Clinical Trials & Research Studies in United Kingdom(Updated 8/25)

CARPALL: Immunotherapy with CD19+CD22 CAR T-cells for CD19+ and CD22+ Acute Lymphoblastic Leukaemia

NCT02443831

Recruiting

This study aims to evaluate the safety, efficacy and duration of response of CD19+CD22 Chimeric Antigen Receptor (CAR) redirected autologous T-cells in children with high risk, relapsed CD19+ and CD22+ acute lymphoblastic leukaemia

Gender:

ALL

Ages:

24 years and below

Trial Updated:

03/26/2025

Locations: Great Ormond Street Hospital, London, Not set +2 locations

Conditions: Acute Lymphoblastic Leukemia

Register for Updates

Learn More ›

Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)

NCT04185883

Recruiting

To evaluate the safety and tolerability of sotorasib administered in investigational regimens in adult participants with KRAS p.G12C mutant advanced solid tumors.

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

03/26/2025

Locations: Arizona Oncology Associates Professional Corporation, Tucson, Arizona +89 locations

Arizona Oncology Associates Professional Corporation, Tucson, Arizona

City of Hope National Medical Center, Duarte, California

University of California San Diego Moores Cancer Center, La Jolla, California

Loma Linda University Cancer Center, Loma Linda, California

University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California

University of California Davis Medical Center, Sacramento, California

University of California San Francisco Mission Bay Campus, San Francisco, California

University of California Los Angeles, Santa Monica, California

Rocky Mountain Cancer Centers Denver Midtown, Denver, Colorado

Sarah Cannon Research Institute, Denver, Colorado

Yale New Haven Hospital, New Haven, Connecticut

Norwalk Hospital, Norwalk, Connecticut

Memorial Cancer Institute, Pembroke Pines, Florida

Moffitt Cancer Center, Tampa, Florida

Emory University, Atlanta, Georgia

Northwestern University, Chicago, Illinois

University of Chicago, Chicago, Illinois

Indiana University, Indianapolis, Indiana

University of Iowa Hospitals and Clinics, Iowa City, Iowa

Johns Hopkins University, Baltimore, Maryland

University of Michigan, Ann Arbor, Michigan

Henry Ford Cancer Detroit (Brigitte Harris Cancer Pavilion), Detroit, Michigan

Washington University, Saint Louis, Missouri

Montefiore Medical Center, Bronx, New York

Roswell Park Cancer Institute, Buffalo, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Columbia University Irving Medical Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Levine Cancer Institute, Charlotte, North Carolina

Duke University, Durham, North Carolina

University of Cincinnati Medical Center, Cincinnati, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Providence Portland Medical Center, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Thomas Jefferson University, Philadelphia, Pennsylvania

Fox Chase Cancer Center, Philadelphia, Pennsylvania

University of Pennsylvania, Philadelphia, Pennsylvania

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Gibbs Cancer Center and Research Institute - Spartanburg, Spartanburg, South Carolina

Avera Cancer Institute, Sioux Falls, South Dakota

United States Oncology Regulatory Affairs Corporate Office, Nashville, Tennessee

Vanderbilt University Medical Center, Nashville, Tennessee

Texas Oncology Central-South, Austin, Texas

Mary Crowley Cancer Research, Dallas, Texas

University of Texas Southwestern Medical Center, Dallas, Texas

Oncology Consultants, Houston, Texas

University of Texas MD Anderson Cancer Center, Houston, Texas

US Oncology Research Investigational Products Center, The Woodlands, Texas

Texas Oncology Northeast Texas, Tyler, Texas

Huntsman Cancer Institute, Salt Lake City, Utah

University of Virginia Cancer Center, Charlottesville, Virginia

Virginia Cancer Specialists, PC, Fairfax, Virginia

Fred Hutchinson Cancer Center, Seattle, Washington

Northwest Medical Specialties, PLLC, Tacoma, Washington

Northwest Cancer Specialists - Vancouver, Vancouver, Washington

Nepean Cancer Centre, Kingswood, New South Wales

GenesisCare -North Shore Oncology, St Leonards, New South Wales

Icon Cancer Care South Brisbane, South Brisbane, Queensland

The Queen Elizabeth Hospital, Woodville South, South Australia

St John of God Healthcare, Subiaco, Western Australia

Medizinische Universitaet Graz, Graz, Not set

Landeskrankenhaus Salzburg, Salzburg, Not set

Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Bruxelles, Not set

Universitair Ziekenhuis Antwerpen, Edegem, Not set

CHU de Quebec Hopital de l Enfant Jesus, Quebec, Not set

Charite Universitaetsmedizin Berlin, Campus Virchow, Berlin, Not set

Universitaetsklinikum Dresden, Dresden, Not set

Universitaetsklinikum Essen, Essen, Not set

Universitatsklinikum Koln, Koeln, Not set

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set

Azienda Ospedaliero Universitaria Pisana, Pisa, Not set

Centro Ricerche Cliniche Di Verona Societa responsabilita limitata, Verona, Not set

Aichi Cancer Center, Nagoya-shi, Aichi

National Cancer Center Hospital East, Kashiwa-shi, Chiba

The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Tokyo

Seoul National University Hospital, Seoul, Not set

The Catholic University of Korea Seoul St Marys Hospital, Seoul, Not set

Asan Medical Center, Seoul, Not set

Universitair Medisch Centrum Utrecht, Utrecht, Not set

Hospital Universitari Vall d Hebron, Barcelona, Cataluña

Hospital Clinic i Provincial de Barcelona, Barcelona, Cataluña

Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals, Hospitalet de Llobregat, Cataluña

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid

Hospital Universitario Ramon y Cajal, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

National Cheng Kung University Hospital, Tainan, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan, Not set

Sarah Cannon Research Institute UK, London, Not set

Conditions: Advanced Solid Tumors, Kirsten Rat Sarcoma (KRAS) pG12C Mutation

Register for Updates

Learn More ›

A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC

NCT04550104

Recruiting

CONCORDE is a multi-institution, multi-arm, Phase IB study that will determine the recommended phase II dose (RP2D) and safety profiles of different DNA damage repair inhibitors (DDRis) when given in an open label fashion in combination with fixed dose curative intent radiotherapy (RT) in patients with stage IIB/IIIA/IIIB NSCLC, followed by up to 12 months of consolidation durvalumab immunotherapy in selected study arms. The RP2D will be evaluated by incorporating the number of observed dose lim... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/26/2025

Locations: Belfast City Hospital, Belfast, Not set +10 locations

Conditions: Non Small Cell Lung Cancer

Register for Updates

Learn More ›

STI Prophylaxis and Emergence of Antimicrobial Resistance

NCT06778083

Recruiting

The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted infections (STI prophylaxis, doxycycline post-exposure prophylaxis, or 'doxyPEP'). The study will assess how easy and acceptable it is to find antibiotic resistance and microbiome changes in the throats and guts of men-who-have-sex-with-men (MSM) who use STI prophylaxis. The st... Read More

Gender:

MALE

Ages:

18 years and above

Trial Updated:

03/26/2025

Locations: Central and North West London NHS Foundation Trust, London, Not set

Conditions: Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis, Antibiotic Resistance, Bacterial, Microbiome, Doxycycline

Register for Updates

Learn More ›

Restoration of Bladder Function in Spinal Cord Injury

NCT05968352

Recruiting

The aim of this study is to develop improved methods of restoring function to the neurogenic bladder, using electrical stimulation without cutting nerves in patients with spinal cord injury. The investigators will test 5-10 subjects with existing sacral anterior root stimulation (SARS) devices and look at the effects of high frequency (up to 600Hz) compared to the usual low frequency stimulation on bladder function. The investigators are particularly interested in whether it is possible to repr... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/26/2025

Locations: University of Oxford, Oxford, Oxon

Conditions: Bladder Dysfunction, Spinal Cord Injuries

Register for Updates

Learn More ›

DBS and Respiration

NCT04058457

Recruiting

Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of neurological conditions, most commonly Parkinson's disease. The investigators have observed that respiratory problems (breathlessness) sometimes occur subsequent to DBS of the subthalamic nucleus (STN). This study aims to determine whether this is indeed a consequence of STN stimulation. Secondary objectives include identification of the respiratory physiological mediators of any interoc... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/26/2025

Locations: John Radcliffe Hospital, Oxford, Oxfordshire

Conditions: Parkinson Disease

Register for Updates

Learn More ›

Mechanisms Underlying Antidepressant Effects of Physical Activity

NCT06387732

Recruiting

It is well established that any level of physical activity can help prevent and treat depression, with more strenuous activity having a greater effect. Understanding the mechanisms driving this antidepressant effect is important because it could allow exercise programmes to be made more effective, accessible, and targeted. Such knowledge could contribute to social prescribing, increasingly a priority for mental healthcare. Importantly, physical activity is highly scalable, low cost, well suited... Read More

It is well established that any level of physical activity can help prevent and treat depression, with more strenuous activity having a greater effect. Understanding the mechanisms driving this antidepressant effect is important because it could allow exercise programmes to be made more effective, accessible, and targeted. Such knowledge could contribute to social prescribing, increasingly a priority for mental healthcare. Importantly, physical activity is highly scalable, low cost, well suited to early intervention, and has beneficial impacts on physical health co-morbidities. This trial may provide initial indications of whether there are sub-groups of depressed individuals who are particularly likely to benefit from physical activity, lead to strategies to personalise physical activity prescription based on motivational factors, and pave the way for augmentative approaches, for example combining physical activity with psychological interventions. To date the mechanisms driving the antidepressant effects of physical activity in humans are poorly understood. Building on links between depressive symptoms, reward processing and dopamine, plus evidence from animal studies that physical activity is anti-inflammatory and boosts both dopamine and reward processing, the overarching aim of this trial is to understand the mechanisms underlying the effects of physical activity in depression, focusing on the concept of motivation. The key objective is to conduct a randomised controlled trial (RCT) in N=250 depressed participants comparing aerobic exercise to a stretching/relaxation control condition, examining a range of mechanistic factors. The proposed trial will examine the impact of physical activity at multiple, linked potential levels of explanation: (1) immune-metabolic markers; (2) dopamine synthesis capacity; (3) activation in the brain's reward and effort processing circuitry;(4) effort-based decision making incorporating computational analysis; and (5) symptom networks based on fine-grained, daily measurements. Read Less

Gender:

ALL

Ages:

Between 18 years and 60 years

Trial Updated:

03/26/2025

Locations: Institute of Cognitive Neuroscience, University College London, London, Not set

Conditions: Depression

Register for Updates

Learn More ›

The Krill Ageing Muscle Mechanisms (KAMM) Study

NCT06296875

Recruiting

This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oil Objective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle archite... Read More

Gender:

ALL

Ages:

Between 65 years and 90 years

Trial Updated:

03/25/2025

Locations: University of Glasgow, Glasgow, Not set

Conditions: Sarcopenia

Register for Updates

Learn More ›

IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2

NCT03194815

Recruiting

A randomised phase II double-blinded placebo-controlled trial designed to explore the utility of immunotherapy for patients with acute psychosis associated with anti-neuronal membranes (NMDA-receptor or Voltage Gated Potassium Channel). Primary objective: To test the efficacy of immunotherapy (IVIG and rituximab) for patients with acute psychosis associated with anti-neuronal membranes. Secondary objective: To test safety of immunotherapy (IVIG and rituximab) for patients with acute psychosis... Read More

Gender:

ALL

Ages:

Between 16 years and 70 years

Trial Updated:

03/25/2025

Locations: Cambridge University Hospitals NH Foundation Trust, Cambridge, Not set +9 locations

Conditions: Psychosis, Autoimmune Encephalitis

Register for Updates

Learn More ›

Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism

NCT05774444

Recruiting

The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.

Gender:

ALL

Ages:

Between 60 years and 90 years

Trial Updated:

03/25/2025

Locations: Stuart Robert Gray, Glasgow, Not set

Conditions: Hypertrophy

Register for Updates

Learn More ›

Evaluating Treatable Traits Across the Spectrum of Chronic Obstructive Airways Disease

NCT05976919

Recruiting

Respiratory disease affects one in five people and is a leading cause of global morbidity and mortality. Chronic obstructive airways diseases encompass conditions characterised by expiratory airflow limitation, exertional dyspnoea, activity limitation and impaired quality of life. The most common conditions include chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, cystic fibrosis and primary ciliary dyskinesia. In recent years, there has been concerted effort in the scientifi... Read More

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

03/25/2025

Locations: University of Leeds, Leeds, Not set

Conditions: Airway Disease

Register for Updates

Learn More ›

Middle Age MuScle Krill Study

NCT06005064

Recruiting

This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.

Gender:

ALL

Ages:

Between 35 years and 60 years

Trial Updated:

03/25/2025

Locations: University of Glasgow, Glasgow, Not set

Conditions: Sarcopenia

Register for Updates

Learn More ›

All Clinical Trials in United Kingdom

Match to Clinical Trials