Clinical Trials & Research Studies in United Kingdom(Updated 8/25)

An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene

NCT06435000

Recruiting

This is an Observational Study to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene This is a multicenter study which will enroll approximately 75 subjects

Gender:

ALL

Ages:

Between 12 years and 65 years

Trial Updated:

04/24/2025

Locations: Shiley Eye Institute, San Diego, California +12 locations

Conditions: Stargardt, Stargardt's Disease, Stargardt Disease, STGD1

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Clinical Experience of Maintaining Patient Safety in Hospital

NCT06738316

Recruiting

The key purpose of the study is to establish what the barriers to preventing accidental falls in hospital are, what interventions are perceived to work best in preventing falls and what could help. The study will attempt to disprove the null hypothesis that "there is no universal clinical experience of accidental fall prevention in hospitals with patients who have impaired cognitive function". To gather an evidence base for the co-created design and testing of fall prevention interventions as p... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/24/2025

Locations: University Hospitals of Leicester, Leicester, Not set +2 locations

Conditions: Patient Safety

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Characterisation of Skin Microstructure Under Normal and Atrophied States

NCT06954272

Recruiting

Skin dermatoses are a major health concern around the world, with heavy economic, social, and psychological burdens. Due to their chronic and incurable nature, they are serious diseases that cause physical pain in patients and reduced quality of life. Atopic dermatitis is the most common inflammatory skin disease with a prevalence of almost 20% in children and 10% in adults. Current therapies are designed to control the condition rather than cure it. Therefore, these therapies are lifelong and,... Read More

Gender:

ALL

Ages:

6 months and above

Trial Updated:

04/24/2025

Locations: Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS FT, Sheffield, South Yorkshire

Conditions: Atopic Dermatitis

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A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

NCT06329401

Recruiting

A randomized, double-blind, placebo-controlled clinical study to evaluate the safety and efficacy of 2 doses of inhaled pirfenidone (AP01) versus placebo on top of standard of care in participants with PPF over 52 weeks.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/23/2025

Locations: University of Alabama at Birmingham, Birmingham, Alabama +117 locations

University of Alabama at Birmingham, Birmingham, Alabama

Pulmonary Associates, PA, Phoenix, Arizona

University of Southern California, Los Angeles, California

Cedars-Sinai, Los Angeles, California

UCLA, Los Angeles, California

Newport Native MD, Inc., Newport Beach, California

Paradigm Clinical Research - Redding, Redding, California

University of Colorado, Anschutz Medical Campus, Aurora, Colorado

National Jewish Health, Denver, Colorado

UCONN Health, Farmington, Connecticut

Yale University, New Haven, Connecticut

Clinical Site Partners, LCC, Leesburg, Florida

Renstar Medical Research, Ocala, Florida

Central Florida Pulmonary Group, Orlando, Florida

SEC Clinical Research, Pensacola, Florida

Clinical Site Partners, Winter Park, Florida

Piedmont Healthcare, Inc., Atlanta, Georgia

Northwestern University, Chicago, Illinois

Endeavor Health, Evanston, Illinois

Loyola University Medical Center, Maywood, Illinois

The University of Kansas Medical Center, Kansas City, Kansas

University of Maryland, Baltimore, Maryland

Johns Hopkins University, Baltimore, Maryland

Beth Israel Deaconess Medical Center, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

University of Minnesota, Minneapolis, Minnesota

Mayo Clinic Rochester, Rochester, Minnesota

Hannibal Regional Healthcare System, Hannibal, Missouri

Montefiore Medical Center, Bronx, New York

Northwell Health - Mount Kisco, Mount Kisco, New York

NYU Langone Health, New York, New York

Weill Cornell, New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Columbia University, New York, New York

Duke University, Durham, North Carolina

Pulmonix, Greensboro, North Carolina

Piedmont HealthCare, PA, Statesville, North Carolina

Accellacare, Wilmington, North Carolina

Southeastern Research Center, Winston-Salem, North Carolina

University of Cincinnati, Cincinnati, Ohio

Summit Health, Bend, Oregon

The Oregon Clinic Pulmonary East, Portland, Oregon

The Oregon Clinic Pulmonary West, Portland, Oregon

The Pennsylvania State University, Hershey, Pennsylvania

Thomas Jefferson University, Philadelphia, Pennsylvania

Temple University, Philadelphia, Pennsylvania

Lowcountry Lung and Critical Care, Charleston, South Carolina

Medical University of South Carolina, Charleston, South Carolina

Clinical Trials Center of Middle Tennessee, Franklin, Tennessee

Vanderbilt Lung Institute, Nashville, Tennessee

Baylor Scott & White Research Institute, Baylor University Medical Center, Dallas, Texas

El Paso Pulmonary Association, El Paso, Texas

Baylor College of Medicine, Houston, Texas

The University of Texas Health Science Center, Houston, Texas

Metroplex Pulmonary and Sleep Center, PA, McKinney, Texas

Intermountain Medical Center, Murray, Utah

University of Utah Health, Salt Lake City, Utah

Inova Healthcare, Falls Church, Virginia

University of Washington, Seattle, Washington

Fundacion Respirar, Buenos Aires, Not set

CINME, Buenos Aires, Not set

Instituto de Medicina Respiratoria, Córdoba, Not set

CIMER Centro Integral de Medicina Respiratoria, Tucumán, Not set

Investigaciones En Patologias Respiratorias, Tucumán, Not set

Royal Prince Alfred Hospital, Camperdown, New South Wales

Nepean Lung & Sleep, Kingswood, New South Wales

John Hunter Hospital, New Lambton, New South Wales

Macquarie University Clinical Trials Unit, Sydney, New South Wales

Westmead Hospital, Westmead, New South Wales

Institute for Respiratory Health, Nedlands, Perth West Australia

Lung Research Victoria, Footscray, Victoria

Alfred Health, Melbourne, Victoria

Vancouver General Hospital, Vancouver, British Columbia

Dynamic Drug Advancement, Ajax, Ontario

St. Joseph's Healthcare Hamilton, Hamilton, Ontario

Research Institute McGill University Health Center, Montreal, Quebec

Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, Québec, Quebec

CIC Mauricie, Trois-Rivières, Quebec

CHU de Rennes, Rennes, Cedex NA

CHU Tours, Tours, Indre et Loire

Robert Schuman Hospital UNEOS, Metz, Lorraine

CHU Angers, Angers, Not set

Louis Pradel Hospital, Lyon, Not set

University of Montpellier, Montpellier, Not set

Hôpital Haut-Lévêque, Pessac, Not set

Pneumologisches Studienzentrum München-West, Muenchen, Bavaria

RoMed Klinikum Rosenheim, Rosenheim, Bavaria

Medizinische Hochschule Hannover, Hannover, Lower Saxony

Studienzentrum Dr. Claus Keller, Frankfurt, Main Hessia

Ruhrlandklinik Essen, Klinik fuer Pneumologie, Essen, Northrhine westphalia

Universitätsmedizin Mainz - Zentrum für Thoraxerkrankungen, Mainz, Rhineland-Palatinate

Uniklinikum Leipzig Medizinische Klinik II - Bereich, Leipzig, Saxony

A.O.U. delle Marche - Ospedale di Torrette, Torrette, Ancona

Azienda Sanitaria Universitaria Giuliano Isontina, Venezia, Giulia

Fondazione IRCCS Policlinico San Matteo - UOC Pneumologia, Pavia, Lombardia

HUMANITAS Research Hospital, Rozzano, Milano

IRCCS AOU di Bologna - Policlinico Sant' Orsola, Bologna, Romagna

A.O.U. Policlinico G. Rodolico, Catania, Sicilia

Ospedale San Giuseppe, Milano, Not set

Health New Zealand, Christchurch, Canterbury

Dunedin Hospital, Dunedin, Dunedine

Bay of Plenty Clinical School, Tauranga, South Tauranga

Greenlane Clinical Centre, Auckland, Not set

Vitamed Galaj I Cichomski sp.j., Bydgoszcz, Bydgoszc

AppleTreeClinics Network, Lodz, Not set

Hospital Universitario Virgen de las Nieves, Granada, Andalucía

Hospital Universitario Central de Asturias, Oviedo, Asturias

Hospital de Sant Pau y la Santa Creu, Barcelona, Not set

Hospital Universitario Puerta del Mar - Leon-Jimenez, Cadiz, Not set

Hospital Gregorio Marañon, Madrid, Not set

Hospital Universitario Virgen de la Victoria, Málaga, Not set

Ege University Medical Faculty Hospital, Bornova, Izmir

Hull University Teaching Hospital NHS Trust, Cottingham, East Yorkshire

Leicester Biomedical Research Centre - Respiratory Theme, Glenfield, Leicester

Royal Devon, Exeter, South West

The Royal Wolverhampton NHS Trust, New Cross Hospital, Research and Development, Wolverhampton, West Midlands

St James University Hospital - LTHT, Leeds, West Yorkshire

St George's University Hospitals NHS Foundation Trust, London, Not set

Conditions: Progressive Pulmonary Fibrosis

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A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma

NCT05650632

Recruiting

Multiple Myeloma (MM) is a cancer of the blood's plasma cells ( blood cell). The cancer is typically found in the bones and bone marrow (the spongy tissue inside of the bones) and can cause bone pain, fractures, infections, weaker bones, and kidney failure. Treatments are available, but MM can come back (relapsed) or may not get better (refractory) with treatment. This is a study to determine adverse events and change in disease symptoms of ABBV-383 in adult participants with relapsed/refractory... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/23/2025

Locations: Mayo Clinic Arizona /ID# 251405, Phoenix, Arizona +40 locations

Mayo Clinic Arizona /ID# 251405, Phoenix, Arizona

Highlands Oncology Group - Springdale /ID# 267742, Springdale, Arkansas

Rocky Mountain Cancer Centers - Aurora /ID# 268574, Aurora, Colorado

Medical Oncology Hematology Consultants /ID# 268560, Newark, Delaware

Hope And Healing Cancer Services /ID# 268536, Hinsdale, Illinois

Fort Wayne Medical Oncology And Hematology /ID# 268179, Fort Wayne, Indiana

Tulane University School of Medicine /ID# 251204, New Orleans, Louisiana

Mayo Clinic - Rochester /ID# 251164, Rochester, Minnesota

NHO Revive Research Institute, LLC /ID# 267869, Lincoln, Nebraska

Mt Sinai /ID# 251166, New York, New York

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 251167, New York, New York

University of North Carolina /ID# 251203, Chapel Hill, North Carolina

Wake Forest Univ HS /ID# 251165, Winston-Salem, North Carolina

University Of Cincinnati Medical Center /ID# 251746, Cincinnati, Ohio

Willamette Valley Cancer Institute and Research Center /ID# 267088, Eugene, Oregon

Vanderbilt Ingram Cancer Center /ID# 252470, Nashville, Tennessee

Texas Oncology - Central/South Texas /ID# 268563, Austin, Texas

Oncology Consultants /ID# 268323, Houston, Texas

Texas Oncology - Northeast Texas /ID# 268877, Tyler, Texas

Virginia Cancer Specialists - Fairfax /ID# 268559, Fairfax, Virginia

Fred Hutchinson Cancer Center /ID# 267940, Seattle, Washington

Northwest Medical Specialties Tacoma /ID# 267117, Tacoma, Washington

Juravinski Cancer Centre /ID# 252053, Hamilton, Ontario

Ottawa Hospital Research Institute /ID# 252151, Ottawa, Ontario

Odense University Hospital /ID# 251261, Odense, Syddanmark

Sygehus Lillebalt, Vejle /ID# 251260, Vejle, Syddanmark

Institut Paoli-Calmettes /ID# 252100, Marseille, Bouches-du-Rhone

Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 252101, Creteil, Paris

CHU de Nantes, Hotel Dieu -HME /ID# 251196, Nantes, Pays-de-la-Loire

HCL - Hopital Lyon Sud /ID# 251223, Pierre Benite CEDEX, Rhone

CHU Poitiers - La miletrie /ID# 251219, Poitiers, Vienne

AP-HP - Hopital Saint-Antoine /ID# 252326, Paris, Not set

The Chaim Sheba Medical Center /ID# 251329, Ramat Gan, Tel-Aviv

Tel Aviv Sourasky Medical Center /ID# 251573, Tel Aviv, Tel-Aviv

Hadassah Medical Center-Hebrew University /ID# 252079, Jerusalem, Yerushalayim

Rabin Medical Center /ID# 251330, Petah Tikva, Not set

Hospital Universitario Marques de Valdecilla /ID# 251528, Santander, Cantabria

Hospital Universitario Puerta de Hierro - Majadahonda /ID# 251545, Majadahonda, Madrid

Hospital Universitario de Salamanca /ID# 251529, Salamanca, Not set

University College London Hospital /ID# 251357, London, Greater London

The Christie Hospital /ID# 251774, Manchester, Not set

Conditions: Multiple Myeloma

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This Study Aims to Measure the Effect of Acute Hospitalisation on the Physical and Cognitive Functioning of Older Orthopaedic Patients (Aged 65 or Above).

NCT06932224

Recruiting

This study aims to investigate the impact of hospitalisation on physical and cognitive performance in patients aged 65 and older admitted with an orthopaedic injury. This will be achieved by asking patients to participate in a series of physical and cognitive performance questionnaires and tests. These questionnaires and tests will be performed by the patients as close to their admission as possible and then again at day 7 of hospitalisation (or discharge if earlier) and at 4-6 weeks after disch... Read More

Gender:

ALL

Ages:

65 years and above

Trial Updated:

04/23/2025

Locations: University Hospitals Southampton Foundation Trust, Southampton, Hampshire

Conditions: Deconditioning, Orthopedic Fractures, Hospital Associated Deconditioning, Orthopaedic Injuries

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Pulmonary Hemodynamics During Exercise - Research Network

NCT03954574

Recruiting

The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/23/2025

Locations: University of Arizona, Banner University Medical Center, Phoenix, Arizona +31 locations

University of Arizona, Banner University Medical Center, Phoenix, Arizona

University of California, Los Angeles, Lung & Heart-Lung Transplant and Pulmonary Hypertension Programs, David Geffen School of Medicine, Los Angeles, California

Johns Hopkins Hospital, Advanced HF, MCS, Transplant Cardiology, Baltimore, Maryland, USA, Baltimore, Maryland

Massachusetts General Hospital, Cardiology Division and Pulmonary Unit, Boston, Massachusetts

Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts

University of Minnesota Medical School, Division of Cardiology, Department of Medicine, Lillehei Heart Institute Minneapolis, Minnesota, USA, Minneapolis, Minnesota

Mayo Clinic, Division of Cardiovascular Diseases, Department of Medicine, Rochester, Minnesota

Medical University of South Carolina, Charleston, South Carolina

Royal Prince Alfred Hospital, Respiratory Medicine, Camperdown, Not set

Medical University of Graz, Graz, Not set

Free University of Brussels, Faculty of Medicine, Physiology, Brussels, Not set

University of São Paulo Medical School, São Paulo, Not set

Department of Cardiology, Aarhus University Hospital, Denmark, Aarhus, Not set

Université de Lorraine, Nancy, Not set

Centre Chirurgical Marie Lannelongue, Thoracic and Vascular Surgery, Paris, Not set

Centre de Référence de l'Hypertension Pulmonaire, Université ParisSud - Université Paris-Saclay, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, Paris, Not set

Sorbonne Universités, Neurophysiologie respiratoire expérimentale et clinique, Paris, Not set

University of Cologne, Klinik III fuer Innere Medizin, Cologne, Not set

Justus-Liebig-University Giessen, Department of Internal Medicine, Gießen, Not set

University of Greifswald, Greifswald, Not set

Thorax Clinic Heidelberg, Centre for Pulmonary Hypertension, Heidelberg, Not set

Academic Teaching Hospital of the Julius Maximilian University of Würzburg, Würzburg, Not set

University of Bologna, Bologna, Not set

University of Rome La Sapienza, Cardiovascular and Respiratory Sciences, Roma, Not set

VU Medisch Centrum, Pulmonology, Amsterdam, Not set

Otwock Medical Center of Postgraduate Education, Department of Pulmonary Circulation and Thromboembolic Diseases, Otwock, Not set

Barcelona Hospital Clínic, Pneumologia, Barcelona, Not set

University Hospital of Zurich, Internal Medicine, Zürich, Not set

Scottish Pulmonary Vascular Unit, Glasgow, Not set

Imperial College, NHS Healthcare NHS Trust, National Pulmonary Hypertension Service, London, Not set

Royal Brompton Hospital, London, Not set

Royal Hallamshire Hospital, Sheffield Pulmonary Vascular Disease Unit, Sheffield, Not set

Conditions: Pulmonary Circulation Diseases

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Cognitive Health in Ageing Register: Investigational and Observational Trial Studies in Dementia Research (CHARIOT): Prospective Readiness Cohort (PRO) Longitudinal Study

NCT06953167

Recruiting

Alzheimer's disease is a degenerative condition affecting the brain and is the most frequent form of dementia in older adults. Dementia is currently a major healthcare issue in the UK, affecting approximately a million people. The progression of the disease varies between individuals and the early stages may be characterised by only minimal changes in memory and thinking. These changes could remain undetected as the symptoms may be mistakenly regarded as normal age-related forgetfulness. However... Read More

Alzheimer's disease is a degenerative condition affecting the brain and is the most frequent form of dementia in older adults. Dementia is currently a major healthcare issue in the UK, affecting approximately a million people. The progression of the disease varies between individuals and the early stages may be characterised by only minimal changes in memory and thinking. These changes could remain undetected as the symptoms may be mistakenly regarded as normal age-related forgetfulness. However, dementia is not part of the normal ageing process. The disease process is now known to start at least 20 years prior to the emergence of symptoms. A protein called amyloid starts to deposit in the brain, forming clumps referred to as 'plaques'. Another protein called tau sticks to other tau molecules inside the brain cell and forms structures called 'tangles'. These changes cause damage to the brain cells, disrupting their normal functioning, leading to inflammation and ultimately destruction of the brain cells. So far, there is no cure for Alzheimer's disease, but by better understanding the changes that occur over time in the brain, scientists can find ways of detecting and therefore diagnosing and treating the disease earlier. One way in which scientists learn about how a disease develops, is by following people unaffected by the condition over an extended period of time. The same tests and sample collections are repeated to monitor any clinical changes. These are known as longitudinal studies, and CHARIOT:PRO studies are examples of this. The CHARIOT:PRO Longitudinal Study (CPLS) is an observational study of 600 participants aged \>65 years old which aims to evaluate cognition (thinking abilities) and biomarkers (biological markers which indicate the presence of disease e.g. amyloid) over time in older adults. The participants in CPLS were all screened as part of the CHARIOT:PRO Sub-Study (CPSS1) in 2015-2017. Visit 1 will be conducted within eight weeks after the Study Entry Visit (SEV). Visits 2-7 will follow at six-monthly intervals from Visit 1. During visits, information relating to health, medication, family history of dementia, self-reported cognitive function and anthropometrics will be collected. The cognitive assessments PACC5 and RBANS will be administered along with a measure of executive function (Trail Making Test). Participants will be provided with self-reported questionnaires to be completed at each onsite visit. Blood samples will be taken once a year i.e. Month 0, 12, 24 and 36. The purpose of CPLS is to continue to build on the vital data and samples already kindly donated by participants screened for CPSS1. This will provide valuable information that will enhance understanding of the earliest stages of Alzheimer's disease before obvious symptoms start to appear. Importantly, the Investigators hope to identify predictive markers of disease, which will help doctors to select the right drugs, and develop other approaches like lifestyle guidance to prevent or delay Alzheimer's disease in the future. This study is sponsored by Imperial College London, led by the Principal Investigator Professor Lefkos Middleton and is funded by Gates Ventures. Read Less

Gender:

ALL

Ages:

65 years and above

Trial Updated:

04/23/2025

Locations: Imperial College London, London, Not set

Conditions: Alzheimer's Disease (AD)

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5G-EMERALD: Amivantamab in Malignant Brain Tumours

NCT06632236

Recruiting

The purpose of this clinical trial is to evaluate the safety and tolerability of amivantamab and to determine the preliminary antitumour activity of amivantamab administered at the recommended Phase 2 dose (RP2D). In the Phase 1b of this study a biomarker defined arm will be opened, initially in the relapsed GMB setting, enrolling 12 patients. These patients will be treated with amivantamab monotherapy. Amivantamab will be administered intravenously (IV) weekly for the first 4 weeks, then every... Read More

Gender:

ALL

Ages:

16 years and above

Trial Updated:

04/23/2025

Locations: Cambridge University Hospitals, Cambridge, Not set +1 locations

Conditions: Malignant Primary Gliomas, Glioblastoma Multiform (Grade IV Astrocytoma), Diffuse Hemispheric Glioma, H3 G34-Mutant, Glioblastoma Multiforme (GBM)

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SCOOT: Sample Collection for DART

NCT05368298

Recruiting

The study will use a blood sample collected from participants to: * Develop new ways of finding and diagnosing lung health problems, such as lung cancer. * Develop tools which make it easier to screen people with possible lung health problems, diagnose problems earlier and with fewer tests, and start the best treatment faster. * Help improve the early diagnosis of lung cancer, as finding lung cancer early means that it can be treated more easily and successfully.

Gender:

ALL

Ages:

Between 55 years and 75 years

Trial Updated:

04/23/2025

Locations: Lung Health Check Centre: Royal Sussex, Brighton, Not set +9 locations

Conditions: Lung Cancer

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Validation of Sensors for Long-term Non-Invasive Fetal Monitoring

NCT06952777

Recruiting

A multidisciplinary team of a doctor and engineers have developed a new sensor that will be able to detect mothers' and babies' heartbeat and babies movements in late pregnancy. This sensor can be placed in contact with the mothers' skin over the pregnant uterus without having to be stuck down. We anticipate that this sensor would allow us to monitor babies for longer periods of time which might help us to better identify babies who are being deprived of oxygen during pregnancy. We need to test... Read More

Gender:

FEMALE

Ages:

Between 16 years and 50 years

Trial Updated:

04/23/2025

Locations: Manchester University NHS Foundation Trust, Manchester, Not set

Conditions: Fetal Distress With Antenatal Problem, Fetal Growth Retardation

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Muscle Health and Recovery in Older Adults

NCT06205537

Recruiting

This is a prospective, randomized, placebo controlled, double-blinded study to evaluate the efficacy of a combination of nutritional ingredients on muscle health and recovery from a short bout of exhaustive exercise in healthy older adults.

Gender:

ALL

Ages:

Between 60 years and 75 years

Trial Updated:

04/23/2025

Locations: University of Nottingham, Derby, Not set

Conditions: Muscle Injury

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