A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE
NCT05171075
Recruiting
This is a Phase 3, multicenter, open-label, blinded endpoint study to evaluate the effect of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and bleeding in patients with gastrointestinal (GI)/genitourinary (GU) cancer associated VTE (Magnolia)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado +184 locations
Conditions: Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism
Register for Updates
Hemithoracic Irradiation With Proton Therapy in Malignant Pleural Mesothelioma
NCT05655078
Recruiting
Phase III randomised-controlled trial for patients with unilateral malignant pleural mesothelioma (MPM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: Royal Berkshire Hospital, Reading, England +10 locations
Conditions: Malignant Pleural Mesothelioma
Register for Updates
The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function.
NCT06151015
Recruiting
This pilot study will compare the effect of combining dietary nitrate and caloric restriction versus dietary nitrate alone. The participant will be contacted, having responded to an advertisement on social media and posters, to attend the screening visit. They will be asked about their health status, suitability for MRI and availability. The investigators will use physical activity and eating attitude questionnaires. The investigators will also measure their height, weight, body mass index (BMI)... Read More
Gender:
ALL
Ages:
Between 60 years and 75 years
Trial Updated:
12/18/2024
Locations: The University of Nottingham, Nottingham, Nottinghamshire
Conditions: Healthy, Older Adults, Overweight and Obesity
Register for Updates
Nerve Composition of Human Lumbar Dorsal Primary Rami and Its Medial Branch
NCT05091112
Recruiting
The purpose of the study is to understand the composition of the nerves supplying the facet joints in low back.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: Woodend Hospital, Aberdeen, Scotland
Conditions: Lumbar Facet Arthrosis, Nerve Degeneration
Register for Updates
Understanding the Benefits of Dietary Fibre Supplementation in Patients With Prostate Cancer
NCT06661044
Recruiting
The digestive tract (large intestine) contains microorganisms that digest complex carbohydrates in food to produce chemical substances which are beneficial to human health. The population of these microorganisms in faeces (stool samples) could be used to diagnose the health status of a person and this can be changed with the use of antibiotics, diet, radiotherapy or infection. Dietary fibre supplements can help provide nutrients for the beneficial bacteria from the large intestine to produce us... Read More
Gender:
MALE
Ages:
60 years and above
Trial Updated:
12/18/2024
Locations: University of Aberdeen, Aberdeen, Scotland
Conditions: Prostate Cancer (Adenocarcinoma)
Register for Updates
Pain AND Opioids After Surgery
NCT05877157
Recruiting
The aim of this study is to document the perioperative opioid use and its safety in the UK and countries in Europe and to describe its association with surgical complications, persistent pain and quality of life. In an international, prospective, observational cohort study, data about the perioperative pain management will be collected in all eligible hospitalised adult patients who undergo surgery in a designated "study week" in as many hospitals as possible in Europe. Baseline data will be col... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: Department of Anaesthesiology Sestre Milosrdnice, University Hospital Center, Zagreb, Vinogradska 29 +3 locations
Conditions: Opioid Use, Pain, Chronic, Pain, Postoperative, Quality of Life
Register for Updates
Exploring Mechanism of Action of Dietary Fibre on the Gut Microbiota and Metabolites
NCT05906589
Recruiting
Cancer patients receiving pelvic radiotherapy suffer side effects to the intestine, including diarrhoea and occasionally rectal bleeding, often worsened by chemoradiation. Many pelvic radiotherapy patients receive a form of dietary fibre, psyllium husk, to manage their diarrhoeal symptoms. There is evidence in mice that dietary fibre supplementation can improve tumour response and reduce normal tissue side effects caused by radiation. If this were to be confirmed in humans, it would be a major a... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
12/18/2024
Locations: Rowett Institute, Aberdeen, Not set
Conditions: Psyllium, Inulin
Register for Updates
An Evaluation of Remote Care (questionnaire+hybrid) in Patients Who Are Post-lung Transplant
NCT05916495
Recruiting
Lung transplantation is used to treat patients with lung damage when there is no other treatment option. Patients require close monitoring following their transplant, with hospital check-ups every 3-4 months usually lasting all day. Although check-ups often result in no change to patient management they are essential as patients have better outcomes if complications are detected quickly. The aim is to explore whether remote monitoring via an app (patientMpower) ± questionnaire (specifically des... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
12/18/2024
Locations: Manchester University NHS Foundation Trust, Manchester, Not set
Conditions: Lung Transplant; Complications
Register for Updates
A Trial of Polatuzumab Vedotin, Obinutuzumab and Glofitamab As a Peri-CAR-T Cell Treatment Strategy in Large B-cell Lymphoma
NCT06071871
Recruiting
The PORTAL study will test a new combination of drugs (glofitamab, polatuzumab vedotin and obinutuzumab) in patients with large B-cell lymphoma (LBCL) that has come back (relapsed) or not responded to previous treatment. It will determine how safe and effective the combination of these cancer drugs is in treating LBCL before and after CAR-T cell therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: Kings College Hospital NHS Foundation Trust, London, Not set +4 locations
Conditions: Large B-cell Lymphoma
Register for Updates
A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents With Fabry Disease
NCT06328608
Recruiting
A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents with Fabry Disease.
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
12/18/2024
Locations: Phoenix Children's, Phoenix, Arizona +11 locations
Conditions: Fabry Disease
Register for Updates
STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
NCT03935750
Recruiting
Anterior cruciate ligament (ACL) rupture is one of the most common musculoskeletal injuries in young individuals, particularly those that are active in sports. Up to 30% of individuals under the age of 20 years suffer a re-injury to the reconstructed ACL. Revision ACLR has been associated with degeneration of the articular cartilage and increased rates of meniscal tears, increasing the risk of post-traumatic osteoarthritis (PTOA), additional surgical procedures, reduced physical function and qua... Read More
Gender:
ALL
Ages:
Between 14 years and 25 years
Trial Updated:
12/17/2024
Locations: Stanford University, Redwood City, California +30 locations
Conditions: Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
Register for Updates
Photobiomodulation with REd Vs BluE Light (REBEL)
NCT06371300
Recruiting
The use of photobiomodulation or low-level light therapy (LLLT) in the ophthalmic field stemmed from dermatology which has shown impact on skin blood flow and regeneration. There has been a rise in clinical interest with emerging evidence in the benefits of photobiomodulation in managing chronic inflammatory conditions such as dry eye disease including improvements in ocular discomfort symptoms, tear film stability and tear volume. Despite the observed clinical benefits, limited research has bee... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: Aston Dry Eye Clinic, Birmingham, West Midlands
Conditions: Dry Eye Syndromes, Meibomian Gland Dysfunction, Blepharitis
Register for Updates