The Second Affiliated Hospital of Nanchang University ( Site 3206), Nanchang, Jiangxi
Jilin Cancer Hospital ( Site 3230), Changchun, Jilin
Shanghai Chest Hospital ( Site 3207), Shangai, Shanghai
Zhongshan Hospital Fudan University ( Site 3220), Shanghai, Shanghai
Shanghai Pulmonary Hospital ( Site 3203), Shanghai, Shanghai
West China Hospital of Sichuan University ( Site 3202), Chengdu, Sichuan
Tianjin Medical University Cancer Institute & Hospital ( Site 3204), Tianjin, Tianjin
The 1st Affil Hosp of College of Medicine, Zhejiang Univ ( Site 3232), Hangzhou, Zhejiang
Masarykuv onkologicky ustav ( Site 2206), Brno, Brno-mesto
Fakultni nemocnice Ostrava ( Site 2201), Ostrava, Ostrava Mesto
Fakultni nemocnice Kralovske Vinohrady-Radioterapeuticka a onkologicka klinika ( Site 2200), PRague, Praha 10
Fakultni nemocnice v Motole ( Site 2210), Praha, Praha 5
Nemocnice Na Plesi s.r.o. ( Site 2202), Nova Ves pod Plesi, Pribram
Krajska nemocnice Liberec, a.s. ( Site 2209), Liberec, Not set
Vseobecna fakultni nemocnice v Praze ( Site 2208), Praha 2, Not set
Nemocnice Na Bulovce ( Site 2205), Praha 8, Not set
North Estonia Medical Centre Foundation ( Site 1601), Tallin, Harjumaa
Tartu University Hospital ( Site 1600), Tartu, Tartumaa
Clinique Clairval ( Site 0802), Marseille, Bouches-du-Rhone
C.H.R.U. de Brest - Hopital Cavale Blanche ( Site 0806), Brest, Bretagne
Centre Hospitalier Annecy Genevois ( Site 0811), Epagny Metz Tessy, Haute-Savoie
Clinique Teissier Groupe ( Site 0808), Valenciennes, Nord
Hopital Avicenne ( Site 0803), Bobigny, Seine-Saint-Denis
Clinique de l'Europe-Service de pneumologie ( Site 0816), Amiens, Somme
H.I.A. Sainte-Anne ( Site 0815), Toulon, Var
CHD Vendee ( Site 0807), La Roche sur Yon, Vendee
Universitätsmedizin Göttingen - Georg-August-Universität ( Site 0917), Göttingen, Niedersachsen
Johannes Wesling Klinikum Minden ( Site 0908), Minden, Nordrhein-Westfalen
GEHO Muenster ( Site 0910), Muenster, Nordrhein-Westfalen
Johanna Etienne Hospital-Klinik für Onkologie ( Site 0916), Neuss, Nordrhein-Westfalen
LungenClinic Grosshansdorf GmbH ( Site 0901), Grosshansdorf, Schleswig-Holstein
Zentralklinik Bad Berka GmbH ( Site 0905), Bad Berka, Thuringen
Universitaetsklinikum Jena ( Site 0911), Jena, Thuringen
Charite-Universitaetsmedizin Berlin Campus Virchow-Klinikum ( Site 0900), Berlin, Not set
Katholisches Marienkrankenhaus gGmbH ( Site 0902), Hamburg, Not set
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 2302), Kecskemét, Bacs-Kiskun
Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 2303), Gyula, Bekes
Petz Aladar Megyei Oktato Korhaz ( Site 2306), Gyor, Gyor-Moson-Sopron
Orszagos Koranyi Pulmonologiai Intezet ( Site 2305), Budapest, Not set
Országos Korányi Pulmonológiai Intézet-VI. Tüdöbelosztály és Bronchológia ( Site 2309), Budapest, Not set
Azienda Ospedaliera Umberto I- Torrette ( Site 1009), Torrette, Ancona
Policlinico Agostino Gemelli ( Site 1002), Roma, Lazio
Istituto Clinico Humanitas Research Hospital ( Site 1000), Rozzano, Lombardia
Azienda Ospedaliero Universitaria Careggi ( Site 1001), Firenze, Not set
Azienda Ospedaliera Vito Fazzi ( Site 1003), Lecce, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1008), Milano, Not set
Policlinico di Modena ( Site 1007), Modena, Not set
A.O.U. Santa Maria della Misericordia di Udine ( Site 1004), Udine, Not set
Kurume University Hospital ( Site 3112), Kurume, Fukuoka
Kobe Minimally Invasive Cancer Center ( Site 3100), Kobe, Hyogo
Kanagawa Cancer Center ( Site 3101), Yokohama, Kanagawa
Kansai Medical University Hospital ( Site 3103), Hirakata, Osaka
Osaka Medical and Pharmaceutical University Hospital ( Site 3110), Takatsuki, Osaka
National Hospital Organization Kyushu Cancer Center ( Site 3104), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 3109), Niigata, Not set
Osaka International Cancer Institute ( Site 3106), Osaka, Not set
Juntendo University Hospital ( Site 3111), Tokyo, Not set
Tokyo Metropolitan Komagome Hospital ( Site 3108), Tokyo, Not set
Cancer Institute Hospital of JFCR ( Site 3107), Tokyo, Not set
Showa Medical University Hospital ( Site 3105), Tokyo, Not set
Chungbuk National University Hospital ( Site 2802), Cheongju-si, Chungbuk
National Cancer Center ( Site 2800), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 2801), Seongnam-si, Kyonggi-do
Ajou University Hospital ( Site 2803), Suwon-si, Kyonggi-do
The Catholic University of Korea St. Vincent s Hospital ( Site 2805), Suwonsi, Kyonggi-do
Gyeongsang National University Hospital ( Site 2804), Jinju-si, Kyongsangnam-do
Keimyung University Dongsan Hospital CRC room 1 ( Site 2807), Daegu, Taegu-Kwangyokshi
Kangbuk Samsung Hospital ( Site 2806), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 2808), Seoul, Not set
Pauls Stradins Clinical University Hospital ( Site 1501), Riga, Not set
Riga East Clinical University Hospital ( Site 1500), Riga, Not set
Hospital of Lithuanian University of Health Sciences Kauno klinikos-Pulmonology ( Site 4201), Kaunas, Kauno Apskritis
National Cancer Institute-Department of Thoracic Surgery and Oncology ( Site 4200), Vilnius, Vilniaus Miestas
Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0500), Guadalajara, Jalisco
Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 0508), Monterrey, Nuevo Leon
CLIMERS Clinical Medical Research ( Site 0506), Orizaba, Veracruz
Instituto Nacional de Cancerologia ( Site 0502), Tlalpan, Not set
Akershus Universitetssykehus HF ( Site 1106), Lorenskog, Akershus
Vestre Viken HF Drammen Sykehus ( Site 1101), Drammen, Buskerud
Sykehuset Oestfold ( Site 1107), Gralum, Ostfold
Helse Stavanger HF Stavanger Universitetssjukehus ( Site 1103), Stavanger, Rogaland
Oslo Universitetssykehus HF. Ulleval ( Site 1100), Oslo, Not set
Hospital Nacional Carlos Alberto Seguin Escobedo ESSALUD ( Site 0604), Arequipa, Ariqipa
Detecta Clínica ( Site 0607), Surquillo, Muni Metro De Lima
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0606), Lima, Not set
Oncosalud ( Site 0605), Lima, Not set
Clinica San Gabriel ( Site 0601), Lima, Not set
Hospital Nacional Cayetano Heredia ( Site 0602), Lima, Not set
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2404), Siedlce, Mazowieckie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2402), Warszawa, Mazowieckie
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 2400), Gdynia, Pomorskie
SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 2401), Olsztyn, Warminsko-mazurskie
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 2500), Bucharest, Bucuresti
Spitalul Universitar de Urgenta Bucuresti ( Site 2508), Bucharest, Bucuresti
Gral Medical SRL-Medical Oncology ( Site 2511), București, Bucuresti
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2506), Cluj Napoca, Cluj
S.C. Radiotherapy Center Cluj S.R.L ( Site 2503), Comuna Floresti, Cluj
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2510), Craiova, Dolj
Radiology Therapeutic Center-Oncology ( Site 2502), Otopeni, Ilfov
Policlinica Oncomed SRL ( Site 2504), Timisoara, Timis
S C Oncocenter Oncologie Clinica S R L-Medical Oncology ( Site 2509), Timișoara, Timis
Spitalul Clinic Judetean De Urgenta Constanta ( Site 2501), Constanta, Not set
Institutul Regional de Oncologie Iasi ( Site 2505), Iasi, Not set
Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1913), Chelyabinsk, Chelyabinskaya Oblast
MSROI named after P.A. Hertsen branch of FSBI NMRC Radiology ( Site 1903), Moscow, Moskva
Nizhniy Novgorod Region Oncology Dispensary ( Site 1914), Nizhniy Novgorod, Nizhegorodskaya Oblast
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1905), Saint-Petersburg, Sankt-Peterburg
Medical institute named after Berezin Sergey ( Site 1906), St. Petersburg, Sankt-Peterburg
Sverdlovsk Regional Oncology Hospital ( Site 1909), Ekaterinburg, Sverdlovskaya Oblast
Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 1911), Kazan, Tatarstan, Respublika
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 1910), Yaroslavl, Yaroslavskaya Oblast
Hospital Universitario Puerta de Hierro (Majadahonda) ( Site 1202), Majadahonda, Madrid
Hospital Universitario Quiron Madrid ( Site 1200), Pozuelo de Alarcon, Madrid
H.R.U Malaga - Hospital General ( Site 1206), Málaga, Malaga
H.U. Vall de Hebron ( Site 1201), Barcelona, Not set
Hospital Clinic de Barcelona ( Site 1204), Barcelona, Not set
Hospital Universitario Virgen Macarena ( Site 1205), Sevilla, Not set
Hospital Universitario La Fe ( Site 1203), Valencia, Not set
Chulalongkorn University ( Site 3003), Bangkok, Krung Thep Maha Nakhon
Ramathibodi Hospital. ( Site 3000), Bangkok, Krung Thep Maha Nakhon
Chiang Mai University Maharaj Nakorn Chiang Mai Hospital ( Site 3001), Chiang Mai, Not set
Srinagarind Hospital. Khon Kaen University ( Site 3002), Khon Kaen, Not set
Ankara Bilkent Sehir Hastanesi ( Site 2002), Ankara, Adana
Memorial Ankara Hastanesi ( Site 2006), Ankara, Not set
Istanbul Uni. Cerrahpasa Tip Fakultesi ( Site 2000), Istanbul, Not set
Medipol Universite Hastanesi ( Site 2003), Istanbul, Not set
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2001), Istanbul, Not set
Ege University Medical Faculty ( Site 2005), Izmir, Not set
Medical center Medikal Plaza of Ecodnipro LLC ( Site 2107), Dnipro, Dnipropetrovska Oblast
SOGrigoriev Inst for Med Radiolgy and Oncology of NAMS of Ukraine-Clinical oncology and hematology ( Site 2110), Kharkiv, Kharkivska Oblast
Communal nonprofit enterprise "Kherson Regional Oncology Dispensary" of Kherson Regional Council ( Site 2109), Antonivka Village, Khersonska Oblast
LLC Ukrainian Center of Tomotherapy ( Site 2105), Kropyvnytskyi, Kirovohradska Oblast
Medical Center of Yuriy Spizhenko LLC.-Clinical Trial ( Site 2104), Kapitanivka Village, Kyivska Oblast
SNPE National Cancer Institute ( Site 2101), Kyiv, Kyivska Oblast
Medical Center Verum ( Site 2106), Kyiv, Kyivska Oblast
Kyiv City Clinical Oncology Center ( Site 2100), Kyiv, Not set
Weston Park Hospital ( Site 1406), Sheffield, Derbyshire
University College Hospital NHS Foundation Trust ( Site 1403), London-Camden, London, City Of
Guys and St Thomas NHS Foundation Trust ( Site 1410), London, London, City Of
Royal Marsden Hospital (Sutton) ( Site 1407), London, Surrey
Southampton General Hospital ( Site 1400), Southampton, Worcestershire
Leeds Teaching Hospitals NHS Trust ( Site 1401), Leeds, Not set
Christie NHS Foundation Trust ( Site 1409), Manchester, Not set
Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
Study of Efficacy and Safety of Pembrolizumab Plus Platinum-based Doublet Chemotherapy With or Without Canakinumab in Previously Untreated Locally Advanced or Metastatic Non-squamous and Squamous NSCLC Subjects
Active Not Recruiting
This was a Phase III study of pembrolizumab plus platinum-based doublet chemotherapy with or without canakinumab in previously untreated locally advanced or metastatic non-squamous and squamous NSCLC participants.
This was a Phase III study of pembrolizumab plus platinum-based doublet chemotherapy with or without canakinumab in previously untreated locally advanced or metastatic non-squamous and squamous NSCLC participants. Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/12/2025
Locations: Pacific Shores Medical Group, Long Beach, California +152 locations
Pacific Shores Medical Group, Long Beach, California
USC Kenneth Norris Comprehensive Cancer Center, Los Angeles, California
Advent Health Cancer Institute, Orlando, Florida
Dana Farber Cancer Institute, Boston, Massachusetts
Novartis Investigative Site, Caba, Buenos Aires
Novartis Investigative Site, Caba, Not set
Novartis Investigative Site, Westmead, New South Wales
Novartis Investigative Site, Wooloongabba, Queensland
Novartis Investigative Site, Melbourne, Victoria
Novartis Investigative Site, Murdoch, Western Australia
Novartis Investigative Site, Linz, Oberoesterreich
Novartis Investigative Site, Salzburg, Not set
Novartis Investigative Site, Barretos, SP
Novartis Investigative Site, Sao Paulo, SP
Novartis Investigative Site, Sao Paulo, SP
Novartis Investigative Site, Edmonton, Alberta
Novartis Investigative Site, Brampton, Ontario
Novartis Investigative Site, Toronto, Ontario
Novartis Investigative Site, Temuco, Region De La Araucania
Novartis Investigative Site, Santiago, Not set
Novartis Investigative Site, Harbin, Heilongjiang
Novartis Investigative Site, Wuhan, Hubei
Novartis Investigative Site, Wuhan, Hubei
Novartis Investigative Site, Changsha, Hunan
Novartis Investigative Site, Changchun, Jilin
Novartis Investigative Site, XI An, Shanxi
Novartis Investigative Site, Hangzhou, Zhejiang
Novartis Investigative Site, Beijing, Not set
Novartis Investigative Site, Valledupar, Cesar
Novartis Investigative Site, Brno Bohunice, Not set
Novartis Investigative Site, Brno, Not set
Novartis Investigative Site, Ostrava Vitkovice, Not set
Novartis Investigative Site, Praha 2, Not set
Novartis Investigative Site, Herning, Not set
Novartis Investigative Site, Oulu, Not set
Novartis Investigative Site, Marseille, Bouches Du Rhone
Novartis Investigative Site, Lyon, Not set
Novartis Investigative Site, Montpellier, Not set
Novartis Investigative Site, Nantes Cedex 1, Not set
Novartis Investigative Site, Paris, Not set
Novartis Investigative Site, Goettingen, Niedersachsen
Novartis Investigative Site, Koeln, Nordrhein-Westfalen
Novartis Investigative Site, Halle Saale, Sachsen-Anhalt
Novartis Investigative Site, Leipzig, Sachsen
Novartis Investigative Site, Berlin, Not set
Novartis Investigative Site, Dresden, Not set
Novartis Investigative Site, Essen, Not set
Novartis Investigative Site, Georgsmarienhuette, Not set
Novartis Investigative Site, Gerlingen, Not set
Novartis Investigative Site, Heidelberg, Not set
Novartis Investigative Site, Koeln, Not set
Novartis Investigative Site, Muenchen, Not set
Novartis Investigative Site, Athens, GR
Novartis Investigative Site, Athens, Not set
Novartis Investigative Site, Kowloon, Not set
Novartis Investigative Site, Kowloon, Not set
Novartis Investigative Site, Veszprem, Not set
Novartis Investigative Site, Reykjavik, Not set
Novartis Investigative Site, Hyderabad, Andhra Pradesh
Novartis Investigative Site, Gurgaon, Haryana
Novartis Investigative Site, Pune, Maharashtra
Novartis Investigative Site, Jaipur, Rajasthan
Novartis Investigative Site, Hyderabad, Telangana
Novartis Investigative Site, Kolkata, West Bengal
Novartis Investigative Site, Avellino, AV
Novartis Investigative Site, Genova, GE
Novartis Investigative Site, Milano, MI
Novartis Investigative Site, Milano, MI
Novartis Investigative Site, Milano, MI
Novartis Investigative Site, Rozzano, MI
Novartis Investigative Site, Modena, MO
Novartis Investigative Site, Padova, PD
Novartis Investigative Site, Perugia, PG
Novartis Investigative Site, Parma, PR
Novartis Investigative Site, Orbassano, TO
Novartis Investigative Site, Nagoya, Aichi
Novartis Investigative Site, Sapporo city, Hokkaido
Novartis Investigative Site, Himeji, Hyogo
Novartis Investigative Site, Yokohama-city, Kanagawa
Novartis Investigative Site, Sakai, Osaka
Novartis Investigative Site, Sunto Gun, Shizuoka
Novartis Investigative Site, Chuo ku, Tokyo
Novartis Investigative Site, Ube-city, Yamaguchi
Novartis Investigative Site, Osaka, Not set
Novartis Investigative Site, Gyeonggi do, Korea
Novartis Investigative Site, Seoul, Seocho Gu
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Ashrafieh, Not set
Novartis Investigative Site, Saida, Not set
Novartis Investigative Site, Kuantan, Pahang
Novartis Investigative Site, Kuching, Sarawak
Novartis Investigative Site, Kuala Lumpur, Wilayah Persekutuan
Novartis Investigative Site, Kuala Lumpur, Not set
Novartis Investigative Site, Groningen, Not set
Novartis Investigative Site, Groningen, Not set
Novartis Investigative Site, Drammen, Not set
Novartis Investigative Site, Taguig City, Metro Manila
Novartis Investigative Site, Makati City, Not set
Novartis Investigative Site, Quezon, Not set
Novartis Investigative Site, San Juan City, Not set
Novartis Investigative Site, Gliwice, Not set
Novartis Investigative Site, Poznan, Not set
Novartis Investigative Site, Tomaszw Mazowiecki, Not set
Novartis Investigative Site, Lisboa, Not set
Novartis Investigative Site, Porto, Not set
Novartis Investigative Site, Craiova, Dolj
Novartis Investigative Site, Cluj-Napoca, Not set
Novartis Investigative Site, Arkhangelsk, Not set
Novartis Investigative Site, Omsk, Not set
Novartis Investigative Site, Pushkin Saint Petersburg, Not set
Novartis Investigative Site, Saint Petersburg, Not set
Novartis Investigative Site, St Petersburg, Not set
Novartis Investigative Site, Singapore, Not set
Novartis Investigative Site, Singapore, Not set
Novartis Investigative Site, Singapore, Not set
Novartis Investigative Site, Bratislava, Slovak Republic
Novartis Investigative Site, Partizanske, Not set
Novartis Investigative Site, Granada, Andalucia
Novartis Investigative Site, Badalona, Catalunya
Novartis Investigative Site, Barcelona, Catalunya
Novartis Investigative Site, San Sebastian, Pais Vasco
Novartis Investigative Site, Barcelona, Not set
Novartis Investigative Site, Las Palmas de Gran Canaria, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Malaga, Not set
Novartis Investigative Site, Valencia, Not set
Novartis Investigative Site, Zaragoza, Not set
Novartis Investigative Site, Stockholm, Not set
Novartis Investigative Site, Basel, Not set
Novartis Investigative Site, Kaohsiung, Not set
Novartis Investigative Site, Tainan, Not set
Novartis Investigative Site, Taipei, Not set
Novartis Investigative Site, Taipei, Not set
Novartis Investigative Site, Taoyuan, Not set
Novartis Investigative Site, Songkhla, Hat Yai
Novartis Investigative Site, Khon Kaen, THA
Novartis Investigative Site, Bangkok, Not set
Novartis Investigative Site, Bangkok, Not set
Novartis Investigative Site, Bangkok, Not set
Novartis Investigative Site, Ankara, Not set
Novartis Investigative Site, Ankara, Not set
Novartis Investigative Site, Edirne, Not set
Novartis Investigative Site, Istanbul, Not set
Novartis Investigative Site, High Heaton, Newcastle Upon Tyne
Novartis Investigative Site, London, Not set
Novartis Investigative Site, Manchester, Not set
Novartis Investigative Site, Plymouth, Not set
Novartis Investigative Site, Hanoi, Not set
Conditions: Non-small Cell Lung Cancer
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