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Cisplatin Treatment Options in United Kingdom
A collection of 298 research studies where Cisplatin is the interventional treatment. These studies are located in the United Kingdom . Cisplatin is used for conditions such as Head and Neck Cancer, Lung Cancer and Non-Small Cell Lung Cancer.
217 - 228 of 298
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Clinical Trial Phase
Randomized Trial of Gemcitabine/Cisplatin + PF-3512676 vs Gemcitabine/Cisplatin Alone in Patients With Advanced NSCLC
Terminated
To assess the efficacy and safety of PF-3512676 administered in combination with gemcitabine/cisplatin chemotherapy as first-line treatment in patients with locally advanced or metastatic Non-Small-Cell Lung Cancer (NSCLC) and to compare it to the efficacy and safety of gemcitabine/cisplatin alone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2015
Locations: Pfizer Investigational Site, Birmingham, Alabama +120 locations
Conditions: Carcinoma, Non-Small-Cell Lung
Etoposide and Cisplatin or Carboplatin as First-Line Chemotherapy With or Without Pravastatin in Treating Patients With Small Cell Lung Cancer
Completed
RATIONALE: Drugs used in chemotherapy, such as etoposide, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Pravastatin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by making tumor cells more sensitive to chemotherapy. It is not yet known whether etoposide and cisplatin or carboplatin are more effective with or without pravastatin in treating small c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/01/2014
Locations: William Harvey Hospital, Ashford-Kent, England +85 locations
Conditions: Lung Cancer
ToGA Study - A Study of Herceptin (Trastuzumab) in Combination With Chemotherapy Compared With Chemotherapy Alone in Patients With HER2-Positive Advanced Gastric Cancer
Completed
This parallel, randomized, open-label, multi-centre study will evaluate the effect on overall survival of trastuzumab (Herceptin) in combination with a chemotherapy compared to the chemotherapy alone in patients with HER2-positive advanced gastric cancer. Trastuzumab (Herceptin) will be administered as intravenous infusion of 6 mg/kg (loading dose 8 mg/kg) every 3 weeks. The chemotherapy consists of a combination of 6 cycles of fluorouracil (800 mg/m2/day intravenous infusion every 3 weeks) and... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2014
Locations: Not set, Adelaide, Not set +141 locations
Conditions: Gastric Cancer
Cediranib Versus Placebo Plus Cisplatin/Gemcitabine Chemotherapy for Patients With Advanced Biliary Tract Cancers
Completed
As a result of our previous NCRN study (ABC-02) cisplatin and gemcitabine (CisGem) is likely to become the international standard of care for patients with advanced biliary tract cancer (submitted: ASCO 2009).
This study, ABC-03, will determine whether the addition of cediranib(an oral Vascular Endothelial Growth Factor Receptor inhibitor) to CisGem will improve the time to disease progression in this patient group.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2014
Locations: University College London Hospitals NHS Foundation Trust, London, Not set +1 locations
Conditions: Biliary Tract Neoplasms
Cetuximab (Erbitux) in Combination With Cisplatin or Carboplatin and 5-Fluorouracil in the First Line Treatment of Subjects With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck (EXTREME)
Completed
The purpose of this trial is to investigate the efficacy of cetuximab in combination with chemotherapy in comparison to chemotherapy alone in patients with recurrent or metastatic head and neck cancer. Overall survival will be taken as the primary measure of efficacy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2014
Locations: Research Site, Innsbruck, Not set +69 locations
Conditions: Head and Neck Cancer
Erbitux in Combination With Xeloda and Cisplatin in Advanced Esophago-gastric Cancer
Completed
The primary objective of this study is to demonstrate that addition of cetuximab to 1st-line treatment with capecitabine (Xeloda, X) and cisplatin (P) \[XP\] chemotherapy regimen has a clinically relevant benefit for subjects with advanced gastric adenocarcinoma including gastroesophageal junction (GEJ) adenocarcinoma, in terms of progression free survival (PFS).
Secondary objectives are to assess cetuximab plus XP versus XP alone with respect to overall survival, overall tumor response, qualit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2014
Locations: Research site, Rosario, Not set +129 locations
Conditions: Gastric Cancer
Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma
Unknown
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving radiation therapy in different ways with combination chemotherapy may kill any remaining tumor cells following surgery. It is not yet known which radiation therapy regimen combined with combination chemotherapy is more effective in treating medulloblastoma.
PURPOSE: Randomized phase III trial to compare di... Read More
Gender:
ALL
Ages:
Between 3 years and 21 years
Trial Updated:
06/23/2014
Locations: U.Z. Gasthuisberg, Leuven, Not set +7 locations
Conditions: Brain and Central Nervous System Tumors
Intensive Neoadjuvant Chemotherapy in Treating Young Patients Undergoing Surgical Resection for High-Risk Hepatoblastoma
Unknown
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed.
PURPOSE: This phase II trial is studying how well neoadjuvant chemotherapy works in treating young patients who are undergoing surgical resection for high-risk hepatoblastoma.
Gender:
ALL
Ages:
17 years and below
Trial Updated:
06/23/2014
Locations: Institut Gustave Roussy, Villejuif, Not set +23 locations
Conditions: Liver Cancer
Study of Cisplatin/Vinorelbine +/- Cetuximab as First-line Treatment of Advanced Non Small Cell Lung Cancer (FLEX)
Completed
The purpose of this trial is to investigate the efficacy of cetuximab in combination with chemotherapy in comparison to chemotherapy alone in patients with advanced non small cell lung cancer who did not received prior chemotherapy. Overall survival will be taken as primary measure of efficacy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2014
Locations: Research Site, Buenos Aires, Not set +117 locations
Conditions: Non Small Cell Lung Cancer (NSCLC)
A Dose Ascending Study of Gemcitabine Elaidate (CO-101) in Combination With Cisplatin
Terminated
The purpose of the first part of the study is to evaluate the safety, tolerability, and pharmacokinetics of ascending doses of gemcitabine elaidate in combination with cisplatin given to patients with advanced solid tumors, and to select a dose for further evaluation in the second part of the study.
The purpose of the second part of the study is to determine the safety, tolerability, and exploratory clinical activity of gemcitabine elaidate in combination with cisplatin given to patients with S... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2014
Locations: Florida Cancer Specialists, Sarasota, Florida +3 locations
Cetuximab and Cisplatin in the Treatment of "Triple Negative" (Estrogen Receptor [ER] Negative, Progesterone Receptor [PgR] Negative, and Human Epidermal Growth Factor Receptor 2 [HER2] Negative) Metastatic Breast Cancer
Completed
The primary objective of this study is to determine whether overall response to cetuximab combined with cisplatin is better than overall response to cisplatin alone together with showing that the overall response for cetuximab and cisplatin was above a pre-specified threshold of 0.2 in the treatment of "triple negative" metastatic breast cancer.
The secondary objective of this study is to compare the differences between the two treatment groups using the following criteria : Progression-Free Su... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/20/2014
Locations: Research Site, Campbelltown, New South Wales +45 locations
Conditions: Breast Neoplasm
Surgery With or Without Combination Chemotherapy in Treating Patients With Stomach Cancer
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not known whether receiving chemotherapy before surgery may be more effective than surgery alone in treating patients with stomach cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of surgery plus combination chemotherapy with surgery alone in treating patients with stomach cancer.
Gender:
ALL
Ages:
All
Trial Updated:
12/18/2013
Locations: Epsom General Hospital, Epsom, Surrey, Not set
Conditions: Gastric Cancer
217 - 228 of 298