Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia
NCT00003437
Unknown
RATIONALE: Hormone therapy may stop the growth of cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining hormone therapy with chemotherapy may kill more cancer cells. It is not yet known which hormone therapy and chemotherapy regimen is most effective for acute lymphoblastic leukemia. PURPOSE: Randomized phase III trial to compare the effectiveness of different steroid therapy and chemotherapy regimens in treating ch... Read More
Gender:
ALL
Ages:
Between 1 year and 18 years
Trial Updated:
12/03/2013
Locations: Oxford Radcliffe Hospital, Oxford, England
Conditions: Leukemia
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Chemotherapy Plus Steroid Therapy in Treating Patients With Multiple Myeloma
NCT00003603
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. Steroids, such as dexamethasone or prednisolone, may help relieve some of the side effects of chemotherapy. It is not yet known which regimen of chemotherapy plus steroid therapy is more effective in treating patients with multiple myeloma. PURPOSE: Randomized phase III trial to compare the effectiveness of two differen... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/19/2013
Locations: Hammersmith Hospital, London, England
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
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Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Non-Hodgkin's Lymphoma
NCT00006250
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known which combination chemotherapy regimen is more effective for non-Hodgkin's lymphoma. PURPOSE: Randomized phase III trial to compare the effectiveness of two different combination chemotherapy regimens in treating patients who have stage III or stage IV non-Hodgkin's lymphoma.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/19/2013
Locations: Stoke Mandeville Hospital, Aylesbury-Buckinghamshire, England +58 locations
Conditions: Lymphoma
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Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma
NCT00003639
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells and slow the growth of non-Hodgkin's lymphoma. It is not yet known whether combining more than one chemotherapy drug with interferon alfa is more effective than chemotherapy alone in treating patients with low-grade non-Hodgkin's lymphoma. PURPOSE: Randomized phase III trial to compare the effectiveness of combinat... Read More
Gender:
ALL
Ages:
Between 15 years and 70 years
Trial Updated:
09/16/2013
Locations: Royal Victoria Infirmary, Newcastle-upon-Tyne, England
Conditions: Lymphoma
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Combination Chemotherapy Followed By Donor Stem Cell Transplant in Treating Patients With Hemophagocytic Lymphohistiocytosis
NCT00334672
Unknown
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of hemophagocytic lymphohistiocytosis cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more hemophagocytic lymphohistiocytosis cells. A donor stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy. Sometimes the transplanted cells from a donor can make an immune response against the body's n... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
09/16/2013
Locations: Birmingham Children's Hospital, Birmingham, England +12 locations
Conditions: Nonneoplastic Condition
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Dexamethasone and Supportive Care With or Without Whole-Brain Radiation Therapy in Treating Patients With Non-Small Cell Lung Cancer That Has Spread to the Brain and Cannot Be Removed By Surgery
NCT00403065
Completed
RATIONALE: Steroid therapy, such as dexamethasone, may reduce swelling, pain, and other symptoms of inflammation and may be effective in treating some of the problems caused by cancer and cancer treatment. Supportive care improves the quality of life of patients with a serious or life-threatening disease, and prevents or treats symptoms of cancer, side effects of treatment, and other problems related to cancer or its treatment. Radiation therapy uses high-energy x-rays to kill tumor cells. It is... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2013
Locations: Wansbeck General Hospital, Ashington, England +69 locations
Conditions: Lung Cancer, Metastatic Cancer
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Dexamethasone and Chemotherapy With or Without Plasma Exchange in Patients With Newly Diagnosed Multiple Myeloma and Acute Kidney Failure
NCT00416897
Completed
RATIONALE: Dexamethasone is used to treat multiple myeloma. Drugs used in chemotherapy may stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Plasma exchange is a process in which certain cells are separated from the plasma in the blood by a machine and then only the cells are returned to the patient. Dexamethasone and plasma exchange may be an effective treatment for acute kidney failure caused by multiple myeloma. It is not yet known whether giving... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2013
Locations: Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke, England +38 locations
Conditions: Multiple Myeloma and Plasma Cell Neoplasm, Renal Failure
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Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
NCT00967057
Completed
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It is not yet known which combination chemotherapy regimen is more effective in treating young patients with acute lymphoblastic leukemia. PURPOSE: This partially randomized phase III trial is studying how well combination chemotherapy works in treating young patients with relapsed or refractory acute lymphoblastic leukemia.
Gender:
ALL
Ages:
Between 1 year and 18 years
Trial Updated:
08/09/2013
Locations: Women's and Children's Hospital, North Adelaide, South Australia +5 locations
Conditions: Leukemia
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Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma
NCT00275106
Terminated
RATIONALE: Drugs used in chemotherapy, such as prednisolone and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. It is not yet known whether prednisolone is more effective than dexamethasone when given together with combination chemotherapy in treating lymphoblastic lymphoma. PURPOSE: This phase III randomized clinical trial is... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
07/09/2013
Locations: Kinderklinik, Giessen, Not set +21 locations
Conditions: Lymphoma
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Dexamethasone, Aspirin, and Diethylstilbestrol in Treating Patients With Locally Advanced or Metastatic Prostate Cancer
NCT00316927
Completed
RATIONALE: Giving dexamethasone together with aspirin and diethylstilbestrol may be effective in lowering prostate-specific antigen levels and may slow or stop the growth of prostate cancer. It is not yet known which schedule of dexamethasone, aspirin, and diethylstilbestrol is more effective in treating prostate cancer. PURPOSE: This randomized phase III trial is studying dexamethasone and aspirin when given together with two different schedules of diethylstilbestrol to compare how well they w... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
06/25/2013
Locations: Bristol Haematology and Oncology Centre, Bristol, England +14 locations
Conditions: Prostate Cancer
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Combination Chemotherapy in Treating Patients With Stage II or Stage III Multiple Myeloma
NCT00006232
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which combination chemotherapy regimen is more effective for multiple myeloma. PURPOSE: This randomized phase III trial is comparing two combination chemotherapy regimens to see how well they work in treating patients with stage II or stage III multiple myeloma.
Gender:
ALL
Ages:
75 years and below
Trial Updated:
05/14/2013
Locations: Birmingham Heartlands Hospital, Birmingham, England +11 locations
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
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A Phase II Trial to Assess TroVax® Plus Chemotherapy in Patients With Malignant Pleural Mesothelioma
NCT01569919
Unknown
This study is for patients with malignant mesothelioma of the lung lining (called pleura) who are planning to have pemetrexed-cisplatin chemotherapy. We are investigating whether giving a vaccine called TroVax® with pemetrexed-cisplatin chemotherapy is both safe and potentially beneficial in patients with mesothelioma. This vaccine has been used in combination with chemotherapy in other types of cancer and has been shown to be safe. Cancer vaccines work by stimulating the person's immune system... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2013
Locations: Velindre Cancer Centre, Cardiff, South Wales
Conditions: Malignant, Pleural, Mesothelioma
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