Saracatinib Trial TO Prevent FOP
NCT04307953
Recruiting
This is a phase 2 study, designed as a European multicentre 6-month double blind random-ized controlled trial (RCT) of AZD0530 versus matched placebo, followed by a 12 month trial comparing open-label extended AZD0530 treatment with historical control data. Study population: Male and female adult patients aged 18 years and older with a diagnosis of FOP who meet the inclusion (active disease) and exclusion criteria will be eligible for participation in this study. The total number of enrolled pa... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/02/2024
Locations: Klinikum Garmish-Partenkirchen, Garmisch-Partenkirchen, Not set +2 locations
Conditions: Fibrodysplasia Ossificans Progressiva
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Oncologic, Cosmetic and Patient Reported Outcomes in Value-Based Breast Surgery (OnCoPRO Value)
NCT06401304
Recruiting
The study aspires to provide outcomes on surgery, quality of life and time-to-event outcomes following the development and validation of a standardised surgical assessment tool in a shared decision-making framework for patients with pre-invasive or invasive breast cancer with breast conservation.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/02/2024
Locations: Westmead Breast Cancer Institute, Sydney, Not set +2 locations
Conditions: Breast Cancer, Breast Carcinoma in Situ, Breast Cancer Invasive, Breast Asymmetry
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Ablation of Focal Activation in Atrial Fibrillation
NCT06402617
Recruiting
Recurrent focal electrical activation (or ectopy) superseding sinus activation is the only mechanism proven to drive paroxysmal atrial fibrillation (AF). However, it has not been possible to show similar focal drivers during AF, owing to the limitations of mapping in persistent AF. RETRO-Mapping has been developed as a method to generate activation maps during AF to test the hypothesis that persistent AF is also maintained by focal drivers. RETRO-Mapping is able to locate sites of focal activat... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/02/2024
Locations: Hammersmith Hospital, London, Not set
Conditions: Atrial Fibrillation, Atrial Fibrillation, Persistent, Arrhythmia, Arrhythmias, Cardiac, Cardiac Arrhythmia
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A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation
NCT06399393
Recruiting
The purpose of this study is to compare the efficacy, safety, and tolerability of ide-cel with lenalidomide (LEN) maintenance to that of LEN maintenance alone in adult participants with Newly Diagnosed Multiple Myeloma (NDMM) who have achieved a suboptimal response post autologous stem cell transplantation (ASCT).
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +117 locations
Conditions: Multiple Myeloma
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Mind and Skin - the Neurocutaneous Axis in Atopic Eczema
NCT05790330
Recruiting
'Mind and Skin': A prospective cohort study evaluating the impact of inflammation, itch and sleep disturbance on the brain, mental health and cognition, in patients with severe atopy.
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
05/01/2024
Locations: Unit for Paediatric and Population-based Dermatology Research, London, Not set
Conditions: Atopic Dermatitis
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Robot-Assisted Gait Training in Early-Subacute Stroke
NCT06233734
Recruiting
A stroke happens when blood flow to the brain is cut off. Many people struggle to walk after having a stroke. Regaining the ability to walk is a key aim for many stroke survivors and rehabilitation practitioners as it allows improved independence and better health. This study will assess a rehabilitation method called robot-assisted gait training (RAGT) with stroke patients. RAGT uses a robotic device to assist the patient in taking steps. The RAGT device being investigated in this study is call... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Royal Bournemouth Hospital, Bournemouth, Not set +1 locations
Conditions: Stroke
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Enhanced Rehabilitation After Major Trauma (PROPERLY)
NCT05652790
Recruiting
The goal of this study is to assess the feasibility of recruitment, and barriers to delivery of an enhanced rehabilitation service, in patients surviving major trauma. The main questions it aims to answer are: are the investigators able to recruit patients to a research study are the investigators able to retain patients in the research study are the investigators able to identify appropriate primary outcome measures are the investigators able to identify barriers to future large-scale definit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Manchester University NHS Foundation Trust - St Mary's, Manchester, Greater Manchester
Conditions: Major Trauma
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Bioimpedance In Pregnancy and Labour: A Fluid Balance Concept Study.
NCT03823820
Recruiting
The purpose of our study is to find out if using a simple bed side test can tell us information about changes that occur in women's body water content. We would like to check if certain medical conditions could affect body water contents.
Gender:
FEMALE
Ages:
16 years and above
Trial Updated:
04/30/2024
Locations: Univercity Hospitals of Leicester NHS Trust, Leicester, Leicestershire
Conditions: Hydration
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LEICeSter Tendon Extracorporeal Shockwave Studies
NCT02546128
Recruiting
To assess whether the addition of Extra-corporeal Shockwave Therapy (ESWT) to a structured home-exercise programme has any additional benefit to patients with tendinopathies
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
04/30/2024
Locations: University Hospitals of Leicester NHS Trust, Leicester, Not set
Conditions: Tendinopathy
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Shoulder Surgery Traditional vs Accelerated Rehabilitation Trial
NCT03913611
Recruiting
This is a randomised controlled trial involving patients who have a double-row arthroscopic rotator cuff repair. Null hypothesis: There is no difference in outcome between standard rehabilitation and accelerated rehabilitation after arthroscopic rotator cuff repair. Following surgery, they will be randomised to one of two groups: 1. Standard rehabilitation, with enforced sling use for 6 weeks and a structured exercise programme. 2. Accelerated rehabilitation with no requirement to use a sling... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
04/30/2024
Locations: Manchester University Foundation NHS Trust, Manchester, Not set
Conditions: Rotator Cuff Tear, Rotator Cuff Tear or Rupture, Not Specified as Traumatic
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Correlation of Non-invasive CPM Wearable Device With Measures of Congestion in Heart Failure in Exercise
NCT06393842
Recruiting
Fluid status and congestion can be determined by the CPM wearable device and correlates with non-invasive measures and biochemical markers of congestion and changes in congestion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Glasgow Cardiovascular Research Centre, Glasgow, Scotland
Conditions: Heart Failure
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PUMA (Paediatric Osseous Marrow Assessment)
NCT03466944
Recruiting
This is a pilot cancer imaging study investigating change in the apparent diffusion coefficient (ADC) at a single time point post-transplantation in patients. The treatment is bone marrow transplant as per standard patient care, without change for trial purposes. Its main aim is to evaluate the engraftment of bone marrow after transplantation performing functional Magnetic Resonance Imaging (MRI) of the lumbar spine and pelvis at baseline and after 2-3 weeks after the transplantation (according... Read More
Gender:
ALL
Ages:
Between 5 years and 24 years
Trial Updated:
04/30/2024
Locations: The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey
Conditions: Leukaemia
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