Beyond TME Origins
NCT02292641
Recruiting
All patients with recurrent colorectal cancer in the pelvis are eligible. The original primary tumour staging scans and resected surgical specimen needs to be available. Patients' recurrence will be staged using our proposed MRI classification. We will be assessing the original primary staging scans and histopathology to learn about risk factors for recurrence. We will record treatment for the recurrence, and patients will be followed up for three years.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
10/16/2024
Locations: Oslo University Hospital, Oslo, Not set +3 locations
Conditions: Neoplasms, Adenocarcinoma, Carcinoma
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A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice
NCT04475926
Recruiting
This study will follow participants who are screened and confirmed with a genetic diagnosis of Limb-girdle muscular dystrophy type 2E (LGMD2E/R4), Limb-girdle muscular dystrophy type 2D (LGMD2D/R3), Limb-girdle muscular dystrophy type 2C (LGMD2C/R5), or Limb-girdle muscular dystrophy type 2A (LGMD2A/R1). These enrolled participants will be followed to evaluate mobility and pulmonary function for up to 5 years after enrollment for participants with LGMD2C/R5, LGMD2D/R3, and LGMD2E/R4 with a Nort... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
10/16/2024
Locations: Barrow Neurological Institute, Phoenix, Arizona +25 locations
Conditions: Limb-girdle Muscular Dystrophy
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Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
NCT05329649
Recruiting
This is a single-dose, open-label study in pediatric participants with severe SCD and hydroxyurea (HU) failure or intolerance. The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) (CTX001).
Gender:
ALL
Ages:
Between 2 years and 11 years
Trial Updated:
10/16/2024
Locations: Atrium Health Levine Children's Hospital, Charlotte, North Carolina +6 locations
Conditions: Sickle Cell Disease, Hydroxyurea Failure, Hydroxyurea Intolerance, Hemoglobinopathies, Hematological Diseases
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Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation
NCT05955365
Recruiting
Patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation require treatment with different antithrombotic drugs. Oral anticoagulants are prescribed to reduce the risk of stroke associated with atrial fibrillation. Antiplatelet substances are prescribed after stent implantation to reduce the risk of adverse cardiac events such as myocardial infarction or stent thrombosis. Treatment with antithrombotic medications can cause bleeding complications, part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: Hartcentrum Hasselt, Hasselt, Not set +14 locations
Conditions: Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF), Oral Anticoagulation, P2Y12 Inhibitor
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A Long-term Observational Study Evaluating the Presentation and Management of Acute Respiratory Tract Infections in Primary Care Across Europe
NCT06282718
Recruiting
Acute respiratory infection (ARI) is the commonest reason for consulting in community care. Furthermore, new and re-emerging pathogens are often first noticed in primary care (PC). The POS-ARI-PC study is a long-term study, with the aim of describing the nature of ARI in adults and children presenting to PC across Europe. The POS-ARI-PC study will provide critically important data on the presentation and management of ARI, and build a research-ready infrastructure for studies related to the trea... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/16/2024
Locations: Universiteit Antwerpen, Antwerp, Not set +2 locations
Conditions: Acute Respiratory Tract Infection
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Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits
NCT03303547
Recruiting
Any patient with a suspected primary adenocarcinoma of the colon, sigmoid or rectum undergoing surgery are eligible. The date of surgery must be known prior to registration. This trial aims to determine if image mapping techniques can improve the concordance between imaging and pathology detection of tumour deposits. Lymph nodes and tumour deposits will be identified on pre-operative scans and mapped by radiologists then shared with pathologists prior to processing the resected specimen. Patient... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
10/16/2024
Locations: Royal Marsden Hospital NHS Foundation Trust, London, Surrey
Conditions: Adenocarcinoma of the Rectum
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The National Musculoskeletal Audit and Research Database
NCT05842915
Recruiting
Developing and testing a musculoskeletal national audit in community/primary care
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: Keele University, Keele, Staffordshire
Conditions: Musculoskeletal Diseases
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Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes
NCT06645626
Recruiting
The study will compare health care utilisation and quality of life for patients with progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy in different parts of the region that our specialist clinic operates in with different services as well as in other regions with no specialist clinics. This study aims to investigate which aspects of the service are most beneficial for the patients and to determine the influence of support services and specialty clinics on patients... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: Wessex Neurological Centre, Southampton, Hampshire
Conditions: Progressive Supranuclear Palsy, Cortico Basal Degeneration, Multiple System Atrophy
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Early Atrial Fibrillation Ablation for Stroke Prevention in Patients with High Comorbidity Burden (EASThigh-AFNET 11)
NCT06324188
Recruiting
EASThigh-AFNET 11 is an international, prospective, randomized, open, blinded endpoint assessment, multicenter trial (Treatment Strategy trial). The objective of EASThigh-AFNET 11 is to investigate whether early atrial fibrillation ablation in patients with atrial fibrillation (AF) and a high comorbidity burden (CHA2DS2-VASc ≥4) reduces cardiovascular events (stroke, cardiovascular death, or heart failure events) compared to usual care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: Several sites, Multiple Locations, Not set +4 locations
Conditions: Atrial Fibrillation
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The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
NCT04204915
Recruiting
Aortic stenosis (AS) affects approximately 5% of individuals \>65 years old, with \~3% of people \>75 years having moderate to severe disease. The prevalence of AS is rising rapidly due to an ageing population and is projected to double in the next two decades. Increasingly clinicians face the dilemma of how to best manage this growing population of mainly elderly patients, many of whom are asymptomatic but have been identified as having severe AS, often as an incidental finding. Reduced aortic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: Canberra Hospital, Garran, Canberra +97 locations
Conditions: Aortic Stenosis
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Cryopreservation of Prepubertal Testicular Tissue for Preservation of Fertility in Young Boys With Cancer
NCT06063551
Recruiting
Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys. With informed consent, the investigators aim to cryopreserve (freeze) testis tissue biopsies taken from boys undergoing cancer therapy with a high risk of infertility. A portion of cryopreserved tissue will be securely stored, which in the future may be used to restore fertility in the patients. A second portion of the tissue will be... Read More
Gender:
MALE
Ages:
Between 1 day and 18 years
Trial Updated:
10/14/2024
Locations: University of Edinburgh, Edinburgh, Lothian
Conditions: Fertility Disorders, Childhood Cancer
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Rare AutoImmune SElf-management Programme Development
NCT06642870
Recruiting
The rare autoimmune rheumatic diseases (RAIRDs) are life-long multi-system diseases that are life or organ threatening. RAIRDs can impair quality of life similar to chronic diseases such as heart failure. The aim of the study is to explore content and structure of a support programme for people with RAIRDs in focus groups and survey meetings.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: University of the West of England/ Bristol Royal Infirmary, Bristol, Not set
Conditions: Systemic Lupus Erthematosus, Systemic Vasculitis, Inflammatory Myositis, Systemic Sclerosis (SSc), ANCA Associated Vasculitis (AAV), Sjogren Syndrome
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