Cisplatin Treatment Options in United Kingdom

A collection of 298 research studies where Cisplatin is the interventional treatment. These studies are located in the United Kingdom . Cisplatin is used for conditions such as Head and Neck Cancer, Lung Cancer and Non-Small Cell Lung Cancer.

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A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01

NCT05570422

Not Yet Recruiting

This is a seamless Phase 1/2 study consisting of two components. Phase 1 component is a dose-escalation, single arm, open label study in 10 patients to evaluate the safety and tolerability of KRC 01. Phase 2 component is a randomized, open label, controlled, multi-center study in 60 patients to evaluate the preliminary antitumor effect of KRC-01 in combination with CRT.

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

07/10/2024

Locations: Site 2, Chandigarh, Not set +4 locations

Conditions: Cervical Cancer

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A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer

NCT04025879

Active Not Recruiting

The main purpose of the study is to examine if periadjuvant (neoadjuvant, then adjuvant) immunotherapy will prolong event free survival in participants with early stage non-small cell lung cancer.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/26/2024

Locations: Local Institution - 0104, Tampa, Florida +107 locations

Local Institution - 0104, Tampa, Florida

Local Institution - 0040, Atlanta, Georgia

Local Institution - 0120, Augusta, Georgia

Local Institution - 0145, Chicago, Illinois

Local Institution - 0078, Chicago, Illinois

Local Institution - 0121, Orland Park, Illinois

Rcca Md Llc, Bethesda, Maryland

Local Institution - 0074, Boston, Massachusetts

Local Institution - 0076, Boston, Massachusetts

Local Institution - 0086, Traverse City, Michigan

Local Institution - 0100, Lebanon, New Hampshire

Local Institution - 0055, Cincinnati, Ohio

Local Institution - 0102, Cleveland, Ohio

Local Institution - 0054, Houston, Texas

Local Institution - 0103, Fredericksburg, Virginia

Local Institution - 0032, Ciudad Autonoma Beunos Aires, Buenos Aires

Local Institution - 0031, ABB, Ciudad Autónoma De Buenos Aires

Local Institution - 0043, Buenos Aires, Not set

Local Institution - 0030, Caba, Not set

Local Institution - 0020, Sydney, New South Wales

Local Institution - 0033, Heidelberg, Victoria

Local Institution - 0122, Melbourne, Victoria

Local Institution - 0023, North Ballarat, Victoria

Local Institution - 0002, Edegem, Not set

Local Institution - 0005, Liege, Not set

Local Institution - 0001, Roeselare, Not set

Local Institution - 0035, Belo Horizonte, Minas Gerais

Local Institution - 0029, Ijui, RIO Grande DO SUL

Local Institution - 0034, São Paulo, SAO Paulo

Local Institution - 0036, Sao Paulo, São Paulo

Local Institution - 0106, São Paulo, Not set

Local Institution - 0062, Oshawa, Ontario

Local Institution - 0115, Beijing, Beijing

Local Institution - 0096, Beijing, BEI

Local Institution - 0137, Fuzhou, Fujian

Local Institution - 0136, Fuzhou, Fujian

Local Institution - 0151, Hubei Sheng, Hubei

Local Institution - 0092, Changsha, Hunan

Local Institution - 0093, Changsha, Hunan

Local Institution - 0091, Changsha, Hunan

Local Institution - 0098, Shanghai, Shanghai

Local Institution - 0165, Shanghai, Shanghai

Local Institution - 0113, Shanghai, Shanghai

Local Institution - 0088, Chengdu, Sichuan

Local Institution - 0099, Hangzhou, Zhejiang

Local Institution - 0095, Shanghai, Not set

Local Institution - 0041, Praha 2, Not set

Local Institution - 0042, Praha 4, Not set

Local Institution - 0073, Besancon, Not set

Local Institution - 0037, La Tronche, Not set

Local Institution - 0050, Montpellier, Not set

Local Institution - 0038, Paris Cedex 18, Not set

Local Institution - 0051, Paris Cedex 20, Not set

Local Institution - 0083, Rennes Cedex 9, Not set

Local Institution - 0146, Rouen, Not set

Local Institution - 0110, Köln, Nordrhein-Westfalen

Local Institution - 0085, Berlin, Not set

Local Institution - 0065, Frankfurt, Not set

Local Institution - 0072, Georgsmarienhuette, Not set

Local Institution - 0071, Hamm, Not set

Local Institution - 0108, Heidelberg, Not set

Local Institution - 0109, Immenstadt, Not set

Local Institution - 0064, Loewenstein, Not set

Local Institution - 0147, Ludwigsburg, Not set

Local Institution - 0063, Luebeck, Not set

Local Institution - 0070, Moers, Not set

Local Institution - 0066, Muenchen, Not set

Local Institution - 0016, Dublin, Not set

Local Institution - 0024, Forlì, Not set

Local Institution - 0026, Milano, Not set

Azienda Ospedaliera Di Parma, Parma, Not set

Local Institution - 0135, Nagoya-shi, Aichi

Local Institution - 0124, Kashiwa-shi, Chiba

Local Institution - 0129, Kitakyushu-shi, Fukuoka

Local Institution - 0127, Kobe-shi, Hyogo

Local Institution - 0144, Kanazawa-shi, Ishikawa

Local Institution - 0125, Yokohama, Kanagawa

Local Institution - 0131, Sendai-shi, Miyagi

Local Institution - 0126, Sakai-shi, Osaka

Local Institution - 0130, Kitaadachigun, Saitama

Local Institution - 0142, Bunkyo-ku, Tokyo

Local Institution - 0133, Bunkyo-ku, Tokyo

Local Institution - 0143, Chuo-ku, Tokyo

Local Institution - 0134, Chuo-ku, Tokyo

Local Institution - 0132, Fukushima-shi, Not set

Local Institution - 0128, Hiroshima, Not set

Local Institution - 0077, Guadalajara, Jalisco

Local Institution - 0027, Monterrey, Nuevo Leon

Local Institution - 0028, Chihuahua, Not set

Local Institution - 0004, Groningen, Not set

Local Institution - 0003, Rotterdam, Not set

Local Institution - 0049, Kraków, Małopolskie

Local Institution - 0117, Hato Rey, Not set

Local Institution - 0013, Cluj-Napoca, Cluj

Local Institution - 0011, Bucuresti, Not set

Local Institution - 0012, Floresti, Not set

Local Institution, Moscow, Not set

Local Institution, Saint-Petersburg, Not set

Local Institution, St. Petersburg, Not set

Local Institution - 0046, Madrid, Not set

Local Institution - 0044, Majadahonda - Madrid, Not set

Local Institution - 0045, Valencia, Not set

Local Institution - 0149, Kaohsiung City, Not set

Local Institution - 0119, Kaohsiung, Not set

Local Institution - 0116, New Taipei City, Not set

Local Institution - 0112, Taipei City, Not set

Local Institution - 0007, Taunton, Not set

Conditions: Carcinoma, Non-Small-Cell Lung

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A Study of Atezolizumab With or Without Bevacizumab in Combination With Cisplatin Plus Gemcitabine in Patients With Untreated, Advanced Biliary Tract Cancer

NCT04677504

Completed

This study will evaluate the efficacy and safety of atezolizumab with bevacizumab in combination with cisplatin and gemcitabine(CisGem), compared with atezolizumab in combination with CisGem, in participants with advanced biliary tract cancer (BTC) who have not received prior systemic therapy. Treatment will consist of a chemotherapy combination phase followed by a cancer immunotherapy (CIT)/placebo phase.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/11/2024

Locations: City of Hope Cancer Center, Duarte, California +48 locations

City of Hope Cancer Center, Duarte, California

Massachusetts General Hospital, Boston, Massachusetts

Duke Cancer Center, Durham, North Carolina

Sarah Cannon Research Institute / Tennessee Oncology, Nashville, Tennessee

University of Virginia, Charlottesville, Virginia

Nanfang Hospital, Southern Medical University, Guangzhou, Not set

Sir Run Run Shaw Hospital Zhejiang University, Hangzhou City, Not set

Zhongshan Hospital Fudan University, Shanghai, Not set

Queen Mary Hospital; Dept. Of Haematology & Oncology, Hong Kong, Not set

Prince of Wales Hosp; Dept. Of Clinical Onc, Shatin, Not set

Fondazione Pascale; U.O. Sperimentazioni Cliniche, Napoli, Campania

Azienda Ospedaliero Universitaria di Bologna; Istituto di Ematologia "Lorenzo e Ariosto Seragnoli", Bologna, Emilia-Romagna

Istituto Clinico Humanitas - Humanitas Cancer Center, Rozzano, Sicilia

IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II, Padova, Veneto

CHA Bundang Medical Center, Gyeonggi-do, Not set

Seoul National University Bundang Hospital, Seongnam-si, Not set

Seoul National University Hospital, Seoul, Not set

Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

SP ZOZ Wojewódzki Szpital Specjalistyczny nr 4; Oddzial Onkologii Klinicznej, Bytom, Not set

Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii, Gdansk, Not set

Szpital Wojewódzki im. Miko?aja Kopernika; Oddzia? Dzienny Chemioterapii, Koszalin, Not set

NIO im Marii Sklodowskiej-Curie; Klinika Onkologii i Radioterapii, Warszawa, Not set

Dolno?l?skie Centrum Onkologii; Oddzia? Onkologii Klinicznej i Chemioterapii, Wroc?aw, Not set

FSBI "National Medical Research Center of Oncology N.N. Blokhin?, Moscow, Moskovskaja Oblast

First Moscow State Medical University n.a. I.M. Sechenov, Moscow, Moskovskaja Oblast

SBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM", Moskva, Moskovskaja Oblast

GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology), Saint Petersburg, Sankt Petersburg

Complejo Hospitalario de Navarra; Servicio de Oncologia, Pamplona, Navarra

Hospital Universitari Vall d'Hebron; Oncology, Barcelona, Not set

Hospital Ramon y Cajal; Servicio de Oncologia, Madrid, Not set

Complejo Hospitalario de Orense; Servicio de Oncologia, Orense, Not set

Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza, Not set

Taipei Veterans General Hospital; Department of Oncology, Taipei City, Not set

National Taiwan Uni Hospital; Dept of Oncology, Taipei, Not set

Maharaj Nakorn Chiang Mai Hosp; Oncology Unit, Chiangmai, Not set

Srinagarind Hospital; Medical Oncology Unit, Khon Kaen, Not set

Sunpasitthiprasong Hospital; Oncology and/or Hematology, Ubon Ratchathani, Not set

Adana Ac?badem Hospital Oncology Department, Adana, Not set

Memorial Ankara Hastanesi, Ankara, Not set

Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department, Malatya, Not set

Koc Universitesi Hastanesi; T?bbi Onkoloji, Zeyt?nburnu, Not set

SI Institute of general&urgent surgery n/a Zaytseva V.T NAMSU, Kharkiv, Kharkiv Governorate

?Kharkov Regional Oncology Center, Kharkiv, Kharkiv Governorate

SI "Shalimov National Institute of Surgery and Transplantation" of Nat.Acad of Med.Sci of Ukraine, Kyiv, KIEV Governorate

Beatson West of Scotland Cancer Centre, Glasgow, Not set

Royal Free Hospital, London, Not set

Churchill Hospital, Oxford, Not set

Royal Marsden Hospital (Sutton), Sutton, Not set

Conditions: Biliary Tract Cancer

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Paediatric Hepatic International Tumour Trial

NCT03017326

Active Not Recruiting

The PHITT trial is an over-arching study for patients with Hepatoblastoma (HB) and Hepatocellular Carcinoma (HCC). This trial will use a risk-adapted approach to the treatment of children diagnosed with HB. Children with HCC will be included as a separate cohort.

Gender:

ALL

Ages:

30 years and below

Trial Updated:

05/09/2024

Locations: St. Anna Kinderspital, Vienna, Not set +31 locations

St. Anna Kinderspital, Vienna, Not set

Cliniques Universitaires Saint-Luc, Brussels, Woluwe-Saint-Lambert

University Hospital Motol, Prague, Not set

Kuopio University Hospital, Kuopio, Not set

CHU de Rennes, Rennes, Not set

Ludwig-Maximillians-University Munich, Munich, Not set

Children's Health Ireland Crumlin, Dublin, Not set

Schneider Children's Medical Center, Petach Tikva, Not set

Prinses Maxima Center, Utrecht, Not set

Oslo University Hospital, Nydalen, Not set

Medical University of Gdansk, Gdańsk, Not set

University Hospital Reina Sofia, Córdoba, Not set

Hopitaux Universitaires de Geneve, Geneva, Not set

Royal Aberdeen Children's Hospital, Aberdeen, Not set

Royal Belfast Hospital for Sick Children, Belfast, Not set

Birmingham Children's Hospital, Birmingham, Not set

Bristol Royal Hospital for Children, Bristol, Not set

Addenbrooke's Hospital, Cambridge, Not set

Noah's Ark Children's Hospital for Wales, Cardiff, Not set

Royal Hospital for Children, Edinburgh, Not set

Royal Hospital for Children, Glasgow, Not set

Leeds General Infirmary, Leeds, Not set

Leicester Royal Infirmary, Leicester, Not set

Alder Hey Children's Hospital, Liverpool, Not set

Great Ormond Street Hospital, London, Not set

Royal Manchester Children's Hospital, Manchester, Not set

Great North Children's Hospital, Newcastle Upon Tyne, Not set

Nottingham Children's Hospital, Nottingham, Not set

Oxford Children's Hospital, Oxford, Not set

Sheffield Children's Hospital, Sheffield, Not set

University Hospital Southampton, Southampton, Not set

The Royal Marsden Hospital, Sutton, Not set

Conditions: Hepatoblastoma, Carcinoma, Hepatocellular

Learn More ›

Phase I Study of Olaparib Combined With Cisplatin-based Chemoradiotherapy to Treat Locally Advanced Head and Neck Cancer

NCT02308072

Active Not Recruiting

The phase I trial aims to determine the recommended phase II dose (RP2D) and schedule of olaparib in combination with standard cisplatin-based chemoradiotherapy, in patients with high-risk locally advanced squamous cell carcinoma of the head and neck (HNSCC), by assessing the safety and tolerability of the treatment combination.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/07/2024

Locations: Guy's and St Thomas' NHS Foundation Trust, London, Not set +2 locations

Conditions: Head and Neck Cancer

Learn More ›

An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma

NCT02265770

Recruiting

The overall aim of this project is to improve the outcome of patients diagnosed with ependymoma by improving and harmonising the staging and the standard of care of this patient population and to improve the investigators understanding of the underlying biology thereby informing future treatment. The program will evaluate new strategies for diagnosis (centralized reviews of pathology and imaging) and new therapeutic strategies in order to develop treatment recommendations. Patients will be str... Read More

Gender:

ALL

Ages:

22 years and below

Trial Updated:

04/25/2024

Locations: Medical University of Graz-Department of Pediatrics and Adolescent Medicine, Graz, Not set +39 locations

Medical University of Graz-Department of Pediatrics and Adolescent Medicine, Graz, Not set

CHR de la CITADELLE, Liege, Not set

University Hospital Brno, Brno, Not set

Aarhus University Hospital, Aarhus, Not set

CHRU STRASBOURG - Hôpital de Hautepierre, Strasbourg, Bas-Rhin

AP-HM - Hôpital d'Enfants de La Timone, Marseille, Bouches-du-Rhône

CHU Dijon - Hôpital des Enfants, Dijon, Côte d'Or

CHRU BESANCON - Hôpital Jean Minjoz, Besançon, Doubs

CHRU BREST - Hôpital Morvan, Brest, Finistère

CHU de Bordeaux-Hôpital des enfants Pellegrin, Bordeaux, Gironde

CHU de TOULOUSE - Hôpital des Enfants, Toulouse, Haute-Garonne

CHRU MONTPELLIER - Hôpital Arnaud de Villeneuve, Montpellier, Herault

Fondation Institut Curie, Paris, Ile-De-France

Institut Gustave Roussy, Villejuif, Ile-de-France

CHU de RENNES - Hôpital Sud, Rennes, Ille-et-Vilaine

CHRU Tours - Hôpital Clocheville, Tours, Indre-et-Loire

CHU GRENOBLE - Hôpital Couple-Enfant, La Tronche, Isère

CHRU Saint-Etienne, Saint-Etienne, Loire

Chu Angers, Angers, Maine-et-Loire

CHU REIMS - American Memorial Hospital, Reims, Marne

CHU NANCY - Brabois Hôpital d'Enfants, Vandoeuvre-les-Nancy, Meurthe-et-Moselle

Centre OSCAR LAMBRET, Lille, Nord

CHU Clermont- Ferrand - Hôpital Estaing, Clermont-Ferrand, Puy-de-Dôme

Centre LEON BERARD, Lyon, Rhône

CHU Rouen - Hôpital Charles Nicolle, Rouen, Seine Maritime

CHU AMIENS-PICARDIE - Hôpital Nord, Amiens, Somme

CHU POITIERS - Hôpital de la Milétrie, Poitiers, Vienne

CHU Limoges, Limoges, Not set

CHU Nice - Hôpital de l'Archet 2, Nice, Not set

CHU La Réunion, Saint-Denis, Not set

University Medical Center Hamburg-Eppendorf, Hamburg, Not set

Our Lady's Children's Hospital, Dublin, Not set

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Not set

Princess Maxima Center for pediatric oncology, Utrecht, Not set

Department of Paediatric, Haukeland University Hospital, Bergen, Not set

University Medical Center Ljubljana, Ljubljana, Not set

Hospitales Universitarios Virgen Macarena y Virgen del Rocío Avda, Sevilla, Not set

Skåne University Hospital, Lund, Not set

University Children's Hospital, Zurich, Not set

Queen's Medical Centre, Nottingham, Not set

Conditions: Childhood Ependymoma

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Study of Nivolumab Combined With Ipilimumab Versus Pemetrexed and Cisplatin or Carboplatin as First Line Therapy in Unresectable Pleural Mesothelioma Patients

NCT02899299

Completed

The purpose of this study is to test the effectiveness and tolerability of the combination of Nivolumab and Ipilimumab compared to Pemetrexed and Cisplatin or Carboplatin in patients with unresectable pleural mesothelioma.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/24/2024

Locations: Ucsf, San Francisco, California +108 locations

Ucsf, San Francisco, California

Local Institution - 0014, New Haven, Connecticut

H. Lee Moffitt Cancer Center & Research Inst, Inc, Tampa, Florida

Local Institution - 0002, Chicago, Illinois

Univ Of Maryland Greenbaum Cancer Center, Baltimore, Maryland

Local Institution - 0013, Detroit, Michigan

Cancer & Hematology Centers Of Western Michigan, Grand Rapids, Michigan

Local Institution - 0004, Rochester, Minnesota

Memorial Sloan Kettering Nassau, New York, New York

Local Institution - 0007, Cleveland, Ohio

University Of Pennsylvania, Philadelphia, Pennsylvania

Allegheny Cancer Center, Pittsburgh, Pennsylvania

Local Institution - 0005, Houston, Texas

West Virginia University, Morgantown, West Virginia

Local Institution - 0032, Sydney, New South Wales

Local Institution - 0031, Birtinya, Queensland

Local Institution - 0033, Clayton, Victoria

Local Institution - 0030, Malvern, Victoria

Local Institution - 0034, Nedlands, Western Australia

Local Institution - 0089, Brussels, Not set

Local Institution - 0086, Edegem, Not set

Local Institution - 0087, Liège, Not set

Local Institution - 0088, Sint-Niklaas, Not set

Local Institution, Barretos, Sao Paulo

Local Institution - 0064, Sao Paulo, Not set

Local Institution - 0018, Santiago, Metropolitana

Local Institution - 0133, Harbin Shi, Heilongjiang

Local Institution, Changchun, Jilin

Local Institution, Shenyang, Liaoning

Local Institution - 0124, Kunming, Not set

Local Institution - 0120, Shanghai, Not set

Local Institution - 0039, Bogota, Not set

Local Institution - 0040, Bogota, Not set

Local Institution - 0057, Caen, Not set

Local Institution - 0073, Creteil, Not set

Local Institution - 0074, La Tronche, Not set

Local Institution - 0067, Lille Cedex, Not set

Local Institution - 0069, Marseille Cedex 20, Not set

Local Institution - 0056, Paris, Not set

Local Institution - 0080, Saint Herblain, Not set

Local Institution - 0093, Strasbourg Cedex, Not set

Local Institution - 0058, Toulon Cedex, Not set

Local Institution - 0068, Toulouse Cedex 9, Not set

Local Institution - 0026, Cologne, Not set

Local Institution - 0054, Coswig, Not set

Local Institution - 0038, Essen, Not set

Local Institution - 0023, Gottingen, Not set

Local Institution - 0024, Grosshansdorf, Not set

Local Institution - 0027, Hamburg, Not set

Local Institution - 0037, Heidelberg, Not set

Local Institution - 0021, Homburg an d. Saar, Not set

Local Institution - 0022, Immenhausen, Not set

Local Institution - 0019, Moers, Not set

Local Institution - 0017, Athens, Not set

Local Institution - 0016, Thessaloniki, Not set

Local Institution - 0042, Ravenna, Emilia-Romagna

Local Institution - 0047, Aviano, Not set

Local Institution - 0044, Bari, Not set

Local Institution - 0046, Catania, Not set

Local Institution - 0045, Genova, Not set

Local Institution - 0043, Napoli, Not set

Local Institution - 0048, Rozzano, Not set

Local Institution - 0041, Siena, Not set

Local Institution - 0105, Nagoya-shi, Aichi

Local Institution - 0097, Chiba-shi, Chiba

Local Institution - 0108, Fukuyama-shi, Hiroshima

Local Institution - 0114, Hiroshima-Shi, Hiroshima

Local Institution - 0101, Sapporo-shi, Hokkaido

Local Institution - 0106, Amagasaki-shi, Hyogo

Local Institution - 0098, Nishinomiya-shi, Hyogo

Local Institution - 0095, Yokohama-shi, Kanagawa

Local Institution - 0104, Natori-shi, Miyagi

Local Institution - 0107, Niigata-shi, Niigata

Local Institution - 0100, Okayama-shi, Okayama

Local Institution - 0096, Kitaadachi-gun, Saitama

Local Institution - 0094, Chuo-ku, Tokyo

Local Institution - 0099, Ube-shi, Yamaguchi

Local Institution - 0113, Osakasayama-city, Not set

Local Institution - 0079, Df, Distrito Federal

Local Institution - 0053, Mexico, Distrito Federal

Local Institution - 0050, Mexico, Distrito Federal

Local Institution - 0051, Guadalajara, Jalisco

Local Institution - 0118, Chihuahua, Not set

Local Institution - 0092, Amsterdam, Not set

Local Institution - 0091, Rotterdam, Not set

Local Institution - 0078, Bytom, Not set

Local Institution - 0076, Krakow, Not set

Local Institution - 0077, Warszawa, Not set

Local Institution - 0115, Bucharest, Not set

Local Institution - 0109, Bucuresti, Not set

Local Institution - 0102, Craiova, Not set

Local Institution - 0055, Romania, Not set

Local Institution - 0150, Moscow, Not set

Local Institution - 0071, Moscow, Not set

Local Institution - 0072, Saint Petersburg, Not set

Local Institution - 0060, Pretoria, Gauteng

Local Institution - 0059, Cape Town, Western Cape

Local Institution - 0049, Bern, Not set

Local Institution - 0036, Lausanne, Not set

Local Institution - 0029, Zurich, Not set

Local Institution - 0111, Diyarbakır, Not set

Local Institution - 0112, Istanbul, Not set

Local Institution - 0110, Seyhan, Not set

Local Institution - 0085, Truro, Cornwall

Local Institution - 0084, Edinburgh, Midlothian

Local Institution - 0081, Leicester, Not set

Local Institution - 0083, London, Not set

Local Institution - 0116, Manchester, Not set

Local Institution - 0090, Southampton, Not set

Conditions: Mesothelioma

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Phase 3 Study of BGJ398 (Oral Infigratinib) in First Line Cholangiocarcinoma With FGFR2 Gene Fusions/Translocations

NCT03773302

Terminated

Infigratinib is an oral drug which selectively binds to fibroblast growth factor receptor (FGFR) 2 and is being developed to treat participants with FGFR2 mutated cholangiocarcinoma. The purpose of the study is to evaluate the efficacy and safety of the investigational agent oral infigratinib vs standard of care chemotherapy (gemcitabine plus cisplatin) in first-line treatment of participants with unresectable locally advanced or metastatic cholangiocarcinoma with FGFR2 fusion/rearrangement. Sub... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/15/2024

Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +115 locations

Banner MD Anderson Cancer Center, Gilbert, Arizona

University of Arizona, Tucson, Arizona

University of Arkansas for Medical Sciences, Little Rock, Arkansas

St. Joseph Heritage Healthcare, Fullerton, California

USC Norris Cancer Center, Los Angeles, California

University of California Los Angeles, Los Angeles, California

Florida Hospital Medical Group, Orlando, Florida

UF Health Cancer Center at Orlando Health, Orlando, Florida

Northwestern Memorial Hospital, Chicago, Illinois

University Medical Center - New Orleans, New Orleans, Louisiana

Frederick Regional Healthcare Systems/James M. Stockman Cancer Institute, Frederick, Maryland

Massachusetts General Hospital, Boston, Massachusetts

Barbara Ann Karmanos Cancer Institute - Lawrence and Idell Weisberg Cancer Treatment Center, Detroit, Michigan

Cancer and Hematology Centers of Western Michigan, Grand Rapids, Michigan

William Beaumont Hospital, Royal Oak, Michigan

NYU Langone Medical Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Levine Cancer Institute - Charlotte, Charlotte, North Carolina

University of Cincinnati Medical Center, Cincinnati, Ohio

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Charleston Oncology, Charleston, South Carolina

Parkland Health and Hospital System, Dallas, Texas

University of Texas Southwestern Medical Center, Dallas, Texas

University of Texas MD Anderson Cancer Center, Houston, Texas

Baylor College of Medicine, Houston, Texas

Chris O'Brien Lifehouse Hospital, Camperdown, New South Wales

Blacktown Hospital, Darlinghurst, New South Wales

Royal Adelaide Hospital, Adelaide, South Australia

Monash Medical Centre, Bentleigh East, Victoria

Peninsula & South Eastern Haematology and Oncology Group, Frankston, Victoria

St John of God Hospital Subiaco, Subiaco, Western Australia

Cliniques Universitaires Saint-Luc, Bruxelles, Brussels

Grand Hopital de Charleroi, Charleroi, Not set

Universitair Ziekenhuis Antwerpen, Edegem, Not set

Cross Cancer Institute, Edmonton, Alberta

Ottawa Hospital, Ottawa, Ontario

St. Josephs Health Centre, Toronto, Ontario

Jewish General Hospital, Montréal, Quebec

Peking University People's Hospital, Beijing, Not set

Beijing Cancer Hospital, Beijing, Not set

Peking University Third Hospital, Beijing, Not set

Hunan Cancer Hospital, Changsha, Not set

Guangzhou First People's Hospital, Guangzhou, Not set

Hubei Cancer Hospital, Hubei, Not set

Liaoning Cancer Hospital & Institute, Shenyang, Not set

The First Affiliated Hospital, Sun Yat-sen University, Zhongshan, Not set

Hopital Henri Mondor, Créteil, Val-de-Marne

CHRU Dijon, Dijon, Not set

Centre Georges-Francois Leclerc, Dijon, Not set

Hopital Claude Huriez Rue Michel Polonovski (CHRU) Lille, Lille, Not set

Groupement Hospitalier Edouard Herriot, Lyon, Not set

Hopital Nord Franche-Comte, Montbéliard, Not set

Groupe Hospitalier Archet I Et II, Nice, Not set

Hopital Cochin, Paris, Not set

Hôpital Saint Antoine, Paris, Not set

L'Institut Mutualiste Montsouris, Paris, Not set

Universitätsklinikum Tübingen, Tübingen, Baden-Wurttemberg

Klinikum rechts der Isar der Technischen Universität München, München, Bayern

Klinikum Dortmund gGmbH, Dortmund, Not set

University Clinic Heidelberg, Heidelberg, Not set

Azienda Socio Sanitaria Territoriale di Cremona (ASST), Cremona, Not set

Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST, Meldola, Not set

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Not set

ASST Grande Ospedale Metropolitano Niguarda, Milano, Not set

Istituto Oncologico Veneto - I.R.C.C.S., Padova, Not set

Policlinico Universitario Campus Biomedico Di Roma, Roma, Not set

Pusan National University Hospital, Pusan, Not set

Seoul National University Bundang Hospital, Seongnam-si, Not set

SMG - SNU Boramae Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Seoul National University Hospital, Seoul, Not set

Severance Hospital Yonsei University Health System, Seoul, Not set

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set

Ajou University Hospital, Suwon-si, Not set

Hospital Beatriz Angelo, Loures, Lisboa

Hospital Garcia de Orta, Almada, Not set

Centro Hospitalar E Universitário de Coimbra EPE, Coimbra, Not set

Instituto Português de Oncologia Francisco Gentil Centro Regional de Oncologia de Coimbra EPE, Coimbra, Not set

Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisboa, Not set

Hospital CUF Descobertas, Lisboa, Not set

Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E., Lisbon, Not set

Centro Hospitalar do Porto - Hospital de Santo António, Porto, Not set

Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS, Porto, Not set

Centro Hospitalar de São João, E.P.E., Porto, Not set

Hospital Oncologico, Puerto Rico Medical Center, Rio Piedras, Not set

Hospital Universitario Virgen Macarena, Sevilla, Andalucia

Hospital Universitario Miguel Servet, Zaragoza, Aragon

Complejo Asistencial Universitario de Salamanca - Hospital Clinico, Salamanca, Castilla Y Leon

Hospital Universitario Germans Trias i Pujol, Badalona, Cataluna

Instituto Catalan de Oncologio ICO I'Hospitalet, Barcelona, Cataluna

Hospital Universitario Vall d'Hebrón - PPDS, Barcelona, Not set

Hospital General Universitario Gregorio Maranon, Madrid, Not set

Hospital Universitario Ramon y Cajal, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario HM Sanchinarro - CIOCC, Madrid, Not set

Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set

National Cheng Kung University Hospital, Tainan City, Tainan

National Taiwan University Hospital - YunLin Branch, Huwei, Not set

Chang Gung Memorial Hospital - Kaohsiung, Kaohsiung, Not set

China Medical University Hospital, Taichung City, Not set

Chi Mei Hospital, Liouying, Tainan, Not set

Taipei Veterans General Hospital, Taipei, Not set

National Taiwan University Hospital, Taipei, Not set

Chang Gung Memorial Hospital, Linkou, Taoyuan City, Not set

Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Songkla

Chulalongkorn University, Bangkok, Not set

Ramathibodi Hospital Mahidol University, Bangkok, Not set

Maharaj Nakorn Chiang Mai Chiang Mai University, Chiang Mai, Not set

Srinagarind Hospital, Khon Kaen, Not set

Naresuan University, Phitsanulok, Not set

Nottingham City Hospital, Nottingham, Nottinghamshire

Royal Marsden Hospital, Sutton, Surrey

The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, Wirral

Guys Hospital, London, Not set

The Christie NHS Foundation Trust - PPDS, Manchester, Not set

Conditions: Advanced Cholangiocarcinoma, FGFR2 Gene Mutation

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GAMEC-II, Risk-adapted Protocol for Relapsed Germ Cell Tumours (GCT)

NCT06309732

Completed

St Bartholomew's hospital completed a study using the regimen GAMEC (PEG-filgrastim, actinomycin-D, methotrexate, etoposide, cisplatin). The results of this study showed that 50% of patients with relapsed testicular cancer could be cured using this treatment. These results are very encouraging and compare very favourably to other treatment protocols. In reviewing this study, it became clear that of the 5 cycles of treatment which were proposed, the first 3 seemed to matter and the last 2 did not... Read More

Gender:

MALE

Ages:

Between 16 years and 35 years

Trial Updated:

03/07/2024

Locations: Barts and the London NHS Trust, London, Not set

Conditions: Testicular Neoplasms

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M6620 Plus Standard Treatment in Oesophageal and Other Cancer

NCT03641547

Completed

This Phase I study will test the combination of a novel ATR inhibitor (M6620) with chemoradiotherapy in oesophageal cancer; utilizing three experimental cohorts (Stage A1, A2 and B).

Gender:

ALL

Ages:

16 years and above

Trial Updated:

02/02/2024

Locations: Velindre Cancer Centre, Cardiff, Not set +4 locations

Conditions: Oesophageal Adenocarcinoma, Squamous Cell Carcinoma, Solid Tumor

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A Study of Atezolizumab in Combination With Carboplatin or Cisplatin + Pemetrexed Compared With Carboplatin or Cisplatin + Pemetrexed in Participants Who Are Chemotherapy-Naive and Have Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower 132)

NCT02657434

Completed

This is a randomized, Phase III, multicenter, open-label study designed to evaluate the safety and efficacy of atezolizumab in combination with cisplatin or carboplatin + pemetrexed compared with treatment with cisplatin or carboplatin + pemetrexed in participants who are chemotherapy-naive and have Stage IV non-squamous NSCLC. Eligible participants will be randomized by a 1:1 ratio into 2 groups: Arm A (Atezolizumab + Carboplatin or Cisplatin + Pemetrexed) and Arm B (Carboplatin or Cisplatin +... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

11/20/2023

Locations: Los Angeles Hematology Oncology Medical Group, Los Angeles, California +182 locations

Los Angeles Hematology Oncology Medical Group, Los Angeles, California

St. Joseph Heritage Healthcare, Sebastopol, California

Stamford Hospital; BCC, MOHR, Stamford, Connecticut

Orlando Health Inc., Orlando, Florida

Tallahassee Memorial Hospital, Tallahassee, Florida

Northside Hospital, Atlanta, Georgia

Ingalls Memorial Hospital, Harvey, Illinois

Illinois Cancer Care, Peoria, Illinois

HealthCare Research Network II, LLC - PPDS, Tinley Park, Illinois

Fort Wayne Med Oncology & Hematology Inc, Fort Wayne, Indiana

Goshen Health System, Goshen, Indiana

University of Kentucky; Markey Cancer Center, Lexington, Kentucky

University of Michigan, Ann Arbor, Michigan

CHI Health St. Francis, Grand Island, Nebraska

Nebraska Methodist Hospital, Omaha, Nebraska

Montefiore Medical Center, Bronx, New York

Swedish Cancer Institute, Cary, North Carolina

Providence Portland Medical Center, Portland, Oregon

Gettysburg Cancer Center, Gettysburg, Pennsylvania

Allegheny Cancer Center, Pittsburgh, Pennsylvania

Oncology Consultants PA, Houston, Texas

Virginia Cancer Specialists (Fairfax) - USOR, Fairfax, Virginia

Peninsula Cancer Institute, Newport News, Virginia

Blue Ridge Cancer Care, Roanoke, Virginia

University of Washington, Seattle, Washington

St. Vincent Hospital, Green Bay, Wisconsin

Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich, Buenos Aires, Not set

Fundacion Clinica Colombo, Cordoba, Not set

Clinica Viedma S.A., Viedma, Not set

St Vincent's Hospital Sydney, Darlinghurst, New South Wales

Sydney Adventist Hospital; Clinical Trial Unit, Sydney, New South Wales

St George Hospital; Medical Oncology, Sydney, New South Wales

Redcliffe Hospital, Redcliffe, Queensland

Mater Adult Hospital, South Brisbane, Queensland

Royal Hobart Hospital, Hobart, Tasmania

Ballarat Health Services, Ballarat, Victoria

Peninsula and South Eastern Haematology and Oncology Group, Frankston, Victoria

Barwon Health, Geelong, Victoria

Klinikum Wels-Grieskirchen GmbH, Wels, Not set

AZ Maria Middelares, Gent, Not set

Clinique André Renard; Pneumologie, Herstal, Not set

AZ Delta (Campus Rumbeke), Apotheek, Roeselare, Not set

Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia, Not set

Health & Care SPA, Santiago, Not set

Sociedad de Investigaciones Medicas Ltda (SIM), Temuco, Not set

Hospital Clinico Vina del Mar?, Viña del Mar, Not set

Beijing Friendship Hospital Affiliated of Capital University of Medical Science, Beijing Shi, Not set

Beijing Cancer Hospital, Beijing, Not set

Hunan Cancer Hospital, Changsha CITY, Not set

Changzhou First People's Hospital, Changzhou, Not set

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set

The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou City, Not set

Sir Run Run Shaw Hospital Zhejiang University, Hangzhou City, Not set

Anhui Provincial Hospital; 2F,Tumor chemotherapy Department, Hefei, Not set

Anhui Provincial Hospital; Respiratory Department, Hefei, Not set

Qilu Hospital, Jinan City, Not set

Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University), Nanjing City, Not set

Shanghai Chest Hospital, Shanghai, Not set

Zhongshan Hospital Fudan University, Shanghai, Not set

First Hospital of China Medical University, Shenyang, Not set

Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set

Tianjin Medical University General Hospital, Tianjin, Not set

Tongji Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan City, Not set

Tumor Center,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Not set

Zhejiang Cancer Hospital, Zhejiang, Not set

Institut Sainte Catherine, Avignon, Not set

Hopital Louis Pradel; Pneumologie, Bron, Not set

Centre Jean Perrin Centre Regional de Lutte Contre Le Cancer D auvergne, Clermont-ferrand, Not set

Centre Hospitalier Intercommunal; Service de Pneumologie, Creteil, Not set

Polyclinique de Limoges - Site Chenieux; Oncologie Medicale, Limoges, Not set

Hopital Nord AP-HM, Marseille, Not set

Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque; Service d oncologie, Montpellier, Not set

Centre Hospitalier de Mulhouse - Hopital Emile Muller, Mulhouse, Not set

Hopital d'Instruction des Armees de Begin, Saint-Mande, Not set

Hopital d Instruction des Armees de Sainte Anne, Toulon, Not set

Veszprem Megyei Tudogyogyintezet, Farkasgyepu, Not set

Petz Aladar Megyei Oktato Korhaz, Gyor, Not set

Markusovszky Hospital, Szombathely, Not set

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz, Székesfehérvár, Not set

Tudogyogyintezet Torokbalint, Torokbalint, Not set

Mater Misecordiae University Hospital, Dublin, Not set

St James's Hospital, Dublin, Not set

Barzilai Medical Center, Ashkelon, Not set

Edith Wolfson Medical Center, Holon, Not set

Rabin Medical Center, Petach Tiqwa, Not set

Azienda Ospedaliero Universitaria di Parma, Parma, Emilia-Romagna

Ospedale Santa Maria Delle Croci, Ravenna, Emilia-Romagna

Istituto Nazionale Tumori Regina Elena, Roma, Lazio

Azienda Policlinico Umberto I, Roma, Lazio

Azienda Sanitaria Ospedaliera S Luigi Gonzaga; S.C.D.U. di Oncologia Toracica, Orbassano (TO), Piemonte

Presidio Ospedaliero Vito Fazzi; Unita Operativa Di Oncologia Medica, Lecce, Puglia

Ospedale Casa Sollievo Della Sofferenza IRCCS, San Giovanni Rotondo, Puglia

Ospedale San Vincenzo Taormina :Divisione di Oncologia Medica, Taormina, Sicilia

Ospedale San Luca - USL2 Lucca, Lucca, Toscana

National Hospital Organization Nagoya Medical Center, Aichi, Not set

National Cancer Center Hospital East, Chiba, Not set

Hiroshima University Hospital, Hiroshima, Not set

National Hospital Organization Asahikawa Medical Center, Hokkaido, Not set

National Hospital Organization Himeji Medical Center, Hyogo, Not set

Kanazawa University Hospital, Ishikawa, Not set

Kagoshima University Hospital, Kagoshima, Not set

Kanagawa Cancer Center, Kanagawa, Not set

Tohoku University Hospital, Miyagi, Not set

Niigata University Medical & Dental Hospital, Niigata, Not set

Osaka University Hospital, Osaka, Not set

Osaka Medical and Pharmaceutical University Hospital, Osaka, Not set

Saga University Hospital, Saga, Not set

Tokushima University Hospital, Tokushima, Not set

Juntendo University Hospital, Tokyo, Not set

Nippon Medical School Hospital, Tokyo, Not set

Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Tokyo, Not set

The Cancer Institute Hospital of JFCR, Tokyo, Not set

NTT Medical Center Tokyo, Tokyo, Not set

National Hospital Organization Yamaguchi - Ube Medical Center, Yamaguchi, Not set

Seoul National University Hospital, Seoul, Not set

Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Riga East Clinical University Hospital Latvian Oncology Centre, Riga, Not set

Panevezys Hospital, Panevezys, Not set

Hospital Kuala Lumpur, Kuala Lumpur, FED. Territory OF Kuala Lumpur

Advanced Medical and Dental Institute; Kompleks Klinikal, Kepala Batas, Penang

Amphia Ziekenhuis, Breda, Not set

Haga Ziekenhuis, Den Haag, Not set

Ziekenhuis Gelderse Vallei, EDE, Not set

Ziekenhuis St. Jansdal, Harderwijk, Not set

Zuyderland Medisch Centrum - Sittard Geleen, Sittard-Geleen, Not set

ETZ TweeSteden, Tilburg, Not set

Hospital Nacional Cayetano Heredia, Lima, Not set

Hospital Beatriz Angelo, Loures, Not set

Unidade Local de Saude de Matosinhos SA, Matosinhos, Not set

Hospital CUF Porto; Servico de Imunoalergologia, Senhora Da Hora - Porto, Not set

Medisprof SRL, Cluj-Napoca, Not set

Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta, Constanta, Not set

Euroclinic Center of Oncology SRL, Iasi, Not set

Chelyabinsk Regional Clinical Oncology Dispensary, Chelyabinsk, Moskovskaja Oblast

Moscow City Oncology Hospital #62, Moscovskaya Oblast, Moskovskaja Oblast

Regional Clinical Oncology Hospital, Yaroslavl, Not set

Hospital General Universitario de Elche; Servicio de Oncologia, Elche, Alicante

Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona

ICO L'Hospitalet; Servicio de oncologia medica, L'Hospitalet de Llobregat, Barcelona

Corporacio Sanitaria Parc Tauli; Servicio de Oncologia, Sabadell, Barcelona

Hospital Univ Vall d'Hebron; Servicio de Oncologia, Sant Andreu de La Barca, Barcelona

Hospital de Mataro, Mataro, Cantabria

Onkologikoa; Ensayos Clinicos, Donostia, Guipuzcoa

Centro Oncologico de Galicia COG; Medical Oncology, A Coruna, LA Coruña

Hospital Universitario Virgen de La Arrixaca; Servicio De Oncologia, El Palmar, Murcia

Clinica Universitaria de Navarra; Servicio de Oncologia, Pamplona, Navarra

Complejo Hospitalario de Navarra; Servicio de Oncologia, Pamplona, Navarra

Complejo Hospitalario Nuestra Senora de Valme, Seville, Sevilla

Hospital General Univ. de Alicante, Alicante, Not set

Hospital de la Santa Creu i Sant Pau, Barcelona, Not set

Hospital Universitari Dexeus - Grupo Quironsalud; Servicio de Oncologia Medica, Barcelona, Not set

C.A.U de Burgos- Hospital Universitario de Burgos; Servicio de Oncologia, Burgos, Not set

Hospital Universitari de Girona Dr Josep Trueta; Departamento de Oncologia Medica, Girona, Not set

Hospital Lucus Augusti; Servicio de Oncologia, Lugo, Not set

MD Anderson Cancer Center, Madrid, Not set

Hospital Universitario Ramon y Cajal, Madrid, Not set

HM Sanchinarro ? CIOCC, Madrid, Not set

Hospital Regional Universitario de Malaga ? Hospital General; Servicio de Neurologia, Malaga, Not set

Instituto Valenciano Oncologia; Oncologia Medica, Valencia, Not set

Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set

Buddhist Dalin Tzuchi General Hospital, Dalin, Chiayi, Not set

E-DA Hospital; Chest, Kaohsiung, Not set

Chi Mei Medical Center Liou Ying Campus, Liuying Township, Not set

Taipei Veterans General Hospital, Taipei City, Not set

National Taiwan Uni Hospital; Internal Medicine, Taipei, Not set

Tri-Service General Hospital, Taipei, Not set

MI Dnipropetrovsk City Multifield Clinical Hospital 4 of Dnipropetrovsk Regional Council, Dnipropetrovsk, Katerynoslav Governorate

Kyiv Railway Clinical Hospital #3 of Branch Health Center of PJSC Ukrainian Railway; Surgery Dept, Kyiv, Kharkiv Governorate

MICR Oncology Dispensary of Cherkasy Regional Council; Regional Center of Clinical Oncology, Cherkasy, Not set

Private Enterprise Private Manufacturing Company Acinus, Kirovograd, Not set

Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary; Oncothoracic department, Sumy, Not set

MI Zaporizhzhia Regional Clinical Oncological Dispensary Zaporizhzhia SMU Ch of Oncology, Zaporizhzhya, Not set

Bristol Haematology and Oncology centre, Bristol, Not set

Velindre Hospital, Cardiff, Not set

Gartnavel General Hospital; Beatson West of Scotland Cancer Centre, Glasgow, Not set

Raigmore Hospital, Inverness, Not set

St George?s Hospital, London, Not set

Charing Cross Hospital, London, Not set

Churchill Hospital, Oxford, Not set

Derriford Hospital; Plymouth Oncology Centre, Plymouth, Not set

Queen's Hospital, Romford, Not set

Royal Cornwall Hospital, Truro, Not set

Conditions: Non-Small Cell Lung Cancer

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A Study of FT-2102 in Patients With Advanced Solid Tumors and Gliomas With an IDH1 Mutation

NCT03684811

Completed

This Phase 1/2 study will evaluate the safety, efficacy, PK, and PD of FT-2102 as a single agent and in combination with other anti-cancer drugs in patients with advanced solid tumors and gliomas. The study is divided into two parts: single agent FT-2102 followed by combination therapy. Part 1: A single agent, open-label study in up to five cohorts (glioma, hepatobiliary tumors, chondrosarcoma, intrahepatic cholangiocarcinoma, and other IDH1 mutant solid tumors) that will include a Phase 1 dos... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

11/16/2023

Locations: Banner MD Anderson, Gilbert, Arizona +25 locations

Banner MD Anderson, Gilbert, Arizona

University of Colorado Anschutz Medical Campus, Aurora, Colorado

University of Miami, Sylvester Comprehensive Cancer Center, Miami, Florida

Northwestern University, Lurie Comprehensive Cancer Center, Chicago, Illinois

University of Iowa, Holden Comprehensive Cancer Institute, Iowa City, Iowa

Massachusetts General Hospital, Boston, Massachusetts

Dana Farber Cancer Institute, Boston, Massachusetts

Henry Ford Hospital, Detroit, Michigan

Washington University School of Medicine, Saint Louis, Missouri

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Columbia University Medical Center, New York, New York

Baylor Scott and White Medical Center, Temple, Texas

University of Utah, Huntsman Cancer Hospital, Salt Lake City, Utah

Medical College of Wisconsin, Froedtert Hospital, Milwaukee, Wisconsin

Austin Hospital, Heidelberg, Victoria

Peter MacCallum Cancer Centre, Melbourne, Not set

Centre de Lutte Contre Cancer (CLCC) - Institute Bergonie, Bordeaux, Not set

Centre de Lutte Cancre (CLCC) - Lyon, Lyon, Not set

Hospital de la Timone, Marseille, Not set

Institut Gustave Roussy Cancer Campus, Villejuif, Not set

Seoul National University Hospital, Seoul, Not set

Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Vall D'Hebron University Hospital, Barcelona, Not set

Cancer Research Beatson Institute, Glasgow, Not set

The Royal Marsden Hospital, London, Not set

Conditions: Cohort 2a and 2b: Hepatobiliary Tumors (Hepatocellular Carcinoma, Bile Duct Carcinoma, Intrahepatic Cholangiocarcinoma, Other Hepatobiliary Carcinomas), Cohort 3a and 3b: Chondrosarcoma, Cohort 4a and 4b: Intrahepatic Cholangiocarcinoma, Cohort 1a and 1b: Glioma (Advanced Gliomas and Glioblastoma Multiforme), Cohort 5a: Other Non-Central Nervous System Solid Tumors With IDH1 Mutations

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