Investigating the Clinical Utility of the Oxford Virtual Autism Assessment Tool (OVAAT)
NCT06582290
Recruiting
The goal of the study is to evaluate a new Autism Spectrum Disorder (ASD) diagnostic tool (Oxford Virtual Autism Assessment Tool (OVAAT)) to see whether it can: * Be able to identify autistic traits * Be able to distinguish between autistic and non-autistic young people * Is the tool better, similar or worse than another evidence-based observational tool (ADOS-2) in identifying features of autism?
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
08/30/2024
Locations: Oxford Health NHS Foundation Trust, Oxford, Not set
Conditions: Autism Spectrum Disorder, Healthy, Neurotypical
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Value of Inhaled Treatment With Aztreonam Lysine in Bronchiectasis
NCT03696290
Recruiting
A randomised controlled trial of the safety, tolerability and effectiveness of Cayston Cayston (Aztreonam Lysine) compared to placebo in participants with bronchiectasis. Bronchiectasis not due to cystic fibrosis is a chronic inflammatory disease characterised by cough, sputum production and frequent respiratory tract infections. There are currently no licensed therapies for bronchiectasis approved by regulators in the United States or Europe. The disease has a high morbidity, particularly in t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/29/2024
Locations: Torbay Hospital, Torquay, Devon +13 locations
Conditions: Bronchiectasis Adult
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Trial of an Exercise Intervention for Children With Haemophilia
NCT05895032
Recruiting
"Being able to participate in games and activities with their friends" is one of the things that matters most to boys with haemophilia. At present, there is a lack of robust evidence to determine whether muscle strengthening exercise can improve or negatively affect outcomes for young children with haemophilia. With the help of boys with haemophilia, their parents and physiotherapists the investigators have developed an exercise programme designed to increase muscle strength. Using this interven... Read More
Gender:
MALE
Ages:
Between 6 years and 12 years
Trial Updated:
08/29/2024
Locations: Haemophilia Centre, Canterbury, Kent
Conditions: Hemophilia, Child, Only, Musculoskeletal Diseases or Conditions
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A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Patients With HER2-Positive Advanced Solid Tumors
NCT05593094
Recruiting
This will be a Phase 1, multicenter, open-label trial to evaluate the safety, tolerability, PK and efficacy of ZN-A-1041 as a monotherapy or in combination in patients with HER2-positive advanced solid tumors with or without brain metastases. The study will consist of three phases: Phase 1a (dose escalation with ZN-A-1041 monotherapy), Phase 1b (dose escalation with ZN-A-1041 combination therapy) and Phase 1c (dose expansion with ZN-A-1041 combination therapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/29/2024
Locations: ACRC/Arizona Clinical Research Center, Inc, Tucson, Arizona +22 locations
Conditions: Advanced Solid Tumors, HER2-positive Breast Cancer
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Defining Outcome Measures for Behavioural and Emotional Problems in Dystrophinopathies
NCT06581887
Recruiting
Study aims to develop and to evaluate the neurophysiological and physiological response to a classical conditioning task.To better understand how Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) impacts mental health and how to assess it. Participants invited to complete questionnaires about behaviour, cognitive function and social interactions, complete computer tasks and have an optional MRI brain scan,
Gender:
MALE
Ages:
Between 7 years and 17 years
Trial Updated:
08/29/2024
Locations: UCL GOS Institute of Child Health, London, Not set
Conditions: DMD, BMD
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Calcification on CTCA of a CTO and PCI Outcomes
NCT06414551
Recruiting
A chronic total occlusion (CTO) is present in 15-20% of patients who are referred for invasive coronary angiography. CTO Percutaneous Coronary Intervention (PCI) procedure success rates have increased over the years and can be as high as 90% when performed by high-volume CTO operators.Procedurally, excess calcification in the CTO anatomy is one factor which makes it difficult to complete the procedure or obtain ideal stent expansion. Excess calcification is best identified by Computed Tomography... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: Birmingham City Hospital, Sandwell and West Birmingham NHS Trust, Birmingham, West Midlands
Conditions: Chronic Total Occlusion of Coronary Artery, Calcification, Computed Tomography Angiography
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Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
NCT06025240
Recruiting
The purpose of this study is to assess a new test to detect antibodies which may form following kidney transplant. These antibodies can be difficult to detect as they do not cause any symptoms but can lead to kidney damage. A new blood test will be performed alongside existing antibody tests to see how well the test functions in comparison and to see how well it is able to distinguish between inflammation caused by antibodies and other sorts of inflammation such as a urinary tract infection. The... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: Liverpool University Hospitals NHS Foundation Trust, Liverpool, Merseyside
Conditions: Kidney Transplant, Renal Transplant Failure, Kidney Transplant Rejection, Frailty, Kidney Transplant; Complications, Transplant Dysfunction, Diagnosis, Renal Transplant
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DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
NCT05389774
Recruiting
This study is a multi-centre prospective observational cohort study recruiting patients with 5-30mm solid and part-solid pulmonary nodules that have been detected on CT chest scans performed as part of routine practice. The aim is to determine whether physician decision making with the AI-based LCP tool, generates clinical and health-economic benefits over the current standard of care of these patients.
Gender:
ALL
Ages:
35 years and above
Trial Updated:
08/28/2024
Locations: Betsi Cadwaladr University Health Board, Bangor, Not set +9 locations
Conditions: AI (Artificial Intelligence), Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
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Hospitalised COVID-19 Patients Cohort Study in the EuCARE Project
NCT05463380
Recruiting
The WP3 hospitalized cohort in EuCARE is an observational multicentre study including collection of retrospective (historical) and prospective data from hospitalized COVID-19 patients followed at 12 clinics from 11 countries from 4 continents. In a subset of patients, peripheral blood, viral isolates and/or viral sequences are collected for analysis in WP2 with regards to neutralising antibodies, cellular immunity and SARS-CoV-2 diagnostics. Data and results from analysis of biological material... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Not set +9 locations
Conditions: COVID-19
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Post COVID-19 Condition
NCT05531773
Recruiting
The EuCARE-POSTCOVID study is an observational multicentre study enrolling COVID-19 patients recovered from the acute phase of disease to investigate the prevalence and possible predictors of post COVID-19 condition. The study will retrospectively analyze data already collected at the post COVID-19 outpatients services of the participating centers; furthermore, a prospective cohort study will be performed.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: University Hospital Heinrich Heine, Düsseldorf, Not set +6 locations
Conditions: COVID-19
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NOVEL Program for Stroke Telerehabilitation
NCT06409598
Recruiting
Strokes are estimated to be the third most common cause of death in the world and the second most common cause of disability. Recently, the incidence of stroke has increased due to population aging. It is common for stroke survivors to experience a functional decline in their capacity to carry out daily activities as a consequence of their increasing dependence, which ultimately affects motivation levels, self-efficacy, and quality of life. Following a stroke, people often experience problems wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: University of Exeter, Exeter, Not set
Conditions: Chronic Stroke
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Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921
Recruiting
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-thre... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/27/2024
Locations: Cedars-Sinai Comprehensive Transplant Center, Los Angeles, California +105 locations
Conditions: Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
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