BCG Revaccination Study in Diabetic and Non-Diabetic Adults
NCT06246851
Recruiting
The purpose of this study is to: 1. explore whether investigators can make BCG more effective by giving it in a different way. For this, aerosol inhaled BCG will be compared against the conventional BCG injection. 2. explore if there are differences in response to re-vaccination in healthy volunteers with and without Type 2 Diabetes. It will involve 36 previously BCG-vaccinated participants. Bronchoscopies will be performed 14 days post-challenge to measure BCG recovered from bronchial samples... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/29/2024
Locations: Centre for Clinical Vaccinology and Tropical Medicine, Oxford, Oxfordshire
Conditions: Tuberculosis
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Global FKRP Registry
NCT04001595
Recruiting
Mutations in the Fukutin Related Protein (FKRP) gene cause the condition Limb Girdle Muscular Dystrophy type R9 (LGMDR9) also known as LGMD2I, and the rarer conditions Congenital Muscular Dystrophy (MDC1C), Muscle Eye Brain Disease (MEB) and Walker-Warburg Syndrome (WWS). LGMDR9 is the most common FKRP-related condition, and is especially prevalent in Northern Europe. The aim is to facilitate a questionnaire based research study in order to better characterise and understand the disease globall... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/26/2024
Locations: John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle upon Tyne, Not set
Conditions: LGMD2I, LGMDR9, Limb Girdle Muscular Dystrophy, Congenital Muscular Dystrophy, Muscle-Eye-Brain Disease, Walker-Warburg Syndrome, FKRP Gene Mutation
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Hyperoxia Induced Pulmonary Inflammation and Organ Injury: a Human in Vivo Model
NCT05414370
Recruiting
Oxygen is the most commonly administered therapy in critical illness. Accumulating evidence suggests that patients often achieve supra-physiological levels of oxygenation in the critical care environment. Furthermore, hyperoxia related complications following cardiac arrest, myocardial infarction and stroke have also been reported. The underlying mechanisms of hyperoxia mediated injury remain poorly understood and there are currently no human in vivo studies exploring the relationship between hy... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
01/26/2024
Locations: Belfast Health and Social Care Trus, Belfast, Not set
Conditions: Oxygen Toxicity, Pulmonary Injury, Acute Lung Injury
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Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma
NCT05278975
Recruiting
This is an open-label, non-randomized, multicenter, translational Phase 1/2 dose-escalation and expansion study designed to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of RSO-021 after intrapleural (IP) administration in patients with malignant pleural effusion (MPE) (non-mesothelioma) and MPE from mesothelioma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/25/2024
Locations: South Mead North Bristol Hopsital, Bristol, Not set +9 locations
Conditions: Malignant Pleural Effusion, Malignant Pleural Mesothelioma, Mesothelioma, Mesotheliomas Pleural, Mesothelioma; Lung, Pleural Effusion, Malignant
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A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Pinnacle Research Group, Anniston, Alabama +493 locations
Conditions: NASH - Nonalcoholic Steatohepatitis
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Clinical and Functional Outcome of the MobileLink Acetabular Cup System in the Short-, Mid-, and Longterm Follow-up
NCT04688593
Recruiting
The implantation of artificial hip joints is one of the most frequently performed surgeries. Normally, patients are very satisfied with the results. The MobileLink hip prosthesis system is a CE marked medical device. This means the the safety and performance of the prosthesis ist approved. Aim of the study is to collect clinical data about the outcome of the MobileLink hip prosthesis system under routine condition and to determine the satisfaction of the patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Lubinus Stiftung, Kiel, Not set +1 locations
Conditions: Osteoarthritis, Hip, Hip Osteoarthritis, Prosthesis Survival, Prosthesis Failure
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Anti-psychotic Drug Prescribing Patterns Within Specialist Adult ID Services in England and Wales
NCT06238089
Recruiting
The overall aim of this observational study is to establish the anti-psychotic prescribing patterns across specialist intellectual disability (ID) services in England and Wales by collecting cross-sectional retrospective data at 7 annual time-points (1st July) from 2017 to 2023.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Cheshire and Wirral Partnership NHS Foundation Trust, Chester, Not set +7 locations
Conditions: Intellectual Disability
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The Microbrect-FFC Study
NCT06236321
Recruiting
This study will focus on two points: 1. To determine if response to neoadjuvant chemoradiotherapy treatment in rectal cancer can be predicted by analysing data from Fast Field Cycling imaging (FFC), a novel type of MRI technique. 2. To determine if there is evidence that the bacteria living in our mouth and in our large bowel influence the way our body responds to cancer treatment. Rectal cancer which is locally advanced is often managed with pre-operative chemoradiotherapy. The idea is to red... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2024
Locations: University of Aberdeen, Aberdeen, Not set
Conditions: Colorectal Cancer
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Identification of Patients at Risk of CKD After AKI
NCT05740709
Recruiting
The investigators will investigate whether new kidney biomarkers can identify patients who are at risk of chronic kidney disease after an episode of moderate / severe acute kidney injury in ICU.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2024
Locations: Guy's & St Thomas Foundation Hospital, London, Not set
Conditions: Acute Kidney Injury, Kidney Diseases
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Efficacy of Juniver, a Digital Self-help Intervention, on Symptoms of Eating Disorders: A Randomised Controlled Trial
NCT06226233
Recruiting
This project aims to assess the efficacy of the Juniver program on symptoms of eating disorders via a randomised controlled trial. The Juniver program is a self-help intervention for eating disorders delivered digitally, through an iPhone app. It features three components: an evidence-based curriculum, interactive tools, and moderated peer support groups. These three components integrate the evidence for (a) Cognitive-Behavioural Therapy (CBT) and Dialectical Behaviour Therapy for eating disord... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
01/17/2024
Locations: King's College London, London, Not set
Conditions: Feeding and Eating Disorders, Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, Binge Eating, Eating Disorders, Disordered Eating
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Cerebellar Mutism Syndrome Study
NCT02300766
Recruiting
The purpose of this study is to determine why up to 25% of the pediatric patients who have surgery for a tumor in the posterior fossa develops the Cerebellar Mutism Syndrome (CMS). Furthermore the purpose is to explore the clinical course and the best treatment of the syndrome.
Gender:
ALL
Ages:
18 years and below
Trial Updated:
01/15/2024
Locations: Medical University of Vienna, Vienna, Not set +29 locations
Conditions: Infratentorial Neoplasms, Mutism
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Immune Cell Dysfunction in Severe Alcoholic Hepatitis
NCT02275195
Recruiting
Through bio-sampling this study investigates the relationship between the frequency and function of the cells of a patients immune system and how these change and impact on the outcome of alcoholic hepatitis. the investigators will examine the role of different cells of the immune system and how they may determine the outcome of this condition. The investigators will also look at how established treatment strategies impact on the frequency and function of these cell subsets.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/11/2024
Locations: Basildon Hospital, Basildon, Essex
Conditions: Hepatitis
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