All Clinical Trials in United Kingdom

A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma

NCT05352672

Recruiting

This study is researching an experimental drug called REGN3767, also known as fianlimab (R3767), when combined with another medication called REGN2810, also known as cemiplimab (each individually called a "study drug" or called "study drugs" when combined). The study is focused on patients with a type of skin cancer known as melanoma. The aims of the study are to see how effective the combination of fianlimab and cemiplimab are in treating the melanoma skin cancer, in comparison with a medicati... Read More

Gender:

ALL

Ages:

12 years and above

Trial Updated:

10/28/2024

Locations: University of California San Diego, La Jolla, California +218 locations

University of California San Diego, La Jolla, California

The Angeles Clinic and Research Institute, Los Angeles, California

Miami Cancer Institute, Miami, Florida

Orlando Health, Inc, Orlando, Florida

Atlantic Health System - Morristown Medical Center, Morristown, New Jersey

University Hospitals Seidmand Cancer Center, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

University of Tennessee Medical Center, Knoxville, Tennessee

Fundacion Cenit para la Investigacion en Neurociencias, Buenos Aires, Not set

DIABAID - Instituto de Asistencia Integral en Diabetes, Buenos Aires, Not set

Clinica Adventista Belgrano, Caba, Not set

Fundacion CENIT Centro Medico de Neurociencias, Ciudad Autonoma de Buenos Aires, Not set

Instituto de Oncologia de Rosario, Rosario, Not set

Centro Medico San Roque, San Miguel de Tucuman, Not set

Calvary North Adelaide Hospital, Adelaide, Not set

Barwon Health Andrew Love Cancer Centre, University Hospital Geelong, Geelong, Not set

Icon Cancer Centre Hobart, Hobart, Not set

The Alfred Hospital, Melbourne, Not set

Gold Coast University Hospital, Southport, Not set

The Townsville Hospital and Health Service, Townsville, Not set

Ballarat Oncology and Haematology Clinical Trials Unit, Wendouree, Not set

Medical University Innsbruck, Innsbruck, Tyrol

Medical University of Graz, Graz, Not set

University Hospital St. Poelten, St. Poelten, Not set

Medical University Of Vienna, Vienna, Not set

Cliniques Universitaires Saint-Luc, Brussels, Not set

AZ Groeninge, Campus Kennedylaan, Kortrijk, Not set

Clinique et Maternite Sainte-Elisabeth (CMSE), Namur, Not set

AZ Nikolaas, Sint Niklaas, Not set

Fundacao Pio XII - Hospital de Amor de Barretos, Barretos, Not set

Centro Avancado de Tratamento Oncologico (CENANTRON), Belo Horizonte, Not set

Liga Paranaense de Combate ao Cancer - Hospital Erasto Gaertner, Curitiba, Not set

Oncosite Centro De Pesquisa Clinica Em Oncologia, Ijui, Not set

Clinica de Neoplasias Litoral/atarina Pesquisa Clínica, Itajai, Not set

Instituto Joinvilense De Hematologia E Oncologia, Joinville, Not set

Animi Unidade de Tratamento Oncologico Ltda, Lages, Not set

Hospital Bruno Born, Lajeado, Not set

Hospital Sao Vicente de Paulo (HSVP) Instituto do Cancer, Passo Fundo, Not set

Hospital Moinhos de Vento, Porto Alegre, Not set

Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, Not set

CPO - Centro de Pesquisas em Oncologia, Porto Alegre, Not set

Fundacao PIO XII - Hospital de Amor Amazonia, Porto Velho, Not set

Instituto COI, Rio de Janeiro, Not set

Hospital Sao Rafael, Salvador, Not set

INCA - Brazilian National Cancer Institute, Santo Cristo, Not set

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, Not set

Hemomed, Sao paulo, Not set

Hospital Sirio Libanes (HSL), Sao Paulo, Not set

Sao Camilo Oncologia, Sao Paulo, Not set

Sunnybrook Research Institute, Toronto, Ontario

Royal Victoria Regional Health Centre, Barrie, Not set

Cross Cancer Institute (CCI), Edmonton, Not set

Dr. Everett Chalmers Hospital, Fredericton, Not set

Saskatoon Cancer Centre (SCC), Saskatoon, Not set

University Health Network, Princess Margaret Cancer Centre, Toronto, Not set

Centro De Investigacion Clinica Bradford Hill, Recoleta, Chi

Oncovida, Santiago, Region Metropolitana De Santiago

Centro Oncologico Antofagasta Bradford Hill Norte, Antofagasta, Not set

Universidad Mayor - Centro Oncologia de Precision, Santiago, Not set

Hospital Clinico Universidad de Chile, Santiago, Not set

Oncocentro, Vina del Mar, Not set

Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set

University Hospital Ostrava, Ostrava, Not set

Fakultni nemocnice Kralovske Vinohrady, Dermatovenerologicka klinika, Prague 10, Not set

CHU Jean MINJOZ, Besancon Cedex, Not set

Hopital Avicenne Service de Dermatologie du Pr Caux, Bobigny, Not set

HOPITAL SAINT ANDRE Chu De Bordeaux, Bordeaux Cedex, Not set

Hopital Ambroise Pare, Boulogne Billancourt, Not set

CHU Estaing, Service de Dermatologie, Clermont-Ferrand, Not set

Hopitaux Universitaires Henri-Mondor, Creteil, Not set

CHU de DIJON - Service de Dermatologie, Dijon, Not set

Centre Hospitalier Universitaire De Grenoble Alpes Service Dermatologie, Grenoble, Not set

CH Le Mans - Plateforme de recherche clinique, Le Mans, Not set

Chru De Lille, Lille Cedex, Not set

Centre Leon Berard, Lyon cedex 08, Not set

Centre Hospitalier Universitaire de Nantes (CHU de Nantes) Hotel Dieu, Nantes, Not set

Hopital Cochin APHP, Paris, Not set

Hospices Civils de Lyon, Pierre Benite Cedex, Not set

Hopital de la Miletrie Centre Hospitalier Universitaire de Poitiers, Poitiers Cedex, Not set

CHU Charles Nicolle Dermatologie, Rouen, Not set

CHU Saint-Etienne - Hopital Nord, Saint-Etienne, Not set

Clinique Sainte Anne/Strasbourg Oncologie Liberale, Strasbourg, Not set

Institut Gustave Roussy Cancer Center DITEP, Villejuif Cedex, Not set

LTD High Technology Hospital Medcenter, Batumi, Not set

Israeli Georgian medical research clinic Helsicore, Tbilisi, Not set

LTD New Hospitals, Tbilisi, Not set

LTD Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic, Tbilisi, Not set

JSC K. Eristavi National Center of Experimental and Clinical Surgery, Tbilisi, Not set

TIM -Tbilisi Institute of Medicine, Tbilisi, Not set

Medulla - Clinics And Medical Centers, Tbilisi, Not set

LLC Todua Clinic, Tbilisi, Not set

Universitatsklinikum Augsburg Klinik fur Dermatologie und Allergologie Campus Sud, Augsburg, Not set

Charite - Universitaetsmedizin Berlin, Berlin, Not set

Universitaetsklinikum der Ruhr Universitaet Bochum (UKRUB) St Josef Hospital, Bochum, Not set

Elbekliniken Buxtehude, Buxtehude, Not set

Staedtisches Klinikum Dessau, Dessau, Not set

Universitaetsklinikum Carl Gustav Carus an der Technischen Universitaet, Dresden, Not set

Helios Klinikum Erfurt Klinik fur Hautkrankheiten und Allergologie, Erfurt, Not set

Universitatsklinik Frankfurt, Frankfurt, Not set

University Hospital Giessen, Giessen, Not set

Universitatsmedizin Gottingen Klinik fur Dermatologie, Göttingen, Not set

University of Kiel, Kiel, Not set

Universitaetsklinikum Leipzig, Leipzig, Not set

Universitaetsklinikum Schleswig-Holstein Campus Luebeck, Luebeck, Not set

Universitatsmedizin der Johanned Gutenberg-Universitat Mainz, Mainz, Not set

University Medical Center Mannheim, Mannheim, Not set

Fachklinik Hornheide, Muenster, Not set

Klinikum der Universitat Munchen - LMU Klinik und Poliklinik fur Dermatologie und Allergologie Hautt, Munchen, Not set

Universitätsklinik der Paracelsus Medizinischen Privatuniversität, Nuremberg, Not set

Harzklinikum, Klinik fur Dermatologie und Allergologie, Quedlinburg, Not set

University Clinic Regensburg, Regensburg, Not set

Helios Klinik Schwerin, Schwerin, Not set

Universitaetsapotheke Tuebingen, Tuebingen, Not set

University of Debrecen, Debrecen, Not set

Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktato Korhazak, Nyíregyhaza, Not set

University of Pecs Medical School, Pecs, Not set

University of Szeged, Szeged, Not set

Cork University Hospital, Cork, Not set

St. Vincents University Hospital, Dublin 4, Not set

St. James Hospital, Dublin, Not set

University College Hospital Galway, Galway, Not set

Istituto dei Tumori, Bari, Not set

ASST Spedali Civili Brescia, Brescia, Not set

Istituto di Candiolo, FPO IRCCS, Candiolo, Not set

Azienda Sanitaria Ospedaliera Santa Croce E Carle - Cuneo, Cuneo, Not set

Ospedale Policlinico San Martino - IRCCS, Genova, Not set

Istituto Europeo di Oncologia, Milano, Not set

Fondazione IRCCS San Gerardo dei Tintori, Monza, Not set

Università della Campania Luigi Vanvitella, Napoli, Not set

IRCCS Istituto Nazionale dei Tumori di Napoli Fondazione G. Pascale, Napoli, Not set

SCDU di Oncologia AOU Maggiore Della Carita, Novara, Not set

IOV - Istituto Oncologico Veneto - IRCCS, Padova, Not set

U.O. Oncologia Medica Universitaria - Istituto Toscano Tumori Polo Oncologico, Pisa, Not set

Istituti Fisioterapici Ospitalieri (IFO), Roma, Not set

Campus Bio-Medico di Roma, Rome, Not set

Istituto Dermopatico Dell'Immacolata Irccs, Rome, Not set

IRCCS Istituto Clinico Humanitas, Rozzano, Not set

Fondazione IRCSS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Not set

Azienda Ospedaliera S. Maria, Terni, Not set

Santa Chiara Regional Hospital, Trento, Not set

AOU Citta della Salute e della Scienza di Torino, Turin, Not set

Azienda Sanitaria Universitaria Friuli Centrale (ASU FC) - Ospedale Udine, Udine, Not set

Centro Estatal de Cancerologia de Chihuahua, Chihuahua, Not set

Neurociencias Estudios Clinicos SC, Culiacan, Not set

Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Not set

Preparaciones Oncologicas SC, Leon, Not set

Centro De Atencion E Investigacion Clinica En Oncologia Scp, Merida, Not set

iCan Oncology Center, Monterrey, Not set

Centro De Estudios Y Prevencion Del Cancer A. C., Tuxtla Gutierrez, Not set

FAICIC S. de R.L. de C.V., Veracruz, Not set

Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V., Zapopan, Not set

The Netherlands Cancer Institute (NKI) - Antoni van Leeuwenhoek Hospital, Amsterdam, Not set

University Medical Center Groningen, Groningen, Not set

Hospital Goyeneche, Arequipa, Not set

Centro Medico Monte Carmelo, Arequipa, Not set

Hospital Nacional Daniel Alcides Carrion, Bellavista, Not set

Instituto Regional de Enfermedades Neoplasicas del Centro - IREN CENTRO, Concepcion, Not set

Instituto Peruano de Oncologia and Radioterapia, Lima, Not set

Instituto Nacional de Enfermedades Neoplasicas, Lima, Not set

Clinica Internacional San Borja, San Borja, Not set

Clinica Peruano Americana, Trujillo, Not set

Uniwersyteckie Centrum Kliniczne (UCK), Gdansk, Not set

Narodowego Instytutu Onkologii im Maria Sklodowska Curie, Krakow, Not set

Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan, Not set

Mazowiecki Szpital Wojewodzki, Siedleckie Centrum Onkologii, Siedlce, Not set

Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka, Slupsk, Not set

Klinika Nowotworow Tkanek Miekkich, Kosci i Czerniakow, Warszawa, Not set

Institute of Oncology Bucharest, Bucharest, Not set

Medisprof, Cluj Napoca, Not set

Cardiomed SRL, Cluj-Napoca, Not set

SC Radiotherapy Center Cluj SRL, Cluj, Not set

Centrul de Oncologie Sf. Nectarie S.R.L, Craiova, Not set

SC Centrul de Oncologie Euroclinic SRL, Iasi, Not set

Regional Institute of Oncology, Iasi, Not set

RTC Radiology Therapeutic Center SRL, Otopeni, Not set

Oncocenter Oncologie Clinica S.R.L, Timisoara, Not set

Oncomed, Timisoara, Not set

Groote Schuur Hospital, Cape Town, Not set

The Medical Oncology Centre of Rosebank, Johannesburg, Not set

Cape Town Oncology Trials, Kraaifontein, Not set

Hospital Teresa Herrera-Chuac (CHUAC), A Coruna, Not set

Hospital Universitari Germans Trias i Pujol (HUGTP), Badalona, Not set

Instituto Oncologico Dr Rosel, Barcelona, Not set

Hospital de la Santa Creu i Sant Pau, Barcelona, Not set

Catalan Institute of Oncology (ICO) Hospitalet, Barcelona, Not set

Hospital Universitario Reina Sofia, Cordoba, Not set

Catalan Institute Of Oncology - Girona, Girona, Not set

Hospital Universitario Virgen de las Nieves, Granada, Not set

Hospital Universitario Lucus Augusti, Lugo, Not set

Hospital General Universitario Gregorio Maranon, Madrid, Not set

Hospital Universitario Ramon y Cajal, Madrid, Not set

Hospital Fundacion Jimenez Diaz, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Centro integral Oncologico HM Clara Campal, Madrid, Not set

Hospital Regional Universitario de Malaga, Malaga, Not set

Hospital Universitario Virgen de la Arrixaca, Múrcia, Not set

Hospital Universitario Central de Asturias, Oviedo, Not set

Onkologikoa, San Sebastian, Not set

Hospital Universitario Virgen Macarena, Sevilla, Not set

Instituto Valenciano de Oncologia, Valencia, Not set

INCLIVA-Instituto de Investigacion Sanitaria, Valencia, Not set

Adana Baskent Hospital, Adana, Not set

Gulhane Training and Research Hospital, Ankara, Not set

Memorial Ankara Hospital, Ankara, Not set

Ozel Liv Hospital, Ankara, Not set

Dicle University Medical Faculty, Diyarbakir, Not set

Trakya University, Edirne, Not set

Gaziantep University Medical Faculty, Gaziantep, Not set

Bezmialem University, Istanbul, Not set

Cerrahpasa Medical Hospital, Istanbul, Not set

Bakirkoy Sadi Konuk Training Hospital, Istanbul, Not set

Prof. Dr. Suleyman Yalcin Sehir Hospital, Istanbul, Not set

Ege University hospital, Izmir, Not set

Kocaeli Universitesi, Kocaeli, Not set

Royal Devon and Exeter Hospital NHS Trust, Exeter, Devon

Royal Surrey NHS Foundation Trust, Guildford, Not set

Hull University Teaching Hospitals NHS Trust, Hull, Not set

Leeds Teaching Hospitals NHS Trust, Leeds, Not set

Guy's Hospital, London, Not set

Conditions: Melanoma

Learn More ›

A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction

NCT05887271

Recruiting

Heart failure with preserved ejection fraction (HFpEF) is a common and serious complication of obesity and type 2 diabetes (T2D). HFpEF occurs when the heart muscle unable to relax efficiently to pump the blood around the body. This leads to fluid build-up, breathlessness and inability to tolerate physical exertion. People who develop HFpEF do less well because treatment options are limited. Pilot data in patients with obesity and diabetes and a small number of patients with HFpEF have shown imp... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/28/2024

Locations: University of Leicester, Glenfield Hospital, Groby Road, Leicester, Leicestershire +2 locations

Conditions: Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic, Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese, Obesity Adult Onset

Learn More ›

Developing a Falls Management Tool for Adults With ID-POC

NCT06392113

Recruiting

Falls can have a significant impact on the lives of adults with intellectual disabilities. The ACTION FALLS programme is a systematic falls management intervention that has been shown to be of benefit for older people however this programme in its current form needs to be adapted for use with adults with intellectual disabilities who have specific risk factors for falling and specific actions to reduce these risks. An adapted version of the programme to account for the different needs of adults... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/28/2024

Locations: Nottingham University Hospitals NHS Trust, Nottingham, Not set +1 locations

Conditions: Intellectual Disability, Fall

Learn More ›

SCAD : a Registry of Spontaneous Coronary Artery Dissection

NCT06601270

Recruiting

Spontaneous coronary artery dissection (SCAD) is an increasingly recognised cause of non-atherosclerotic acute coronary syndromes (ACS), predominantly afflicting young women without conventional atherosclerotic risk factors. Knowledge of SCAD has advanced considerably in the last few years as a result of data from a number of local and national registries 1-6. Like all rarer diseases however, a better understanding of SCAD will require international collaboration. At present, there is no Europea... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/28/2024

Locations: ICBA - Instituto Cardiovascular de Buenos Aires, Buenos Aires, Not set +72 locations

ICBA - Instituto Cardiovascular de Buenos Aires, Buenos Aires, Not set

Medical University of Innsbruck, Internal Medicine III, Innsbruck, Not set

Klinik Landstrasse, Vienna, Not set

Klinik Ottakring, Vienna, Not set

Medical University of Vienna, Vienna, Not set

Landesklinikum Wiener Neustadt, Wiener Neustadt, Not set

AZ Sint jan, current president of Belgian ACCA, Bruges, Not set

Cliniques Universitaires Saint-Luc (UCL), Brussels, Not set

Universitair Ziekenhuis Brussels, Brussels, Not set

Antwerp University Hospital, Edegem, Not set

Ziekenhuis Oost Limburg, Interventional cardiology/Coronary Care, Genk, Not set

AZ Sint Lucas hospital, Gent, Not set

Ghent University Hospital, Gent, Not set

University Hospitals Leuven, Leuven, Not set

CHR La Citadelle, Liège, Not set

Les cliniques Saint Pierre, Ottignies, Not set

AZ Delta, Roeselare, Not set

AZ Nikolaas, Sint-Niklaas, Not set

Clinical Center University of Sarajevo, Sarajevo, Not set

Hospital Israelita Albert Einstein, Sao Paulo, Not set

Instituto do Coração do HCFMUSP, Sao Paulo, Not set

Universidade Federal de São Paulo (UNIFESP), São Paulo, Not set

University Hospital of Split (KBC Split), Split, Not set

Nicosia General Hospital, Nicosia, Not set

Nemocnice Pardubického kraje, Pardubice, Not set

Hospital Na Homolce, Prague, Not set

Aarhus University Hospital, Aarhus, Not set

Rigshospitalet, Copenhagen, Not set

Herlev and Gentofte Hospital, Hellerup, Not set

Odense University Hospital, Odense, Not set

CHRU Jean Minjoz, Besançon, Not set

Gabriel Montpied Hospital - CHU Clermont-Ferrand, Clermont-Ferrand, Not set

Hôpital de Chartres Louis Pasteur, Le Coudray, Not set

Cardiovascular Hospital Louis Pradel - Hospices Civils de Lyon, Lyon, Not set

Hôpital Jacques Cartier, Massy, Not set

Hôpital Cardiologique du Haut Lévêque - Bordeaux University, Pessac, Not set

Schüchtermann-Klinik Bad Rothenfelde, Bad Rothenfelde, Not set

Vivantes Klinikum in Friedrichshain, Berlin, Not set

University Heart and Vascular Center Hamburg Eppendorf, Hamburg, Not set

Robert Bosch Hospital, Stuttgart, Not set

Sotiria Thoracic Diseases Hospital, Athens, Not set

General Hospital of Kozani, Kozani, Not set

Tehran Heart Center, Tehran, Not set

Papa Giovanni XXIII Azienda Ospedaliera, Bergamo, Not set

Policlinico Riuniti Foggia, Foggia, Not set

Ospedale Policlinico San Martino IRCCS, Genova & Università di Genova, Genoa, Not set

Presidio Ospedaliero Carlo Poma, Mantua, Not set

ASST Grande Ospedale Niguarda, Milan, Not set

Centro Cardiologico Monzino, IRCCS, Milan, Not set

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Not set

Fondazione IRCCS San Gerardo dei Tintori, Monza, Not set

Noordwest Ziekenhuisgroep / NorthWest Clinics, Alkmaar, Not set

Amphia Hospital, Breda, Not set

Radboud University Medical Centre, Nijmegen, Not set

Auckland City Hospital - Green Lane Cardiovascular Service, Auckland, Not set

Haukeland University Hospital - Invasive cardiology, Bergen, Not set

Institute of Cardiology - Department of Interventional Cardiology and Angiology, Warsaw, Not set

Hospital Fernando Fonseca, Amadora, Not set

Hospital de Braga, Braga, Not set

Centro Hospitalar Tondela Viseu, Tondela, Not set

Hospital do Espirito Santo de Evora, Évora, Not set

University Hospital Centre Bezanijska Kosa, Belgrade, Not set

Cardiology Clinic, UCC Nis, Nis, Not set

National University Heart Centre Singapore, Singapore, Not set

Stredoslovensky ustav srdcovych a cievnych chorob a.s, Banska Bystrica, Not set

Hospital Universitario de la Princesa, Madrid, Not set

William Harvey Hospital, Ashford, Not set

Glan Clwyd Hospital, Bodelwyddan, Not set

Bournemouth Hospital, Bournemouth, Not set

Bristol Heart Institute, Bristol, Not set

University Hospitals, Leicester, Not set

Royal Brompton & Chelsea & Westminster Hospital, London, Not set

Royal Free Hospital, London, Not set

Conditions: Spontaneous Coronary Artery Dissection

Learn More ›

Stratified Medicine of Eplerenone in Acute MI/injury (StratMed-MINOCA)

NCT05198791

Recruiting

Patients with heart attack or heart injury are tested (angiogram) for blockages in their arteries. Many patients develop heart problems caused by damage to small (microvascular) blood vessels. These issues are also relevant to patients with coronarvirus-19 disease (COVID-19). Eplerenone reduces blood vessel injury and is used to treat heart failure. Aim: to test the use of eplerenone in patients with heart attack/heart injury who have small vessel disease, including patients with COVID-19 Patients referred to the Golden Jubilee hospital with a suspected heart attack heart / injury will be invited to participate into a registry-based clinical trial. Screening, enrolment and verbal, informed consent will be obtained during the angiogram then written consent on the ward. Small vessel disease will be assessed using a 'diagnostic' guidewire during the standard angiogram. People with small vessel problems will be allocated to a clinical trial of usual care or eplerenone. Coronary microvascular dysfunction is defined as an index of microvascular resistance ≥25. Coronary flow reserve (CFR abnormal \<2.0) and resistance reserve ratio (RRR abnormal \<2.0), measured simultaneously with IMR, are predefined parameters of interest. Patients will be allocated into one of the 3 groups: * Group 1: Patients without coronary microvascular dysfunction. No eplerenone * Group 2: Patient with coronary microvascular dysfunction. Usual care, no eplerenone. * Group 3: Small vessels abnormal. Eplerenone tablets. The primary outcome for the trial will be reduced heart injury (biomarkers) in patients with microvascular disease. We will also test heart function (MRI scan) at enrolment and at six months. All patients (Groups 1, 2 and 3) will have an angiogram. Standard blood tests will be collected during the hospital stay, and then again at 1 and 6 months. Other outcomes include questionnaires (health status). We will gather information on longer-term health outcomes (hospitalisation, death) using confidential electronic record linkage. We will ask for permission to store blood samples for future research. The research will improve scientific knowledge about eplerenone therapy in this patient group. The study will create a repository of clinical samples and images which will provide vital data for studies of COVID-19. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/27/2024

Locations: University Hospital Hairmyres, East Kilbride, Lanarkshire +1 locations

Conditions: Myocardial Infarction, Acute, Myocardial Infarction With Nonobstructive Coronary Arteries, Myocardial Injury

Learn More ›

COPD Case Finding in Nottingham and District: C-FIND COPD a Pilot Study

NCT06008145

Recruiting

The Targeted Lung Health Check (TLHC) is currently being rolled out in many regions of the United Kingdom and has just started in Nottingham. The same cohort of people are also at high risk for Chronic Obstructive Pulmonary Disease (COPD), a lung condition often caused by smoking and leading to breathlessness and cough. This study aims to provide pilot evidence of the role of breathing tests in those who have had a Computerised Tomography (CT) scan, in order to early diagnose COPD. Currently, at... Read More

Gender:

ALL

Ages:

40 years and above

Trial Updated:

10/25/2024

Locations: Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire

Conditions: COPD

Learn More ›

Brief ES for Recovery of Autonomic Function in CES

NCT06416878

Recruiting

BESCES is a study that aims to explore the feasibility of intraoperative brief epidural electrical stimulation (ES) for patients undergoing routine decompression for cauda equina syndrome. In consenting patients, brief ES will be applied using a CE-marked SCS trial kit once sufficient decompression is achieved. In participants who do not recover function following decompression, brief post-op ES will be applied to see if can facilitate micturition and/or removal of the catheter. The study will... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/24/2024

Locations: The Walton Centre NHS Foundation Trust, Liverpool, Merseyside

Conditions: Cauda Equina Syndrome

Learn More ›

Infant and Child European Cryoablation Project ICECaP

NCT03721783

Recruiting

A registry to audit the current range of applications, technical success rate, safety profile, complication rate and efficacy of cryoablation procedures being performed in children.

Gender:

ALL

Ages:

18 years and below

Trial Updated:

10/24/2024

Locations: Great, London, Not set

Conditions: Therapy, Soft Tissue Lesion, Cryoablation, Pediatric

Learn More ›

Axillary Management in Breast Cancer Patients with Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy

NCT04109079

Recruiting

The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment in terms of disease free survival (DFS) and results in reduced risk of lymphoedema at 5 years.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/22/2024

Locations: Galway University Hospitals, Galway, Not set +87 locations

Galway University Hospitals, Galway, Not set

Airedale NHS Foundation Trust, Keighley, Bd20 6td

North Cumbria Integrated Care NHS Foundation Trust, Carlisle, Ca2 7hy

Frimley Health NHS Foundation Trust, Camberley, Gu16 7uj

NHS Highland, Inverness, Iv2 3uj

James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Nr31 6la

Royal Berkshire NHS Foundation Trust, Reading, Rg1 5an

East Cheshire NHS Trust, Macclesfield, Sk10 3bl.

The Shrewsbury and Telford Hospitals NHS Trust, Shrewsbury, Sy3 8xq

NHS Grampian, Aberdeen, Not set

Ashford and St Peter's Hospitals NHS Foundation Trust, Ashford, Not set

Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-Lyne, Not set

NHS Ayrshire and Arran, Ayr, Not set

Belfast Health and Social Care Trust, Belfast, Not set

University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set

Sandwell and West Birmingham NHS Trust, Birmingham, Not set

Bolton NHS Foundation Trust, Bolton, Not set

Bradford Teaching Hospitals NHS Foundation Trust, Bradford, Not set

University Hospitals Sussex NHS Foundation Trust, Brighton, Not set

North Bristol NHS Trust, Bristol, Not set

East Lancashire Hospitals NHS Trust, Burnley, Not set

Cambridge University Hospitals NHS Foundation Trust, Cambridge, Not set

Gloucestershire General Hospitals NHS Foundation Trust, Cheltenham, Not set

Countess of Chester Hospital NHS Trust, Chester, Not set

Mid Cheshire NHS Foundation Trust, Crewe, Not set

County Durham and Darlington NHS Foundation Trust, Darlington, Not set

University Hospitals of Derby and Burton NHS Foundation Trust, Derby, Not set

Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Doncaster, Not set

The Dudley Group NHS Foundation Trust, Dudley, Not set

NHS Dumfries and Galloway, Dumfries, Not set

NHS Fife, Dunfermline, Not set

NHS Lanarkshire, East Kilbride, Not set

NHS Lothian, Edinburgh, Not set

Royal Devon and Exeter NHS Foundation Trust, Exeter, Not set

Gateshead Health NHS Foundation Trust, Gateshead, Not set

Harrogate and District NHS Foundation Trust, Harrogate, Not set

Wye Valley NHS Trust, Hereford, Not set

Buckinghamshire Healthcare NHS Trust, High Wycombe, Not set

Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, Not set

Hull University Teaching Hospitals NHS Trust, Hull, Not set

East Suffolk and North Essex NHS Foundation Trust, Ipswich, Not set

Chelsea and Westminster Hospital NHS Foundation Trust, Isleworth, Not set

University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, Not set

NHS Forth Valley, Larbert, Not set

Leeds Teaching Hospitals NHS Trust, Leeds, Not set

University Hospitals of Leicester NHS Trust, Leicester, Not set

United Lincolnshire Hospitals NHS Trust, Lincoln, Not set

Hywel Dda University Health Board, Llanelli, Not set

North Middlesex University Hospital NHS Trust, London, Not set

Whittington Health NHS Trust, London, Not set

University College London Hospitals NHS Foundation Trust, London, Not set

Royal Free London NHS Foundation Trust, London, Not set

King's College Hospital NHS Foundation Trust, London, Not set

The Royal Marsden NHS Foundation Trust, London, Not set

Imperial College Healthcare NHS Trust, London, Not set

Bedfordshire Hospitals NHS Foundation Trust, Luton, Not set

Manchester University NHS Foundation Trust, Manchester, Not set

NHS Borders, Melrose, Not set

South Tees Hospitals NHS Foundation Trust, Middlesbrough, Not set

Milton Keynes University Hospital NHS Trust, Milton Keynes, Not set

Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, Not set

Northumbria Healthcare NHS Foundation Trust, North Shields, Not set

Oxford University Hospitals NHS Foundation Trust, Oxford, Not set

NHS Greater Glasgow and Clyde, Paisley, Not set

University Hospitals Plymouth NHS Trust, Plymouth, Not set

Portsmouth Hospitals University NHS Trust, Portsmouth, Not set

St Helens and Knowsley Teaching Hospitals NHS Trust, Prescot, Not set

Lancashire Teaching Hospitals NHS Foundation Trust, Preston, Not set

Surrey & Sussex Healthcare NHS Trust, Redhill, Not set

The Rotherham NHS Foundation Trust, Rotherham, Not set

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, Not set

West Hertfordshire Hospitals NHS Trust, St Albans, Not set

East and North Hertfordshire NHS Foundation Trust, Stevenage, Not set

North Tees and Hartlepool NHS Foundation Trust, Stockton-on-Tees, Not set

University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, Not set

Swansea Bay University Health Board, Swansea, Not set

Somerset NHS Foundation Trust, Taunton, Not set

Croydon Health Services NHS Trust, Thornton Heath, Not set

Royal Cornwall Hospitals NHS Trust, Truro, Not set

Mid Yorkshire Hospitals NHS Trust, Wakefield, Not set

Mid and South Essex NHS Foundation Trust, Westcliff-on-Sea, Not set

Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust, Wigan, Not set

Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, Not set

Wirral University Teaching Hospital NHS Foundation Trust, Wirral, Not set

The Royal Wolverhampton NHS Trust, Wolverhampton, Not set

Worcestershire Acute Hospitals NHS Trust, Worcester, Not set

Yeovil District Hospital NHS Trust, Yeovil, Not set

York and Scarborough Teaching Hospitals NHS Foundation Trust, York, Not set

Conditions: Breast Cancer, Sentinel Lymph Node, Neoplasm, Breast

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Clinical Outcome Modelling of Rapid Dynamics in Acute Stroke

NCT04641286

Recruiting

Stroke - still the second commonest cause of death and principal cause of adult neurological disability in the Western World - is characterised by rapid changes over time and marked variability in outcomes. A patient may improve or deteriorate over minutes, and the resultant disability may range from an obvious complete paralysis to subtle, task dependent incoordination of a single limb. Unlike many other neurological disorders, stroke can be exquisitely sensitive to prompt and intelligently ta... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/22/2024

Locations: King's College Hospital NHS Foundation Trust, London, Not set

Conditions: Stroke

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Use of DTT to Define Facial Nerve Position in Vestibular Schwannomas

NCT04057976

Recruiting

Vestibular schwannomas (VS) arise from the vestibulocochlear (hearing and balance) nerve, located at the base of the brain. Although benign, VS can enlarge over time, resulting in debilitating symptoms; therefore, surgical removal is frequently offered. One significant risk of surgery is inadvertent injury to the facial nerve, which lies adjacent to the vestibulocochlear nerve. Currently, the nerve's course is only revealed during surgical dissection and injury can cause permanent facial weaknes... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/21/2024

Locations: King's College Hospital NHS Foundation Trust, London, Not set

Conditions: Vestibular Schwannoma

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Improving Patient Reported Outcome Measures in Catheter Ablation

NCT04499326

Recruiting

This study will assess whether more frequent measurement of patient reported outcome measures (PROMs) - specifically health related quality of life (HRQL) - can improve the evaluation of the clinical effectiveness and cost-effectiveness of catheter ablation of ventricular tachycardia (VT) in patients with an Implantable Cardioverter Defibrillator (ICD). It is designed to have feasibility outcomes which contribute to answering the above.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

10/21/2024

Locations: St Bartholomew's Hospital, London, Not set

Conditions: Ventricular Tachycardia, ICD, Quality of Life

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