Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847
Recruiting
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
05/24/2024
Locations: University of Aizona Health Sciences, Tucson, Arizona +46 locations
Conditions: Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
Register for Updates
Adiposity, Cardiometabolic and Neurocognitive Health Among Ethnic Groups: a Feasibility and Pilot Study
NCT06435611
Recruiting
The goal of this pilot and feasibility study is to is to test the feasibility of conducting a cross-sectional study on adiposity and cardiometabolic and neurocognitive risk factors at Kings College Hospital NHS Foundation Trust (KCH). The main aim is to assess and compare anthropometric measurements of adiposity (weight, Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip ratio (WHR), Neck circumference (NC)), liver fat (hepatic steatosis and fibrosis), cardiometabolic risk factors (d... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/24/2024
Locations: King's College Hospital NHS Foundation Trust, London, United Kingdom Of Great Britain And Northern Ireland +1 locations
Conditions: Metabolic Disease, Obesity, Hepatic Steato-Fibrosis, Cardiovascular Diseases, Cognitive Impairment
Register for Updates
Microbiome Molecular Charaterisation
NCT06423976
Recruiting
Preclinical models of prostate cancer have proved to be poorly predictive of the behaviour of the disease in patients. This protocol describes the acquisition of prostate cancer tissue or cells from patients with treatment naïve/hormone-sensitive and castration-resistant prostate cancer or patients undergoing diagnostic or follow up investigations. The knowledge gained will improve the investigators' understanding of the steps leading to the development of castration resistance and identify new... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: Institute of Cancer Research/Royal Marsden NHS FT, Sutton, Surrey
Conditions: Prostate Cancer
Register for Updates
Bioavailability and Bioactivity of Orange Polyphenols
NCT06430138
Recruiting
This study will provide a greater insight into the relationship between orange consumption and health (particularly gut health) and could be used to help with the development of novel food products. Oranges are a rich source of (poly)phenols, and although the advantages of a (poly)phenol-rich diet are well-established, the bioavailability and bioactivity of orange (poly)phenols in the context of human digestion are poorly understood. This study will address this gap in research.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/22/2024
Locations: Ulster University,Human Intervention Studies Unit,, Coleraine, Co. Londonderry
Conditions: Healthy Nutrition
Register for Updates
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
NCT04625907
Recruiting
FaR-RMS is an over-arching study for children and adults with newly diagnosed and relapsed rhabdomyosarcoma (RMS)
Gender:
ALL
Ages:
All
Trial Updated:
05/22/2024
Locations: Queensland Children's Hospital, Brisbane, Not set +127 locations
Conditions: Rhabdomyosarcoma
Register for Updates
Determining the Mechanisms of Loss of CAR T Cell Persistence
NCT05809284
Recruiting
A prospective observational study of pediatric and young adult acute lymphoblastic leukaemia (ALL) patients treated with CD19 chimeric antigen receptor T-cells (CAR-T cells). The study will examine changes in CAR-T persistence over time and causal factors.
Gender:
ALL
Ages:
25 years and below
Trial Updated:
05/22/2024
Locations: Great Ormond Street Hospital, London, Not set +2 locations
Conditions: Acute Lymphoblastic Leukemia With Failed Remission, Acute Lymphoblastic Leukemia Not Having Achieved Remission, Acute Lymphoblastic Leukemia, Pediatric, Acute Lymphoblastic Leukemia, Adult, Acute Lymphoblastic Leukemia, in Relapse
Register for Updates
Utility of PET-MRI in Surveillance of Paediatric Brain Tumours
NCT05553899
Recruiting
This is a pilot project to explore the utility of PET-MRI in the post-treatment surveillance of high-grade gliomas or medulloblastomas in children in our institution.
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
05/22/2024
Locations: Sheffield Children's Hospital, Sheffield, South Yorkshire
Conditions: Brain Tumor, Pediatric
Register for Updates
Early Liver Disease Breath Detection
NCT05935488
Recruiting
The Early Liver Disease Breath Detection Study is a cross-sectional study where subjects with advanced liver fibrosis will ingest a mixture of food-grade compounds (known as Exogenous Volatile Organic Compound or EVOCs) in the form of an emulsion and then provide multiple breath samples. These EVOCs can be measured on exhaled breath and it has been found that liver diseases can affect the way EVOCs are processed in the body. The objective is to identify if changes in the way these EVOCs are proc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: North Norfolk Primary Care, Norwich, Norfolk
Conditions: Liver Fibrosis, NASH, Liver Diseases
Register for Updates
Integrated Short-Term Palliative Rehabilitation in Incurable Cancer
NCT05984797
Recruiting
The goal of this intervention trial is to determine if palliative rehabilitation in addition to usual care is more effective than usual care at improving health-related quality of life in patients with incurable solid cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: Herlev Hospital, Herlev, Not set +10 locations
Conditions: Cancer
Register for Updates
The Youth - Physical Activity Towards Health Intervention in Northern Ireland
NCT06242990
Recruiting
The Y-PATH programme is an evidence-based intervention programme that has been found to be successful at increasing levels of physical activity in school children in the Republic of Ireland. The Irish Heart Foundation collaborated with Dublin City University and University College Cork to disseminate the programme nationally. The intervention programme aims to improve physical activity levels of adolescents through education about the importance of physical activity for health and the developmen... Read More
Gender:
ALL
Ages:
Between 10 years and 14 years
Trial Updated:
05/21/2024
Locations: Ulster University, Derry / Londonderry, Not set
Conditions: Physical Inactivity
Register for Updates
Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment
NCT06427317
Recruiting
The primary aim of the study is to determine the proportion of individuals receiving beta-lactam antibiotics at Imperial College Healthcare NHS Trust in whom drug concentration targets are achieved.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: Imperial College Healthcare NHS Trust, London, Not set
Conditions: Infections, Bacterial, Pharmacokinetics, Drug Monitoring, Drug-Related Side Effects and Adverse Reactions
Register for Updates
Useability and Acceptability of the CUE1 Device in Older People With Parkinson's Disease
NCT06430151
Recruiting
The CUE1 device is a non-invasive wearable device for people with Parkinson's Disease (PD) approved for sale in the UK. The CUE1 device utilises two established methods to improve motor symptoms in PD, namely pulsed cueing and vibrotactile stimulation. Many people with PD wish to explore non-pharmacological interventions as an adjunct to manage their motor symptom. Study design and eligibility: This feasibility study is to establish whether the CUE1 device is a useable and acceptable device for... Read More
Gender:
ALL
Ages:
Between 60 years and 100 years
Trial Updated:
05/21/2024
Locations: Cambridge University Hospitals Foundation Trust, Cambridge, Not set
Conditions: Parkinson Disease
Register for Updates