Neoadjuvant Study With Combination Immuno-oncology for Primary Clear Cell Renal Cell Cancer
NCT05148546
Recruiting
The NESCIO-trial is a multicenter, randomized, open-label, three-arm phase II trial investigating different combinations of neoadjuvant immunotherapy in patients with primary, resectable, intermediate to high-risk, clear-cell renal cell carcinoma. In this trial patients will be randomized 1:1:1 to receive either 2 cycles of nivolumab 360mg every 3 weeks (arm A), 2 cycles of ipilimumab 1 mg/kg + nivolumab 3 mg/kg every 3 weeks (arm B) or 2 cycles of relatlimab 360mg + nivolumab 360mg every 3 week... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/03/2022
Locations: Netherlands Cancer Institute, Amsterdam, NH +1 locations
Conditions: Renal Cell Carcinoma
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International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors
NCT05363657
Recruiting
Partial nephrectomy (PN) is the standard treatment for localized renal masses and should be preferred in clinical T1 (\<7 cm tumor diameter) renal tumors over radical nephrectomy (RN) whenever technically feasible. Nonetheless, indications, approaches, techniques for PN, and correct reporting of outcomes, are still a matter of great debate within the urology community. Concurrently, case-report series suggested that alternative strategies for the treatment of localized renal tumors (ablation tec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2022
Locations: Institute of Urology, University of Southern California., Los Angeles, California +36 locations
Conditions: Kidney Cancer
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Muscle Connective Tissue in Limb Development and Disease
NCT02611089
Recruiting
The objective of this work is to understand how the disruption of the muscle connective tissue contributes to the limb soft-tissue defects in radial dysplasia. In parallel, the researchers will investigate the role of muscle connective tissue in normal limb development.
Gender:
ALL
Ages:
All
Trial Updated:
04/13/2022
Locations: Oxford University Hospitals, Oxford, Oxfordshire +3 locations
Conditions: Radial Dysplasia
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MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)
NCT04578392
Recruiting
Study description - Patients will be randomized according to post-operative recurrence risk to either a high ligation of ileocolic artery or mesenteric sparing ileocolic resection for terminal ileal Crohn's disease. The primary endpoint 6-month endoscopic recurrence. Endpoints - Primary endpoint; 6 months Secondary endpoints at 1 and 5 years post ileocecal resection Study population - Adult Crohn's disease patients with medically refractory terminal ileal Crohn's disease undergoing a primary i... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/01/2022
Locations: Cedars-Sinai Hospital System, Los Angeles, California +6 locations
Conditions: Crohn Disease
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Defining the Genetics, Biomarkers and Outcomes for Dilated Cardiomyopathy
NCT03843255
Recruiting
Finding new ways to diagnose and treat Dilated Cardiomyopathy (DCM) could improve the health and well-being of patients with this condition. The main aim of this research study is to help develop better ways of diagnosing and treating patients with DCM. The information that is collected may help develop tailored treatments for patients with this disease in the future. This research study will recruit patients with DCM from a number of centres across England and follow their health over a period... Read More
Gender:
ALL
Ages:
99 years and below
Trial Updated:
03/29/2022
Locations: Leeds Teaching Hospitals NHS Trust, Leeds, Not set +5 locations
Conditions: Dilated Cardiomyopathy, Cardiovascular Diseases
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Deep Liver Phenotyping and Immunology Study
NCT04946773
Recruiting
Hepatocellular carcinoma (HCC) and cholangiocarcinoma are the two most common causes of primary liver cancer and HCC is the second highest cause of cancer death worldwide. It is known that most of these cancers occur in patients who already have a liver condition. Despite close monitoring of many patients who have liver disease with regular ultrasound scans, HCC and cholangiocarcinoma are often discovered at a late stage. This is because they rarely cause symptoms until they have reached an adva... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/28/2022
Locations: John Radcliffe Hospital, Oxford, Oxfordshire
Conditions: Hepatocellular Carcinoma, Cholangiocarcinoma
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Sodium (23Na) MRI for Tumour Characterisation and Assessment of Therapy Response in Breast Cancer
NCT03940092
Recruiting
The scope of this study is the methodological development and optimisation of sodium MRI (23Na-MRI) protocols for breast cancer imaging. The study further proposes to utilise biomarkers obtained from 23Na-imaging (cell integrity), FDG-PET (metabolism), multi-parametric MRI (perfusion, vascularity, cellularity, morphology) to generate parameter maps specific for physiological processes in breast cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/24/2022
Locations: Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire
Conditions: Breast Cancer
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ACTIVE-IBD Study: Physical Activity and Sleep in Paediatric Inflammatory Bowel Disease
NCT05224193
Recruiting
Assessment of physical activity on children with Inflammatory Bowel Disease using questionnaires and wrist watch based activity monitors. The participants will be recruited from paediatric IBD clinics and will undergo questionnaires to assess their activity level, disease activity and quality of life scores. The participants will then be invited to wear a wrist based accelerometer for a week. The participants will complete a physical activity diary, food diary and stool chart at the same time.... Read More
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
02/22/2022
Locations: Univeristy Hospital Southampton, Southampton, Hampshire
Conditions: Inflammatory Bowel Diseases, Exercise
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European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD)
NCT04190849
Recruiting
The EU-PNAFLD (The European Paediatric NALFD Registry) will be a network composed of European centres involved in the care of children with NAFLD, and will include Hepatologists, Endocrinologists, and Scientists, supported by relevant international specialists. This collaboration will build on existing infrastructure (local databases and bio-repositories) and will align with the adult European NAFLD Registry ("EPoS", Elucidating Pathways of Steatohepatitis study) to allow long-term follow-up sup... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
02/17/2022
Locations: Maastricht UMC, Maastricht, Not set +2 locations
Conditions: Non-Alcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver, Non-alcoholic Steatohepatitis
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Qualification for Cone-Optogenetics
NCT05218928
Recruiting
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Gender:
All
Ages:
All
Trial Updated:
01/19/2022
Locations: University of California San Francisco, Department of Ophthalmology, San Francisco, California +8 locations
Conditions: Retinal Dystrophies
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Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT05211856
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Fountain Valley, California +277 locations
Conditions: Chronic Lymphocytic Leukemia
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Regeneration in Cervical Degenerative Myelopathy
NCT04631471
Recruiting
Degenerative (wear and tear arthritis of the spine) Cervical (concerning the neck) Myelopathy (injury to the spinal cord), DCM, is the most common spinal cord disorder of adulthood. In DCM, arthritis of the spine causes compression of the spinal cord. The symptoms of DCM are often mistaken for natural consequences of ageing, including numb and clumsy hands, loss of coordination, imbalance, bladder and bowel problems. The weakness can progress to severe paralysis. Every year approximately 4 indi... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/24/2021
Locations: Addenbrooke's Hospital, Cambridge, Not set
Conditions: Myelopathy, Spinal Cord Diseases
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