All Clinical Trials in United Kingdom

A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Fosfomycin I.v. for Treatment of Severely Infected Patients

NCT02979951

Recruiting

The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin, including patients with osteomyelitis, complicated urinary tract infection, nosocomial lower respiratory tract infection, bacterial meningitis/central nervous system infection, bacteraemia/sepsis, skin and soft tissue infection, endocarditis or other infections, each as far... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/27/2024

Locations: Landeskrankenhaus Hall - Tirol Kliniken, Hall In Tirol, Not set +49 locations

Landeskrankenhaus Hall - Tirol Kliniken, Hall In Tirol, Not set

A.ö. Bezirkskrankenhaus, Reutte, Not set

Klinikum Wels-Grieskirchen, Institut für Hygiene und Mikrobiologie, Wels, Not set

AKH Wien, Universitätsklinik für Innere Medizin 1, Wien, Not set

Universitätsmedizin Charité, Berlin, Not set

Vivantes Kliniken Neukölln, Berlin, Not set

Städtisches Klinikum Braunschweig, Braunschweig, Not set

Universitäts Düsseldorf; Klinik für Anästhesiologie, Dusseldorf, Not set

Universitätsklinikum Frankfurt, Frankfurt, Not set

Universität Hamburg-Eppendorf, Hamburg, Not set

Universitätsklinikum Jena; Zentrum für Infektionsmedizin, Jena, Not set

Universitätsklinikum Schleswig-Holstein, Kiel, Not set

Universitätsklinik Schleswig-Holstein, Lübeck, Not set

LMU München, München, Not set

Universitätsklinikum Münster, Münster, Not set

Klinikum Oldenburg, Oldenburg in Holstein, Not set

Universitätsklinik Regensburg; Klinik für Anästhesiologie, Regensburg, Not set

Kliniken Nordoberpfalz, Weiden, Not set

General Oncology Hospital of Kifissia "Agioi Anargiroi", Kifissia, Athens

General Hospital of Athens "Evangelismos", Athens, Not set

Sotiria Thoracic Diseases Hospital of Athens, Athens, Not set

University General Hospital "ATTIKON", Athens, Not set

General Hospital of Attica "KAT", Kifissia, Not set

General Hospital of Lamia, Lamia, Not set

RIO Univ. Hospital, Dept of Pathology, Division of Infectious Diseases, Patras, Not set

"AHEPA" University General Hospital of Thessaloniki, Thessaloniki, Not set

General Hospital of Thessaloniki "G. GENIMMATAS", Thessaloniki, Not set

General Hospital of Thessaloniki "Hippokration", Thessaloníki, Not set

General Hospital of Thessaloniki "G. Papanikolaou", Thessaloníki, Not set

Clinical Malattie Infettive, Bari, Not set

Azienda Ospedaliera S.Croce e Carle, Cuneo, Not set

Ospedal Policlinico San Martino, Genova, Not set

Ospedale L. Sacco, Mailand, Not set

Istituto Mediterraneo per i Trapianti Ismett IRCCS, Palermo, Not set

Policlinico Paolo Giaccone, Palermo, Not set

Policlinico Umberto I, Malattie Infettive, Rom, Not set

Lazzaro Spallanzani, Rom, Not set

Polocinico Tor Vergata, Rom, Not set

AOU Città della Salute e Scienza-Presidio Molinette, Torino, Not set

Ospedale S.M.della Misericordia, Udine, Not set

ASST-Sette Lagh Viale Borre, Varese, Not set

Royal Bolton Hospital, Bolton, Not set

Hull & East Yorkshire Hospitals NHS Trust, Cottingham, Not set

Ninewells Hospital, Dundee, Not set

Queen Elisabeth University Hospital, Glasgow, Not set

University of Glasgow/Royal Infirmary, Glasgow, Not set

University Hospital Crosshouse, Kilmarnock, Not set

Chelsea & Westminster Hospial, London, Not set

Queen Elisabeth Hospital, London, Not set

Univresity College Londen (UCL) Hospital, London, Not set

Conditions: Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections, Meningitis, Bacterial, Encephalitis, Brain Abscess, Urinary Tract Infections, Respiratory Tract Infections, Pneumonia, Bacterial, Skin Diseases, Bacterial, Soft Tissue Infections, Intraabdominal Infections, Sepsis, Bacteremia, Endocarditis, Bacterial

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Cognitive Muscular Therapy for People Awaiting Knee Joint Replacement

NCT05801510

Recruiting

The primary aim will seek to understand whether Cognitive Muscular Therapy (CMT) could provide pain relief for people on a waiting list for joint replacement.

Gender:

ALL

Ages:

40 years and above

Trial Updated:

09/26/2024

Locations: University of Salford, Manchester, Greater Manchester

Conditions: Knee Osteoarthritis

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Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies

NCT04561362

Recruiting

This study is a Phase I/II, multicenter, first-in-human, open-label dose-escalation study of BT8009 given as a single agent and in combination with pembrolizumab in participants with advanced solid tumors associated with Nectin-4 expression or in participants with advanced solid tumor malignancies having renal insufficiency. The primary endpoints are: Dose limiting toxicities (Parts A-1 and A-2), Overall response rate per RECIST v1.1 (Parts B1-B7), Safety and tolerability (Parts B-8, B-9 and C),... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/26/2024

Locations: Sarah Cannon Research Institute at HealthONE, Denver, Colorado +28 locations

Sarah Cannon Research Institute at HealthONE, Denver, Colorado

Ocala Oncology Center, Ocala, Florida

Advent Health, Orlando, Florida

Horizon Oncology Research, Lafayette, Indiana

Norton Cancer Institute, Downtown, Louisville, Kentucky

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada

Icahn School of Medicine at Mount Sinai, New York, New York

University Hospitals Cleveland Medical Center, Cleveland, Ohio

Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania

Tennessee Oncology, PLLC, Nashville, Tennessee

Mary Crowley Cancer Research Center, Dallas, Texas

The University of Texas MD Anderson Cancer Center, Houston, Texas

Cross Cancer Institute, Edmonton, Alberta

University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario

Institut Bergonie, Bordeaux, Not set

Centre Leon Berard, Lyon, Not set

Institut Paoli-Calmettes, Marseille, Not set

Centre Eugene Marquis, Rennes, Not set

Institut Gustave Roussy, Villejuif, Not set

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, MI

Ospedale San Raffaele, Milan, Not set

Vall d'Hebron Institute of Oncology, Barcelona, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

START Madrid Fundacion Jimenez Diaz, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Next Oncology - Hospital Quironsalud Madrid, Pozuelo de Alarcon, Not set

Hospital Universitario Marques de Valdecilla, Santander, Not set

Sarah Cannon Research Institute UK, London, Not set

The Christie NHS Foundation Trust, Manchester, Not set

Conditions: Advanced Solid Tumor, Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms, Ovarian Neoplasm, Hormone Receptor Positive, HER2-negative Neoplasms, Hormone Receptor Positive, HER2-low Neoplasms, Breast Neoplasms, Non-Small-Cell Lung Neoplasms

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Olorofim Aspergillus Infection Study

NCT05101187

Recruiting

The purpose of this study is to compare treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with IFD caused by proven IA or probable lower respiratory tract disease Aspergillus species (invasive aspergillosis, IA).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/26/2024

Locations: University of Alabama at Birmingham, Birmingham, Alabama +139 locations

University of Alabama at Birmingham, Birmingham, Alabama

City of Hope National Medical Center, Duarte, California

University of California Davis Health System, Sacramento, California

UCSF Helen Diller Medical Center at Parnassus Heights, San Francisco, California

University of Florida, Gainesville, Florida

Augusta University, Augusta, Georgia

University of Chicago Medical Center, Chicago, Illinois

University of Kansas Medical Center, Kansas City, Kansas

The Johns Hopkins Hospital, Baltimore, Maryland

NIH Clinical Center ,NIAID,NIH, Bethesda, Maryland

Massachusetts General Hospital, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

University of Minnesota, Minneapolis, Minnesota

Mayo Clinic - Rochester, Rochester, Minnesota

Washington University School of Medicine, Saint Louis, Missouri

Clairvoyant Research Group, LLC, Las Vegas, Nevada

Rutgers RWJMS, New Brunswick, New Jersey

Weill Cornell Medicine NY Presbyterian Hospital, New York, New York

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Duke Department of Medicine Infectious Diseases Division, Durham, North Carolina

OU Health OU Medical Center, Oklahoma City, Oklahoma

University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania

Houston Methodist, Houston, Texas

Fred Hutchinson Cancer Center, Seattle, Washington

Royal NorthShore Hospital, Saint Leonards, New South Wales

Royal Brisbane & Women's Hospital, Herston, Queensland

The Alfred Hospital, Melbourne, Victoria

Royal Melbourne Hospital, Parkville, Victoria

Fiona Stanley Hospital, Murdoch, Western Australia

AZ Sint-Jan, Brugge, Not set

Hôpital Erasme, Bruxelles, Not set

Universitair Ziekenhuis Gent, Gent, Not set

UZ Leuven, Leuven, Not set

Hospital Felício Rocho, Belo Horizonte, Minas Gerais

Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Minas Gerais

Santa Casa de Misericórdia de Passos, Passos, Minas Gerais

Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba, Paraná

Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Hospital São Lucas da PUCRS, Porto Alegre, Rio Grande Do Sul

Hospital da Universidade Federal de Santa Maria CEP/UFSM, Santa Maria, Rio Grande Do Sul

University of Alberta Hospital, Edmonton, Alberta

Hamilton Health Sciences - Juravinski Site, Hamilton, Ontario

Toronto General Hospital, Toronto, Ontario

University Health Network, Toronto, Ontario

The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui

Huazhong University of Science and Technology, Wuhan, Hubei

The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi

Qilu Hospital of Shandong University, Jinan, Shandong

Huashan Hospital Fudan University, Shanghai, Shanghai

Institute of Hematology and Blood Diseases Hospital, Heping, Tianjin

The 1st Affiliated Hosp of Wenzhou Medical University, Wenzhou, Zhejiang

Peking University People's Hospital, Beijing, Not set

Peking University Third Hospital, Beijing, Not set

The First Hospital of Jilin University, Changchun, Not set

Xiangya Hospital, Central South University, Changsha, Not set

Chenzhou No.1 People's Hospital, Chenzhou, Not set

Fujian Medical University Union Hospital, Fuzhou, Not set

Guangdong Provincial People's Hospital, Guangzhou, Not set

The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Not set

Nanfang Hospital of Southern Medical University, Guangzhou, Not set

The First Affiliated Hospital of Zhejiang University school of medicine, Hangzhou, Not set

Anhui Provincial Hospital, Hefei, Not set

The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Not set

Shengjing Hospital of China Medical University, Shengyang, Not set

The Second Hospital of Hebei Medical University, Shijiazhuang, Not set

Xi'an International Medical Center, Xi'an, Not set

Henan Provincial People's Hospital, Zhengzhou, Not set

Institut de Cancérologie de Strasbourg Europe - ICANS, Strasbourg, Bas Rhin

CHU Besançon - Hôpital Jean Minjoz, Besançon Cedex, Doubs

CHU de Besancon, Besançon, Doubs

CHU Bordeaux Hopital Saint André, Bordeaux, Gironde

Institut Universitaire du Cancer de Toulouse- IUCT-O, Toulouse, Haute Garonne

CHU de Rennes - Hôpital Pontchaillou, Rennes, Ille-et-Vilaine

CHU de Nantes CIC Hematologie, Nantes, Loire Atlantique

Hospital Claude Huriez, Lille, Nord

Hôpital Necker - Enfants Malades, Paris cedex 15, Paris

Universitatsklinikum Leipzig, Leipzig, Saxony

Charite Universitatsmedizin Berlin, Berlin, Not set

UKE Universitaetsklinikum-Hamburg Eppendorf, Hamburg-Eppendorf, Not set

Universitaetsklinikum Koeln, Koeln, Not set

Soroka University Medical Center, Beer-Sheva, Not set

Hadassah University Hospital - Ein Kerem, Jerusalem, Not set

Chaim Sheba Medical Center, Ramat Gan, Not set

Tel Aviv Sourasky Medical Center Pt, Tel Aviv, Not set

Azienda Ospedaliera Universitaria Luigi Vanvitelli, Napoli, Campania

Fondazione IRCCS San Gerardo dei Tintori, Monza, Di Monza E Della Brianza

Istituto Clinico Humanitas, Rozzano, Milano

IRCCS Ospedale Policlinico San Martino, Genova, Not set

Ospedale San Raffaele, Milano, Not set

ASST Grande Ospedale Metropolitano Niguarda, Milano, Not set

AOU Policlinico di Modena, Modena, Not set

Clinica Malattie Infettive Dipartimento di Medicina e Chirurgia dell'Università, Perugia, Not set

Azienda Ospedaliero Universitaria Pisana (Presidio di Cisanello), Pisa, Not set

Inmi Lazzaro Spallanzani Irccs, Roma, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Not set

Chiba University Hospital, Chiba, Chiba Ken

Kyushu University Hospital, Fukuoka shi, Fukuoka Ken

Tohoku University Hospital, Sendai-shi, Miyagi Ken

Osaka International Cancer Institute, Osaka shi, Osaka Fu

Osaka Metropolitan University Hospital, Osaka, Osaka Fu

Kindai University Hospital, Ōsaka-sayama, Osaka Fu

Toranomon Hospital, Minato-Ku, Tokyo To

The Jikei University Hospital, Minato-Ku, Tokyo

Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Bunkyō-Ku, Not set

Nagasaki University Hospital, Nagasaki, Not set

Okayama University Hospital, Okayama, Not set

Saitama Medical Center Jichi Medical University, Saitama, Not set

Jichi Medical University Hospital, Shimotsuke, Not set

The Catholic University of Korea, Bucheon-si, Seoul

Samsung Medical Center, Irwon-dong, Seoul

Radboud Nijmegen, Nijmegen, Not set

UMC Utrecht, Utrecht, Not set

Wellington Regional Hospital, Newtown, Wellington

Auckland City Hospital, Auckland, Not set

National University Hospital, Singapore, Not set

Singapore General Hospital- Parent, Singapore, Not set

Hospital General Universitario Gregorio Marañón, Retiro, Madrid

Hospital Universitari Vall d'Hebron, Barcelona, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital Universitario Ramon y Cajal, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitari i Politecnic La Fe, Valencia, Not set

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set

Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Not set

China Medical University Hospital, Taichung, Not set

Taipei Veterans General Hospital, Taipei, Not set

National Taiwan University Hospital, Taipei, Not set

Siriraj Hospital, Bangkok-noi, Bangkok

Srinagarind Hospital, Khon Kaen, Not set

Hacettepe University Medical Faculty, Ankara, Not set

Ankara City Hospital, Ankara, Not set

Dicle University, Medical Faculty, Diyarbakir, Not set

Acibadem Atakent Hospital, Istanbul, Not set

Ege University Medical Faculty, Izmir, Not set

Ondokuz Mayis Univ. Med. Fac., Samsun, Not set

University Hospital of Wales, Cardiff, Wales

Kings College Hospital, London, Not set

Imperial College London, London, Not set

Conditions: Invasive Aspergillosis

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Low Energy Availability and Cardiovascular Disease

NCT06615388

Recruiting

Low energy availability (LEA) signifies a condition where the body lacks sufficient energy to support essential physiological functions crucial for maintaining optimal health (1). This energy insufficiency can be exacerbated by the demands of sports and exercise, resulting in negative impacts on various physiological, psychological, and sports performance (11, 8, 2). While LEA is commonly associated with cardiovascular abnormalities, such as early atherosclerosis, endothelial dysfunction, and lo... Read More

Gender:

FEMALE

Ages:

Between 18 years and 35 years

Trial Updated:

09/24/2024

Locations: Liverpool Hope University, Liverpool, Merseyside

Conditions: Low Energy Availability, Cardiovascular Diseases

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Optimising Pacing for Contractility 2

NCT04201015

Recruiting

The investigators have demonstrated that they can reliably identify an optimum heart rate range for contractility of the left ventricle in patients with chronic heart failure (CHF). They have also demonstrated in an acute cross-over and a small parallel group feasibility study that keeping the heart rate in this range (versus standard rate-response programming) in patients with CHF is associated with increased exercise time on a treadmill (around 60s or 10%). They now want to explore in a random... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/24/2024

Locations: Leeds General Infirmary, Leeds, Not set

Conditions: Heart Failure, Systolic, Pacemaker

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Predicting the Risk of Non-culprit Coronary Artery Disease After a Heart Attack

NCT05781087

Recruiting

Heart attacks caused by the complete blockage of a heart artery are treated by opening it with a stent. However, most people will also have 'non-culprit' narrowings found in their other arteries at this time. Although in general people do better if these non-culprit narrowings are also treated with stents if they look severe, this process has problems. This is because narrowings that look severe may be stable and not cause any trouble. For these people a stent is a wasted procedure and unnecess... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/24/2024

Locations: St Thomas' Hospital, London, Not set +1 locations

Conditions: Coronary Artery Disease, ST Elevation Myocardial Infarction, Ischemic Heart Disease

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A Study of Radspherin® in Patients with Primary Advanced Epithelial Cancer, with Peritoneal Metastasis That Are Homologous Recombination Proficient Scheduled to Undergo Neoadjuvant Chemotherapy and Interval Debulking Surgery

NCT06504147

Recruiting

This is a Phase 2, controlled, randomised, parallel assignment, open label, multicentre study to evaluate efficacy and safety of a single intraperitoneal injection of Radspherin® in patients with primary advanced high-grade serous or high-grade endometrioid epithelial ovarian cancer, fallopian tube, or primary peritoneal cancer, with peritoneal metastasis that are HR proficient and scheduled to undergo NACT and IDS. The study will be conducted in 2 parts; first, a Safety Lead-in Cohort will be r... Read More

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

09/24/2024

Locations: Moffitt Cancer Center, Tampa, Florida +5 locations

Conditions: Peritoneal Carcinomatosis, Ovarian Cancer

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Impact of Tixel Treatment on Symptoms and Signs in Patients with Dry Eye Disease

NCT06615453

Recruiting

This study will examine how a standard Tixel treatment versus a sham treatment for eye wrinkles affects the symptoms and signs of Dry Eye Disease.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/24/2024

Locations: Vision Science, School of Optometry, Birmingham, Not set

Conditions: Dry Eye Disease (DED)

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Remote Ischaemic Conditioning (RIC) in Heart Failure

NCT06616233

Recruiting

This study will test the impact of remote ischaemic conditioning combined with exercise on myocardial perfusion in patients with or at risk of heart failure

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/23/2024

Locations: Glenfield Hospital, Leicester, Leics

Conditions: Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes, Dilated Cardiomyopathy

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Characterisation of Endothelial Cells in Different Inflammatory Pathologies

NCT06613256

Recruiting

The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery. The main question we plan to answer is: 'What molecular pathways are differentially expressed during inflammatory pathologies?'

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/23/2024

Locations: Royal Surrey NHS Foundation Trust, Guildford, Surrey

Conditions: Sepsis, Vasoplegia

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A Multicentre Observational Study to Assess Long-term Outcome of Participants in the EXCELLENT Clinical Trial

NCT06521047

Recruiting

The PERFECT study is an observational study designed to follow patients randomised in the EXCELLENT study (NCT02669810) for 10 years. The aim is to assess the long-term clinical outcomes for patients randomised to the Standard of Care arm or the ProtheraCytes arm.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/23/2024

Locations: CHU DIJON Hôpital François Mitterrand 14 rue Gaffarel, Dijon, Not set +9 locations

Conditions: Acute Myocardial Infarction

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