Simplified Tai Chi Exercises to Improve Function in People with Chronic Ankle Instability
NCT06682897
Recruiting
The goal of this interventional trial is to evaluate the effectiveness of the simplified four-week Tai Chi training in improving function in people with chronic ankle instability. The main questions it aims to answer are: 1. Does the 4-week Tai Chi training increase ankle muscle activation? 2. Does the 4-week Tai Chi training enhance ankle proprioception? 3. Does the 4-week Tai Chi training improve ankle muscle strength？ 4. Does the 4-week Tai Chi training boost balance performance？ 5. Does t... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
11/08/2024
Locations: Loughborough University, Loughborough, Leicester
Conditions: Chronic Ankle Instability
Register for Updates
Tamibarotene Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome
NCT04797780
Recruiting
This study compares the efficacy of Tamibarotene in combination with azacitidine to azacitidine in combination with placebo in participants who are Retinoic Acid Receptor Alpha (RARA) positive, and newly diagnosed with higher-risk myelodysplastic syndrome (HR-MDS), and who have not received treatment for this diagnosis. The primary goal of the study is to compare the complete remission rate between the two treatment arms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: University of Arizona, Tucson, Arizona +136 locations
Conditions: Myelodysplastic Syndromes
Register for Updates
First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors
NCT05277051
Recruiting
This is a first time in-human (FTIH) study designed to investigate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of GSK4381562 in participants with select loco-regionally recurrent solid tumors or metastatic solid tumors where curative or standard treatment options have been exhausted.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: GSK Investigational Site, San Francisco, California +23 locations
Conditions: Neoplasms
Register for Updates
HEM ISMART-D: Trametinib + Dexamethasone + Chemotherapy in Children with Relapsed or Refractory Hematological Malignancies
NCT05658640
Recruiting
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL. Sub-protocol D is a phase I/II trial evaluating the safety and efficacy of trametinib in combination with dexamethasone, cyclophosphamide and cytarabine in children and AYA with R/R ped ALL/LBL whose tumor present with alterations in the RAS-RAF-MAPK pathway.
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
11/07/2024
Locations: St. Anna Kinderspital, Vienna, Not set +35 locations
Conditions: Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory
Register for Updates
Developing ctDNA Guided Adjuvant Therapy for Gastrooesophageal Cancer
NCT05965479
Recruiting
Multicentre, single arm, open label UK phase II trial to assess the efficacy of trastuzumab deruxtecan in reducing micrometastatic disease burden in HER2 positive GOA patients who are ctDNA positive after chemotherapy and surgery. 25 patients will be recruited from approximately 15 NHS secondary care sites.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: Royal Surrey NHS Foundation Trust, Royal Surrey County Hospital, Guildford, Surrey +13 locations
Conditions: Gastrooesophageal Cancer
Register for Updates
A Study of VERVE-102 in Patients with Familial Hypercholesterolemia or Premature Coronary Artery Disease
NCT06164730
Recruiting
VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Base-editing Technology Designed to Disrupt the Expression of the PCSK9 Gene in the Liver and Lower Circulating PCSK9 and LDL-C. This Study is Designed to Determine the Safety and Pharmacodynamic Profile of VERVE... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/07/2024
Locations: Clinical Study Center, Adelaide, Not set +7 locations
Conditions: Heterozygous Familial Hypercholesterolemia, Premature Coronary Heart Disease
Register for Updates
Breast Cancer Evolution During Neoadjuvant Systemic Therapy
NCT06681064
Recruiting
BELIEVE is a translational research study that aims to collect samples of breast cancer tissue and blood from individuals undergoing breast cancer treatment (such as chemotherapy, targeted therapy and immunotherapy) before surgery. In certain cases, MRI scans and stool samples will also be obtained before and during treatment. The samples collected from this study will be used for molecular and genetic research to understand why some cancers respond very well to anticancer treatments, and some d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: Royal Marsden NHS Foundation Trust, London, Not set
Conditions: Breast Cancer, Triple Negative Breast Cancer, ER+ Breast Cancer, HER2+ Breast Cancer
Register for Updates
PLatform Study for INTracerebral Haemorrhage (PLINTH): Community-based Feasibility Study
NCT06078020
Recruiting
The goal of this observational study is to answer three uncertainties about the design of a platform study for adults with stroke due to intracerebral haemorrhage. The main things the investigators aim to find out are: * The acceptability of a platform trial and its comparisons to brain haemorrhage survivors or their carers, and their clinicians. * Estimates of eligibility, willingness to participate, diversity, representativeness, adherence, retention, data completion, and event rates of inte... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: The Royal Infirmary of Edinburgh, Edinburgh, City Of Edinburgh +1 locations
Conditions: Cerebral Hemorrhage
Register for Updates
Evaluation of Neoplasia with Artificial Intelligence in Gastrointestinal Endoscopy
NCT04937647
Recruiting
This study aims to validate and evaluate AI algorithms for detection and characterization of early GI neoplasia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Portsmouth Hospitals NHS University Trust, Portsmouth, Hampshire
Conditions: Gastrointestinal Neoplasms
Register for Updates
A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma
NCT05991388
Recruiting
The Glo-BNHL trial is trying to find better medicines for children and young people with B-cell non-Hodgkin Lymphoma (B-NHL) that does not go away (refractory B-NHL) or does but comes back again (relapsed B-NHL). B-NHL is a type of cancer that develops inside or outside of lymph nodes (glands) and organs such as the liver or spleen. Examples of B-NHL are Burkitt Lymphoma and Diffuse Large B Cell Lymphoma, which may be other names used to describe this type of cancer. It is very difficult to cure... Read More
Gender:
ALL
Ages:
25 years and below
Trial Updated:
11/05/2024
Locations: Birmingham Children's Hospital, Birmingham, Not set +2 locations
Conditions: B-cell Non Hodgkin Lymphoma
Register for Updates
ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer
NCT06579417
Recruiting
This is a multicenter, multinational trial to evaluate advanced MRI techniques for improved detection of clinically significant prostate cancer (csPCa). The study will enroll 500 participants at 5 clinical centers (100 participants per center). The current standard MRI technique for prostate cancer screening is multiparametric MRI (mpMRI), but two drawbacks include need for intravenous (IV) contrast and dependence on radiologist expertise. The investigators expect that the combination of two oth... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: University of California San Diego, San Diego, California +4 locations
Conditions: Prostate Cancer
Register for Updates
Multifidus PET Scan Study
NCT04327817
Recruiting
The study involves investigating phenotypic changes (ie metabolic activity in brain pain matrix areas, metabolic activity and textural analysis of multifidus muscle) following multifidus stimulation and establishing relationship with the change in pain, functionality and quality of life.
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
11/04/2024
Locations: Barts Health NHS Trust, London, Not set
Conditions: Low Back Pain
Register for Updates