Search
All Clinical Trials in United Kingdom
A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
445 - 456 of 3097
Show Filters
Match to Clinical Trials
Access to cutting-edge treatments
Latest clinical trials
Find trials in your area
Search by Name
Filter by Condition
Filter by Age
Filter by Type
Gender
Male
Female
Both
Type of Study
Interventional
Observational
Clinical Trial Phase
Phase 1
Phase 2
Phase 3
Phase 4
Phase 1/2
Phase 2/3
Unknown
A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced Participants With Active Psoriatic Arthritis
Recruiting
The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in biologic-experienced participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.
The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in biologic-experienced participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: AARA Clinical Research, Glendale, Arizona +194 locations
AARA Clinical Research, Glendale, Arizona
AARA Clinical Research, Mesa, Arizona
Arthritis and Rheumatism Associates ARA Jonesboro, Jonesboro, Arkansas
Clinical Research of West Florida, Clearwater, Florida
Omega Research Consultants, DeBary, Florida
Suncoast Clinical Research, New Port Richey, Florida
Integral Rheumatology And Immunology Specialists, Plantation, Florida
Clinical Research of West Florida, Tampa, Florida
Clinic of Robert Hozman, Skokie, Illinois
Klein And Associates M D P A, Hagerstown, Maryland
DM Clinical Research, Brookline, Massachusetts
St Paul Rheumatology PA, Eagan, Minnesota
Albuquerque Rehabilitation and Rheumatology, Albuquerque, New Mexico
Joint and Muscle Research Institute, Charlotte, North Carolina
Rheumatology Associates of Oklahoma, Oklahoma City, Oklahoma
Altoona Center For Clinical Research, Duncansville, Pennsylvania
Arthritis and Rheumatology Research Institute, Allen, Texas
UT Southwestern, Dallas, Texas
Naiara Alvarez MD Integrative Rheumatology of South TX, Harlingen, Texas
AARA Clinical Research Lone Star Arthritis and Rheumatology, Irving, Texas
DM Clinical Research, Tomball, Texas
Velocity Clinical Research, Waco, Texas
Instituto Medico De Alta Complejidad (IMAC), Buenos Aires, Not set
ARCIS Salud SRL Aprillus asistencia e investigacion, Buenos aires, Not set
Hospital Militar Central Cir. My. Dr. Cosme Argerich, Ciudad Autonoma de Buenos Aires, Not set
Arsema, Ciudad de Buenos Aires, Not set
Centro Medico Privado de Reumatologia Tucuman, Ciudad De San Miguel De Tucuman, Not set
MR Medicina Reumatologica, San Fernando, Not set
Ipswich Hospital, Ipswich, Not set
Rheumatology Research Unit, Maroochydore, Not set
Queen Elizabeth Hospital, South Woodville, Not set
Royal North Shore Hospital, St Leonards, Not set
Royal Darwin Hospital, Tiwi, Not set
Universidade Federal de Minas Gerais UFMG Faculdade de Medicina, Belo Horizonte, Not set
LMK Servicos Medicos S S, Porto Alegre, Not set
BR TRIALS Ensaios Clinicos e Consultoria Ltda, Sao Paulo, Not set
Hospital Das Clinicas Da Faculdade De Medicina Da USP, Sao Paulo, Not set
UMHAT Kaspela, Plovdiv, Not set
Multiprofile Hospital for Active Treatment Plovdiv, Plovdiv, Not set
Diagnostic Consulting Center I Sliven, Sliven, Not set
Multiprofile Hospital for Active Treatment - MHAT Lyulin EAD, Sofia, Not set
Diagnostic-Consultative Center (DCC) Aleksandrovska, Sofia, Not set
UMHAT St. Ivan Rilski, Sofia, Not set
ASIMP Rheumatology Centre St Irina EOOD, Sofia, Not set
Eastern Regional Health Authority St Clares Mercy Hospital, St Johns, Newfoundland and Labrador
The Waterside Clinic, Orillia, Ontario
Womens College Hospital, Toronto, Ontario
Alliance Clinical Trials, Waterloo, Ontario
Dr Sabeen Anwar Medicine Professional Corporation, Windsor, Ontario
Centre de Recherche Musculo Squelettique, Trois Rivieres, Quebec
Peking University Third Hospital, Beijing, Not set
Beijing Tong Ren Hospital Capital Medical University, Beijing, Not set
The First Bethune Hospital of Jilin University, Changchun, Not set
Xiangya Hospital Central South University, ChangSha, Not set
West China Hospital Sichuan University, Chengdu, Not set
Sichuan Provincial Peoples Hospital, Chengdu, Not set
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Not set
Nanfang Hospital of Southern Medical Hospital, Guangzhou, Not set
The Affiliated Hospital of Guizhou Medical University, Guiyang, Not set
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou, Not set
The First Hospital of Jiaxing, Jiaxing, Not set
Jinhua municipal central hospital, Jinhua, Not set
Linyi City People Hospital, Linyi City, Not set
The Second Affiliated Hospital of Nanchang University, Nanchang, Not set
Affiliated Hospital of Nantong University, Nantong, Not set
Pingxiang People's Hospital, Pingxiang, Not set
Huashan Hospital Fudan University, Shanghai, Not set
Shanghai skin disease hospital, Shanghai, Not set
Shenzhen People s Hospital, Shenzhen, Not set
Second Affiliated Hospital of Soochow University, Suzhou, Not set
Shanxi Bethune Hospital, Taiyuan, Not set
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Not set
The Second Affiliated Hospital of Xi'an Jiaotong University, Xian City, Not set
RHEUMA s r o, Breclav, Not set
Revmacentrum MUDr Mostera s r o, Brno, Not set
Revmatologie s r o, Brno, Not set
L K N Arthrocentrum, Hlucin, Not set
CCR Ostrava S R O, Ostrava, Not set
MUDr Rosypalova s r o, Ostrava, Not set
FN Motol, Praha, Not set
Medical Plus S R O, Uherske Hradiste, Not set
PV Medical S R O, Zlin, Not set
Aarhus University Hospital, Aarhus N, Not set
Sydvestjysk Sygehus, Esbjerg, Not set
Frederiksberg Hospital, Frederiksberg, Not set
Regionshospitalet Godstrup, Herning, Not set
Svendborg Hospital Odense University Hospital, Svendborg, Not set
Vejle Sygehus, Vejle, Not set
Charite - Campus Mitte, Berlin, Not set
ISA - Interdisciplinary Study Association GmbH, Berlin, Not set
Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden, Dresden, Not set
Hamburger Rheuma Forschungszentrum II, Hamburg, Not set
Rheumazentrum Ruhrgebiet, Herne, Not set
Praxis Dr. med. Beate Schwarz - Germany, Langenau, Not set
Rheumaforschung - Studienambulanz Dr. Wassenberg, Ratingen, Not set
Universitatsklinikum Tubingen, Tubingen, Not set
Prince of Wales Hospital, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Betegapolo Irgalmas Rend Budai Irgalmasrendi Korhaz, Budapest, Not set
Revita Kft, Budapest, Not set
Qualiclinic Kft, Budapest, Not set
Uno Medical Trials Ltd., Budapest, Not set
Debreceni Egyetem Reumatologiai Klinika, Debrecen, Not set
Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz, Gyula, Not set
Obudai Egeszsegugyi Centrum Kft, Kaposvar, Not set
Bacs Kiskun Varmegyei Oktatokorhaz, Kecskemet, Not set
University of Szeged, Szeged, Not set
MAV Korhaz es Rendelointezet, Szolnok, Not set
Vital Medical Center Orvosi es Fogaszati Kozpont, Veszprem, Not set
Marengo Cims Hospital, Ahmedabad, Not set
Apollo Hospitals, Bhubaneswar, Not set
Sushruta Multispeciality Hospital, Hubballi, Not set
Apollo Multispeciality Hospital Ltd, Kolkata, Not set
JSS Hospital, Mysuru, Not set
Indraprastha Apollo Hospital, New Delhi, Not set
Fortis Hospital, Noida, Not set
SIDS (Surat Institute of Digestive Sciences) Hospital and Research Centre, Surat, Not set
A.O. Universitaria Ospedali Riuniti di Ancona, Ancona, Not set
Policlinico San Marco, Catania, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Ospedaliero Universitaria Luigi Vanvitelli, Napoli, Not set
IRCCS Policlinico San Matteo, Pavia, Not set
Fondazione Policlinico Universitario A Gemelli IRCCS, Roma, Not set
Istituto Clinico Humanitas, Rozzano, Not set
A O Universitaria Senese Ospedale Santa Maria alle Scotte, Siena, Not set
Ospedale S. Maria Della Misericordia, Udine, Not set
St. Luke's International Hospital, Chuo ku, Not set
Kansai Medical University Hospital, Hirakata, Not set
Kita-harima Medical Center, Hyogo, Not set
Nagoya City University Hospital, Nagoya City, Not set
Maeshima Rheumatology Clinic, Oita, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Sanuki Municipal Hospital, Sanuki, Not set
Sasebo Chuo Hospital, Sasebo, Not set
Tohoku University Hospital, Sendai, Not set
Dokkyo Medical University Hospital, Shimotsuga Gun, Not set
Kyorin University Hospital, Tokyo, Not set
Mie University Hospital, Tsu, Not set
Hospital Raja Permaisuri Bainun, Ipoh, Not set
RM Pharma Specialists, Ciudad de Mexico, Not set
Centro de Investigacion de Tratamientos Innovadores de Sinaloa, Culiacan, Not set
Grupo Clinico CATEI, Guadalajara, Not set
Centro Medico del Angel, Mexicali, Not set
Osteo-Medic s.c A. Racewicz, J Supronik, Bialystok, Not set
Specderm Poznanska sp j, Bialystok, Not set
ClinicMed Daniluk Nowak Spolka Komandytowa, Bialystok, Not set
Szpital Uniwersytecki Nr 2 w Bydgoszczy, Bydgoszcz, Not set
Ambulatorium sp. z o.o., Elblag, Not set
Centrum Kliniczno Badawcze, Elblag, Not set
Centrum Medyczne Pratia Gdynia, Gdynia, Not set
Malopolskie Badania Kliniczne Sp z o o, Krakow, Not set
Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna, Krakow, Not set
Centrum Medyczne All Med, Krakow, Not set
Pratia MCM Krakow, Krakow, Not set
Dermed Centrum Medyczne Sp z o o, Lodz, Not set
Zespol Poradni Specjalistycznych Reumed Filia nr 1, Lublin, Not set
NZOZ Lecznica MAK MED S C, Nadarzyn, Not set
MICS Centrum Medyczne Torun, Torun, Not set
MICS Centrum Medyczne Warszawa, Warszawa, Not set
Centrum Medyczne Reuma Park, Warszawa, Not set
DermMedica Sp z o o, Wroclaw, Not set
Centrum Medyczne Oporow, Wroclaw, Not set
S C Delta Health Care S R L, Bucharest, Not set
Ecomed Research SRL, Craiova, Not set
Centrul Medical Unirea, Iasi, Not set
Medaudio Optica S R L, Ramnicu Valcea, Not set
Hosp Univ A Coruna, A Coruna, Not set
Hosp Reina Sofia, Cordoba, Not set
Hosp. Univ. de Bellvitge, L Hospitalet De Llobregat, Not set
Hosp. Univ. Infanta Leonor, Madrid, Not set
Hosp Regional Univ de Malaga, Malaga, Not set
Hosp. Univ. Marques de Valdecilla, Santander, Not set
Hosp. Clinico Univ. de Santiago, Santiago de Compostela, Not set
Hosp. Virgen Macarena, Sevilla, Not set
Hosp. Infanta Luisa, Sevilla, Not set
Hosp. Virgen Del Rocio, Sevilla, Not set
National Taiwan University Hospital Hsin Chu Branch, Hsin Chu, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Chi Mei Medical Center, Tainan, Not set
Taipei Veterans General Hospital, Taipei, Not set
Phramongkutklao Hospital, Bangkok, Not set
Rajavithi Hospital, Bangkok, Not set
Siriraj Hospital, Bangkok, Not set
Saraburi Hospital, Saraburi, Not set
Songklanagarind hospital, Songkhla, Not set
Royal Free London NHS Foundation Trust, Barnet, Not set
Basingstoke And North Hampshire Hospital, Basingstoke, Not set
University Hospitals Dorset NHS Foundation Trust, Christchurch, Not set
Western General Hospital, Edinburgh, Not set
Hereford County Hospital, Hereford, Not set
Forth Valley Royal Hospital, Larbert, Not set
Haywood Hospital, Staffordshire, Not set
Torbay Hospital-Devon, Torquay, Not set
New Cross Hospital, Wolverhampton, Not set
Betsi Cadwaladr University Health Board BCUHB, Wrexham, Not set
Conditions: Arthritis, Psoriatic
Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents
Recruiting
The intention of the study is to demonstrate superiority of Saruparib (AZD5305) + physician's choice NHA relative to placebo + physician's choice NHA by assessment of radiographic progression-free survival (rPFS) in participants with mCSPC.
The intention of the study is to demonstrate superiority of Saruparib (AZD5305) + physician's choice NHA relative to placebo + physician's choice NHA by assessment of radiographic progression-free survival (rPFS) in participants with mCSPC. Read Less
Gender:
MALE
Ages:
Between 18 years and 130 years
Trial Updated:
08/06/2025
Locations: Research Site, Chandler, Arizona +408 locations
Research Site, Chandler, Arizona
Research Site, Gilbert, Arizona
Research Site, Phoenix, Arizona
Research Site, Tucson, Arizona
Research Site, Little Rock, Arkansas
Research Site, Springdale, Arkansas
Research Site, Bakersfield, California
Research Site, Fountain Valley, California
Research Site, Fullerton, California
Research Site, Los Angeles, California
Research Site, Los Angeles, California
Research Site, Montebello, California
Research Site, Pasadena, California
Research Site, Pomona, California
Research Site, Sacramento, California
Research Site, San Diego, California
Research Site, San Francisco, California
Research Site, Santa Barbara, California
Research Site, Santa Monica, California
Research Site, Santa Rosa, California
Research Site, Golden, Colorado
Research Site, Lakewood, Colorado
Research Site, New Haven, Connecticut
Research Site, Norwich, Connecticut
Research Site, Newark, Delaware
Research Site, Jacksonville, Florida
Research Site, Jacksonville, Florida
Research Site, Palm Bay, Florida
Research Site, Saint Petersburg, Florida
Research Site, Tampa, Florida
Research Site, Atlanta, Georgia
Research Site, Glenview, Illinois
Research Site, Lake Barrington, Illinois
Research Site, Fort Wayne, Indiana
Research Site, Indianapolis, Indiana
Research Site, Des Moines, Iowa
Research Site, Westwood, Kansas
Research Site, Wichita, Kansas
Research Site, Lexington, Kentucky
Research Site, Louisville, Kentucky
Research Site, Shreveport, Louisiana
Research Site, Scarborough, Maine
Research Site, Baltimore, Maryland
Research Site, Baltimore, Maryland
Research Site, Bethesda, Maryland
Research Site, Towson, Maryland
Research Site, Upper Marlboro, Maryland
Research Site, Grand Rapids, Michigan
Research Site, Troy, Michigan
Research Site, Rochester, Minnesota
Research Site, Columbia, Missouri
Research Site, Billings, Montana
Research Site, Bozeman, Montana
Research Site, Las Vegas, Nevada
Research Site, Las Vegas, Nevada
Research Site, Belleville, New Jersey
Research Site, Brick, New Jersey
Research Site, Camden, New Jersey
Research Site, East Brunswick, New Jersey
Research Site, Voorhees, New Jersey
Research Site, Albuquerque, New Mexico
Research Site, Albuquerque, New Mexico
Research Site, Rio Rancho, New Mexico
Research Site, Albany, New York
Research Site, Bronx, New York
Research Site, East Syracuse, New York
Research Site, New Hyde Park, New York
Research Site, New York, New York
Research Site, New York, New York
Research Site, Shirley, New York
Research Site, Syracuse, New York
Research Site, Durham, North Carolina
Research Site, Fayetteville, North Carolina
Research Site, Cincinnati, Ohio
Research Site, Cincinnati, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Columbus, Ohio
Research Site, Independence, Ohio
Research Site, Wooster, Ohio
Research Site, Florence, Oregon
Research Site, Portland, Oregon
Research Site, Portland, Oregon
Research Site, Bala-Cynwyd, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, York, Pennsylvania
Research Site, Providence, Rhode Island
Research Site, Myrtle Beach, South Carolina
Research Site, North Charleston, South Carolina
Research Site, Sioux Falls, South Dakota
Research Site, Germantown, Tennessee
Research Site, Nashville, Tennessee
Research Site, Dallas, Texas
Research Site, Dallas, Texas
Research Site, Denton, Texas
Research Site, Flower Mound, Texas
Research Site, Grapevine, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Plano, Texas
Research Site, San Antonio, Texas
Research Site, San Antonio, Texas
Research Site, Sugar Land, Texas
Research Site, Tyler, Texas
Research Site, Wichita Falls, Texas
Research Site, Saint George, Utah
Research Site, Salt Lake City, Utah
Research Site, Salt Lake City, Utah
Research Site, Fairfax, Virginia
Research Site, Winchester, Virginia
Research Site, Spokane Valley, Washington
Research Site, Spokane, Washington
Research Site, Tacoma, Washington
Research Site, Chermside, Not set
Research Site, Darlinghurst, Not set
Research Site, Hyde Park, Not set
Research Site, Kurralta Park, Not set
Research Site, Melbourne, Not set
Research Site, Randwick, Not set
Research Site, South Brisbane, Not set
Research Site, Graz, Not set
Research Site, Innsbruck, Not set
Research Site, Krems an der Donau, Not set
Research Site, Linz, Not set
Research Site, Wien, Not set
Research Site, Wien, Not set
Research Site, Charleroi, Not set
Research Site, Gent, Not set
Research Site, Kortrijk, Not set
Research Site, Leuven, Not set
Research Site, Curitiba, Not set
Research Site, Pelotas, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Salvador, Not set
Research Site, Sao Luis, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Calgary, Alberta
Research Site, Calgary, Alberta
Research Site, Edmonton, Alberta
Research Site, Abbotsford, British Columbia
Research Site, Kelowna, British Columbia
Research Site, Vancouver, British Columbia
Research Site, Winnipeg, Manitoba
Research Site, Halifax, Nova Scotia
Research Site, Kingston, Ontario
Research Site, London, Ontario
Research Site, Mississauga, Ontario
Research Site, Newmarket, Ontario
Research Site, Ottawa, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Chicoutimi, Quebec
Research Site, Greenfield Park, Quebec
Research Site, Montreal, Quebec
Research Site, Montréal, Quebec
Research Site, Montréal, Quebec
Research Site, Saskatoon, Saskatchewan
Research Site, Quebec, Not set
Research Site, Concepcion, Not set
Research Site, La Serena, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Temuco, Not set
Research Site, Viña del Mar, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Chongqing, Not set
Research Site, Dongguan, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guilin, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Harbin, Not set
Research Site, Jiaxing, Not set
Research Site, Jinan, Not set
Research Site, Lanzhou, Not set
Research Site, Nanchang, Not set
Research Site, Nanchang, Not set
Research Site, Nanjing, Not set
Research Site, Nantong, Not set
Research Site, Ningbo, Not set
Research Site, Shandong, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shenyang, Not set
Research Site, Shenyang, Not set
Research Site, Shenyang, Not set
Research Site, Suining, Not set
Research Site, Taiyuan, Not set
Research Site, Tianjin, Not set
Research Site, Weifang, Not set
Research Site, Wenzhou, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Yantai, Not set
Research Site, Zhengzhou, Not set
Research Site, Helsinki, Not set
Research Site, Tampere, Not set
Research Site, Turku, Not set
Research Site, Angers, Not set
Research Site, Bayonne, Not set
Research Site, Bordeaux Cedex, Not set
Research Site, Caen Cedex 5, Not set
Research Site, Clermont Ferrand, Not set
Research Site, Creteil, Not set
Research Site, Lyon, Not set
Research Site, Montpellier, Not set
Research Site, Nice, Not set
Research Site, Nîmes, Not set
Research Site, Paris, Not set
Research Site, Pierre Bénite, Not set
Research Site, Poitiers Cedex, Not set
Research Site, Quimper Cedex, Not set
Research Site, Rennes Cedex 9, Not set
Research Site, Strasbourg, Not set
Research Site, Tours, Not set
Research Site, Vandoeuvre les Nancy, Not set
Research Site, Bergisch Gladbach, Not set
Research Site, Berlin, Not set
Research Site, Bonn, Not set
Research Site, Braunschweig, Not set
Research Site, Dresden, Not set
Research Site, Duisburg, Not set
Research Site, Erlangen, Not set
Research Site, Frankfurt am Main, Not set
Research Site, Frankfurt, Not set
Research Site, Freiburg, Not set
Research Site, Göttingen, Not set
Research Site, Hamburg, Not set
Research Site, Heidelberg, Not set
Research Site, Herne, Not set
Research Site, Homburg, Not set
Research Site, Köln, Not set
Research Site, Magdeburg, Not set
Research Site, Mannheim, Not set
Research Site, Marburg, Not set
Research Site, Mettmann, Not set
Research Site, München, Not set
Research Site, Münster, Not set
Research Site, Nürtingen, Not set
Research Site, Oldenburg, Not set
Research Site, Regensburg, Not set
Research Site, Stuttgart, Not set
Research Site, Trier, Not set
Research Site, Tübingen, Not set
Research Site, Ulm, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Győr, Not set
Research Site, Miskolc, Not set
Research Site, Nyíregyháza, Not set
Research Site, Szeged, Not set
Research Site, Szekszárd, Not set
Research Site, Bangalore, Not set
Research Site, Calicut, Not set
Research Site, Delhi, Not set
Research Site, Hyderabad, Not set
Research Site, JAipur, Not set
Research Site, Kanpur, Not set
Research Site, Kolkata, Not set
Research Site, Kolkata, Not set
Research Site, Mohali, Not set
Research Site, Nagpur, Not set
Research Site, New Delhi, Not set
Research Site, New Delhi, Not set
Research Site, Pune, Not set
Research Site, Surat, Not set
Research Site, Vadodara, Not set
Research Site, Varanasi, Not set
Research Site, Bari, Not set
Research Site, Genoa, Not set
Research Site, Meldola, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Napoli, Not set
Research Site, Padova, Not set
Research Site, Rome, Not set
Research Site, Rozzano, Not set
Research Site, Terni, Not set
Research Site, Trento, Not set
Research Site, Chiba-shi, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Fukuoka, Not set
Research Site, Hirakata-shi, Not set
Research Site, Hirosaki-shi, Not set
Research Site, Kanazawa-shi, Not set
Research Site, Kashihara-shi, Not set
Research Site, Kawagoe-shi, Not set
Research Site, Kisarazu-shi, Not set
Research Site, Kita-gun, Not set
Research Site, Kobe-shi, Not set
Research Site, Kumamoto-shi, Not set
Research Site, Kyoto-shi, Not set
Research Site, Maebashi-shi, Not set
Research Site, Nagano-shi, Not set
Research Site, Nagasaki-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Nagoya, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sagamihara-shi, Not set
Research Site, Sakura-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Shiwa-gun, Not set
Research Site, Suita-shi, Not set
Research Site, Tsu-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yufu-shi, Not set
Research Site, Daejeon, Not set
Research Site, Seongnam-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon, Not set
Research Site, George Town, Not set
Research Site, Johor Bahru, Not set
Research Site, Kota Kinabalu, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuching, Not set
Research Site, Amsterdam, Not set
Research Site, Hilversum, Not set
Research Site, Nijmegen, Not set
Research Site, Arequipa, Not set
Research Site, Bellavista, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Bydgoszcz, Not set
Research Site, Koszalin, Not set
Research Site, Poznań, Not set
Research Site, Rzeszów, Not set
Research Site, Szczecin, Not set
Research Site, Warszawa, Not set
Research Site, Wrocław, Not set
Research Site, Żory, Not set
Research Site, San Juan, Not set
Research Site, Barcelona, Not set
Research Site, Córdoba, Not set
Research Site, L'Hospitalet de Llobregat, Not set
Research Site, Lugo, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Sabadell, Not set
Research Site, Valencia, Not set
Research Site, Göteborg, Not set
Research Site, Malmo, Not set
Research Site, Solna, Not set
Research Site, Stockholm, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Taoyuan, Not set
Research Site, Yung Kang City, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Chiang Mai, Not set
Research Site, Khlong Luang, Not set
Research Site, Songkla, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Bornova-Izmir, Not set
Research Site, Fatih-Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Karsiyaka, Not set
Research Site, Aberdeen, Not set
Research Site, Birmingham, Not set
Research Site, Cambridge, Not set
Research Site, Glasgow, Not set
Research Site, Guildford, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Newcastle upon Tyne, Not set
Research Site, Oxford, Not set
Research Site, Plymouth, Not set
Research Site, Preston, Not set
Research Site, Swansea, Not set
Research Site, Truro, Not set
Conditions: Metastatic Castration-Sensitive Prostate Cancer
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response
Recruiting
This is a study to confirm the clinical efficacy and safety of sonelokimab compared with placebo in the treatment of adults with active psoriatic arthritis who have had a previous inadequate response or intolerance to anti-tumor necrosis factor (TNF)α therapy.
This is a study to confirm the clinical efficacy and safety of sonelokimab compared with placebo in the treatment of adults with active psoriatic arthritis who have had a previous inadequate response or intolerance to anti-tumor necrosis factor (TNF)α therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Clinical Site, Avondale, Arizona +114 locations
Clinical Site, Avondale, Arizona
Clinical Site, Chandler, Arizona
Clinical Site, Flagstaff, Arizona
Clinical Site, Mesa, Arizona
Clinical Site, Phoenix, Arizona
Clinical Site, Scottsdale, Arizona
Clinical Site, Tucson, Arizona
Clinical Site, Jonesboro, Arkansas
Clinical Site, Pomona, California
Clinical Site, San Diego, California
Clinical Site, Thousand Oaks, California
Clinical Site, Upland, California
Clinical Site, Avon Park, Florida
Clinical Site, Clearwater, Florida
Clinical Site, Hialeah, Florida
Clinical Site, Miami Gardens, Florida
Clinical Site, Tampa, Florida
Clinical Site, Zephyrhills, Florida
Clinical Site, Gainesville, Georgia
Clinical Site, Springfield, Illinois
Clinical Site, Lake Charles, Louisiana
Clinical Site, Grand Blanc, Michigan
Clinical Site, Charlotte, North Carolina
Clinical Site, Leland, North Carolina
Clinical Site, Middleburg Heights, Ohio
Clinical Site, Portland, Oregon
Clinical Site, Duncansville, Pennsylvania
Clinical Site, Jackson, Tennessee
Clinical Site, Memphis, Tennessee
Clinical Site, Murfreesboro, Tennessee
Clinical Site, Allen, Texas
Clinical Site, Austin, Texas
Clinical Site, Baytown, Texas
Clinical Site, Colleyville, Texas
Clinical Site, Houston, Texas
Clinical Site, Lubbock, Texas
Clinical Site, Plano, Texas
Clinical Site, Beckley, West Virginia
Clinical Site, Pleven, Not set
Clinical Site, Plovdiv, Not set
Clinical Site, Plovdiv, Not set
Clinical Site, Plovdiv, Not set
Clinical Site, Plovdiv, Not set
Clinical Site, Ruse, Not set
Clinical Site, Sofia, Not set
Clinical Site, Stara Zagora, Not set
Clinical Site, Calgary, Not set
Clinical Site, Trois-Rivières, Not set
Clinical Site, Waterloo, Not set
Clinical Site, Winnipeg, Not set
Clinical Site, Brno, Not set
Clinical Site, Ostrava, Not set
Clinical Site, Studénka, Not set
Clinical Site, Zlín, Not set
Clinical Site, Caluire-et-Cuire, Not set
Clinical Site, Montpellier, Not set
Clinical Site, Narbonne, Not set
Clinical Site, Nice, Not set
Clinical Site, Rouen, Not set
Clinical Site, Tours, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Tbilisi, Not set
Clinical Site, Berlin, Not set
Clinical Site, Berlin, Not set
Clinical Site, Berlin, Not set
Clinical Site, Erlangen, Not set
Clinical Site, Hamburg, Not set
Clinical Site, Herne, Not set
Clinical Site, Muenchen, Not set
Clinical Site, Munich, Not set
Clinical Site, Munich, Not set
Clinical Site, Budapest, Not set
Clinical Site, Budapest, Not set
Clinical Site, Debrecen, Not set
Clinical SIte, Gyula, Not set
Clinical Site, Hódmezővásárhely, Not set
Clinical Site, Nyíregyháza, Not set
Clinical Site, Székesfehérvár, Not set
Clinical Site, Veszprém, Not set
Clinical Site, Białystok, Not set
Clinical Site, Bydgoszcz, Not set
Clinical Site, Częstochowa, Not set
Clinical Site, Elbląg, Not set
Clinical Site, Kraków, Not set
Clinical Site, Kraków, Not set
Clinical Site, Nadarzyn, Not set
Clinical Site, Poznań, Not set
Clinical Site, Poznań, Not set
Clinical Site, Poznań, Not set
Clinical Site, Poznań, Not set
Clinical Site, Sochaczew, Not set
Clinical Site, Warsaw, Not set
Clinical Site, Warszawa, Not set
Clinical Site, Warszawa, Not set
Clinical Site, Warszawa, Not set
Clinical Site, Warszawa, Not set
Clinical Site, Wołomin, Not set
Clinical Site, Wrocław, Not set
Clinical Site, Wrocław, Not set
Clinical Site, Świdnica, Not set
Clinical Site, A Coruña, Not set
Clinical Site, Castellón De La Plana, Not set
Clinical Site, Madrid, Not set
Clinical SIte, Sabadell, Not set
Clinical Site, Santiago De Compostela, Not set
Clinical Site, Santiago De Compostela, Not set
Clinical Site, Sevilla, Not set
Clinical Site, Sevilla, Not set
Clinical Site, Sevilla, Not set
Clinical Site, Barnet, Not set
Clinical Site, Leeds, Not set
Conditions: Arthritis, Psoriatic
A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Recruiting
The primary objective of this study is to evaluate the effect of tolvaptan on the need for renal replacement therapy in pediatric subjects with autosomal recessive polycystic kidney disease (ARPKD)
The primary objective of this study is to evaluate the effect of tolvaptan on the need for renal replacement therapy in pediatric subjects with autosomal recessive polycystic kidney disease (ARPKD) Read Less
Gender:
ALL
Ages:
Between 4 weeks and 12 weeks
Trial Updated:
08/06/2025
Locations: Children's National Medical Center, Washington, District of Columbia +17 locations
Children's National Medical Center, Washington, District of Columbia
Emory University Hospital, Atlanta, Georgia
Northwestern University Feinberg School of Medicine - Ann & Robert H. Lurie Children's Hospital of Chicago - Neonatology, Chicago, Illinois
Johns Hopkins Pediatric Specialty Clinic, Baltimore, Maryland
C.S. Mott Children's Hospital, Ann Arbor, Michigan
Mayo Clinic - Rochester, Rochester, Minnesota
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Cleveland Clinic, Cleveland, Ohio
Primary Children's Hospital, Salt Lake City, Utah
Universitair Ziekenhuis Gent, Gent, Oost-Vlaanderen
UZ Leuven, Leuven, Vlaams Brabant
Universitätsklinikum Köln, Köln, Nordrhein-Westfalen
Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Mazowieckie
Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa, Białystok, Not set
Universitat de Barcelona - Hospital Sant Joan de Deu Barcelona (HSJDB), Esplugues De Llobregat, Barcelona
Hospital Universitari Vall D Hebron, Barcelona, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Great Ormond Street Hospital for Children NHS Trust, London, Not set
Conditions: Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
Recruiting
This clinical trial is designed to assess the efficacy and safety of the triplet combination of trastuzumab deruxtecan (ENHERTU, T-DXd, DS-8201a) plus a fluoropyrimidine plus pembrolizumab versus standard of care (SoC) chemotherapy plus trastuzumab plus pembrolizumab as first-line therapy in participants with unresectable, locally advanced or metastatic HER2-positive tumor PD-L1 CPS ≥1 gastric or GEJ cancer in the Main Cohort. An Exploratory Cohort will also be evaluated to assess the efficacy a... Read More
This clinical trial is designed to assess the efficacy and safety of the triplet combination of trastuzumab deruxtecan (ENHERTU, T-DXd, DS-8201a) plus a fluoropyrimidine plus pembrolizumab versus standard of care (SoC) chemotherapy plus trastuzumab plus pembrolizumab as first-line therapy in participants with unresectable, locally advanced or metastatic HER2-positive tumor PD-L1 CPS ≥1 gastric or GEJ cancer in the Main Cohort. An Exploratory Cohort will also be evaluated to assess the efficacy and safety of T-DXd plus a fluoropyrimidine versus SoC chemotherapy plus trastuzumab in participants with unresectable, locally advanced or metastatic HER2-positive tumor PD-L1 CPS \<1 gastric or GEJ cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Yale Cancer Center, New Haven, Connecticut +244 locations
Yale Cancer Center, New Haven, Connecticut
Orchard Healthcare Research Inc., Skokie, Illinois
University of Kansas Medical Center Research Institute, Inc., Kansas City, Kansas
Maryland Oncology Hematology, P.A., Silver Spring, Maryland
Tufts Medical Center, Boston, Massachusetts
University of Michigan Comprehensive Cancer Center Michigan Medicine, Ann Arbor, Michigan
Minnesota Oncology Hematology, P.A., Minneapolis, Minnesota
Montefiore Medical Center, Bronx, New York
Memorial Sloan Kettering Cancer Center - MAIN, New York, New York
Providence Portland Medical Center, Portland, Oregon
Penn State University Milton S. Hershey Medical Center, Hershey, Pennsylvania
Prisma Health Cancer Institute, ITOR, CRU, Greenville, South Carolina
Tennessee Oncology Nashville Midtown, Nashville, Tennessee
UT Southwestern Medical Center, Dallas, Texas
Texas Oncology, P.A. - Tyler, Tyler, Texas
Virginia Oncology Associates, Norfolk, Virginia
Blue Ridge Cancer Care, Roanoke, Virginia
Wenatchee Valley Hospital & Clinics, Wenatchee, Washington
CEMIC Ciudad Autonoma, Buenos Aires, Not set
Instituto Medico Especializado Alexander Fleming, Buenos Aires, Not set
Clinica Universitaria Privada Reina Fabiola, Cordoba, Not set
Centro de Investigaciones Medicas Mar del Plata, Mar del Plata, Not set
Instituto Medico de la Fundacion Estudios Clinicos, Rosario, Not set
Flinders Medical Centre, Bedford Park, Not set
Monash Medical Centre Clayton, Clayton, Not set
Townsville University Hospital, Douglas, Not set
Peter MacCallum Cancer Centre, North Melbourne, Not set
GenesisCare North Shore (Oncology), St Leonards, Not set
St John of God Subiaco Hospital, Subiaco, Not set
Wollongong Hospital, Wollongong, Not set
LKH - Universitaetsklinikum Graz, Graz, Not set
Medizinische Universität Innsbruck, Innsbruck, Not set
St. Josef Krankenhaus Wien, Vienna, Not set
Landesklinikum Wiener Neustadt, Wiener Neustadt, Not set
Medizinische Universität Wien, Wien, Not set
Institut Jules Bordet, Anderlecht, Not set
AZ Sint-Lucas, Brugge, Not set
Cliniques Universitaires Saint-Luc, Bruxelles, Not set
UZ Leuven, Leuven, Not set
Centre Hospitalier Universitaire de Liege, Liege, Not set
CHU UCL Namur, Namur, Not set
Centro de Oncologia - Unidade Brasilia - Hospital Sirio Libanes, Brasilia, Not set
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira Sao Paulo, Brazil, Not set
CEPON - Centro de Pesquisas Oncológicas de Santa Catarina, Florianópolis, Not set
Fundação Doutor Amaral Carvalho, Jaú, Not set
Liga Norte-Rio-Grandense Contra o Câncer, Natal, Not set
Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set
Hospital São Lucas da PUCRS, Porto Alegre, Not set
IMIP - Instituto de Medicina Integral Professor Fernando Figueira, Recife, Not set
Hospital das Clínicas FMRP-USP, Ribeirão Preto, Not set
INCA - Instituto Nacional de Câncer, Rio de Janeiro, Not set
Obras Sociais Irmã Dulce - Hospital Santo Antônio, Salvador, Not set
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, Sao Jose Rio Preto, Not set
Cité de la Santé de Laval, Laval, Not set
CHUS - Hôtel-Dieu, Sherbrooke, Not set
Mount Sinai Hospital, Toronto, Not set
Sunnybrook Health Sciences Centre, Toronto, Not set
University Health Network - Princess Margaret Cancer Centre, Toronto, Not set
Biocenter, Concepcion, Not set
URUMED Spa, Rancagua, Not set
Centro de Investigacion del Maule, Region Del Maule, Not set
Centro de Estudios Clinicos SAGA, Santiago, Not set
FALP - Fundación Arturo López Pérez, Santiago, Not set
Hospital Clinico Universidad de Chile, Santiago, Not set
Beijing Cancer Hospital, Beijing, Not set
Peking University Third Hospital, Beijing, Not set
Fujian Cancer Hospital, Fuzhou, Not set
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Not set
The First Affiliated Hospital of Zhejiang University school of medicine, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Anhui Provincial Cancer Hospital, Hefei City, Not set
Shandong Cancer Hospital, Jinan, Not set
Gansu Provincial Cancer Hospital, Lanzhou, Not set
Lanzhou University Second Hospital, Lanzhou, Not set
Linyi Cancer Hospital, Linyi, Not set
Meizhou People's Hospital, Meizhou, Not set
Liaoning Cancer Hospital & Institute, Shenyang, Not set
The Second Affiliated Hospital of Soochow University, Suzhou, Not set
Shanxi Provincial Cancer Hospital, Taiyuan, Not set
Shanxi Provincial People's Hospital, Taiyuan, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
The Affiliated Cancer Hospital of Xinjiang Medical university, Urumqi, Not set
Hubei Cancer Hospital, Wuhan, Not set
Wuxi 4th People's Hospital, Wuxi, Not set
The First Affiliated Hospital of Xian Jiaotong University, Xi'an, Not set
The First Affiliated Hospital of Xiamen University, Xiamen, Not set
Fudan University Shanghai Cancer Center, Xuhui District, Not set
Xuzhou Central Hospital, Xuzhou, Not set
General Hospital of Ningxia Medical University, Yinchuan, Not set
Masarykuv onkologicky ustav, Brno, Not set
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni nemocnice Olomouc, Olomouc, Not set
Fakultni nemocnice v Motole, Praha 5, Not set
Institut Sainte Catherine, Avignon Cedex 9, Not set
CHU de Brest - Hopital de la Cavale Blanche, Brest, Not set
Centre Georges François Leclerc, Dijon cedex, Not set
CHU Grenoble - Hopital Michallon, Grenoble, Not set
Centre Oscar Lambret, Lille cedex, Not set
Hopital Prive Jean Mermoz, Lyon Cedex 08, Not set
CHU Montpellier, Saint Eloi, Montpellier, Not set
Chru De Nantes Hotel-Dieu, Nantes Cedex 01, Not set
Hôpital Saint-Antoine, Paris cedex 12, Not set
Hôpital Européen Georges Pompidou, Paris Cedex 15, Not set
Institut Mutualiste Montsouris, Paris, Not set
CHU Bordeaux - Hôpital Haut-Lévêque, Pessac, Not set
CHU Poitiers - Hôpital la Milétrie, Poitiers Cedex, Not set
Institut de Cancérologie de Strasbourg Europe - ICANS, Strasbourg, Not set
Hôpital Foch, Suresnes Cedex, Not set
Hopital Rangueil, Toulouse Cedex 9, Not set
Charité Universitätsmedizin Berlin - Campus Virchow-Klinikum, Berlin, Not set
Vivantes Klinikum im Friedrichshain, Berlin, Not set
Klinikum Chemnitz gGmbH, Chemnitz, Not set
Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden, Not set
Universitaetsklinikum Frankfurt Goethe-Universitaet, Frankfurt am Main, Not set
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Universitaetsklinikum Leipzig AoeR, Leipzig, Not set
Klinikum rechts der Isar der TU Muenchen, Muenchen, Not set
Presidio Ospedaliero Garibaldi Nesima, Catania, Not set
Azienda Ospedaliera Universitaria Careggi, Florenze, Not set
IRCCS Ospedale Policlinico San Martino, Genova, Not set
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda), Milano, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Not set
Ospedale San Raffaele, Milano, Not set
A.O.U. Policlinico di Modena, Modena, Not set
Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli", Napoli, Not set
IOV - Istituto Oncologico Veneto IRCCS, Padova, Not set
Azienda Ospedaliero Universitaria Pisana, Pisa, Not set
Azienda Unità Sanitaria Locale- Ravenna, Ravenna, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Not set
Istituto Clinico Humanitas, Rozzano, Not set
IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Not set
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Not set
Azienda Ospedaliera Card. G. Panico, Tricase, Not set
Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Bunkyo-ku, Not set
National Cancer Center Hospital, Chuo-ku, Not set
Gifu University Hospital, Gifu-shi, Not set
Hiroshima City Hiroshima Citizens Hospital, Hiroshima-shi, Not set
National Cancer Center Hospital East, Kashiwa-shi, Not set
JCHO Kyushu Hospital, Kitakyushu, Not set
Kochi Health Sciences Center, Kochi-shi, Not set
Cancer Institute Hospital of JFCR, Koto-ku, Not set
NHO Shikoku Cancer Center, Matsuyama-shi, Not set
Aichi Cancer Center Hospital, Nagoya-shi, Not set
Miyagi Cancer Center, Natori-shi, Not set
Niigata Cancer Center Hospital, Niigata-shi, Not set
Osaka International Cancer Institute, Osaka-shi, Not set
Kindai University Hospital, Osakasayama-shi, Not set
Hokkaido University Hospital, Sapporo-shi, Not set
Osaka University Hospital, Suita-shi, Not set
Kanagawa Cancer Center, Yokohama-shi, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
National Cancer Center, Goyang-si, Not set
Chonnam National University Hwasun Hospital, Hwasun-gun, Not set
Gachon University Gil Medical Center, Incheon, Not set
Jeonbuk national university hospital, Jeonju-si, Not set
CHA Bundang Medical Center, CHA University, Seongnam-si, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
Antoni van Leeuwenhoek, Amsterdam, Not set
Medisch Centrum Leeuwarden, Leeuwarden, Not set
Radboudumc, Nijmegen, Not set
Erasmus Medisch Centrum, Rotterdam, Not set
ETZ Elisabeth, Tilburg, Not set
UMC Utrecht, Utrecht, Not set
Haukeland University Hospital, Bergen, Not set
Akershus universitetssykehus HF, Lørenskog, Not set
Oslo Universitetssykehus HF, Ullevål, Oslo, Not set
St. Olavs Hospital Hf, Universitetssykehuset i Trondheim, Trondheim, Not set
Beskidzkie Centrum Onkologii im.Jana Pawla II, Bielsko-Biała, Not set
Szpital Wojewodzki im. Mikolaja Kopernika, Koszalin, Not set
Wielkopolskie Centrum Onkologii, Poznan, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej Curie Panstwowy Instytut Badawczy W Warszawie, Warsaw, Not set
Warszawski Uniwersytet Medyczny, Warsaw, Not set
Hospital de Braga, Braga, Not set
Hospital da Senhora da Oliveira Guimarães, E.P.E., Guimarães, Not set
Fundação Champalimaud, Lisboa, Not set
Hospital da Luz, Lisboa, Not set
Unidade Local de Saúde de Santa Maria, E.P.E. - Hospital de Santa Maria, Lisboa, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Institutul Clinic Fundeni, Bucuresti, Not set
Institutul Oncologic "Prof. Dr. Ion Chiricuta" Cluj Napoca, Cluj Napoca, Not set
S.C Medisprof S.R.L, Cluj-Napoca, Not set
Centrul de Oncologie Sfantul Nectarie Craiova, Craiova, Not set
Institutul Regional de Oncologie Iasi, Iasi, Not set
S.C Ovidius Clinical Hospital S.R.L, Ovidiu, Not set
S.C. Sigmedical Services SRL, Suceava, Not set
ICO Badalona - Hospital Universitari Germans Trias i Pujol, Badalona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital del Mar, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital General Universitario de Elche, Elche, Not set
ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
MD Anderson Cancer Centre, Madrid, Not set
Hospital General Universitario Morales Meseguer, Murcia, Not set
Hospital Regional Universitario de Malaga, Málaga, Not set
Hospital Universitario Central de Asturias, Oviedo, Not set
Hospital Universitario de Navarra, Pamplona, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
National Cheng Kung University Hospital, Tainan, Not set
Taipei Veterans General Hospital, Taipei, Not set
National Taiwan University Hospital, Taipei, Not set
Chang Gung Memorial Hospital,Linkou, Taoyuan City, Not set
Siriraj Hospital, Bangkoknoi, Not set
Vajira Hospital, Dusit, Not set
Songklanagarind Hospital, Hatyai, Not set
Chulabhorn Hospital, Laksi, Not set
King Chulalongkorn Memorial Hospital, Pathum Wan, Not set
Medical Park Seyhan Hospital, Adana, Not set
Ankara City Hospital, Ankara, Not set
Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital, Ankara, Not set
Hacettepe University Medical Faculty, Ankara, Not set
Dicle University, Medical faculty, Diyarbakir, Not set
Ataturk University Medical Faculty, Erzurum, Not set
Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Not set
Medipol University Medical Faculty, Istanbul, Not set
İ.E.Ü. Medicalpoint İzmir Hastanesi, Izmir, Not set
Medical Park Samsun Hastanesi, Samsun, Not set
Queen Elizabeth Hospital, Birmingham, Not set
Velindre Cancer Centre, Cardiff, Not set
Ninewells Hospital, Dundee, Not set
Castle Hill Hospital, Hull, Not set
St James's University Hospital, Leeds, Not set
Altnagelvin Area Hospital, Londonderry, Not set
Sarah Cannon Research Institute UK, London, Not set
University College London Hospitals, London, Not set
The Christie Hospital, Manchester, Not set
Royal Marsden Hospital, Sutton, Not set
Hanoi Oncology hospital, Hanoi, Not set
National Cancer Hospital, Hanoi, Not set
Cho Ray Hospital, Ho Chi Minh City, Not set
HCMC Oncology Hospital, Ho Chi Minh city, Not set
HCMC University Medical Center, HoChiMinh, Not set
Conditions: Gastric Cancer, Gastroesophageal Junction Cancer
An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a Paediatric Dosing Device is Used in Preterm Babies With Retinopathy of Prematurity in the United Kingdom (UK)
Recruiting
This is an observational study in which only data from babies with retinopathy of prematurity (ROP) who are being treated with aflibercept (Eylea) in prefilled syringe (PFS) using a paediatric dosing device (PDD) are collected and studied.
ROP is a condition that affects the eyes of preterm babies. It occurs when the baby's retina, the part of the eye that senses light, does not develop normally. This may result in vision problems, including blindness, if left untreated. Preterm babies are born... Read More
This is an observational study in which only data from babies with retinopathy of prematurity (ROP) who are being treated with aflibercept (Eylea) in prefilled syringe (PFS) using a paediatric dosing device (PDD) are collected and studied.
ROP is a condition that affects the eyes of preterm babies. It occurs when the baby's retina, the part of the eye that senses light, does not develop normally. This may result in vision problems, including blindness, if left untreated. Preterm babies are born before 37 weeks of pregnancy. ROP is more likely to develop in babies who are born before 32 weeks of pregnancy or weigh less than 1.5 kilograms at birth.
Aflibercept is a drug that is injected into the eye. It works by blocking a protein called vascular endothelial growth factor (VEGF) which causes abnormal growth of blood vessels in the retina.
Aflibercept in PFS given using a PDD is approved for the treatment of babies with ROP. The prefilled syringe will be fitted with an injection needle to give aflibercept. And a PDD is a tool used to give the right amount of aflibercept to children in a safe manner.
Since there are other treatments which are commonly used for babies with ROP, the extent of use of aflibercept given using a PDD is unknown.
The main purpose of this study is to:
* find the number of preterm babies who are treated with aflibercept using a PDD in the UK
* inform whether this number is enough to perform a study to learn about the long-term safety of aflibercept given using a PDD in babies with ROP
An additional purpose of this study is to describe characteristics including age, sex, and race, and signs and symptoms of ROP observed in babies being treated with aflibercept using a PDD.
The data will come from a database called the National Neonatal Research Database. The study will cover the period from March 2024 to March 2025, if the number of babies found is enough to perform the safety study. If not, data will be collected till April 2027.
In this study only available data from preterm babies born during the study period are collected. No visits or tests are required as part of this study. Read Less
Gender:
ALL
Ages:
1 year and below
Trial Updated:
08/06/2025
Locations: Many locations, Multiple Locations, Not set
Many locations, Multiple Locations, Not set
Conditions: Retinopathy of Prematurity, Preterm Infants
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
Recruiting
EFC18419 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 study with 3 treatment groups. The purpose of the study is to evaluate the efficacy, safety and tolerability of 2 dosing regimens of itepekimab compared to placebo as add-on therapy to intranasal corticosteroids (INCS) in male and female participants with chronic rhinosinusitis with nasal polyps (CRSwNP) aged 18 years of age and older.
Study details include:
* The study duration per participant (... Read More
EFC18419 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 study with 3 treatment groups. The purpose of the study is to evaluate the efficacy, safety and tolerability of 2 dosing regimens of itepekimab compared to placebo as add-on therapy to intranasal corticosteroids (INCS) in male and female participants with chronic rhinosinusitis with nasal polyps (CRSwNP) aged 18 years of age and older.
Study details include:
* The study duration per participant (4-week screening, 52-week treatment, 20-week safety follow-up) will be up to 76 weeks. For participants transitioning to the LTS18420 study, the study duration will be 56 weeks.
* The treatment duration will be up to 52 weeks.
* The number of visits will be 9 site visits and 20 phone/home visits. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: One of a Kind CLinical Research Center- Site Number : 8400034, Napa, California +68 locations
One of a Kind CLinical Research Center- Site Number : 8400034, Napa, California
San Diego Clinical Research Center- Site Number : 8400041, San Diego, California
Advanced Research Institute - New Port Richey- Site Number : 8400014, New Port Richey, Florida
Advanced ENT & Allergy- Site Number : 8400007, Louisville, Kentucky
MedPharmics - Lafeyette- Site Number : 8400026, Lafayette, Louisiana
University of Cincinnati - Internal Medicine- Site Number : 8400022, Cincinnati, Ohio
Allergy, Asthma and Clinical Research- Site Number : 8400002, Oklahoma City, Oklahoma
Spartanburg Greer ENT & Allergy- Site Number : 8400039, Greer, South Carolina
Ear and Sinus Institute- Site Number : 8400048, Fort Worth, Texas
Investigational Site Number : 0320005, San Miguel de Tucumán, Tucumán
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0320004, Corrientes, Not set
Investigational Site Number : 0360003, Bella Vista, New South Wales
Investigational Site Number : 0360002, Brisbane, Queensland
Investigational Site Number : 0360001, Spearwood, Western Australia
Investigational Site Number : 0560004, Gesves Namur, Not set
Investigational Site Number : 1240014, Ottawa, Ontario
Investigational Site Number : 1240003, Québec City, Quebec
Investigational Site Number : 1240012, Québec City, Quebec
Investigational Site Number : 1520001, Concepción, Biobío
Investigational Site Number : 1520004, Talcahuano, Biobío
Investigational Site Number : 1520003, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1560020, Baotou, Not set
Investigational Site Number : 1560001, Beijing, Not set
Investigational Site Number : 1560004, Chengdu, Not set
Investigational Site Number : 1560025, Chongqing, Not set
Investigational Site Number : 1560019, Hangzhou, Not set
Investigational Site Number : 1560005, Hefei, Not set
Investigational Site Number : 1560002, Jinan, Not set
Investigational Site Number : 1560012, Jingzhou, Not set
Investigational Site Number : 1560021, Nanning, Not set
Investigational Site Number : 1560006, Shenyang, Not set
Investigational Site Number : 1560024, Suzhou, Not set
Investigational Site Number : 1560017, Taiyuan, Not set
Investigational Site Number : 1560023, Taiyuan, Not set
Investigational Site Number : 1560014, Wuhan, Not set
Investigational Site Number : 1560003, Yantai, Not set
Investigational Site Number : 1560009, Zibo, Not set
Investigational Site Number : 2030002, Hradec Králové, Not set
Investigational Site Number : 2030003, Pardubice, Not set
Investigational Site Number : 2030005, Pilsen, Not set
Investigational Site Number : 2030004, Prague, Not set
Investigational Site Number : 2030001, Prague, Not set
Investigational Site Number : 2500011, Bordeaux, Not set
Investigational Site Number : 2500004, Marseille, Not set
Investigational Site Number : 2500005, Montpellier, Not set
Investigational Site Number : 2500010, Poitiers, Not set
Investigational Site Number : 2500014, Pontoise, Not set
Investigational Site Number : 2760002, Leipzig, Not set
Investigational Site Number : 3480005, Budapest, Not set
Investigational Site Number : 3480001, Szeged, Not set
Investigational Site Number : 3760004, Jerusalem, Not set
Investigational Site Number : 3800001, Milan, Milano
Investigational Site Number : 3800005, Naples, Napoli
Investigational Site Number : 3800003, Catania, Not set
Investigational Site Number : 5280002, Amsterdam, Not set
Investigational Site Number : 6160002, Lodz, Lódzkie
Investigational Site Number : 6160001, Bielsko-Biala, Not set
Investigational Site Number : 6160004, Poznan, Not set
Investigational Site Number : 7240006, Barcelona, Catalunya [Cataluña]
Investigational Site Number : 7240004, L'hospitalet de Llobregat, Catalunya [Cataluña]
Investigational Site Number : 7240008, Pamplona, Navarra
Investigational Site Number : 7240012, Madrid, Not set
Investigational Site Number : 7920003, Ankara, Not set
Investigational Site Number : 7920001, Bursa, Not set
Investigational Site Number : 7920002, Istanbul, Not set
Investigational Site Number : 8260002, Wigan, Lancashire
Investigational Site Number : 8260003, Taunton, Somerset
Investigational Site Number : 8260001, London, Not set
Conditions: Chronic Rhinosinusitis With Nasal Polyps
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
Recruiting
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.
The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood... Read More
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.
The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can help improve kidney function by reducing the activity of the renin-angiotensin-aldosterone system (RAAS). The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can impair the ability of the kidneys to work properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system.
The study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB.
So, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function.
The main purpose of this study is to learn how safe the treatment is when used of finerenone in addition to an ACEI or ARB in long-term.
To see how safe the treatment is, the study team will collect information on medical problems which are also known as "treatment emergent adverse events" (TEAEs). And they will also collect levels of an electrolyte called potassium in the blood by taking blood samples, and measure blood pressure during the study.
The secondary purpose of this study is to learn how well long-term use of finerenone can reduce the amount of protein in the participants' urine and benefit kidney function when taken with standard of care.
To see how the treatment works, the study team will collect participants' urine samples to assess urinary albumin-to-creatinine ratio (UACR) and urinary protein-to-creatinine ratio (UPCR), which are important assessments for calculating the level of protein in the urine. Researchers will also collect blood samples to analyze serum creatinine and calculate estimated glomerular filtration rate (eGFR). A significant decline in eGFR indicates worsening kidney function.
The study will include participants who had previously participated in FIONA study (NCT05196035). The participants will be aged from 1 year up to 18 years.
The participants will be in the study for approximately 19 months. They will take study treatment for up to 18 months and will be follow up for 1 month. During this period, at least 12 visits are planned for patients who newly start finerenone, and at least 8 visits for patients who already received finerenone.
In the visit, the study team will:
* have their blood pressure, heart rate, temperature, height and weight measured
* have blood and urine samples taken
* have physical examinations
* have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart)
* answer questions about their medication and whether they have any adverse events, or have their parents or guardian's answer
* answer questions about how they are feeling, or have their parents or guardian's answer
* answer question about how they like the study medication, or have their parents or guardian's answer The doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.
The doctors will check the participants' health about 30 days after the participants take their last treatment. Read Less
Gender:
ALL
Ages:
Between 1 year and 18 years
Trial Updated:
08/06/2025
Locations: Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona +164 locations
Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona
Cedars-Sinai Samuel Oschin Cancer Center, Los Angeles, California
Lucille Packard Children's Hospital Stanford - Pediatric Nephrology, Palo Alto, California
Rady Children's Hospital San Diego - Cardiology, San Diego, California
Children's National Medical Center - Nephrology, Washington, District of Columbia
Memorial Transplant Institute - Pediatric Nephrology, Hollywood, Florida
Emory University Hospital/Children's Healthcare of Atlanta - Nephrology, Atlanta, Georgia
University of Iowa Health Care Medical Center - Nephrology, Iowa City, Iowa
The Charlotte R. Bloomberg Children's Center Building - Nephrology, Baltimore, Maryland
Boston Children's Hospital - Main Campus - Nephrology, Boston, Massachusetts
Children's Mercy Hospital Kansas City - Nephrology, Kansas City, Missouri
Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension, Cincinnati, Ohio
Cleveland Clinic | Pediatric Nephrology, Cleveland, Ohio
OHSU Doernbecher Children's Hospital - Neurology, Portland, Oregon
Children's Hospital of Philadelphia - Nephrology, Philadelphia, Pennsylvania
University Hospital - San Antonio - Pediatric Nephrology, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
Seattle Children's Hospital - Nephrology, Seattle, Washington
Hospital de Niños Sor María Ludovica, La Plata, Buenos Aires
Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department, Ciudad Autonoma de Buenos Aire, Ciudad Auton. De Buenos Aires
Centro de Rehabilitacion Cardiovascular | San Luis, Argentina, San Luis, Provincia De San Luis
Clinica de Nefrologia, Urologia y Enfermedades Cardiovascualares | Santa Fe, Argentina, Santa Fe, Provincia De Santa Fe
Hospital Italiano de Buenos Aires, Buenos Aires, Not set
Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Not set
Hospital General de Ninos Pedro de Elizalde | Nephrology Department, Ciudad Autonoma de Buenos Aire, Not set
Many Locations, Multiple Locations, Not set
Queensland Children's Hospital, South Brisbane, Queensland
Monash Children's Hospital, Clayton, Victoria
Royal Children's Hospital Melbourne, Parkville, Victoria
Kepler Universitätsklinikum Campus IV, Linz, Oberösterreich
Medizinische Universität Graz, Graz, Steiermark
Many Locations, Multiple Locations, Not set
Uniklinikum Salzburg - Landeskrankenhaus, Salzburg, Not set
Universitätsklinikum AKH Wien, Wien, Not set
Huderf / Ukzkf, Bruxelles - Brussel, Not set
CU Saint-Luc/UZ St-Luc, Bruxelles - Brussel, Not set
UZ Gent, Gent, Not set
UZ Gasthuisberg - Pediatric Nephrology, Leuven, Not set
CHC Montlégia - Pediatrics, Liège, Not set
Many Locations, Multiple Locations, Not set
Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Minas Gerais
Hospital Pequeno Principe, Curitiba, Parana
Hosp Clínicas Facult. Med. de Ribeirão Preto / USP, Ribeirão Preto/SP, Sao Paulo
Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas, São Paulo, Sao Paulo
Hospital Infantil Sabará - Instituto PENSI - Pesquisa e Ensino em Saúde Infantil, Sao Paulo, SP
Instituto da Crianca e do Adolescente, Sao Paulo, Not set
UMHAT Sveti Georgi, Plovdiv, Not set
SHATPD "Prof. Ivan Mitev", Sofia, Not set
MHAT prof. Stoyan Kirkovitch AD, Stara Zagora, Not set
Alberta Children's Hospital - Nephrology Clinic, Calgary, Alberta
The Hospital for Sick Children (SickKids), Toronto, Ontario
CHU Sainte-Justine, Montreal, Quebec
Many Locations, Multiple Locations, Not set
Všeobecná fakultní nemocnice v Praze, Praha 2, Not set
Fakultní nemocnice v Motole, Praha 5, Not set
Rigshospitalet - Børn og Unge, Copenhagen, Not set
Many Locations, Multiple Locations, Not set
Odense Universitetshospital - HC Andersen Børne og Ungehospital, Odense C, Not set
Aarhus Universitetshospital - Børn og Unge, Århus N, Not set
Helsinki University Hospital | Children's Hospital - Clinical Trial Unit, Nephrology Department, Helsinki, Not set
Many Locations, Multiple Locations, Not set
Tays Service Centre | Tampere University Hospital - Pediatric Early Phase Clinical Trials Unit, Tampere, Not set
Turun yliopistollinen keskussairaala, Turku, Not set
CHU bordeaux - Hopital Pellegrin, BORDEAUX cedex, Not set
CHU de Lyon - Hopital Femme Mère Enfant, Bron, Not set
Hopital Arnaud de Villeneuve CHU Montpellier, Montpellier, Not set
Many Locations, Multiple Locations, Not set
Hopital Robert Debre, Paris, Not set
CHU Strasbourg - Hopital Hautepierre, Strasbourg, Not set
Hôpital des Enfants, TOULOUSE Cedex 9, Not set
Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg
Universitätsklinikum Erlangen, Erlangen, Bayern
Medizinische Hochschule Hannover (MHH) | Zentrum Innere Medizin | Klinik fuer Kardiologie und Angiologie, Hannover, Niedersachsen
Kindernierenzentrum Bonn, Bonn, Nordrhein-Westfalen
Kindernierenzentrum Bonn, Bonn, Nordrhein-Westfalen
Universitätsklinikum Essen, Essen, Nordrhein-Westfalen
Universitaetsklinikum Muenster, Münster, Nordrhein-Westfalen
Charité / Pädiatrie, Berlin, Not set
Universitätsklinikum Hamburg Eppendorf (UKE), Hamburg, Not set
Many Locations, Multiple Locations, Not set
Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department, Athens, Not set
Children's Hospital of Athens Agia Sofia - Pediatric Nephrology Department, Athens, Not set
University General Hospital of Heraklion - Department of Paediatrics, Heraklion, Not set
Univ. General Hospital of Ioannina - Department of Paediatrics, Nephrology Unit, Ioannina, Not set
Many Locations, Multiple Locations, Not set
Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit', Thessaloniki, Not set
Semmelweis University, Budapest, Not set
Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set
Many Locations, Multiple Locations, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set
SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont, Szeged, Not set
All India Institute of Medical Sciences (AIIMS) - New Delhi, Delhi, Not set
NRS Medical college, Kolkata, Not set
Clalit Health | Soroka Medical Center - Internal Medicine Department, Beer Sheva, Not set
Wilf Children's Hospital Shaare Zedek Medical Center, Jerusalem, Not set
Many Locations, Multiple Locations, Not set
Health Corporation of Galilee Medical Center, Nahariya, Not set
Clalit Health Services Schneider Children's Medical Center, Petach Tikva, Not set
Dana-Dwek Children's Hospital, Tel Aviv, Not set
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Pediatria, Bologna, Emilia-Romagna
Ospedale Pediatrico Bambino Gesù - Nefrologia, Roma, Lazio
IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene, Genova, Liguria
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia e Dialisi Pediatrica, Trapianti di Rene, Milano, Lombardia
Azienda Ospedaliera Universitaria Meyer IRCCS - Nefrologia e Dialisi, Firenze, Not set
Many Locations, Multiple Locations, Not set
A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Nefrologia Pediatrica, Torino, Not set
Kyungpook National University Hospital, Daegu, Daegu Gwang''yeogsi
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggido
Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnamdo
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Many Locations, Multiple Locations, Not set
Korea University Guro Hospital, Seoul, Not set
Hospital of LT University of Health Sciences Kaunas Clinics, Kaunas, Not set
Klaipeda Children's Hospital, Klaipeda, Not set
Many Locations, Multiple Locations, Not set
Vilnius University Hospital Santaros Klinikos Children's Hospital Paediatrics Centre, Vilnius, Not set
Hospital Tuanku Ja'afar, Seremban, Negeri Sembilan
Sitio Alfredo Chew Wong | Aguascalientes, Mexico, Aguascalientes, Agguascalientes
Hospital Infantil de México "Dr. Federico Gómez", México D.F., Distrito Federal
Instituto Nacional de Pediatría, México, D.F., Distrito Federal
Hospital Universitario "José Eleuterio González", Monterrey, Nuevo Leon
Instituto Veracruzano en Investigación Clinica SC, Veracruz, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Many Locations, Multiple Locations, Not set
University Medical Center Utrecht, Utrecht, Not set
Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa, Bialystok, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Not set
Many Locations, Multiple Locations, Not set
Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Not set
Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu, Wroclaw, Not set
Hospital Santa Maria | Centro de Investigacao Clinica, Missing, Lisboa
Centro Clinico Academico Braga | Braga, Portugal, Braga, Not set
Hospital Pediátrico de Coimbra I ULS Coimbra, Coimbra, Not set
Centro Hospitalar Universitario do Porto | Servico de Investigacao Clinica, Porto, Not set
Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set
Hospital de Sant Joan de Déu, Barcelona, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital la Paz, Madrid, Not set
Many Locations, Multiple Locations, Not set
Hospital Universitario Regional De Malaga - Nefrologia pediatrica, Málaga, Not set
Hospital Universitario Virgen Del Rocio S.L. - Nefrologia pediatrica, Sevilla, Not set
Skåne University Hospital, Lund, Not set
Many Locations, Multiple Locations, Not set
Karolinska University Hospital, Stockholm, Not set
Uppsala University Hospital, Uppsala, Not set
Universitäts-Kinderspital UKBB, Basel, Basel-Stadt
Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud
Hopital des Enfants HUG, Geneva, Not set
Many Locations, Multiple Locations, Not set
Hacettepe Universitesi Tip Fakultesi, Ankara, Not set
Baskent Universitesi Tip Fakultesi Hastanesi, Ankara, Not set
Gazi Universitesi Tip Fakultesi, Ankara, Not set
Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital, Ankara, Not set
Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics, Istanbul, Not set
Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi, Istanbul, Not set
Marmara University Medical Faculty | Pediatric Nephrology, Istanbul, Not set
Many Locations, Multiple Locations, Not set
NHS Greater Glasgow and Clyde | Royal Hospital for Children - Glasgow Clinical Research Facility, Glasgow, Stratchclyde
Birmingham Children's Hospital, Birmingham, West Midlands
Great Ormond Street Hospital for Children, London, Not set
Manchester University NHS Foundation Trust | Royal Manchester Children's Hospital - Clinical Research Facility, Manchester, Not set
Many Locations, Multiple Locations, Not set
Nottingham University Hospitals NHS Trust | Queens Medical Centre - Childrens Clinical Research Facility, Nottingham, Not set
Conditions: Chronic Kidney Disease, Proteinuria, Children
Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib
Recruiting
Alopecia areata (AA) is a chronic relapsing autoimmune disease characterized by nonscarring hair loss affecting children, adolescents, and adults across all ages, races, and genders. AA primarily affects the scalp; however, it also can affect nails, eyelashes, eyebrows, and other hair follicles on the patient's body. The 3 main types of AA are:
* Patchy alopecia (PA), as seen in 90% of clinical diagnoses
* Alopecia totalis (AT), that affects all scalp hair
* Alopecia universalis (AU), involving... Read More
Alopecia areata (AA) is a chronic relapsing autoimmune disease characterized by nonscarring hair loss affecting children, adolescents, and adults across all ages, races, and genders. AA primarily affects the scalp; however, it also can affect nails, eyelashes, eyebrows, and other hair follicles on the patient's body. The 3 main types of AA are:
* Patchy alopecia (PA), as seen in 90% of clinical diagnoses
* Alopecia totalis (AT), that affects all scalp hair
* Alopecia universalis (AU), involving all scalp, face, and body hair Dermatologist preferences for utility and order of skin-directed therapies to treat AA vary widely, with treatment choices based on various factors such as patients' age, disease duration and severity (Meah et al., 2020).
Ritlecitinib is a bioavailable small molecule that irreversibly binds to Janus kinase-3 (JAK3) and Tyrosine kinase Expressed in the hepatocellular Carcinoma kinase family (TEC). Ritlecitinib 50 mg once daily was approved by the FDA 23 June 2023 and EMA 20 July 2023 for the treatment of severe alopecia areata in adults and adolescents 12 years of age and older. In Japan, ritlecitinib was approved on 26 June 2023 for the treatment of alopecia areata (limited to intractable cases involving widespread hair loss). Additional countries have since approved ritlecitinib. Those approvals are based on the results of the ritlecitinib pivotal phase 2b/3 study (ALLEGRO 2b/3) which examined efficacy and safety of ritlecitinib in AA patients globally.
Despite positive results from the ALLEGRO program, there is still lack of evidence on ritlecitinib patients' characteristics and clinical outcomes in routine clinical practice. The investigators will evaluate patient and disease characteristics, treatment patterns, and clinical and patient-reported outcomes among patients with AA who are receiving ritlecitinib.
The aim of this study is to measure effectiveness of ritlecitinib in a real-world setting. Ritlecitinib will be prescribed to patients according to the approved product label. Treatment will be guided by clinical judgement of the treating physician ie, study investigators, according to standard of care, independently of this study. Read Less
Gender:
ALL
Ages:
12 years and above
Trial Updated:
08/06/2025
Locations: C2 Research Center, Montgomery, Alabama +47 locations
C2 Research Center, Montgomery, Alabama
CENTER FOR DERMATOLOGY CLINICAL RESEARCH, Inc, Fremont, California
Rao Dermatology, Fresno, California
Cura Clinical Research, Oxnard, California
Southern California Clinical Research, Santa Ana, California
Dermatology of Boca, Boca Raton, Florida
Pediatric Skin Research,LLC, Coral Gables, Florida
Suncoast Skin Solutions, Jacksonville, Florida
University of Miami, Miami, Florida
Skin Research of South Florida LLC, Miami, Florida
Kindred Hair and Skin Center, Marriottsville, Maryland
Brigham & Women's Hospital/Harvard Medical School, Boston, Massachusetts
Oakland Hills Dermatology, Auburn Hills, Michigan
Michigan Dermatology Institute, Waterford, Michigan
Twin Cities Dermatology Center, Minneapolis, Minnesota
Central Missouri Dermatology Research, Columbia, Missouri
Hickory Dermatology Research Center, Hickory, North Carolina
NW Dermatology Institute, Portland, Oregon
UPMC, Pittsburgh, Pennsylvania
Goodlettsville Dermatology Research, Goodlettsville, Tennessee
Epiphany Dermatology, Southlake, Texas
Raven Clinical Reseach, Fairfax, Virginia
Raven Clinical Reseach, McLean, Virginia
Frontier Dermatology, Mill Creek, Washington
Raven Clinical Reseach, Burlington, Wisconsin
Beijing Tongren Hospital, Beijing, Not set
Peking University First Hospital, Beijing, Not set
Peking University People's Hospital, Beijing, Not set
Dermatology Hospital of Southern Medical University, Guangzhou, Not set
Huashan Hospital Affiliated to Fudan University, Shanghai, Not set
Shanghai Skin Disease Hospital, Shanghai, Not set
Ch Victor Dupouy, Argenteuil, Not set
CHU de CAEN, Caen, Not set
Rouen University Hospital, Rouen, Not set
Hospital of the University of Occupational and Environmental Health, Kitakyushu-shi, Fukuoka
Kurume University Hospital, Kurume-shi, Fukuoka
Nagomi Dermatology Clinic, Ebina, Kanagawa
Niigata University Medical & Dental Hospital, Niigata-shi, Niigata
Osaka Metropolitan University Hospital, Osaka-shi, Osaka
Hamamatsu University Hospital, Hamamatsu, Shizuoka
Juntendo University Hospital, Bunkyo-ku, Tokyo
Tokyo Medical University Hospital, Shinjuku-Ku, Tokyo
Gloucestershire Hospitals NHS Foundation Trust, Gloucester, Gloucestershire
Royal United Hospital Bath, Bath, Not set
NHS Greater Glasgow and Clyde, Glasgow, Not set
Whipps Cross (Barts Health), London, Not set
London North West University Healthcare Trust, London, Not set
Chelsea and Westminster NHS Foundation Trust, London, Not set
Conditions: Alopecia Areata
Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
Recruiting
This is a parallel, Phase 3, 2-arm study to evaluate the efficacy and long-term safety of dupilumab treatment in children 2 to \<6 years of age with uncontrolled asthma and/or recurrent severe asthmatic wheeze. The study will be conducted in 2 parts. Part A will be a 52-week, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of dupilumab in children aged 2 to \<6 years old with uncontrolled asthma and/or recurrent severe asthmatic wheeze. At the end of Part A,... Read More
This is a parallel, Phase 3, 2-arm study to evaluate the efficacy and long-term safety of dupilumab treatment in children 2 to \<6 years of age with uncontrolled asthma and/or recurrent severe asthmatic wheeze. The study will be conducted in 2 parts. Part A will be a 52-week, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of dupilumab in children aged 2 to \<6 years old with uncontrolled asthma and/or recurrent severe asthmatic wheeze. At the end of Part A, all eligible participants will be offered participation in Part B, an optional open-label extension phase.
Study details include:
Part A:
The study duration of part A will be up to 68 weeks consisting of a 4-week Screening, a 52week treatment period, and a 12-week post-treatment follow-up period. For participants who will chose to participate in Part B, the study duration will be up to 120 weeks (additional 52-week treatment period).
Part B:
For participants who will choose to participate in Part B, the study duration will be up to 120 weeks (Part A \[4-week Screening and a 52-week treatment period\] plus additional 52-week treatment period and a 12-week post-treatment follow-up period). Read Less
Gender:
ALL
Ages:
Between 2 years and 5 years
Trial Updated:
08/06/2025
Locations: Phoenix Children's Hospital- Site Number : 8400001, Phoenix, Arizona +73 locations
Phoenix Children's Hospital- Site Number : 8400001, Phoenix, Arizona
Allervie Clinical Research - Destin- Site Number : 8400016, Destin, Florida
EMDA Clinical Research- Site Number : 8400026, Miami, Florida
Ann & Robert H. Lurie Children's Hospital of Chicago- Site Number : 8400011, Chicago, Illinois
Allergy and Asthma Specialist- Site Number : 8400002, Owensboro, Kentucky
Mayo Clinic Hospital Rochester- Site Number : 8400008, Rochester, Minnesota
UBMD Pediatrics- Site Number : 8400013, Buffalo, New York
Boston Children's Health Physicians - Hawthorne- Site Number : 8400010, Hawthorne, New York
UNC Children's Hospital- Site Number : 8400005, Chapel Hill, North Carolina
Cincinnati Children's Hospital Medical Center- Site Number : 8400004, Cincinnati, Ohio
University Hospitals Cleveland Medical Center- Site Number : 8400015, Cleveland, Ohio
Vanderbilt University Medical Center- Site Number : 8400024, Nashville, Tennessee
South Texas Medical Research Institute - TTS Research- Site Number : 8400022, Boerne, Texas
Investigational Site Number : 0320008, Buenos Aires, Ciudad De Buenos Aires
Investigational Site Number : 0320005, Rosario, Santa Fe
Investigational Site Number : 0320002, Buenos Aires, Not set
Investigational Site Number : 0320003, Buenos Aires, Not set
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0320009, Corrientes, Not set
Investigational Site Number : 0320006, Córdoba, Not set
Investigational Site Number : 0320004, Mendoza, Not set
Inst de Medicina Integral Professor Fernando Figueira- Site Number : 0760006, Recife, Pernambuco
Hospital Ernesto Dornelles Site Number : 0760004, Porto Alegre, Rio Grande Do Sul
Hospital Ernesto Dornelles- Site Number : 0760004, Porto Alegre, Rio Grande Do Sul
Clinica de Alergia Martti Antila- Site Number : 0760002, Sorocaba, São Paulo
Hospital das Clinicas FMUSP- Site Number : 0760001, São Paulo, Not set
Investigational Site Number : 1240002, Edmonton, Alberta
Investigational Site Number : 1240001, Vancouver, British Columbia
Investigational Site Number : 1240008, Burlington, Ontario
Investigational Site Number : 1240007, Hamilton, Ontario
Investigational Site Number : 1240006, Montreal, Quebec
Investigational Site Number : 1240005, Sherbrooke, Quebec
Investigational Site Number : 2030001, Prague, Not set
Investigational Site Number : 2500005, Créteil, Not set
Investigational Site Number : 2500001, Lille, Not set
Investigational Site Number : 2500004, Nice, Not set
Investigational Site Number : 2500002, Paris, Not set
Investigational Site Number : 2500003, Paris, Not set
Investigational Site Number : 2760002, Düsseldorf, Not set
Investigational Site Number : 2760004, Frankfurt, Not set
Investigational Site Number : 2760001, Leipzig, Not set
Investigational Site Number : 3000001, Athens, Not set
Investigational Site Number : 3480005, Budapest, Not set
Investigational Site Number : 3480004, Debrecen, Not set
Investigational Site Number : 3480001, Szigetvár, Not set
Investigational Site Number : 3480002, Székesfehérvár, Not set
Buzzi Children's Hospital - Investigational Site Number : 3800003, Milan, Lombardia
Investigational Site Number : 3800005, Padua, Padova
Ospedale Pediatrico Bambino Gesù - Investigational Site Number : 3800002, Rome, Roma
AOU Luigi Vanvitelli - Investigational Site Number : 3800004, Naples, Not set
Fondazione IRCCS Policlinico San Matteo - Investigational Site Number : 3800001, Pavia, Not set
Investigational Site Number : 3920002, Fukuoka, Not set
Investigational Site Number : 3920001, Fukuoka, Not set
Investigational Site Number : 3920006, Isehara, Not set
Investigational Site Number : 3920004, TSU, Not set
Investigational Site Number : 3920003, Ureshino, Not set
Investigational Site Number : 4840001, San Juan Del Río, Querétaro
Investigational Site Number : 4840004, Durango, Not set
Investigational Site Number : 4840002, Veracruz, Not set
Investigational Site Number : 5280001, Rotterdam, Not set
Investigational Site Number : 6160001, Lodz, Lódzkie
Investigational Site Number : 6160004, Tarnow, Not set
Investigational Site Number : 6160003, Warsaw, Not set
Investigational Site Number : 7240001, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240002, Sabadell, Castilla Y León
Investigational Site Number : 7240007, Esplugues de Llobregat, Catalunya [Cataluña]
Investigational Site Number : 7240006, Jerez de La Frontera, Cádiz
Investigational Site Number : 7240003, Santiago de Compostela, Galicia [Galicia]
Investigational Site Number : 7240005, Madrid, Madrid, Comunidad De
Investigational Site Number : 7240004, Valencia, Not set
Investigational Site Number : 8260002, Leicester, Leicestershire
Investigational Site Number : 8260003, Birmingham, Not set
Investigational Site Number : 8260004, Bradford, Not set
Investigational Site Number : 8260001, London, Not set
Conditions: Wheezing, Asthma
A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
Recruiting
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 \< 50%.
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 \< 50%. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Research Site, Prescott, Arizona +297 locations
Research Site, Prescott, Arizona
Research Site, Hot Springs National Park, Arkansas
Research Site, Springdale, Arkansas
Research Site, Long Beach, California
Research Site, Palo Alto, California
Research Site, Lone Tree, Colorado
Research Site, Newark, Delaware
Research Site, Fort Myers, Florida
Research Site, Gainesville, Florida
Research Site, Orlando, Florida
Research Site, Saint Petersburg, Florida
Research Site, Tallahassee, Florida
Research Site, West Palm Beach, Florida
Research Site, Fort Wayne, Indiana
Research Site, Indianapolis, Indiana
Research Site, Des Moines, Iowa
Research Site, Lexington, Kentucky
Research Site, Louisville, Kentucky
Research Site, Baton Rouge, Louisiana
Research Site, Marrero, Louisiana
Research Site, Annapolis, Maryland
Research Site, Baltimore, Maryland
Research Site, Baltimore, Maryland
Research Site, Silver Spring, Maryland
Research Site, Towson, Maryland
Research Site, Detroit, Michigan
Research Site, Hattiesburg, Mississippi
Research Site, Grand Island, Nebraska
Research Site, Lincoln, Nebraska
Research Site, Omaha, Nebraska
Research Site, Belleville, New Jersey
Research Site, Albany, New York
Research Site, East Syracuse, New York
Research Site, Fresh Meadows, New York
Research Site, Westbury, New York
Research Site, Cleveland, Ohio
Research Site, Columbus, Ohio
Research Site, Columbus, Ohio
Research Site, Dayton, Ohio
Research Site, Portland, Oregon
Research Site, Horsham, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, Memphis, Tennessee
Research Site, Nashville, Tennessee
Research Site, Nashville, Tennessee
Research Site, Houston, Texas
Research Site, Irving, Texas
Research Site, Lancaster, Texas
Research Site, Fairfax, Virginia
Research Site, Henrico, Virginia
Research Site, Tacoma, Washington
Research Site, Buenos Aires, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Ciudad de Córdoba, Not set
Research Site, Córdoba, Not set
Research Site, La Plata, Not set
Research Site, La Plata, Not set
Research Site, Rosario, Not set
Research Site, Clayton, Not set
Research Site, Fitzroy, Not set
Research Site, Heidelberg, Not set
Research Site, South Brisbane, Not set
Research Site, Sydney, Not set
Research Site, Linz, Not set
Research Site, Wels, Not set
Research Site, Aalst, Not set
Research Site, Antwerpen, Not set
Research Site, Gent, Not set
Research Site, Barretos, Not set
Research Site, Curitiba, Not set
Research Site, Florianópolis, Not set
Research Site, Fortaleza, Not set
Research Site, Natal, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio De Janeiro, Not set
Research Site, Santa Cruz do Sul, Not set
Research Site, Sao Paulo, Not set
Research Site, Calgary, Alberta
Research Site, Edmonton, Alberta
Research Site, Winnipeg, Manitoba
Research Site, Halifax, Nova Scotia
Research Site, Barrie, Ontario
Research Site, Oshawa, Ontario
Research Site, Toronto, Ontario
Research Site, Levis, Quebec
Research Site, Trois-Rivières, Quebec
Research Site, Chicoutimi, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Bengbu, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Fuzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hefei, Not set
Research Site, Hefei, Not set
Research Site, Lanzhou, Not set
Research Site, Linhai, Not set
Research Site, Linyi, Not set
Research Site, Nanchang, Not set
Research Site, Nanchang, Not set
Research Site, Nanjing, Not set
Research Site, Nanning, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shenzhen, Not set
Research Site, Taiyuan, Not set
Research Site, Tianjin, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Yangzhou, Not set
Research Site, Zhengzhou, Not set
Research Site, Olomouc, Not set
Research Site, Ostrava - Vitkovice, Not set
Research Site, Praha, Not set
Research Site, Praha, Not set
Research Site, Angers, Not set
Research Site, Avignon, Not set
Research Site, Bayonne, Not set
Research Site, Bordeaux, Not set
Research Site, Caen, Not set
Research Site, Lille, Not set
Research Site, Limoges, Not set
Research Site, Marseille, Not set
Research Site, Montpellier, Not set
Research Site, Paris Cedex 5, Not set
Research Site, Quimper, Not set
Research Site, Reims, Not set
Research Site, Saint-Malo, Not set
Research Site, Strasbourg Cedex, Not set
Research Site, Suresnes, Not set
Research Site, Toulon Naval, Not set
Research Site, Berlin-Zehlendorf, Not set
Research Site, Bonn, Not set
Research Site, Bonn, Not set
Research Site, Braunschweig, Not set
Research Site, Dresden, Not set
Research Site, Essen, Not set
Research Site, Freiburg, Not set
Research Site, Gauting, Not set
Research Site, Georgsmarienhuette, Not set
Research Site, Gütersloh, Not set
Research Site, Halle, Not set
Research Site, Hamburg, Not set
Research Site, Heidelberg, Not set
Research Site, Immenhausen, Not set
Research Site, Koblenz, Not set
Research Site, Ludwigsburg, Not set
Research Site, Nürnberg, Not set
Research Site, Tuebingen, Not set
Research Site, Velbert, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Deszk, Not set
Research Site, Gyöngyös - Mátraháza, Not set
Research Site, Gyöngyös, Not set
Research Site, Győr, Not set
Research Site, Kecskemét, Not set
Research Site, Pécs, Not set
Research Site, Szekszárd, Not set
Research Site, Székesfehérvár, Not set
Research Site, Törökbálint, Not set
Research Site, Bengaluru, Not set
Research Site, Delhi, Not set
Research Site, Hyderabad, Not set
Research Site, Kolkata, Not set
Research Site, Kolkata, Not set
Research Site, Mysuru, Not set
Research Site, Nagpur, Not set
Research Site, Nashik, Not set
Research Site, New Delhi, Not set
Research Site, Varanasi, Not set
Research Site, Bari, Not set
Research Site, Bergamo, Not set
Research Site, Catanzaro, Not set
Research Site, Milano, Not set
Research Site, Padova, Not set
Research Site, Parma, Not set
Research Site, Pavia, Not set
Research Site, Ravenna, Not set
Research Site, Roma, Not set
Research Site, Roma, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Kashiwa, Not set
Research Site, Kawasaki-shi, Not set
Research Site, Koto-ku, Not set
Research Site, Matsuyama-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sagamihara-shi, Not set
Research Site, Sapporo-Shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Ube-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Cheongju-si, Not set
Research Site, Daegu, Not set
Research Site, Incheon, Not set
Research Site, Jinju-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon-si, Not set
Research Site, Suwon, Not set
Research Site, Ciudad de México, Not set
Research Site, Ciudad de México, Not set
Research Site, Culiacan, Not set
Research Site, Guadalajara, Not set
Research Site, Guadalajara, Not set
Research Site, Mexico City, Not set
Research Site, Monterrey, Not set
Research Site, Naucalpan, Not set
Research Site, Amsterdam, Not set
Research Site, Groningen, Not set
Research Site, Nieuwegein, Not set
Research Site, Tilburg, Not set
Research Site, Lublin, Not set
Research Site, Olsztyn, Not set
Research Site, Poznań, Not set
Research Site, Przemysl, Not set
Research Site, Radom, Not set
Research Site, Rzeszów, Not set
Research Site, Szklarska Poręba, Not set
Research Site, Tomaszów Mazowiecki, Not set
Research Site, Toruń, Not set
Research Site, Warszawa, Not set
Research Site, Warszawa, Not set
Research Site, Łódź, Not set
Research Site, Banska Bystrica, Not set
Research Site, Bratislava, Not set
Research Site, Bratislava, Not set
Research Site, Kosice, Not set
Research Site, Trnava, Not set
Research Site, Amanzimtoti, Not set
Research Site, Bloemfontein, Not set
Research Site, George, Not set
Research Site, Johannesburg, Not set
Research Site, Johannesburg, Not set
Research Site, Pietermaritzburg, Not set
Research Site, Pretoria, Not set
Research Site, Rondebosch, Not set
Research Site, Soweto, Not set
Research Site, Alicante, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Bilbao (Vizcaya), Not set
Research Site, Madrid, Not set
Research Site, Málaga, Not set
Research Site, Palma, Not set
Research Site, Hsinchu, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, New Taipei, Not set
Research Site, Tainan City, Not set
Research Site, Tainan, Not set
Research Site, Taipei City, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taoyuan, Not set
Research Site, Yunlin, Not set
Research Site, Lampang, Not set
Research Site, Muang, Not set
Research Site, Songkhla, Not set
Research Site, Ankara, Not set
Research Site, Antalya, Not set
Research Site, Diyarbakir, Not set
Research Site, Fatih-Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, İzmir, Not set
Research Site, Pamukkale, Not set
Research Site, Çankaya, Not set
Research Site, Birmingham, Not set
Research Site, Blackpool, Not set
Research Site, Bury St Edmunds, Not set
Research Site, Colchester, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Truro, Not set
Conditions: Metastatic Non-small Cell Lung Cancer
A Study to Evaluate the Safety, Tolerability, and Effects on Blood and Urine Markers of Single Ascending Dose of GSK4771261 in Healthy Participants and Participants With Autosomal Dominant Polycystic Kidney Disease
Recruiting
This is a study where a new drug, called GSK4771261 is being tested. Neither the study doctors, study staff or participants will be aware of what treatment is being given. Part A is testing the new study treatment on healthy people. This is to see if it's safe, what it does to the body, and how the body's defense system responds to it. Part B is similar, but the study treatment will be given to people who have a kidney disease called autosomal dominant polycystic kidney disease (ADPKD).
This is a study where a new drug, called GSK4771261 is being tested. Neither the study doctors, study staff or participants will be aware of what treatment is being given. Part A is testing the new study treatment on healthy people. This is to see if it's safe, what it does to the body, and how the body's defense system responds to it. Part B is similar, but the study treatment will be given to people who have a kidney disease called autosomal dominant polycystic kidney disease (ADPKD). Read Less
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
08/06/2025
Locations: GSK Investigational Site, Bruxelles, Not set +13 locations
GSK Investigational Site, Bruxelles, Not set
GSK Investigational Site, Leuven, Not set
GSK Investigational Site, London, Ontario
GSK Investigational Site, MontrEal, Quebec
GSK Investigational Site, Brest, Not set
GSK Investigational Site, Koeln, Nordrhein- Westfalen
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Cambridge, Not set
GSK Investigational Site, Exeter, Not set
GSK Investigational Site, London, Not set
GSK Investigational Site, Newcastle Upon Tyne, Not set
Conditions: Kidney Disease
445 - 456 of 3097