Novel Technologies for Respiratory Virus Identification
NCT05661032
Recruiting
Current virus detection methods often take significant time or can be limited in sensitivity, specificity or cost. There is therefore a need for diagnostic methods that are simple to use, sensitive, rapid and inexpensive. This is a proof of concept study to determine whether the Pictura Bio system (a new a rapid pathogen identification technology) is able to detect and differentiate different viruses from nasopharyngeal swabs/aspirate specimens. The data collected will be used to "train" the al... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/10/2025
Locations: Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Portsmouth, Hampshire
Conditions: Infections, Respiratory, Respiratory Tract Infections
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Tumour Regulatory Molecules in Early Pancreatic Cancer Detection
NCT03536793
Recruiting
The effective diagnosis of pancreatic cancer is often quite challenging, due to a lack of disease-specific symptoms, resulting in the majority of patients presenting with advanced disease, with an associated dismal prognosis. Earlier detection of pancreatic cancer, at a stage where surgery is feasible, would greatly increase the 5-year survival rate. Detecting pancreatic cancer early is therefore vital to improve the prognosis for these patients. Pre-cancerous pancreatic cysts are an early indi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust, Cottingham, Kingston Upon Hull
Conditions: Cancer of Pancreas, Pancreas Cyst
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Computerized Registry of Patients With Venous Thromboembolism (RIETE)
NCT02832245
Recruiting
The Computerized Registry of Patients with Venous Thromboembolism (RIETE) is a multidisciplinary Project initiated in march 2001 and consisting in obtaining an extensive data registry of consecutive patients with venous thromboembolism. The main objective is to provide information on the Internet to help physicians to improve their knowledge on the natural history of thromboembolic disease, particularly in those subgroups of patients who are usually not recruited in randomized clinical trials (... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/10/2025
Locations: Yale University School of Medicine, New Haven, Connecticut +249 locations
Conditions: Venous Thromboembolism
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Skeletal Muscle-derived Cell Implantation for Treatment of Fecal Incontinence
NCT04976153
Recruiting
The objective of this study is the final assessment of clinical safety and efficacy of autologous autologous skeletal muscle derived cells for patients with urge fecal incontinence due to external anal sphincter dysfunction caused by its disruption and/or weakness.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: Landeskrankenhaus Feldkirch, Feldkirch, Not set +30 locations
Conditions: Fecal Incontinence
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The Lived Experience of People With Von Willebrand Disease
NCT06064643
Recruiting
von Willebrand disease (vWD) is reported to be the most common bleeding disorder, with prevalence estimated at 1% of the general population. Despite this, little is known about its natural history, or of the impact it has on affected individuals and their families. The Haemnet vWD360 programme is a mixed-methods, natural history study designed to gain a greater understanding of vWD and its impact on individuals and their families. It comprises both qualitative and quantitative approaches and is... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
03/10/2025
Locations: Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire
Conditions: Von Willebrand Diseases
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A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Infants (0 to <2 Years of Age) With Achondroplasia
NCT06079398
Recruiting
This trial is a Phase 2, multicenter, double-blind, randomized (ratio 2:1 TransCon CNP vs. placebo), placebo-controlled trial, designed to evaluate the safety, tolerability, and efficacy of 100 μg CNP/kg of Navepegritide (TransCon CNP) administered SC once-weekly for 52 weeks in infants with genetically verified heterozygous ACH, aged 0 to \< 2 years at the time of randomization.
Gender:
ALL
Ages:
Between 0 years and 2 years
Trial Updated:
03/10/2025
Locations: Ascendis Investigational Site, Saint Paul, Minnesota +15 locations
Conditions: Achondroplasia
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In Vivo Dosimetry for Brachytherapy Study
NCT06863090
Recruiting
The main study aim is the investigate the clinical use of in vivo dosimeters (small measurement devices) for brachytherapy (internal radiotherapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: Mount Vernon Cancer Centre, Northwood, Middlesex
Conditions: Prostate Cancer, Gynaecological Cancer
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Evaluation of the Exercise for Wellbeing Pathway At York St John University
NCT06874699
Recruiting
In autumn 2024, York St John University launched a physical activity programme for university students facing mental health challenges. The purpose of this project is to conduct a mixed-methods evaluative study of this new service over a 6-month period. It is anticipated that 20-40 students will be recruited to the study, which will assess the following: assess the following: feasibility, the extent to which the service can be delivered successfully; acceptability, the extent to which the servic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: York St John University, York, North Yorkshire
Conditions: Mental Health
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Aquatic and Land Exercises for Chronic Low Back Pain
NCT06874881
Recruiting
This study aims to learn about the effects of aquatic and land exercises on managing chronic low back pain in adults aged 18-65. The participants engage in a 12-week supervised land and water-based exercise program. The main questions this study aims to answer are: * How effective are aquatic exercises on low back pain, functional disability, Kinesiophobia, sleep quality, and overall quality of life? * Is aquatic therapy more effective than land exercises for treating LBP or vice versa?
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/07/2025
Locations: St. Leonard building, The University of Edinburgh, Edinburgh, Not set
Conditions: Chronic Low Back Pain (non-specific, Uncomplicated)
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ChariotMS - Cladribine to Halt Deterioration in People With Advanced Multiple Sclerosis
NCT04695080
Recruiting
MS is a chronic inflammatory and degenerative disease of the central nervous system (CNS) affecting more than 120,000 people in the UK.and 2.5 million people worldwide. Without disease modifying treatment (DMT),the majority of people with MS (pwMS) will develop significant disability within 10 years of onset, and 50% will require wheelchair assistance within 20 years. convenient, highly effective and CNS penetrant DMT for patients with relapsing multiple sclerosis (pwRMS) administered in short... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: Queens University Belfast (Belfast Health and Social Care Trust), Belfast, Not set +21 locations
Conditions: Advanced Multiple Sclerosis, Progressive Multiple Sclerosis
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Flow Patterns and Stent Thrombosis
NCT06700018
Recruiting
The goal of this observational study is to study the effect of haemodynamic forces on thrombus formation and identify haemodynamic markers that predict stent thrombosis events in patients who have undergone OCT-guided percutaneous coronary interventions. The primary objective of the study is to examine the efficacy of blood flow patterns in predicting stent thrombosis. Researchers will compare the blood flow patterns of the stent thrombosis group with that of the control group to understand the... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/07/2025
Locations: Queen Mary University of London, London, Not set
Conditions: Stent Thrombosis
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First-in-human Dose Escalation and Expansion Study With the SIRPα-directed Monoclonal Antibody BYON4228
NCT05737628
Recruiting
This is the first-in-human study with BYON4228, a humanized monoclonal antibody (mAb) directed against SIRPα.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: ASST Spedali Civili di Brescia, Brescia, Not set +11 locations
Conditions: Lymphoma
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