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All Clinical Trials in United Kingdom
A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
Recruiting
This is a parallel, Phase 3, 2-arm study to evaluate the efficacy and long-term safety of dupilumab treatment in children 2 to \<6 years of age with uncontrolled asthma and/or recurrent severe asthmatic wheeze. The study will be conducted in 2 parts. Part A will be a 52-week, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of dupilumab in children aged 2 to \<6 years old with uncontrolled asthma and/or recurrent severe asthmatic wheeze. At the end of Part A,... Read More
This is a parallel, Phase 3, 2-arm study to evaluate the efficacy and long-term safety of dupilumab treatment in children 2 to \<6 years of age with uncontrolled asthma and/or recurrent severe asthmatic wheeze. The study will be conducted in 2 parts. Part A will be a 52-week, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of dupilumab in children aged 2 to \<6 years old with uncontrolled asthma and/or recurrent severe asthmatic wheeze. At the end of Part A, all eligible participants will be offered participation in Part B, an optional open-label extension phase.
Study details include:
Part A:
The study duration of part A will be up to 68 weeks consisting of a 4-week Screening, a 52week treatment period, and a 12-week post-treatment follow-up period. For participants who will chose to participate in Part B, the study duration will be up to 120 weeks (additional 52-week treatment period).
Part B:
For participants who will choose to participate in Part B, the study duration will be up to 120 weeks (Part A \[4-week Screening and a 52-week treatment period\] plus additional 52-week treatment period and a 12-week post-treatment follow-up period). Read Less
Gender:
ALL
Ages:
Between 2 years and 5 years
Trial Updated:
08/06/2025
Locations: Phoenix Children's Hospital- Site Number : 8400001, Phoenix, Arizona +73 locations
Phoenix Children's Hospital- Site Number : 8400001, Phoenix, Arizona
Allervie Clinical Research - Destin- Site Number : 8400016, Destin, Florida
EMDA Clinical Research- Site Number : 8400026, Miami, Florida
Ann & Robert H. Lurie Children's Hospital of Chicago- Site Number : 8400011, Chicago, Illinois
Allergy and Asthma Specialist- Site Number : 8400002, Owensboro, Kentucky
Mayo Clinic Hospital Rochester- Site Number : 8400008, Rochester, Minnesota
UBMD Pediatrics- Site Number : 8400013, Buffalo, New York
Boston Children's Health Physicians - Hawthorne- Site Number : 8400010, Hawthorne, New York
UNC Children's Hospital- Site Number : 8400005, Chapel Hill, North Carolina
Cincinnati Children's Hospital Medical Center- Site Number : 8400004, Cincinnati, Ohio
University Hospitals Cleveland Medical Center- Site Number : 8400015, Cleveland, Ohio
Vanderbilt University Medical Center- Site Number : 8400024, Nashville, Tennessee
South Texas Medical Research Institute - TTS Research- Site Number : 8400022, Boerne, Texas
Investigational Site Number : 0320008, Buenos Aires, Ciudad De Buenos Aires
Investigational Site Number : 0320005, Rosario, Santa Fe
Investigational Site Number : 0320002, Buenos Aires, Not set
Investigational Site Number : 0320003, Buenos Aires, Not set
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0320009, Corrientes, Not set
Investigational Site Number : 0320006, Córdoba, Not set
Investigational Site Number : 0320004, Mendoza, Not set
Inst de Medicina Integral Professor Fernando Figueira- Site Number : 0760006, Recife, Pernambuco
Hospital Ernesto Dornelles Site Number : 0760004, Porto Alegre, Rio Grande Do Sul
Hospital Ernesto Dornelles- Site Number : 0760004, Porto Alegre, Rio Grande Do Sul
Clinica de Alergia Martti Antila- Site Number : 0760002, Sorocaba, São Paulo
Hospital das Clinicas FMUSP- Site Number : 0760001, São Paulo, Not set
Investigational Site Number : 1240002, Edmonton, Alberta
Investigational Site Number : 1240001, Vancouver, British Columbia
Investigational Site Number : 1240008, Burlington, Ontario
Investigational Site Number : 1240007, Hamilton, Ontario
Investigational Site Number : 1240006, Montreal, Quebec
Investigational Site Number : 1240005, Sherbrooke, Quebec
Investigational Site Number : 2030001, Prague, Not set
Investigational Site Number : 2500005, Créteil, Not set
Investigational Site Number : 2500001, Lille, Not set
Investigational Site Number : 2500004, Nice, Not set
Investigational Site Number : 2500002, Paris, Not set
Investigational Site Number : 2500003, Paris, Not set
Investigational Site Number : 2760002, Düsseldorf, Not set
Investigational Site Number : 2760004, Frankfurt, Not set
Investigational Site Number : 2760001, Leipzig, Not set
Investigational Site Number : 3000001, Athens, Not set
Investigational Site Number : 3480005, Budapest, Not set
Investigational Site Number : 3480004, Debrecen, Not set
Investigational Site Number : 3480001, Szigetvár, Not set
Investigational Site Number : 3480002, Székesfehérvár, Not set
Buzzi Children's Hospital - Investigational Site Number : 3800003, Milan, Lombardia
Investigational Site Number : 3800005, Padua, Padova
Ospedale Pediatrico Bambino Gesù - Investigational Site Number : 3800002, Rome, Roma
AOU Luigi Vanvitelli - Investigational Site Number : 3800004, Naples, Not set
Fondazione IRCCS Policlinico San Matteo - Investigational Site Number : 3800001, Pavia, Not set
Investigational Site Number : 3920002, Fukuoka, Not set
Investigational Site Number : 3920001, Fukuoka, Not set
Investigational Site Number : 3920006, Isehara, Not set
Investigational Site Number : 3920004, TSU, Not set
Investigational Site Number : 3920003, Ureshino, Not set
Investigational Site Number : 4840001, San Juan Del Río, Querétaro
Investigational Site Number : 4840004, Durango, Not set
Investigational Site Number : 4840002, Veracruz, Not set
Investigational Site Number : 5280001, Rotterdam, Not set
Investigational Site Number : 6160001, Lodz, Lódzkie
Investigational Site Number : 6160004, Tarnow, Not set
Investigational Site Number : 6160003, Warsaw, Not set
Investigational Site Number : 7240001, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240002, Sabadell, Castilla Y León
Investigational Site Number : 7240007, Esplugues de Llobregat, Catalunya [Cataluña]
Investigational Site Number : 7240006, Jerez de La Frontera, Cádiz
Investigational Site Number : 7240003, Santiago de Compostela, Galicia [Galicia]
Investigational Site Number : 7240005, Madrid, Madrid, Comunidad De
Investigational Site Number : 7240004, Valencia, Not set
Investigational Site Number : 8260002, Leicester, Leicestershire
Investigational Site Number : 8260003, Birmingham, Not set
Investigational Site Number : 8260004, Bradford, Not set
Investigational Site Number : 8260001, London, Not set
Conditions: Wheezing, Asthma
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
Recruiting
This study was designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lung cancer (SCLC).
This study was designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lung cancer (SCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Highlands Oncology Group, Springdale, Arkansas +229 locations
Highlands Oncology Group, Springdale, Arkansas
Clinical Research Providence Medical Foundation, Fullerton, California
UCLA Hematology-Oncology, Los Angeles, California
UCSF Mission Bay Mission Hall, San Francisco, California
University of Miami Hospital and Clinics Sylvester Comprehensive Cancer Center, Miami, Florida
AdventHealth Orlando, Cancer Institute, Orlando, Florida
H. Lee Moffitt Cancer Center and Research Institute, Inc, Tampa, Florida
Rush University Medical Center, Chicago, Illinois
Baptist Health Lexington, Lexington, Kentucky
University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
John Hopkins School of Medicine, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
Henry Ford Health System, Detroit, Michigan
Mercy Clinic Oncology and Hematology Sindelar Cancer Center, Saint Louis, Missouri
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Astera Cancer Care, East Brunswick, New Jersey
Meridian Health Systems, Neptune, New Jersey
Montefiore Medical Center Prime, Bronx, New York
Clinical Research Alliance, Inc, Lake Success, New York
New York University Cancer Center - Laura and Isaac, New York, New York
Cleveland Clinic Mercy Hospital, Canton, Ohio
Oncology/Hematology Care Clinical Trials, Llc, Cincinnati, Ohio
Providence Portland Medical Center, Portland, Oregon
THE WEST CLINIC, PLLC dba West Cancer Center, Germantown, Tennessee
Houston Methodist Cancer Center, Houston, Texas
University of Texas Md Anderson Cancer Center, Houston, Texas
Texas Oncology, P.A. - Tyler, Tyler, Texas
Medical College of Wisconsin, Milwaukee, Wisconsin
Ballarat Base Hospital, Ballarat, Not set
Flinders Medical Centre (Fmc), Bedford Park, Not set
Chris O Brien Lifehouse, Camperdown, Not set
Sunshine Hospital, St Albans, Not set
St John of God Subiaco Hospital, Subiaco, Not set
Townsville Cancer Centre, Townsville, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Landeskrankenhaus Feldkirch, Feldkirch, Not set
Landesklinikum Krems, Krems, Not set
Kepler University Hospital, Linz, Not set
Wiener Gesundheitsverband Klinik Penzing, Wien, Not set
Klinik Floridsdorf, Wien, Not set
Cliniques Universitaires Saint-Luc, Bruxelles, Not set
UZA, Edegem, Not set
Jessa Ziekenhuis Hospital, Hasselt, Not set
Centre Hospitalier Universitaire de Liege, Liege, Not set
AZ DELTA, Roeselare, Not set
Chu Ucl Namur, Yvoir, Not set
Departmento de Pesquisa Clinica- Hospital de Amor de Barretos, Barretos, Not set
Cepon - Centro de Pesquisas Oncolăgicas de Santa Catarina, FlorianĂłpolis, Not set
Clínica de Neoplasias Litoral, ItajaĂ-, Not set
Hospital São Lucas Da Pucrs, Porto Alegre, Not set
Cepho Centro de Estudos E Pesquisas de Hematologia E Oncologia, Santo Andre, Not set
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, Sao Jose Rio Preto, Not set
ICESP Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, São Paulo, Not set
Hospital Benefică Ncia Portuguesa de Să O Paulo, São Paulo, Not set
Hospital Alemão Oswaldo Cruz, São Paulo, Not set
Hospital Sirio-Libanes, SĂŁo Paulo, Not set
A. C. Camargo Cancer Center, SĂŁo Paulo, Not set
William Osler Health System - Brampton Civic Hospital, Brampton, Not set
Cross Cancer Institute, Edmonton, Not set
Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec City, Not set
Princess Margaret Cancer Center, Toronto, Not set
Cancercare Manitoba, Winnipeg, Not set
China-Japan Friendship Hospital, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
Beijing Chest Hospital,Capital Medical University, Beijing, Not set
Jilin Province Tumor Hospital, Changchun, Not set
Hunan Cancer Hospital, Changsha, Not set
West China Hospital, Sichuan University, Chengdu Shi, Not set
Sichuan Cancer Hospital, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Harbin Medical University Cancer Hospital, Haerbin, Not set
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
The Second Affiliated Hospital of Nanchang University, Jiangxi, Not set
Shandong Cancer Hospital, Jinan, Not set
Linyi Cancer Hospital, Linyi, Not set
The Second Peoples Hospital of Neijiang, Neijiang, Not set
Yantai Yuhuangding Hospital, Shandong, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Liaoning Cancer Hospital & Institute, Shenyang, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, Not set
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Not set
Huazhong University of Science and Technology - Tongji Medical College - Tongji Hospital Tjh, Wuhan, Not set
Hubei Cancer Hospital, Wuhan, Not set
The First Affiliated Hospital of Xiân Jiaotong University, Xi'an, Not set
Xiangyang Central Hospital, Xiangyang, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Krajska Nemocnice Liberec A.S., Liberec, Not set
Fakultni Nemocnice Olomouc, Olomouc, Not set
Fakultni Thomayerova Nemocnice, Praha 4, Not set
Institut Sainte Catherine, Avignon, Not set
Chu Bordeaux, Bordeaux cedex, Not set
Centre Hospitalier Intercommunal de Cră Teil, Creteil Cedex, Not set
Institut Cœur Poumon CHU de Lille, Lille, Not set
Chu Limoges - Hopital Du Cluzeau, Limoges cedex, Not set
Centre Léon Bérard, Lyon, Not set
Assistance Publique-Hă"Pitaux de Marseille, Marseille, Not set
Hopital Arnaud de Villeneuve, Montpellier cedex 05, Not set
Institut Régional Du Cancer de Montpellier, Montpellier, Not set
Ch de Mulhouse - Hă"Pital Emile Muller, Mulhouse Cedex, Not set
Institut Curie - Site de Paris, Paris Cedex 05, Not set
Hopital Tenon, Paris, Not set
Chu Rennes - Hopital Pontchaillou, Rennes cedex 09, Not set
Chu Nantes - Hă"Pital Guillaume Et Renă Laă<Nnec, Saint Herblain, Not set
Institut de Cancerologie de La Loire, Saint-Priest-En-Jarez, Not set
Hă"Pital Foch, Suresnes Cedex, Not set
Institut Gustave Roussy, Villejuif, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Helios Klinikum Erfurt, Erfurt, Not set
Universtitaetsklinikum Essen, Essen, Not set
Universitaetsklinikum Frankfurt Goethe-Universitaet, Frankfurt am Main, Not set
Krankenhaus Nordwest Gmbh, Frankfurt, Not set
Asklepios Fachkliniken Muenchen-Gauting, Gauting, Not set
Srh Wald-Klinikum Gera Gmbh, Gera, Not set
UNIVERSITATSKLINIKUM GIeBEN UND MARBURG GMBH, Giessen, Not set
Asklepios Klinik Harburg, Hamburg, Not set
Lki Lungenfachklinik Immenhausen, Immenhausen/Krs. Kassel, Not set
Staedtisches Krankenhaus Kiel, Kiel, Not set
Johannes Wesling Klinikum Minden, Minden, Not set
Pius-Hospital Oldenburg, Oldenburg, Not set
Universitaetsklinikum Ulm, Ulm, Not set
'Henry Dynant' Hospital Center, Athens, Not set
General Hospital of Athens of Chest Diseases 'Sotiria', Athens, Not set
General Hospital of Athens Alexandra, Athens, Not set
University General Hospital "Attikon", Chaidari, Not set
University General Hospital of Larissa, Larisa, Not set
General Hospital of Patra Agios Andreas, Patra, Not set
Metropolitan Hospital, Piraeus, Not set
St Luke'S Hospital, Thessaloniki, Not set
Semmelweis Egyetem, Budapest, Not set
Orszagos Koranyi Pulmonologiai Intezet, Budapest, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz, Gyor, Not set
Bács-Kiskun Vármegyei Oktatókórház, Kecskemet, Not set
Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari, Bari, Not set
Humanitas Gavazzeni, Bergamo, Not set
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia (Presidio Spedali Civili), Brescia, Not set
Azienda Ospedaliera Universitaria Policlinico - Vittorio Emanuele (Presidio Gaspare Rodolico), Catania, Not set
Azienda Ospedaliero Universitaria Renato Dulbecco, Catanzaro, Not set
Istituto Nazionale Per La Ricerca Sul Cancro Di Genova, Genova, Not set
Ospedale San Raffaele, Milano, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Not set
IEO Istituto Europeo di Oncologia, Milano, Not set
Azienda Socio Sanitaria Territoriale Di Monza (Presidio San Gerardo), Monza, Not set
Azienda Ospedaliera Universitaria- Universită Degli Studi Della Campania  Luigi Vanvitelliâ, Napoli, Not set
Azienda Ospedaliero Universitaria Di Parma, Parma, Not set
Azienda Ospedaliera Di Perugia Ospedale S. Maria Della Misericordia, Perugia, Not set
Istituto Nazionale Tumori Regina Elena Irccs, Roma, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Centro Ricerche Cliniche Di Verona S.R.L., Verona, Not set
National Cancer Center Hospital, Chuo-ku, Not set
Kyushu University Hospital, Fukuoka, Not set
Kansai Medical University Hospital, Hirakata-shi, Not set
National Cancer Center Hospital East, Kashiwa, Not set
The Cancer Institute Hospital of Jfcr, Koto-ku, Not set
National Hospital Organization Shikoku Cancer Center, Matsuyama, Not set
Okayama University Hospital, Okayama, Not set
Kindai University Hospital, Osaka-Sayama, Not set
Kitasato University Hospital, Sagamihara, Not set
National Hospital Organization Hokkaido Cancer Center, Sapporo, Not set
Shizuoka Cancer Center, Sunto-gun, Not set
Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Chungbuk National University Hospital, Cheongju, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
The Catholic University of Korea, St. Vincent'S Hospital, Suwon-si, Not set
Ajou University Hospital, Suwon, Not set
Netherlands Cancer Institute, Amsterdam, Not set
Maastricht University Medical Center, Maastricht, Not set
Jeroen Bosch Ziekenhuis, s Hertogenbosch, Not set
Etz Elisabeth, Tilburg, Not set
Centrum Onkologii Im. Prof. F. Lukaszczyka W Bydgoszczy, Bydgoszcz, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Not set
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy, Otwock, Not set
Szpital Specjalistyczny W Prabutach, Prabuty, Not set
Provita Prolife, Tomaszow Mazowiecki, Not set
Centro Hospitalar E Universită Rio de Coimbra E.P.E., Coimbra, Not set
Hospital Da Senhora Da Oliveira Guimară Es, Guimarães, Not set
Hospital Da Luz, Lisboa, Not set
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital Pulido Valente, Lisboa, Not set
Centro Hospitalar Do Porto, E.P.E. - Hospital de Santo António, Porto, Not set
Institutul Oncologic 'Prof. Dr. Ion Chiricuta' Cluj Napoca, Cluj Napoca, Not set
S.C Radiotherapy Center Cluj S.R.L, Comuna Floresti, Not set
S.C Centrul de Oncologie Sfantul Nectarie Craiova, Craiova, Not set
S.C. Sigmedical Services Srl, Suceava, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital de La Santa Creu I Sant Pau, Barcelona, Not set
Hospital Universitari Vall D'Hebron, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Universitario Ciudad de Jaen, Jaen, Not set
Hospital de Especialidades de Jerez de La Frontera, Jerez De Frontera, Not set
Ico L'Hospitalet - Hospital Duran I Reynals, L'Hospitalet de Llobregat, Not set
Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario Ramon Y Cajal, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Regional Universitario de Malaga, Malaga, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Hospital Universitario Nuestra Señora de Valme, Sevilla, Not set
Inselspital - Universitaetsspital Bern, Bern, Not set
Kantonsspital St. Gallen, St. Gallen, Not set
Hfr Fribourg/Kantonsspital Fribourg, Villars-sur-Glâne, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Not set
China Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospitalx, Tainan, Not set
National Taiwan University Cancer Centre, Taipei, Not set
Taipei Medical University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Memorial Hospital, Taoyuan County, Not set
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Dicle University, Medical Faculty, Diyarbakir, Not set
Goztepe Prof Dr Suleyman Yalcin City Hospital, Istanbul, Not set
Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty, Istanbul, Not set
Medipol University Medical Faculty, Istanbul, Not set
Izmir Medicalpark Hospital, Izmir, Not set
Birmingham Heartlands Hospital, Birmingham, Not set
St James'S University Hospital, Leeds, Not set
Churchill Hospital, Oxford, Not set
Conditions: Small Cell Lung Cancer
PARASTOP - Paracetamol With Strong Opioids
Recruiting
Current guidelines recommend all people with cancer-related pain should be prescribed paracetamol, even those receiving high doses of strong pain killers (opioids) such as morphine. Although this has been shown in studies to be beneficial in other conditions, for instance dental work and after surgery, it has not been shown to further improve pain in people with cancer-related pain. Taking tablets is burdensome to patients and the study aims to determine whether the inconvenience of taking eight... Read More
Current guidelines recommend all people with cancer-related pain should be prescribed paracetamol, even those receiving high doses of strong pain killers (opioids) such as morphine. Although this has been shown in studies to be beneficial in other conditions, for instance dental work and after surgery, it has not been shown to further improve pain in people with cancer-related pain. Taking tablets is burdensome to patients and the study aims to determine whether the inconvenience of taking eight extra paracetamol tablets per day can be justified.
The study plans to show whether or not pain control is changed (non-inferior) when stopping paracetamol compared to continued use of paracetamol in people already taking strong pain killers for cancer-related pain. Voluntary participants who are taking a combination of paracetamol and a strong opioid are recruited to the study. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Not set +14 locations
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Not set
Østfold Hospital Trust, Sarpsborg, Grålum
Vestre Viken Hospital Trust, Drammen, Not set
Førde Hospital Trust, Førde, Not set
Sørlandet Hospital Trust, Kristiansand, Not set
Akershus University Hospital, Lørenskog, Not set
OsloUH, Oslo, Not set
Telemark Hospital Trust, Skien, Not set
Stavanger University Hospital, Stavanger, Not set
Universitetssykehuset Nord-Norge, Tromsø, Not set
St. Olavs Hospital, Trondheim, Not set
Vestfold Hospital trust, Tønsberg, Not set
Helse Møre og Romsdal, Ålesund, Not set
Makere University Hospital, Kampala, Not set
Edinburgh Cancer Research, Edinburgh, Not set
Conditions: Cancer Pain, Cancer
Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib
Recruiting
Alopecia areata (AA) is a chronic relapsing autoimmune disease characterized by nonscarring hair loss affecting children, adolescents, and adults across all ages, races, and genders. AA primarily affects the scalp; however, it also can affect nails, eyelashes, eyebrows, and other hair follicles on the patient's body. The 3 main types of AA are:
* Patchy alopecia (PA), as seen in 90% of clinical diagnoses
* Alopecia totalis (AT), that affects all scalp hair
* Alopecia universalis (AU), involving... Read More
Alopecia areata (AA) is a chronic relapsing autoimmune disease characterized by nonscarring hair loss affecting children, adolescents, and adults across all ages, races, and genders. AA primarily affects the scalp; however, it also can affect nails, eyelashes, eyebrows, and other hair follicles on the patient's body. The 3 main types of AA are:
* Patchy alopecia (PA), as seen in 90% of clinical diagnoses
* Alopecia totalis (AT), that affects all scalp hair
* Alopecia universalis (AU), involving all scalp, face, and body hair Dermatologist preferences for utility and order of skin-directed therapies to treat AA vary widely, with treatment choices based on various factors such as patients' age, disease duration and severity (Meah et al., 2020).
Ritlecitinib is a bioavailable small molecule that irreversibly binds to Janus kinase-3 (JAK3) and Tyrosine kinase Expressed in the hepatocellular Carcinoma kinase family (TEC). Ritlecitinib 50 mg once daily was approved by the FDA 23 June 2023 and EMA 20 July 2023 for the treatment of severe alopecia areata in adults and adolescents 12 years of age and older. In Japan, ritlecitinib was approved on 26 June 2023 for the treatment of alopecia areata (limited to intractable cases involving widespread hair loss). Additional countries have since approved ritlecitinib. Those approvals are based on the results of the ritlecitinib pivotal phase 2b/3 study (ALLEGRO 2b/3) which examined efficacy and safety of ritlecitinib in AA patients globally.
Despite positive results from the ALLEGRO program, there is still lack of evidence on ritlecitinib patients' characteristics and clinical outcomes in routine clinical practice. The investigators will evaluate patient and disease characteristics, treatment patterns, and clinical and patient-reported outcomes among patients with AA who are receiving ritlecitinib.
The aim of this study is to measure effectiveness of ritlecitinib in a real-world setting. Ritlecitinib will be prescribed to patients according to the approved product label. Treatment will be guided by clinical judgement of the treating physician ie, study investigators, according to standard of care, independently of this study. Read Less
Gender:
ALL
Ages:
12 years and above
Trial Updated:
08/06/2025
Locations: C2 Research Center, Montgomery, Alabama +47 locations
C2 Research Center, Montgomery, Alabama
CENTER FOR DERMATOLOGY CLINICAL RESEARCH, Inc, Fremont, California
Rao Dermatology, Fresno, California
Cura Clinical Research, Oxnard, California
Southern California Clinical Research, Santa Ana, California
Dermatology of Boca, Boca Raton, Florida
Pediatric Skin Research,LLC, Coral Gables, Florida
Suncoast Skin Solutions, Jacksonville, Florida
University of Miami, Miami, Florida
Skin Research of South Florida LLC, Miami, Florida
Kindred Hair and Skin Center, Marriottsville, Maryland
Brigham & Women's Hospital/Harvard Medical School, Boston, Massachusetts
Oakland Hills Dermatology, Auburn Hills, Michigan
Michigan Dermatology Institute, Waterford, Michigan
Twin Cities Dermatology Center, Minneapolis, Minnesota
Central Missouri Dermatology Research, Columbia, Missouri
Hickory Dermatology Research Center, Hickory, North Carolina
NW Dermatology Institute, Portland, Oregon
UPMC, Pittsburgh, Pennsylvania
Goodlettsville Dermatology Research, Goodlettsville, Tennessee
Epiphany Dermatology, Southlake, Texas
Raven Clinical Reseach, Fairfax, Virginia
Raven Clinical Reseach, McLean, Virginia
Frontier Dermatology, Mill Creek, Washington
Raven Clinical Reseach, Burlington, Wisconsin
Beijing Tongren Hospital, Beijing, Not set
Peking University First Hospital, Beijing, Not set
Peking University People's Hospital, Beijing, Not set
Dermatology Hospital of Southern Medical University, Guangzhou, Not set
Huashan Hospital Affiliated to Fudan University, Shanghai, Not set
Shanghai Skin Disease Hospital, Shanghai, Not set
Ch Victor Dupouy, Argenteuil, Not set
CHU de CAEN, Caen, Not set
Rouen University Hospital, Rouen, Not set
Hospital of the University of Occupational and Environmental Health, Kitakyushu-shi, Fukuoka
Kurume University Hospital, Kurume-shi, Fukuoka
Nagomi Dermatology Clinic, Ebina, Kanagawa
Niigata University Medical & Dental Hospital, Niigata-shi, Niigata
Osaka Metropolitan University Hospital, Osaka-shi, Osaka
Hamamatsu University Hospital, Hamamatsu, Shizuoka
Juntendo University Hospital, Bunkyo-ku, Tokyo
Tokyo Medical University Hospital, Shinjuku-Ku, Tokyo
Gloucestershire Hospitals NHS Foundation Trust, Gloucester, Gloucestershire
Royal United Hospital Bath, Bath, Not set
NHS Greater Glasgow and Clyde, Glasgow, Not set
Whipps Cross (Barts Health), London, Not set
London North West University Healthcare Trust, London, Not set
Chelsea and Westminster NHS Foundation Trust, London, Not set
Conditions: Alopecia Areata
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
Recruiting
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors. It will study sigvotatug vedotin to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether sigvotatug vedotin works to treat solid tumors.
The study will have four parts.
* Part A of the study will find out how much sigvotatug vedoti... Read More
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors. It will study sigvotatug vedotin to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether sigvotatug vedotin works to treat solid tumors.
The study will have four parts.
* Part A of the study will find out how much sigvotatug vedotin should be given to participants.
* Part B will use the dose found in Part A to find out how safe sigvotatug vedotin is and if it works to treat solid tumors.
* Part C of the study will find out how safe sigvotatug vedotin is in combination with these other drugs.
* Part D will include people who have not received treatment. This part of the study will find out how safe sigvotatug vedotin is in combination with these other drugs and if these combinations work to treat solid tumors.
* In Parts C and D, participants will receive sigvotatug vedotin with either:
* Pembrolizumab or,
* Pembrolizumab and carboplatin, or
* Pembrolizumab and cisplatin. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Alaska Oncology and Hematology, Anchorage, Alaska +130 locations
Alaska Oncology and Hematology, Anchorage, Alaska
Highlands Oncology Group, Fayetteville, Arkansas
Highlands Oncology Group, Rogers, Arkansas
Highlands Oncology Group, Springdale, Arkansas
Providence Medical Foundation, Fullerton, California
Providence St. Jude Medical Center Virginia K Crosson and Infusion Center, Fullerton, California
Cancer and Blood Research Center, LLC, Los Alamitos, California
Cancer and Blood Specialty Clinic, Los Alamitos, California
Ronald Reagan UCLA Medical Center, Los Angeles, California
UCLA Department of Medicine-Hematology/Oncology, Los Angeles, California
UCLA Department of Medicine - Hematology & Oncology, Santa Monica, California
Cancer AND Blood Specialty Clinic, Torrance, California
Memorial Cancer Institute, Hollywood, Florida
Memorial Healthcare System, Hollywood, Florida
Florida cancer Specialists, Orlando, Florida
Memorial Hospital West, Pembroke Pines, Florida
Ingalls Family Care Center, Calumet City, Illinois
UChicago Medicine - River East, Chicago, Illinois
University of Chicago Medical Center, Chicago, Illinois
UChicago Medicine at Ingalls - Flossmoor, Flossmoor, Illinois
UChicago Medicine Ingalls Memorial, Harvey, Illinois
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox, Illinois
The University of Chicago Medicine Center for Advanced Care Orland Park, Orland Park, Illinois
Southern Illinois University - Simmons Cancer Institute, Springfield, Illinois
Springfield Clinic Radiology - 800 Building, Springfield, Illinois
Springfield Clinic, Springfield, Illinois
Springfield Clinic Radiology - Main Campus, Springfield, Illinois
UChicago Medicine at Ingalls - Tinley Park, Tinley Park, Illinois
UChicago Medicine - Northwest Indiana, Crown Point, Indiana
Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne, Indiana
Community Health Network, Inc, Indianapolis, Indiana
Community Health Network, Indianapolis, Indiana
Community Health Network Investigational Drug Services, Indianapolis, Indiana
Community Health Network, Indianapolis, Indiana
The University of Kansas Cancer Center, Investigational Drug Services, Fairway, Kansas
The University of Kansas Clinical Research Center, Fairway, Kansas
The University of Kansas Hospital, Kansas City, Kansas
The University of Kansas Medical Center Medical Office Building, Kansas City, Kansas
University of Kansas Hospital Cambridge North Tower A, Kansas City, Kansas
The University of Kansas Cancer Center - Indian Creek Campus, Overland Park, Kansas
The University of Kansas Cancer Center - Westwood, Westwood, Kansas
University of Kansas Cancer Center, Westwood, Kansas
Beth Israel Deaconess Medical Center,East Campus Research Pharmacy, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute - Chestnut Hill, Newton, Massachusetts
Allina Health Cancer Institute - Mercy Hospital, Coon Rapids, Minnesota
Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis, Minnesota
Allina Health Cancer Institute, Saint Paul, Minnesota
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Babylon, New York
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Bronx, New York
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, New Hyde Park, New York
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, New York, New York
Columbia University Irving Medical Center, New York, New York
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Patchogue, New York
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Port Jefferson Station, New York
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Riverhead, New York
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, Shirley, New York
University Hospitals Cleveland Medical Center, Cleveland, Ohio
OU Health University of Oklahoma Medical Center, Oklahoma City, Oklahoma
Stephenson Cancer Center (chemo location), Oklahoma City, Oklahoma
University of Oklahoma Health Science Center, Oklahoma City, Oklahoma
Providence Cancer Institute Franz Clinic, Portland, Oregon
Providence Oncology and Hematology Care Clinic - Westside, Portland, Oregon
Providence St. Vincent Medical Center- Investigational Drug Services, Portland, Oregon
Providence St. Vincent Medical Center, Portland, Oregon
Sanford Cancer Center, Sioux Falls, South Dakota
Sanford USD Medical Center, Sioux Falls, South Dakota
Oncology Consultants, PA, Houston, Texas
Oncology Consultants, PA., Houston, Texas
The University of Texas M.D. Anderson Cancer Center, Houston, Texas
US Oncology Investigational Product Center (IPC), Irving, Texas
Houston Medical Imaging, Pearland, Texas
South Texas Accelerated Research Therapeutics, LLC, San Antonio, Texas
UT Health East Texas HOPE Cancer Center, Tyler, Texas
UT Health East Texas Hope Cancer Center, Tyler, Texas
Tranquil Clinical Research, Webster, Texas
Virginia Cancer Specialists, Fairfax, Virginia
Swedish Cancer Institute Edmonds Campus, Edmonds, Washington
American Oncology Network Vista Oncology Division-West office, Olympia, Washington
American Oncology Network Vista Oncology Division-East office, Olympia, Washington
Swedish Cancer Institute, Seattle, Washington
Swedish Medical Center, Seattle, Washington
Northwest Medical Specialities, PLLC, Tacoma, Washington
Center Hospitalier Universitaire d' Angers, Angers, Not set
Institut de Cancérologie de Lorraine, Moselle, Not set
Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne, Nice Cedex 2, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
lnstitut Gustave Roussy, Departement d'lnnovation Therapeutique et d'Essais Precoces (DITEP), Villejuif Cedex, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
National Cancer Center, Goyang-si, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, Seoul, Not set
Seoul National University Boramae Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Farmacia Ensayos Hospital HM Universitario Sanchinarro, Madrid, Agrigento
Elche General University Hospital, Elche, Alicante
Equipo de Farmacia Oncológica- Ensayos Clínicos Servicio de Farmacia Hospital Universitario Marqués, Santander, Cantabria
Hospital HM Nou Delfos, Barcelona, Catalonia
NEXT Oncology Barcelona - IOB - Hospital Quironsalud Barcelona, Barcelona, OTH
Farmacia Ensayos clínicos, Unidad START Barcelona, Barcelona, Not set
Hospital HM Nou Delfos - START Barcelona, Barcelona, Not set
Hospital Quiron Salud Barcelona, Barcelona, Not set
Area general-Planta Baixa | Unitat d'investigacio en terapia Molecular del Cancer "la Caixa", Barcelona, Not set
Hospital Vall d'Hebron, Barcelona, Not set
Elche General University Hospital, Elche, Not set
Hospital Universitario De Jerez, Jerez de la Frontera, Not set
UGC Farmacia Ensayos clinicos - Hospital Universitario de Jerez, Jerez de la Frontera, Not set
Hospital Universitario de Jerez, Jerez de la Frontera, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Servicio de Radiologia Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario 12 Octubre, Madrid, Not set
Hospital HM Sanchinarro, START-Madrid-CIOCC, Madrid, Not set
Quironsalud Malaga, Malaga, Not set
Kantonsspital Graubunden, Chur, Not set
University Hospital Lausanne CHUV, Lausanne, Not set
CHUV - Service de pharmacie BH-04, Essais cliniques, Lausanne, Not set
Kaohsiung Medical University Hospital, Kaohsiung City, R.o.c.
Taipei Veterans General Hospital., Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
The Royal Marsden Hospital (Surrey), Sutton, Queensland
Royal Marsden Hospital, Sutton, Surrey
Queen Elizabeth Hospital, Birmingham, Not set
University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set
The Royal Marsden NHS Foundation Trust, London, Not set
Sarah Cannon Research Institute, London, Not set
Diagnostic centre, London, Not set
The Harley Street Clinic, London, Not set
Radiology, London, Not set
Conditions: Cutaneous Squamous Cell Cancer, Exocrine Pancreatic Adenocarcinoma, Carcinoma, Non-small Cell Lung, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Ovarian Neoplasms, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Stomach Neoplasms, HER2 Negative Breast Neoplasms, Esophageal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
Recruiting
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab alone in participants with advanced or metastatic non-small cell lung cancer (NSCLC) of non-squamous histology.
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab alone in participants with advanced or metastatic non-small cell lung cancer (NSCLC) of non-squamous histology. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Ironwood Cancer and Research Center, Chandler, Arizona +241 locations
Ironwood Cancer and Research Center, Chandler, Arizona
UCLA HemOnc - Clinical Research Unit, Los Angeles, California
Compassionate Cancer Care Medical Group, Riverside, California
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California
Ridley-Tree Cancer Center, Santa Barbara, California
PIH Health Whittier Hospital, Whittier, California
The Oncology Institute of Hope and Innovation, Whittier, California
Uch-Mhs D/B/A Memorial Health System, Colorado Springs, Colorado
Johns Hopkins University, Baltimore, Maryland
American Oncology Partners of Maryland, Bethesda, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
DFCI - Steward St. Elizabeth's Medical Center, Boston, Massachusetts
Dana Farber Cancer Institute - Foxborough, Foxboro, Massachusetts
Dana Farber Cancer Institute - Milford Medical Center, Milford, Massachusetts
DFCI - South Shore Hospital, South Weymouth, Massachusetts
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Astera Cancer Care, East Brunswick, New Jersey
Regional Cancer Care Associates LLC, Freehold, New Jersey
Cooperman Barnabas Medical Center, New Brunswick, New Jersey
The Valley Hospital, Paramus, New Jersey
Montefiore Medical Center, Bronx, New York
Arizona Oncology NAHOA, Irving, Texas
Cancer Care Center of Brevard, Irving, Texas
Illinois Cancer Specialists, Irving, Texas
Maryland Oncology Hematology, Irving, Texas
Southern Cancer Center, Irving, Texas
Texas Oncology - Northeast Texas, Irving, Texas
Texas Oncology Gulf Coast, Irving, Texas
Texas Oncology McAllen, Irving, Texas
Woodlands Medical, Irving, Texas
University of Texas Health Science Center San Antonio, San Antonio, Texas
Utah Cancer Specialists, Salt Lake City, Utah
Providence Regional Cancer System, Lacey, Washington
VA Puget Sound Health Care System - VAPSHCS, Seattle, Washington
Medical College of Wisconsin, Milwaukee, Wisconsin
Fundacion CENIT para la investigación en Neurociencias, Ciudad Autonoma de Buenos Aire, Not set
Hospital Privado de la Comunidad, Mar del Plata, Not set
Centro de Investigación Pergamino S. A., Pergamino, Not set
Instituto de Oncología de Rosario, Rosario, Not set
Sanatorio Parque, Rosario, Not set
Sanatorio Británico de Rosario, Rosario, Not set
CER SAN JUAN - Centro Polivalente de Asistencia e Investigación Clínica, San Juan, Not set
Clinica Viedma SA, Viedma, Not set
Austin Hospital, Heidelberg, Victoria
Peninsula and South Eastern Haematology and Oncology Group, Mount Waverley, Victoria
Chris Obrien Lifehouse, Camperdown, Not set
The Queen Elizabeth Hospital, Woodville South, Not set
Klinikum Klagenfurt am Wörthersee Abteilung für Lungenkrankheiten, Klagenfurt, Not set
Karl-Landsteiner Institute for Lung Research and Pulmonary Oncology c/o Klinik Floridsdorf, Vienna, Not set
Onze-Lieve-Vrouwziekenhuis Olvz - Campus Aalst, Aalst, Not set
Grand Hopital de Charleroi - Hopital Saint Joseph, Charleroi, Not set
Az Maria Middelares - Campus Maria Middelares, Gent, Not set
AZ Nikolaas, Sint-Niklaas, Not set
Instituto de Pesquisas em Saúde - IPS, Caxias Do Sul, Not set
Hospital Erasto Gaertner, Curitiba, Not set
Oncosite - Centro de Pesquisa Clinica Oncologia, Ijui, Not set
Clínica de Neoplasias Litoral, Itajaí, Not set
UPCO - Unidade de Pesquisas Clínicas em Oncologia - Clinica Lacks, Pelotas, Not set
Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set
Instituto Nacional de Câncer - INCA, Rio De Janeiro, Not set
Centro de Estudos e Pesquisa de Hematologia e Oncologia - CEPHO, Santo Andre, Not set
Instituto de Ensino e Pesquisas Sao Lucas, Sao Paulo, Not set
Instituto do Cancer Brasil - Unidade Taubate, Taubate, Not set
McGill University Health Centre, Montreal, Not set
Santa Cabrini Hospital, Montréal, Not set
Centro de Estudios Clínicos SAGA, Santiago de Chile, Metropolitana
Oncovida, Santiago, Not set
Fundación Arturo Pérez López, Santiago, Not set
Orlandi Oncología, Santiago, Not set
Centro de Investigaciones Clinicas Vina Del Mar, Vina Del Mar, Not set
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi
Henan Cancer Hospital, Zhengzhou, Henan
Jilin Cancer Hospital, Changchun, Jilin
Sichuan Cancer Hospital, Chengdu, Sichuan
Peking University Peoples Hospital, Beijing, Not set
Peking University Cancer Hospital, Beijing, Not set
Cangzhou People's Hospital, Cangzhou, Not set
Hunan Cancer Hospital, Changsha, Not set
Army Medical Center of PLA, Chongqing, Not set
Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Not set
Haikou People's Hospital, Haikou, Not set
The First Affiliated Hospital of College of Medicine Zhejiang University, Hanghzou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Inner Mongolia Medical University- the Affiliated Hospital, Hohhot, Not set
Jiamusi Tumor and Tuberculosis Hospital, Jiamusi, Not set
Yunnan Cancer Hospital, Kunming, Not set
Linyi Cancer Hospital, Linyi, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Jiangsu Province Hospital, Nanjing, Not set
The Second People's Hospital of Neijiang, Neijiang, Not set
Fudan University Shanghai Cancer Center, Shanghai Shi, Not set
Shanghai Pulmonary Hospital, Shanghai, Not set
Liaoning Cancer Hospital& Institute, Shenyang City, Not set
The First Hospital of China Medical University, Shenyang, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
Union Hospital Affiliated With Tongji Medical College Huazhong University of Science and Technology, Wuhan, Not set
Hubei Cancer Hospital, Wuhan, Not set
The First Affiliate Hospitalof Xi'An Jiaotong University, Xi'an, Not set
The First Affiliated Hospital Xiamen University, Xiamen, Not set
Xiangyang Central Hospital- 5 Lumen Avenue, Xiangyang, Not set
Xinjiang Tumor Hospital, Ürümqi, Not set
Sainte-Catherine Institut du Cancer Avignon-Provence (ICAP), Avignon, Not set
Bordeaux University Hospital - Hopital Saint Andre, Bordeaux, Not set
Institut Bergonie, Bordeaux, Not set
Centre Hospitalier Universitaire de Lille, Lille, Not set
Centre Leon Berard, Lyon, Not set
Institut Paoli-Calmettes, Marseille Cedex 9, Not set
APHM - Hopital Nord, Marseille, Not set
Centre Hospitalier Universitaire de Montpellier, Montpellier, Not set
Hopital prive du Confluent, Nantes Cedex 2, Not set
CHU de Nantes, Nantes, Not set
AP-HP - Hopital Tenon, Paris, Not set
CHU de Poitier Pole Regional de Cancerologie, Poitiers, Not set
Hopital FOCH, Suresnes, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Klinikum Esslingen GmbH, Esslingen, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Klinikum der Universitaet Muenchen, Muenchen, Not set
Metropolitan Hospital, Neo Faliro, Athens
Sotiria General Hosptial of Chest Diseases, Athens, Not set
University Hospital of Ioannina Uhi, Ioannina, Not set
Metropolitan Hospital, Neo Faliro, Not set
Metropolitan Hospital, Piraeus, Not set
Bioclinic Thessaloniki, Thessaloniki, Not set
St. Luke's Hospital, Thessaloniki, Not set
Prince of Wales Hospital / The Chinese University of Hong Kong 99999, Hong Kong, Not set
Queen Elizabeth Hospital, Hong Kong, Not set
Queen Mary Hospital, Pok Fu Lam, Not set
Semmelweis University Department of Pulmonology, Budapest, Not set
Veszprem Megyei Tudogyogyintezet Farkasgyepu, Farkasgyepű, Not set
Bkmk Hospital, KecskemĂŠt, Not set
Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz, Szekesfehervar, Not set
Pulmonology Hospital Torokbalint, Torokbalint, Not set
IRCCS Istituto Oncologico Giovanni Paolo II, Bari, Not set
UOC Oncologia, Chieti, Not set
Ospedale San Luca, Lucca, Not set
IRCCS Ospedale San Raffaele, Milano, Not set
Irccs Istituto Europeo Di Oncologia, Milano, Not set
Azienda Ospedaliera dei Colli, Naples, Not set
A.O. Perugia Santa Maria della Misericordia, Perugia, Not set
Policlinico Tor Vergata, Rome, Not set
Ifo Regina Elena, Rome, Not set
Asst Sette Laghi Ospedale di Circolo e Fondazione Macchi, Varese, Not set
Aomori Prefectural Central Hospital, Aomori-shi, Aomori
National Cancer Center Hospital East, Kashiwa-shi, Chiba
NHO Shikoku Cancer Center, Matsuyama-shi, Ehime
National Hospital Organization Kyushu Cancer Center, Fukuoka-shi, Fukuoka
Kyushu University Hospital, Fukuoka-shi, Fukuoka
Kurume University Hospital, Kurume-shi, Fukuoka
Kanazawa University Hospital, Kanazawa-shi, Ishikawa
Kanagawa Cancer Center, Yokohama-shi, Kanagawa
Saiseikai Kumamoto Hospital, Kumamoto-shi, Kumamoto
Matsusaka Municipal Hospital, Matsusaka-shi, Mie
Sendai Kousei Hospital, Sendai-shi, Miyagi
Niigata Cancer Center Hospital, Niigata-shi, Niigata
Kansai Medical University Hospital, Hirakata-shi, Osaka
Osaka International Cancer Institute, Osaka-shi, Osaka
NHO Kinki-Chuo Chest Medical Center, Sakai-shi, Osaka
Saitama Cancer Center, Ina-machi, Saitama
Dokkyo Medical University Hospital, Shimotsuga-gun, Tochigi
Juntendo University Hospital, Bunkyo-ku, Tokyo
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyō-Ku, Tokyo
The Cancer Institute Hospital of JFCR, Koto-ku, Toyko
Toho University Omori Medical Center, Ota-ku, Toyko
NHO Iwakuni Clinical Center, Iwakuni-shi, Yamaguchi
Yamaguchi-Ube Medical Center, Ube-shi, Yamaguchi
Yamanashi Prefectural Central Hospital, Kofu-shi, Not set
University Hospital Kyoto Prefectural University of Medicine, Kyoto-shi, Not set
Osaka Toneyama Medical Center, Osaka, Not set
Teine Keijinkai Hospital, Sapporo, Not set
Chungbuk National University Hospital, Cheongju-si, Chungbuk
Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do
Gyeongsang National University Hospital, Jinju-si, Gyeongsangnam-do
Kyungpook National University Chilgok Hospital, Daegu, Not set
National Cancer Center, Goyang-si, Not set
Samsung Medical Center, Seoul, Not set
The Catholic Univ. of Korea, Seoul St. Mary'S Hospital, Seoul, Not set
Asan Medical Center, Songpa-gu, Not set
Cryptex Investigacion Clinica Sa de Cv, Cuauhtémoc, Not set
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Not set
Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey, Not set
Centro de Investigacion Clinica de Oaxaca (CICLO), Oaxaca de Juarez, Not set
Oncologico Potosino, San Luis Potosí, Not set
Rijnstate Ziekenhuis, Arnhem, Gelderland
Amsterdam Umc, Location Vumc, Amsterdam, Not set
Leiden University Medical Center, Leiden, Not set
Jeroen Bosch Ziekenhuis J BZ Hieronymus Bosch Hospital, s-Hertogenbosch, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Iodzkie
Szpitale Pomorskie Sp. z o.o., Gdynia, Pomorskie
Dom Lekarski SA, Szczecin, Zachodniopomorskie
II Klinika Chorob Pluc I Gruzlicy, Bialystok, Not set
MS Pneumed Janusz Milanowski, Katarzyna Szmygin-Milanowska Sp. Jawna, Lublin, Not set
Centro Clinico Champalimau, Lisboa, Not set
Centro Hospitalar e Universitário do Porto, Porto, Not set
Hospital CUF Porto, Porto, Not set
Instituto Portuguas de Oncologia do Porto Francisco Gentil, Porto, Not set
Centro Hospitalar Universitário de São João, Porto, Not set
Onco Clinic Consult SA, Craiova, Not set
Centrul de Oncologie Sf Nectarie S.R.L., Craiova, Not set
Sc Sigmedical Services Srl, Suceava, Not set
Oncocenter-Oncologie Clinica SRL, Timisoara, Not set
SC Oncomed SRL, Timisoara, Not set
Hospital Clinic i Provincial de Barcelona, Barcelona, Not set
Hospital Universitari Vall D'Hebron, Barcelona, Not set
Hospital Universitario Arnau de Vilanova - Lleida, Lleida, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Clinico San Carlos, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Regional Universitario Malaga, Malaga, Not set
CHUO, Ourense, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario de Valme, Sevilla, Not set
Hospital Universitari i Politècnic La Fe, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Kantonsspital Baden, Baden, Not set
University Hospital Basel, Basel, Not set
Kantonsspital Baselland, Liestal, Not set
Kantonsspital St. Gallen, St.Gallen, Not set
E-Da Hospital, Kaohsiung City, Not set
Chang Gung Memorial Hospital Cgmh - Kaohsiung Branch, Kaohsiung, Not set
Chung Shan Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospital Nckuh, Tainan, Not set
Taipei Veterans General Hospital, Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Not set
Chang Gung Memorial Hospital LinKou, Taoyuan, Not set
Srinagarind Hospital, Muaeng, Khon Kaen
Prince of Songkla University PSU - Faculty of Medicine, Hat Yai, Songkhla
Faculty of Medicine Chulalongkorn University, Bangkok, Not set
Siriraj Hospital, Bangkok, Not set
Adana Acibadem Hospital, Adana, Not set
Akdeniz University Hospital, Antalya, Not set
Ege University, Bornova-İzmir, Not set
Memorial Ankara Hospital Ankara, Cankaya, Not set
Goztepe Prof. Dr. Suleyman Yalcin City Hospital, İstanbul, Not set
Medical Park Seyhan Hospital, Seyhan /Adana, Not set
Birmingham Heartlands Hospital, Birmingham, Not set
Beatson West of Scotland Cancer Centre, Glasgow, Not set
Nottingham University Hospitals, Nottingham, Not set
Conditions: Metastatic Non Small Cell Lung Cancer
A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors
Recruiting
This clinical trial is studying solid tumor cancers. A solid tumor is one that starts in part of your body like your lungs or liver instead of your blood. Once they've grown bigger in one spot or spread to other parts of the body, they're harder to treat. This is called advanced or metastatic cancer.
Participants in this study must have breast cancer or gastric cancer. Participants must have tumors that have HER2 on them. This allows the cancer to grow more quickly or spread faster. There are f... Read More
This clinical trial is studying solid tumor cancers. A solid tumor is one that starts in part of your body like your lungs or liver instead of your blood. Once they've grown bigger in one spot or spread to other parts of the body, they're harder to treat. This is called advanced or metastatic cancer.
Participants in this study must have breast cancer or gastric cancer. Participants must have tumors that have HER2 on them. This allows the cancer to grow more quickly or spread faster. There are few treatment options for patients with advanced or metastatic solid tumors that express HER2.
This clinical trial uses an experimental drug called disitamab vedotin (DV). Disitamab vedotin is a type of antibody drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them.
This clinical trial uses a drug called tucatinib, which has been approved to treat cancer in the United States and some other countries. This drug is sold under the brand name TUKYSA®.
This study will test how safe and how well DV with tucatinib works for participants with solid tumors. This study will also test what side effects happen when participants take these drugs. A side effect is anything a drug does to the body besides treating the disease. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Banner-University Medical Center Tucson Campus, Tucson, Arizona +122 locations
Banner-University Medical Center Tucson Campus, Tucson, Arizona
Banner-University Medical Center Tucson Campus, Tucson, Arizona
Banner-University Medical Center Tucson, Tucson, Arizona
The University of Arizona Cancer Center-North Campus Pharmacy, Attn: Kelly Myrdal, Tucson, Arizona
University of Arizona Cancer Center - North Campus, Tucson, Arizona
The University of Arizona Cancer Center-Main, Tucson, Arizona
UC Irvine Medical Center, Orange, California
University of California, San Francisco | HDFCCC - Hematopoietic Malignancies, San Francisco, California
UCLA Department of Medicine - Hematology & Oncology, Santa Monica, California
Colorado West Healthcare System, dba Community Hospital, Grand Junction, Colorado
Colorado West Healthcare, dba Grand Valley Oncology, Grand Junction, Colorado
Danbury Hospital, Danbury, Connecticut
The Whittingham Cancer Center / Norwalk Hospital, Norwalk, Connecticut
Georgetown University Medical Center, Washington, District of Columbia
MedStar Georgetown University Hospital, Washington, District of Columbia
Moffitt Cancer Center - International Plaza, Tampa, Florida
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
Moffitt Cancer Center - McKinley Campus, Tampa, Florida
Moffitt McKinley Hospital, Tampa, Florida
Moffitt Cancer Center at Wesley Chapel, Wesley Chapel, Florida
Georgia Cancer Specialists - Athens, Athens, Georgia
Georgia Cancer Specialists - Annex, Atlanta, Georgia
Atlanta Cancer Care - Atlanta, Atlanta, Georgia
Georgia Cancer Specialists-Northside, Atlanta, Georgia
Northside Hospital, Inc.- Central Research Department, Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
Georgia Cancer Specialists - Blairsville, Blairsville, Georgia
Georgia Cancer Specialists - Canton, Canton, Georgia
Atlanta Cancer Care - Cumming, Cumming, Georgia
Georgia Cancer Specialists - Cumming, Cumming, Georgia
Georgia Cancer Specialists - Decatur, Decatur, Georgia
Suburban Hematology-Oncology Associates - Duluth, Duluth, Georgia
Suburban Hematology-Oncology Associates- Lawrenceville, Lawrenceville, Georgia
Georgia Cancer Specialists - Macon, Macon, Georgia
Georgia Cancer Specialists - Marietta, Marietta, Georgia
Memorial Hospital, Shiloh, Illinois
Siteman Cancer Center - Shiloh, Shiloh, Illinois
Massachusetts General Hospital., Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
Dana Farber Cancer Institute, Boston, Massachusetts
Dana Farber Cancer Institute- Chestnut Hill, Newton, Massachusetts
Siteman Cancer Center - West County, Creve Coeur, Missouri
Siteman Cancer Center - North County, Florissant, Missouri
Saint Luke's Cancer Institute LLC, Kansas City, Missouri
Saint Luke's Hospital Investigational Pharmacy, Kansas City, Missouri
St Lukes Hospital, Kansas City, Missouri
Barnes-Jewish Hospital, Saint Louis, Missouri
Washington University in St Louis., Saint Louis, Missouri
Washington University School of Medicine - Siteman Cancer Center, Saint Louis, Missouri
Siteman Cancer Center - South County, Saint Louis, Missouri
Siteman Cancer Center - St Peters, Saint Peters, Missouri
Renown Regional Medical Center, Reno, Nevada
San Juan Oncology Associates, Farmington, New Mexico
Memorial Sloan Kettering Cancer Center - Main Hospital, New York, New York
Zangmeister Cancer Center, Columbus, Ohio
Saint Francis Hospital / Bon Secours - South Carolina, Greenville, South Carolina
Sarah Cannon Research Institute - Pharmacy, Nashville, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
Tennessee Oncology-Nashville/Sarah Cannon Research Institute, Nashville, Tennessee
Parkland Health and Hospital System, Dallas, Texas
University of Texas Southwestern Medical Center - Simmons Cancer Center, Dallas, Texas
University of Texas Southwestern Medical Center-Simmons Cancer Center Pharmacy, Dallas, Texas
University of Texas Southwestern Medical Center Simmons Cancer Center - Redbird, Dallas, Texas
University of Texas Southwestern Medical Center Clinical Lab-Zale Lipshy University Hospital, Dallas, Texas
University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital, Dallas, Texas
University of Texas Southwestern Medical Center, Dallas, Texas
University of Texas Southwestern Simmons Cancer Center - Fort Worth, Fort Worth, Texas
University of Texas Southwestern Medical Center Simmons Cancer Center - Richardson/Plano, Richardson, Texas
Harborview Medical Center, Seattle, Washington
Fred Hutchinson Cancer Center / Seattle Cancer Care Alliance / University of Washington, Seattle, Washington
University of Washington Medical Center, Seattle, Washington
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
Carbone Cancer Center / University of Wisconsin, Madison, Wisconsin
Peninsula & South Eastern Hematology and Oncology Group (PASO), Frankston, Victoria
Slade Pharmacy Frankston, Frankston, Victoria
Slade Health, Mount Waverley, Victoria
Peninsula & South Eastern Hematology and Oncology Group (PASO), Frankston, Not set
BC Cancer Kelowna., Kelowna, British Columbia
Ottawa Hospital Cancer Centre, Ottawa, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
University Health Network, Princess Margaret Hospital, Toronto, Ontario
Universitatsklinikum Essen, Essen, Not set
Universitatsklinikum Heidelberg, Heidelberg, Not set
Klinikums rechts der Isar der TU München, Muenchen, Not set
A.O.U. Federico II, Napoli, Campania
Azienda Ospedaliera Universitaria (AOU) Federico II, Napoli, Campania
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale., Napoli, Campania
Istituto Europeo di Oncologia, Milano, Lombardia
Niguarda Ca' Granda Hospital, Milano, Lombardia
Humanitas Istituto Clinico Catanese, Misterbianco (CT), Sicilia
Azienda Ospedaliera Universitaria Integrata di Verona., Verona, Veneto
A.O.U. Federico II- U.O.C. Diagnostica per lmmagini e Radioterapia, Napoli, Not set
Dong-A University Hospital, Busan, Other
National Cancer Center, Goyang-si, Other
Chungbuk National University Hospital, Cheongju-si, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Korea University Anam Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
St. Vincent's Hospital, The Catholic University of Korea, Suwon-si, Not set
Quirén Salud Barcelona, Barcelona, Not set
Hospital Universitari Vall d´Hebron, Barcelona, Not set
CETIR Grup Medic, Barcelona, Not set
Hospital Universitario de Basurto, Bilbao, Not set
Grupo Hospitalario QuironSalud, Erandio Bizkaia, Not set
L'Institut Catala d'Oncologia., L'Hospitalet de Llobregat, Not set
Farmacia-Ensayos. Planta S - Hospital Universitario HM Sanchinarro-CIOCC-START Madrid, Madrid, Not set
START Madrid-CIOCC_Hospital HM Sanchinarro, Madrid, Not set
Ecg Medica Sl, Valencia, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
National Taiwan University Hospital, Taipei, Not set
National Taiwan University Cancer Center, Taipei, Not set
The Royal Marsden Hospital, Sutton, Surrey
St Bartholomew's Hospital, London, Not set
The Royal Marsden Hospital, London, Not set
The Royal Marsden NHS Foundation Trust (RM), London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
The Royal Marsden NHS Foundation Trust, Sutton, Not set
Conditions: Breast Neoplasms, Gastroesophageal Junction Adenocarcinoma, HER2 Low Breast Neoplasms, HER2 Positive Breast Neoplasms, Stomach Neoplasms, Triple Negative Breast Neoplasms, Metastatic Breast Cancer, Metastatic Gastric Cancer, Advanced Breast Cancer, Advanced Gastric Cancer
Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents
Recruiting
The intention of the study is to demonstrate superiority of Saruparib (AZD5305) + physician's choice NHA relative to placebo + physician's choice NHA by assessment of radiographic progression-free survival (rPFS) in participants with mCSPC.
The intention of the study is to demonstrate superiority of Saruparib (AZD5305) + physician's choice NHA relative to placebo + physician's choice NHA by assessment of radiographic progression-free survival (rPFS) in participants with mCSPC. Read Less
Gender:
MALE
Ages:
Between 18 years and 130 years
Trial Updated:
08/06/2025
Locations: Research Site, Chandler, Arizona +408 locations
Research Site, Chandler, Arizona
Research Site, Gilbert, Arizona
Research Site, Phoenix, Arizona
Research Site, Tucson, Arizona
Research Site, Little Rock, Arkansas
Research Site, Springdale, Arkansas
Research Site, Bakersfield, California
Research Site, Fountain Valley, California
Research Site, Fullerton, California
Research Site, Los Angeles, California
Research Site, Los Angeles, California
Research Site, Montebello, California
Research Site, Pasadena, California
Research Site, Pomona, California
Research Site, Sacramento, California
Research Site, San Diego, California
Research Site, San Francisco, California
Research Site, Santa Barbara, California
Research Site, Santa Monica, California
Research Site, Santa Rosa, California
Research Site, Golden, Colorado
Research Site, Lakewood, Colorado
Research Site, New Haven, Connecticut
Research Site, Norwich, Connecticut
Research Site, Newark, Delaware
Research Site, Jacksonville, Florida
Research Site, Jacksonville, Florida
Research Site, Palm Bay, Florida
Research Site, Saint Petersburg, Florida
Research Site, Tampa, Florida
Research Site, Atlanta, Georgia
Research Site, Glenview, Illinois
Research Site, Lake Barrington, Illinois
Research Site, Fort Wayne, Indiana
Research Site, Indianapolis, Indiana
Research Site, Des Moines, Iowa
Research Site, Westwood, Kansas
Research Site, Wichita, Kansas
Research Site, Lexington, Kentucky
Research Site, Louisville, Kentucky
Research Site, Shreveport, Louisiana
Research Site, Scarborough, Maine
Research Site, Baltimore, Maryland
Research Site, Baltimore, Maryland
Research Site, Bethesda, Maryland
Research Site, Towson, Maryland
Research Site, Upper Marlboro, Maryland
Research Site, Grand Rapids, Michigan
Research Site, Troy, Michigan
Research Site, Rochester, Minnesota
Research Site, Columbia, Missouri
Research Site, Billings, Montana
Research Site, Bozeman, Montana
Research Site, Las Vegas, Nevada
Research Site, Las Vegas, Nevada
Research Site, Belleville, New Jersey
Research Site, Brick, New Jersey
Research Site, Camden, New Jersey
Research Site, East Brunswick, New Jersey
Research Site, Voorhees, New Jersey
Research Site, Albuquerque, New Mexico
Research Site, Albuquerque, New Mexico
Research Site, Rio Rancho, New Mexico
Research Site, Albany, New York
Research Site, Bronx, New York
Research Site, East Syracuse, New York
Research Site, New Hyde Park, New York
Research Site, New York, New York
Research Site, New York, New York
Research Site, Shirley, New York
Research Site, Syracuse, New York
Research Site, Durham, North Carolina
Research Site, Fayetteville, North Carolina
Research Site, Cincinnati, Ohio
Research Site, Cincinnati, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Cleveland, Ohio
Research Site, Columbus, Ohio
Research Site, Independence, Ohio
Research Site, Wooster, Ohio
Research Site, Florence, Oregon
Research Site, Portland, Oregon
Research Site, Portland, Oregon
Research Site, Bala-Cynwyd, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, Pittsburgh, Pennsylvania
Research Site, York, Pennsylvania
Research Site, Providence, Rhode Island
Research Site, Myrtle Beach, South Carolina
Research Site, North Charleston, South Carolina
Research Site, Sioux Falls, South Dakota
Research Site, Germantown, Tennessee
Research Site, Nashville, Tennessee
Research Site, Dallas, Texas
Research Site, Dallas, Texas
Research Site, Denton, Texas
Research Site, Flower Mound, Texas
Research Site, Grapevine, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Plano, Texas
Research Site, San Antonio, Texas
Research Site, San Antonio, Texas
Research Site, Sugar Land, Texas
Research Site, Tyler, Texas
Research Site, Wichita Falls, Texas
Research Site, Saint George, Utah
Research Site, Salt Lake City, Utah
Research Site, Salt Lake City, Utah
Research Site, Fairfax, Virginia
Research Site, Winchester, Virginia
Research Site, Spokane Valley, Washington
Research Site, Spokane, Washington
Research Site, Tacoma, Washington
Research Site, Chermside, Not set
Research Site, Darlinghurst, Not set
Research Site, Hyde Park, Not set
Research Site, Kurralta Park, Not set
Research Site, Melbourne, Not set
Research Site, Randwick, Not set
Research Site, South Brisbane, Not set
Research Site, Graz, Not set
Research Site, Innsbruck, Not set
Research Site, Krems an der Donau, Not set
Research Site, Linz, Not set
Research Site, Wien, Not set
Research Site, Wien, Not set
Research Site, Charleroi, Not set
Research Site, Gent, Not set
Research Site, Kortrijk, Not set
Research Site, Leuven, Not set
Research Site, Curitiba, Not set
Research Site, Pelotas, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Salvador, Not set
Research Site, Sao Luis, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Calgary, Alberta
Research Site, Calgary, Alberta
Research Site, Edmonton, Alberta
Research Site, Abbotsford, British Columbia
Research Site, Kelowna, British Columbia
Research Site, Vancouver, British Columbia
Research Site, Winnipeg, Manitoba
Research Site, Halifax, Nova Scotia
Research Site, Kingston, Ontario
Research Site, London, Ontario
Research Site, Mississauga, Ontario
Research Site, Newmarket, Ontario
Research Site, Ottawa, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Chicoutimi, Quebec
Research Site, Greenfield Park, Quebec
Research Site, Montreal, Quebec
Research Site, Montréal, Quebec
Research Site, Montréal, Quebec
Research Site, Saskatoon, Saskatchewan
Research Site, Quebec, Not set
Research Site, Concepcion, Not set
Research Site, La Serena, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Temuco, Not set
Research Site, Viña del Mar, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Chongqing, Not set
Research Site, Dongguan, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guilin, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Harbin, Not set
Research Site, Jiaxing, Not set
Research Site, Jinan, Not set
Research Site, Lanzhou, Not set
Research Site, Nanchang, Not set
Research Site, Nanchang, Not set
Research Site, Nanjing, Not set
Research Site, Nantong, Not set
Research Site, Ningbo, Not set
Research Site, Shandong, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shenyang, Not set
Research Site, Shenyang, Not set
Research Site, Shenyang, Not set
Research Site, Suining, Not set
Research Site, Taiyuan, Not set
Research Site, Tianjin, Not set
Research Site, Weifang, Not set
Research Site, Wenzhou, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Yantai, Not set
Research Site, Zhengzhou, Not set
Research Site, Helsinki, Not set
Research Site, Tampere, Not set
Research Site, Turku, Not set
Research Site, Angers, Not set
Research Site, Bayonne, Not set
Research Site, Bordeaux Cedex, Not set
Research Site, Caen Cedex 5, Not set
Research Site, Clermont Ferrand, Not set
Research Site, Creteil, Not set
Research Site, Lyon, Not set
Research Site, Montpellier, Not set
Research Site, Nice, Not set
Research Site, Nîmes, Not set
Research Site, Paris, Not set
Research Site, Pierre Bénite, Not set
Research Site, Poitiers Cedex, Not set
Research Site, Quimper Cedex, Not set
Research Site, Rennes Cedex 9, Not set
Research Site, Strasbourg, Not set
Research Site, Tours, Not set
Research Site, Vandoeuvre les Nancy, Not set
Research Site, Bergisch Gladbach, Not set
Research Site, Berlin, Not set
Research Site, Bonn, Not set
Research Site, Braunschweig, Not set
Research Site, Dresden, Not set
Research Site, Duisburg, Not set
Research Site, Erlangen, Not set
Research Site, Frankfurt am Main, Not set
Research Site, Frankfurt, Not set
Research Site, Freiburg, Not set
Research Site, Göttingen, Not set
Research Site, Hamburg, Not set
Research Site, Heidelberg, Not set
Research Site, Herne, Not set
Research Site, Homburg, Not set
Research Site, Köln, Not set
Research Site, Magdeburg, Not set
Research Site, Mannheim, Not set
Research Site, Marburg, Not set
Research Site, Mettmann, Not set
Research Site, München, Not set
Research Site, Münster, Not set
Research Site, Nürtingen, Not set
Research Site, Oldenburg, Not set
Research Site, Regensburg, Not set
Research Site, Stuttgart, Not set
Research Site, Trier, Not set
Research Site, Tübingen, Not set
Research Site, Ulm, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Győr, Not set
Research Site, Miskolc, Not set
Research Site, Nyíregyháza, Not set
Research Site, Szeged, Not set
Research Site, Szekszárd, Not set
Research Site, Bangalore, Not set
Research Site, Calicut, Not set
Research Site, Delhi, Not set
Research Site, Hyderabad, Not set
Research Site, JAipur, Not set
Research Site, Kanpur, Not set
Research Site, Kolkata, Not set
Research Site, Kolkata, Not set
Research Site, Mohali, Not set
Research Site, Nagpur, Not set
Research Site, New Delhi, Not set
Research Site, New Delhi, Not set
Research Site, Pune, Not set
Research Site, Surat, Not set
Research Site, Vadodara, Not set
Research Site, Varanasi, Not set
Research Site, Bari, Not set
Research Site, Genoa, Not set
Research Site, Meldola, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Napoli, Not set
Research Site, Padova, Not set
Research Site, Rome, Not set
Research Site, Rozzano, Not set
Research Site, Terni, Not set
Research Site, Trento, Not set
Research Site, Chiba-shi, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Fukuoka, Not set
Research Site, Hirakata-shi, Not set
Research Site, Hirosaki-shi, Not set
Research Site, Kanazawa-shi, Not set
Research Site, Kashihara-shi, Not set
Research Site, Kawagoe-shi, Not set
Research Site, Kisarazu-shi, Not set
Research Site, Kita-gun, Not set
Research Site, Kobe-shi, Not set
Research Site, Kumamoto-shi, Not set
Research Site, Kyoto-shi, Not set
Research Site, Maebashi-shi, Not set
Research Site, Nagano-shi, Not set
Research Site, Nagasaki-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Nagoya, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sagamihara-shi, Not set
Research Site, Sakura-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Shiwa-gun, Not set
Research Site, Suita-shi, Not set
Research Site, Tsu-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yufu-shi, Not set
Research Site, Daejeon, Not set
Research Site, Seongnam-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon, Not set
Research Site, George Town, Not set
Research Site, Johor Bahru, Not set
Research Site, Kota Kinabalu, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuching, Not set
Research Site, Amsterdam, Not set
Research Site, Hilversum, Not set
Research Site, Nijmegen, Not set
Research Site, Arequipa, Not set
Research Site, Bellavista, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Bydgoszcz, Not set
Research Site, Koszalin, Not set
Research Site, Poznań, Not set
Research Site, Rzeszów, Not set
Research Site, Szczecin, Not set
Research Site, Warszawa, Not set
Research Site, Wrocław, Not set
Research Site, Żory, Not set
Research Site, San Juan, Not set
Research Site, Barcelona, Not set
Research Site, Córdoba, Not set
Research Site, L'Hospitalet de Llobregat, Not set
Research Site, Lugo, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Sabadell, Not set
Research Site, Valencia, Not set
Research Site, Göteborg, Not set
Research Site, Malmo, Not set
Research Site, Solna, Not set
Research Site, Stockholm, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Taoyuan, Not set
Research Site, Yung Kang City, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Chiang Mai, Not set
Research Site, Khlong Luang, Not set
Research Site, Songkla, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Bornova-Izmir, Not set
Research Site, Fatih-Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Karsiyaka, Not set
Research Site, Aberdeen, Not set
Research Site, Birmingham, Not set
Research Site, Cambridge, Not set
Research Site, Glasgow, Not set
Research Site, Guildford, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Newcastle upon Tyne, Not set
Research Site, Oxford, Not set
Research Site, Plymouth, Not set
Research Site, Preston, Not set
Research Site, Swansea, Not set
Research Site, Truro, Not set
Conditions: Metastatic Castration-Sensitive Prostate Cancer
Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
Recruiting
This is an open-label extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis
This is an open-label extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis Read Less
Gender:
ALL
Ages:
Between 12 years and 100 years
Trial Updated:
08/06/2025
Locations: Childrens Hospital Colorado, Aurora, Colorado +43 locations
Childrens Hospital Colorado, Aurora, Colorado
Georgia Nephrology Research Inst, Lawrenceville, Georgia
University of Iowa Health Care, Iowa City, Iowa
Col Uni Med Center New York Presby, New York, New York
Novartis Investigative Site, Buenos Aires, Not set
Novartis Investigative Site, Belo Horizonte, MG
Novartis Investigative Site, Porto Alegre, RS
Novartis Investigative Site, Botucatu, Sao Paulo
Novartis Investigative Site, Sao Paulo, SP
Novartis Investigative Site, Toronto, Ontario
Novartis Investigative Site, Beijing, Not set
Novartis Investigative Site, Shanghai, Not set
Novartis Investigative Site, Praha 2, Not set
Novartis Investigative Site, Montpellier 5, Not set
Novartis Investigative Site, Paris 15, Not set
Novartis Investigative Site, Paris, Not set
Novartis Investigative Site, Toulouse, Not set
Novartis Investigative Site, Erlangen, Not set
Novartis Investigative Site, Essen, Not set
Novartis Investigative Site, Hamburg, Not set
Novartis Investigative Site, Mainz, Not set
Novartis Investigative Site, Heraklion Crete, Not set
Novartis Investigative Site, Petach Tikva, Not set
Novartis Investigative Site, Petach-Tikva, Not set
Novartis Investigative Site, Ranica, BG
Novartis Investigative Site, Roma, RM
Novartis Investigative Site, Nagoya, Aichi
Novartis Investigative Site, Asahikawa, Hokkaido
Novartis Investigative Site, Sapporo, Hokkaido
Novartis Investigative Site, Takatsuki, Osaka
Novartis Investigative Site, Ohtsu, Shiga
Novartis Investigative Site, Niigata, Not set
Novartis Investigative Site, Leiden, Zuid Holland
Novartis Investigative Site, Sevilla, Andalucia
Novartis Investigative Site, Barcelona, Catalunya
Novartis Investigative Site, Pamplona, Navarra
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Bern, Not set
Novartis Investigative Site, Ankara, Not set
Novartis Investigative Site, Kocaeli, Not set
Novartis Investigative Site, Talas Kayseri, Not set
Novartis Investigative Site, London, Not set
Novartis Investigative Site, Newcastle upon Tyne, Not set
Conditions: C3 Glomerulopathy, Immune-complex-membranoproliferative Glomerulonephritis
A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
Recruiting
In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE). The study will focus on participants who have either active subacute CLE or chronic CLE, or both. They may also have systemic lupus erythematosus (SLE). The participants did not respond to antimalarial therapy or had problems with the treatment that made it hard to continue.
The main objective of the study is to learn about the effect litifilimab h... Read More
In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE). The study will focus on participants who have either active subacute CLE or chronic CLE, or both. They may also have systemic lupus erythematosus (SLE). The participants did not respond to antimalarial therapy or had problems with the treatment that made it hard to continue.
The main objective of the study is to learn about the effect litifilimab has on lowering the activity of the skin disease. Researchers will measure symptoms of CLE over time using a variety of scoring tools. These include the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI), the Cutaneous Lupus Activity of Investigator's Global Assessment-Revised (CLA-IGA-R), and the SELENA-SLEDAI Flare Index (SFI).
The main questions researchers want to answer are:
* How many participants have a score of 0 or 1 on the CLA-IGA-R looking at skin redness after treatment?
* How many participants have their skin disease activity go down by at least 70%?
Researchers will also learn more about the safety of litifilimab. They will study how participants' immune systems respond to litifilimab. Additionally, they will measure the effect litifilimab and CLE have on the quality of life of participants using a group of questionnaires.
The study will be split into 2 parts - Part A and Part B. Both parts will be done as follows:
* After screening, participants will be randomized to receive either litifilimab or placebo for the 1st treatment period. A placebo looks like the study drug but contains no real medicine.
* Participants will receive either litifilimab or placebo as injections under the skin once every 4 weeks.
* The 1st treatment period will be double blinded which means neither the researchers nor the participants will know if the participants are receiving litifilimab or placebo.
* This double blinded treatment period will last 24 weeks, after which the 2nd treatment period will begin.
* During the 2nd treatment period, all participants will receive litifilimab for 28 weeks.
* After completing treatment in this study, participants that qualify will be given the choice to join the Long-Term Extension study, 230LE305. If they do not, they will move into a follow-up safety period that will last up to 24 weeks.
* The total study duration for participants will be up to 80 weeks Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +257 locations
Pinnacle Research Group, LLC, Anniston, Alabama
UAB Center for Women's Reproductive Health, Birmingham, Alabama
Arizona Arthritis & Rheumatology Research, PLLC, Phoenix, Arizona
The Regents of the University of California, La Jolla, California
Dermatology Research Associates, Los Angeles, California
Clinical Science Institute, Santa Monica, California
Inland Rheumatology Clinical Trials, Inc., Upland, California
Denver Arthritis Clinic, Denver, Colorado
Omega Research Debary, LLC, DeBary, Florida
Centre for Rheumatology, Immunology and Arthritis, Fort Lauderdale, Florida
University of Florida, Gainesville, Florida
Charisma Medical and Research Center, Miami Lakes, Florida
University of Miami Miller School of Medicine, Miami, Florida
Medical Research Center of Miami, Miami, Florida
Augusta University, Augusta, Georgia
Rush University Medical Center, Chicago, Illinois
OrthoIllinois, Rockford, Illinois
Dawes Fretzin Clinical Research Group, LLC, Indianapolis, Indiana
LSU Health Sciences Center Shreveport, New Orleans, Louisiana
Tufts Medical Center, Boston, Massachusetts
Brigham And Women's Hospital, Boston, Massachusetts
Essential Dermatology, Natick, Massachusetts
Beacon Clinical Research, LLC, Quincy, Massachusetts
University of Massachusetts, Worcester, Worcester, Massachusetts
David Fivenson, MD, Dermatology, PLLC, Ann Arbor, Michigan
Oakland Hills Dermatology, Auburn Hills, Michigan
AA MRC LLC Ahmed Arif Medical Research Center, Flint, Michigan
Revival Research Institute, LLC, Troy, Michigan
Saint Louis University, Saint Louis, Missouri
University of Nebraska Medical Center, Omaha, Nebraska
Albuquerque Center For Rheumatology, Albuquerque, New Mexico
University of New Mexico School of Medicine, Albuquerque, New Mexico
NYU Langone Brooklyn, Brooklyn, New York
Universal Dermatology, PLLC, Fairport, New York
Northwell Health, Inc. PRIME, Great Neck, New York
Columbia University Medical center, New York, New York
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Duke Dermatology South Durham, Durham, North Carolina
Medication Management, LLC, Greensboro, North Carolina
University of Cincinnati Department of Dermatology, Cincinnati, Ohio
University Hospitals Cleveland Medical Center, Cleveland, Ohio
Ohio State University, Columbus, Ohio
Penn State University Milton S. Hershey Medical Center, Hershey, Pennsylvania
University of Pennsylvania, Philadelphia, Pennsylvania
Vanderbilt University Medical Center, Nashville, Tennessee
Austin Regional Clinic, P.A., Austin, Texas
Precision Comprehensive Clinical Research Solutions, Colleyville, Texas
Metroplex Clinical Research Center, LLC, Dallas, Texas
UT Southwestern Medical Center, Dallas, Texas
North Texas Center for Clinical Research, Frisco, Texas
UTMB Department of Dermatology, Galveston, Texas
University of Texas Health Science Center at Houston, Houston, Texas
Arthritis & Osteoporosis Clinic, Waco, Texas
University of Utah Health Sciences Center, Salt Lake City, Utah
West End Dermatology Associates, Richmond, Virginia
CINME - Centro De Investigaciones Metabolicas, Caba, Buenos Aires
Centro de Investigaciones Medicas Mar del Plata, Mar del Plata, Buenos Aires
Instituto de Investigaciones Clinicas Quilmes, Quilmes, Buenos Aires
APRILLUS Asistencia e Investigacion, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires
Fundacion Respirar, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires
Instituto CAICI, Rosario, Santa Fe
Clinica Mayo de Urgencias Medicas Cruz Blanca SRL, San Miguel de Tucuman, Tucuman
Centro de Investigaciones Medicas Tucuman, San Miguel de Tucuman, Tucuman
Investigaciones Clinicas Tucuman, San Miguel de Tucuman, Tucuman
Hospital Italiano de La Plata, Buenos Aires, Not set
Centro Privado de Medicina Familiar - Mind Out Research, Ciudad Autonoma Buenos Aires, Not set
Clinica Adventista Belgrano, Ciudad Autonoma Buenos Aires, Not set
Instituto de Reumatologia, Mendoza, Not set
CER San Juan Centro Polivalente de Asistencia e Inv. Clinica, San Juan, Not set
Clínica SER da Bahia, Salvador, Bahia
HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará, Fortaleza, Ceará
L2IP - Instituto de Pesquisas Clínicas Ltda., Brasilia, Distrito Federal
CEDOES - Diagnóstico e Pesquisa, Vitória, Espírito Santo
IPC MT Instituto de Pesquisas Clinicas do Mato Grosso, Santo Ângelo, Mato Grosso
Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte, Minas Gerais
CMiP - Centro Mineiro de Pesquisa, Juiz de Fora, Minas Gerais
Instituto Brasil de Pesquisa Clínica-IBPCLIN S/A, Rio de Janeiro, Rio Do Janeiro
IDERJ - Instituto de Dermatologia e Estética do Brasil Ltda, Rio de Janeiro, Rio Do Janeiro
Hospital Bruno Born, Lajeado, Rio Grande Do Sul
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul
Nucleo de Pesquisa Clinica do Rio Grande do Sul, Porto Alegre, Rio Grande Do Sul
LMK Serviços Médicos S/S Ltda, Porto Alegre, Rio Grande Do Sul
CEMEC - Centro Multidisciplinar de Estudos Clínicos, Sao Bernardo Do Campo, Sao Paulo
CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos, São Paulo, Sao Paulo
Medical center Medconsult Pleven OOD, Pleven, Not set
UMHAT 'Dr. Georgi Stranski', EAD, Pleven, Not set
DCC 1 - Ruse, EOOD, Ruse, Not set
DCC 'Alexandrovska', EOOD, Sofia, Not set
DCC Focus 5 - MEOH OOD, Sofia, Not set
DCC Focus 5 - MEOH OOD, Sofia, Not set
Military Medical Academy - MHAT - Sofia, Sofia, Not set
Laser Rejuvenation Clinics, Inc., Calgary, Alberta
Laster Rejuvenation Clinics Edmonton D.T. Inc., Edmonton, Alberta
Dermatology Ottawa Research Centre, Ottawa, Ontario
Medicor Research Inc, Sudbury, Ontario
DIEX Recherche Sherbrooke Inc., Sherbrooke, Quebec
Centro Medico SkinMed, Las Condes, Not set
Dermacross, Santiago, Not set
BioMedica Research Group, Santiago, Not set
CeCim Biocinetic, Santiago, Not set
CIEC - Centro Internacional de Estudios Clínicos, Santiago, Not set
Clinical Research Chile SpA., Valdivia, Not set
Oncocentro APYS, Viña del Mar, Not set
Beijing Tongren Hospital, Capital Medical University, Beijing, Beijing
Peking Union Medical College Hospital, Beijing, Beijing
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing
The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian
Dongguan People's Hospital, Dongguan, Guangdong
Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong
Shenzhen Second People's Hospital, Shenzhen, Guangdong
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangzhou
Nanyang First People's Hospital, Nanyang, Henan
Henan Provincial People's Hospital, Zhengzhou, Henan
The second Xiangya Hospital of Central South University, Changsha, Hunan
The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia
Hospital for Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu
Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu
The First Hospital of Jilin University, Changchun City, Jilin
Qilu Hospital of Shandong University, Jinan, Shandong
Ruijin Hospital of Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai
Zhongshan Hospital Fudan University, Shanghai, Shanghai
Shanghai Skin Disease Hospital, Shanghai, Shanghai
The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan
The First Affiliated Hospital of Zhejiang University school of medicine, Hangzhou, Zhejiang
Hangzhou First People's Hospital, Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang
Centro de Investigacion Medico Asistencial S.A.S, Barranquilla, Atlántico
Healthy Medical Center, Zipaquirá, Cundinamarca
Servimed S.A.S., Bucaramanga, Santander
Centro de Investigacion en Reumatologia y Especialidades Medicas SAS. CIREEM, Bogotá, Not set
CHU Nice - Hopital de l Archet, Nice cedex 3, Alpes Maritimes
Hôpital de la Timone, Marseille cedex 5, Bouches-du-Rhône
CHU de Caen - Hopital de la Cote de Nacre, Caen, Calvados
CHU Besançon - Hôpital Jean Minjoz, Besançon Cedex, Doubs
Hopital Larrey, Toulouse Cedex 9, Haute Garonne
Hôpital Privé d'Antony, Antony, Hauts De Seine
Hopital Saint Eloi, Montpellier Cedex 5, Herault
Hôpital Saint-Louis, Cedex 10, Paris
Hopital Edouard Herriot - CHU Lyon, Lyon, Rhone
Hopital Tenon, Paris, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Baden Wuerttemberg
Universitaetsklinikum Erlangen, Erlangen, Bayern
Fachklinik Bad Bentheim Dermatologie, Bad Bentheim, Niedersachsen
Elbekliniken Buxtehude GmbH, Buxtehude, Niedersachsen
Klinikum Oldenburg AoeR, Oldenburg, Niedersachsen
Universitaetsklinikum Aachen AoeR, Aachen, Nordrhein Westfalen
Universitaetsklinikum Bonn AoeR, Bonn, Nordrhein Westfalen
Universitaetsklinikum Duesseldorf AoeR, Duesseldorf, Nordrhein Westfalen
Universitaetsklinikum Muenster, Muenster, Nordrhein Westfalen
Universitaetsklinikum Halle (Saale), Halle, Sachsen Anhalt
Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden, Sachsen
Universitaetsklinikum Schleswig-Holstein - Campus Kiel, Kiel, Schleswig Holstein
Charité - Campus Charité Mitte, Berlin, Not set
Pecsi Tudomanyegyetem, Pecs, Not set
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS, Bologna, Not set
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili), Brescia, Not set
Università degli studi di Firenze, Firenze, Not set
IRCCS Ospedale Policlinico San Martino, Genova, Not set
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Milano, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Ospedaliera Universitaria Policlinico 'Federico II', Napoli, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Not set
JCHO Chukyo Hospital, Nagoya-shi, Aichi-Ken
NHO Nagoya Medical Center, Nagoya-shi, Aichi-Ken
Fujita Health University Hospital, Toyoake-shi, Aichi-Ken
Aomori Prefectural Central Hospital, Aomori-shi, Aomori-Ken
Juntendo University Urayasu Hospital, Urayasu-shi, Chiba-Ken
University of Fukui Hospital, Yoshida-gun, Fukui-Ken
Hospital of the University of Occupational and Environmental Health, Kitakyushu-shi, Fukuoka-Ken
Hokkaido University Hospital, Sapporo-shi, Hokkaido
Kakogawa Central City Hospital, Kakogawa-shi, Hyogo-Ken
Kita Harima Medical Center, Ono-shi, Hyogo-Ken
Kanazawa University Hospital, Kanazawa-shi, Ishikawa-Ken
St. Marianna University Hospital, Kawasaki-shi, Kanagawa-Ken
Yokohama City University Medical Center, Yokohama-shi, Kanagawa-Ken
Yokohama City University Hospital, Yokohama-shi, Kanagawa-Ken
NHO Yokohama Medical Center, Yokohama-shi, Kanagawa-Ken
Kumamoto University Hospital, Kumamoto-shi, Kumamoto-Ken
Tohoku University Hospital, Sendai-shi, Miyagi-Ken
Nagasaki University Hospital, Nagasaki-Shi, Nagasaki-Ken
Niigata University Medical & Dental Hospital, Niigata-shi, Niigata-Ken
Japanese Red Cross Okayama Hospital, Okayama-shi, Okayama-Ken
NHO Osaka Minami Medical Center, Kawachinagano-shi, Osaka-Fu
Daini Osaka Police Hospital, Osaka-shi, Osaka-Fu
Kindai University Hospital, Osakasayama-shi, Osaka-Fu
Osaka University Hospital, Suita-shi, Osaka-Fu
Takatsuki Red Cross Hospital, Takatsuki-shi, Osaka-Fu
Shiga University of Medical Science Hospital, Otsu-shi, Shiga-Ken
Shimane University Hospital, Izumo-shi, Shimane-Ken
Teikyo University Hospital, Itabashi-ku, Tokyo-To
Showa University East Hospital, Shinagawa-ku, Tokyo-To
Wakayama Medical University Hospital, Wakayama-shi, Wakayama-Ken
Korea University Ansan Hospital, Ansan-si, Gyeonggi-do
Ajou University Hospital, Suwon, Gyeonggi-do
Chonnam National University Hospital, Gwangju, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Hanyang University Seoul Hospital, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
Clinstile, S.A. de C.V., Ciudad de México, Distrito Federal
Centro de Investigacion Clínica GRAMEL S.C, Mexico, Distrito Federal
Centro de investigacion medica y reumatologia, Guadalajara, Jalisco
Consultorio Privado Dr. Miguel Cortes Hernandez, Cuernavaca, Morelos
Medical Care & Research SA de CV, Merida, Yucatán
Derma Norte del Bajio S.C., Aguascalientes, Not set
Investigacion y Biomedicina de Chihuahua, S.C., Chihuahua, Not set
Invest Clinicas Sac Inst de Ginecologia y Reproduccion, Lima, Not set
The Medical City Clark, Mabalacat, Pampanga
Cebu Doctors University Hospital, Cebu City, Not set
Mary Mediatrix Medical Center, Lipa City, Not set
Medical Center Manila, Manila, Not set
Philippine General Hospital, Manila, Not set
Jose R. Reyes Memorial Medical Center, Manila, Not set
Far Eastern University - Dr. Nicanor Reyes Medical Foundation, Quezon City, Metro Manila, Not set
St. Luke's Medical Center, Quezon City, Not set
Ilocos Training and Regional Medical Center, San Fenando, La Union, Not set
Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski, Krakow, Not set
SPZOZ Szpital Uniwersytecki w Krakowie, Kraków, Not set
Dermoklinika Centrum Medyczne SC M Kierstan J Narbutt A Lesiak, Lodz, Not set
Kliniczny Szpital Wojewodzki nr 1 im.F.Chopina, Rzeszow, Not set
Szpital Kliniczny Dzieciatka Jezus, Warszawa, Not set
Royalderm, Warszawa, Not set
Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska, Wroclaw, Not set
Centro Hospitalar e Universitário de Coimbra, E.P.E (HUC), Coimbra, Not set
Hospital de Egas Moniz, Lisboa, Not set
Hospital CUF Descobertas, Lisboa, Not set
Centro Hospitalar Universitártio do Porto, E.P.E., Porto, Not set
Unidade Local de Saúde do Alto Minho, E.P.E., Viana do Castelo, Not set
Dr. Samuel Sanchez PSC, Caguas, Not set
GCM Medical Group PSC - Hato Rey, San Juan, Not set
King Faisal Specialist Hospital & Research Center, Riyadh, Not set
King Saud University, Riyadh, Not set
Institute of Rheumatology, Belgrade, Not set
University Clinical Center of Serbia, Belgrade, Not set
University Clinical Center Kragujevac, Kragujevac, Not set
Clinical Center of Vojvodina, Novi Sad, Not set
Artromac n.o., Kosice, Not set
Narodny ustav reumatickych chorob, Piestany, Not set
Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona
Hospital Universitario Rio Hortega, Valladolid, Cantabria
Hospital Universitario Fundacion Alcorcon, Alcorcón, Madrid
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid
Hospital del Mar, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Complejo Hospitalario Universitario A Coruña, La Coruña, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Karolinska Universitetssjukhuset - Solna, Stockholm, Not set
Universitaetsspital Zuerich, Zurich-Flughafen, Zurich
Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Not set
Kantonsspital St. Gallen, St. Gallen, Not set
Changhua Christian Medical Foundation Changhua Christian Hospital, Changhua, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Taichung Veterans General Hospital, Taichung, Not set
Taipei Veterans General Hospital, Taipei, Not set
Whipps Cross University Hospital, London, Greater London
Manchester Royal Infirmary, Manchester, Greater Manchester
Queen Elizabeth Hospital, Birmingham, West Midlands
Chapel Allerton Hospital, Leeds, West Yorkshire
Conditions: Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
Recruiting
This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML).
This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML). Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/06/2025
Locations: City of Hope Phoenix, Goodyear, Arizona +267 locations
City of Hope Phoenix, Goodyear, Arizona
Mayo Clinic - Phoenix, Phoenix, Arizona
University of Arizona Cancer Center, Tucson, Arizona
Ucsf - School of Medicine, San Francisco, California
Stanford University School of Medicine- Parent, Stanford, California
Colorado Blood Cancer Institute, Denver, Colorado
Yale University, New Haven, Connecticut
Mayo Clinic Hospital, Jacksonville, Florida
Florida Hospital Cancer Institute - Kissimmee, Kissimmee, Florida
Tampa General Hospital, Tampa, Florida
Moffit Cancer Center, Tampa, Florida
Augusta University, Augusta, Georgia
University of Illinois Hospital & Health Sciences System, Chicago, Illinois
The University of Chicago Medical Center, Chicago, Illinois
University of Kentucky, Lexington, Kentucky
Ochsner Medical Center - New Orleans, New Orleans, Louisiana
Johns Hopkins Hospital, Baltimore, Maryland
University of Michigan Comprehensive Cancer Center Michigan Medicine, Ann Arbor, Michigan
Henry Ford Hospital, Detroit, Michigan
University of Minnesota Medical School - Twin Cities Campus, Minneapolis, Minnesota
Mayo Clinic, Rochester, Minnesota
Washington University, Saint Louis, Missouri
Hackensack University Medical Center, Hackensack, New Jersey
Thomas Jefferson Univ Hosp, Haddonfield, New Jersey
Roswell Park Comprehensive Cancer Center, Buffalo, New York
Memorial Sloan Kettering Cancer Center - Main, New York, New York
Upstate University Hospital, Syracuse, New York
University of North Carolina Hospitals, Chapel Hill, North Carolina
Duke Cancer Institute - Sarcoma Research, Durham, North Carolina
University of Cincinnati, Cincinnati, Ohio
Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio
The James Cancer Hospital and Solove Research Institute, Columbus, Ohio
Ohio Health Marion Area Physicians, Columbus, Ohio
Oregon Health & Science University (Ohsu), Portland, Oregon
University of Pennsylvania, Philadelphia, Pennsylvania
Upmc Hillman Cancer Center, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Tristar Bone Marrow Transplant, Nashville, Tennessee
South Austin Medical Center, Austin, Texas
Houston Methodist Hospital, Houston, Texas
The University of Texas Md Anderson Cancer Center, Houston, Texas
Uva Health System, Charlottesville, Virginia
Virginia Commonwealth University (Vcu) Massey Cancer Center, Richmond, Virginia
Medical College of Wisconsin, Milwaukee, Wisconsin
Royal Adelaide Hospital, Adelaide, Not set
Flinders Medical Centre (Fmc), Bedford Park, Not set
Box Hill Hospital, Box Hill, Not set
Concord Repatriation General Hospital, Concord, Not set
St Vincent'S Hospital Melbourne, Darlinghurst, Not set
Townsville University Hospital, Douglas, Not set
Liverpool Hospital, Liverpool, Not set
The Alfred Hospital, Melbourne, Not set
Fiona Stanley Hospital, Murdoch, Not set
Sir Charles Gairdner Hospital, Perth, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Ordensklinikum Linz Gmbh - Elisabethinen, Linz, Not set
LKH - Universitätsklinikum der PMU Salzburg, Salzburg, Not set
Hanusch Krankenhaus Der Wgkk Wien, Wien, Not set
Institut Jules Bordet, Anderlecht, Not set
ZNA, Antwerpen, Not set
Az Sint-Jan, Brugge, Not set
Uz Leuven, Leuven, Not set
Chu of Liège, Liege, Not set
AZ DELTA, Roeselare, Not set
Unesp - Faculdade de Medicina Da Universidade Estadual Paulista - Campus Botucatu, Botucatu, Not set
Centro de Hematologia E Hemoterapia - Hemocentro de Campinas - Unicamp, Campinas, Not set
Centro de Hematologia e Hemoterapia - Hemocentro de Campinas - UNICAMP, Campinas, Not set
Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba, Not set
Hospital Erasto Gaertner - Liga Paranaense de Combate Ao Că'Ncer, Curitiba, Not set
Cepon - Centro De Pesquisas Oncolagicas de Santa Catarina, Florianopolis, Not set
HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará, Fortaleza, Not set
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás, Goiania, Not set
Hc-Ufg - Hospital Das Clă Nicas Da Universidade Federal de Goiă S, Goiania, Not set
Fundacao Doutor Amaral Carvalho, Jau, Not set
Fundaã§Ã£O Doutor Amaral Carvalho, Jaú, Not set
Hospital de Clínicas de Passo Fundo, Passo Fundo, Not set
Hospital de Clă Nicas de Passo Fundo, Passo Fundo, Not set
Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Not set
Hospital de Clă Nicas de Porto Alegre, Porto Alegre, Not set
Hospital Ernesto Dornelles, Porto Alegre, Not set
INCA - Instituto Nacional de Cancer, Rio de Janeiro, Not set
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, Sao Jose Rio Preto, Not set
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, Sao Paulo, Not set
Hospital Beneficencia Portuguesa da Sao Paulo, Sao Paulo, Not set
Hospital Nove de Julho, Sao Paulo, Not set
Icesp - Instituto Do Câncer Do Estado de São Paulo Octavio Frias de Oliveira, SĂŁo Paulo, Not set
Umhat 'Dr. Georgi Stranski', Ead, Pleven, Not set
Umhat 'Sv. Georgi', Ead, Plovdiv, Not set
Umhat  Sv. Ivan Rilskiâ , Ead, Sofia, Not set
Military Medical Academy - Mhat - Sofia, Sofia, Not set
'Shathd' Ead Sofia, Sofia, Not set
Umhat Prof. Dr. Stoyan Kirkovich Ad, Stara Zagora, Not set
London Health Sciences Centre, London, Not set
The Ottawa Hospital - General Campus, Ottawa, Not set
Saskatoon Cancer Centre, Saskatoon, Not set
Princess Margaret Cancer Center, Toronto, Not set
Peking University First Hospital, Beijing, Not set
Peking University Third Hospital, Beijing, Not set
Peking Union Medical College Hospital, Beijing, Not set
The First Hospital of Jilin University, Changchun, Not set
Xiangya Hospital, Central South University, Changsha, Not set
The Second Xiangya Hospital of Central South University, Changsha, Not set
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Not set
Sun Yat-Sen University, Cancer Center, Guangzhou, Not set
Guangdong Provincial People'S Hospital, Guangzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
Qilu Hospital of Shandong University, Jinan, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Zhong Da Hospital, Southeast University, Nanjing, Not set
Affiliated Hospital of Nantong University, Nantong, Not set
The Affiliated Hospital of Qingdao University, Qingdao, Not set
Shanghai Tongren Hospital, Shanghai, Not set
Shengjing Hospital of China Medical University, Shengyang, Not set
Shenzhen Second People'S Hospital, Shenzhen, Not set
The First Affiliated Hospital of Soochow University, Suzhou, Not set
Institute of Hematology and Hospital of Blood Disease, Tianjin, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Not set
Wuxi People'S Hospital, Wuxi, Not set
The First Affiliated Hospital of Xiâ An Jiaotong University, Xi'an, Not set
Yantai Yuhuangding Hospital, Yantai, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Clinical Hospital Centre Rijeka, Rijeka, Not set
Clinical Hospital Centar Zagreb, Zagreb, Not set
Clinical Hospital Dubrava, Zagreb, Not set
Fakultni Nemocnice Brno, Brno, Not set
Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni Nemocnice Ostrava, Ostrava - Poruba, Not set
Fakultni Nemocnice Plzen, Plzen, Not set
Fakultni Nemocnice Kralovske Vinohrady, Praha 10, Not set
Ustav Hematologie A Krevni Transfuze, Praha 2, Not set
Chu Angers - Hă"Pital Hă"Tel Dieu, Angers, Not set
Chu de Caen, Caen, Not set
Chu de Grenoble - Hospital Albert Michallon, La Tronche, Not set
Centre Hospitalier de Versailles, Le Chesnay Cedex, Not set
Hopital Claude Huriez - Chru Lille, Lille cedex, Not set
Centre Léon Bérard, Lyon, Not set
Hopital de La Conception - Aphm, Marseille Cedex 05, Not set
Chu de Nantes - Hotel Dieu, Nantes cedex 1, Not set
CHU Nice - Hôpital de l'Archet 1, Nice, Not set
Hospital Saint-Louis, Paris cedex 10, Not set
Chu de Bordeaux - Hă"Pital Haut-Lă Vă Que, Pessac cedex, Not set
Centre Hospitalier Lyon Sud, Pierre BĂŠnite, Not set
Chu Rennes - Hopital Pontchaillou, Rennes cedex 09, Not set
Chu Amiens - Hopital Sud, Salouel, Not set
Institut de Cancă Rologie de Strasbourg Europe - Icans, Strasbourg, Not set
Institut Universitaire Du Cancer de Toulouse- Iuct-O, Toulouse, Not set
Klinikum Aschaffenburg-Alzenau, Alzenau, Not set
Staedtisches Klinikum Braunschweig Ggmbh, Braunschweig, Not set
Universitaetsklinikum Carl Gustav Carus Tu Dresden, Dresden, Not set
Universitaetsklinikum Essen, Essen, Not set
Krh Klinikum Siloah, Hannover, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Universitaetsklinikum Schleswig-Holstein, Kiel, Not set
Universită"Tsklinikum Leipzig Klinik Fă R Hă"Matologie Internistische Onkologie Hă"Mostaseol, Leipzig, Not set
Universitaetsklinikum Muenster, Münster, Not set
The University of Hong Kong, Hong kong, Not set
The Chinese University of Hong Kong (Cuhk), Shatin, Not set
Semmelweis Egyetem, Budapest, Not set
Debreceni Egyetem, Debrecen, Not set
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz, Gyor, Not set
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Szeged, Not set
Azienda Ospedaliero Universitaria Consorziale Policlinico Di Bari, Bari, Not set
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia (Presidio Spedali Civili), Brescia, Not set
Irccs Istituto Scientifico Romagnolo Per Lo Studio Dei Tumori 'Dino Amadori' - Irst, Meldola, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda), Milano, Not set
Ospedale Maggiore Di Novara, Novara, Not set
Azienda Ospedaliera Vincenzo Cervello, Palermo, Not set
Fondazione Policlinico Universitario Agostino Gemelli Irccs, Roma, Not set
Azienda Ospedaliera Universitaria Policlinico Tor Vergata, Rome, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Irccs Ospedale Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Not set
Azienda Ospedaliero-Universitaria Cittă Della Salute E Della Scienza Di Torino, Torino, Not set
Ospedale Mauriziano Umberto I, Torino, Not set
Asst Dei Sette Laghi Ospedale Di Circolo E Fondazione Macchi Varese, Varese, Not set
Akita University Hospital, Akita, Not set
Aomori Prefetural Central Hospital, Aomori, Not set
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyo-ku, Not set
Chiba Aoba Municipal Hospital, Chiba-shi, Not set
Kyushu University Hospital, Fukuoka, Not set
Chugoku Central Hospital, Fukuyama, Not set
Gifu Municipal Hospital, Gifu, Not set
Hamamatsu University School of Medicine, University Hospital, Hamamatsu, Not set
Tesshokai Kameda General Hospital, Kamogawa-shi, Not set
Kanazawa University Hospital, Kanazawa, Not set
National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set
Saiseikai Maebashi Hospital, Maebashi, Not set
Ehime Prefectural Central Hospital, Matsuyama, Not set
Nagoya University Hospital, Nagoya, Not set
Japan RED CROSS OSAKA HOSPITAL, Osakar, Not set
Hokkaido University Hospital, Sapporo, Not set
Sapporo Hokuyu Hospital, Sapporo, Not set
Tenri Hospital, Tenri, Not set
Inje University Haeundae Paik Hospital, Busan, Not set
Pusan National University Hospital, Busan, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Yeungnam University Hospital, Daegu, Not set
Daegu Catholic University Medical Center, Daegu, Not set
Chonnam National University Hwasun Hospital, Hwasun-gun, Not set
Gachon University Gil Medical Center, Incheon, Not set
Jeonbuk National University Hospital, Jeonju-si, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary'S Hospital, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Ajou University Hospital, Suwon, Not set
Ulsan University Hospital, Ulsan, Not set
Haukeland Universitetssykehus, Bergen, Not set
Oslo University Hospital, Oslo, Not set
University Hospital of North Norway, Tromsø, Not set
Klinika Hematoonkologii I Transplantacji Szpiku, Lublin, Not set
Spzoz Msw Zwarmiĺ Sko-Mazurskimcen.Onko.Wolsztynie, Olsztyn, Not set
Wojewodzki Szpital Zespolony Im. L. Rydygiera W Toruniu, Torun, Not set
Instytut Hematologii I Transfuzjologii, Warszawa, Not set
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisboa, Not set
Instituto Portugues De Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Spitalul Clinic Colentina, Bucuresti, Not set
Institutul Clinic Fundeni, Bucuresti, Not set
Spitalul Clinic Coltea, Bucuresti, Not set
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca, Cluj-Napoca, Not set
Spitalul Clinic Municipal Filantropia Craiova, Craiova, Not set
Military Medical Academy, Belgrade, Not set
University Clinical Center of Serbia, Belgrade, Not set
University Clinical Center Nis, Nis, Not set
National University Hospital, Singapore, Not set
Curie Oncology Pte Ltd, Singapore, Not set
Complejo Hospitalario Universitario de Albacete, Albacete, Not set
Hospital de La Santa Creu I Sant Pau, Barcelona, Not set
Hospital Universitario De Burgos, Burgos, Not set
Hospital San Pedro de Alcantara, Caceres, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas, Not set
Clinica Universidad de Navarra, Madrid, Not set
Md Anderson Cancer Centre, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Not set
Hospital Regional Universitario de Malaga, Malaga, Not set
Hospital General Universitario Morales Meseguer, Murcia, Not set
Hospital Universitari Son Espases, Palma de Mallorca, Not set
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Not set
Hospital Universitario Marques de Valdecilla, Santander, Not set
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Not set
Hospital Universitario Virgen Del Rocio, Seville, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Hospital Universitario Dr. Peset, Valencia, Not set
Hospital Universitari I Politecnic La Fe, Valencia, Not set
Sahlgrenska Universitetssjukhuset, Gasteborg, Not set
Skă Nes Universitetssjukhus, Lund, Lund, Not set
Akademiska Sjukhuset, Uppsala, Not set
Inselspital - Universitaetsspital Bern, Bern, Not set
Luzerner Kantonsspital - Luzern, Lazern 16, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
National Cheng Kung University Hospitalx, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Memorial Hospital, Taoyuan County, Not set
King'S College Hospital, London, Not set
Hammersmith Hospital, London, Not set
Maidstone Hospital, Maidstone, Not set
Manchester Royal Infirmary, Manchester, Not set
Churchill Hospital, Oxford, Not set
Torbay Hospital, Torquay, Not set
Conditions: Leukemia
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
Recruiting
This study is being done to see if a drug called disitamab vedotin, alone or with pembrolizumab, works to treat HER2 expressing urothelial cancer. It will also test how safe the drug is for participants.
Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic).
It will also study what side effects happen when participants get the drug. A side effect is anything a drug does... Read More
This study is being done to see if a drug called disitamab vedotin, alone or with pembrolizumab, works to treat HER2 expressing urothelial cancer. It will also test how safe the drug is for participants.
Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic).
It will also study what side effects happen when participants get the drug. A side effect is anything a drug does to your body besides treating the disease. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: Banner Gateway Medical Center, Gilbert, Arizona +179 locations
Banner Gateway Medical Center, Gilbert, Arizona
Banner MD Anderson Cancer Center, Gilbert, Arizona
Kaiser Permanente Anaheim Kraemer Medical Offices, Anaheim, California
Kaiser Permanente Baldwin Park Medical Center, Baldwin Park, California
Kaiser Permanente Bellflower Medical Offices, Bellflower, California
City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte, California
Kaiser Permanente Fontana Medical Center, Fontana, California
Kaiser Permanente South Bay Medical center, Harbor City, California
Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
Kaiser Permanente Alton/Sand Canyon Medical Offices, Irvine, California
Kaiser Permanente Los Angeles Medical Offices, Los Angeles, California
Kaiser Permanente West Los Angeles Medical Center, Los Angeles, California
Valkyrie Clinical Trials, Los Angeles, California
Ronald Reagan UCLA Medical Center, Drug Information Center, Los Angeles, California
UCLA Hematology Oncology, Los Angeles, California
Kaiser Permanente Ontario Medical Center, Ontario, California
UC Irvine Health, Orange, California
Kaiser Permanente Panorama City Medical Center, Medical Offices 3, Panorama City, California
Kaiser Permanente Riverside Medical Center, Riverside, California
Southern California Permanente Medical Group (SCPMG), Riverside, California
Kaiser Permanente San Diego Mission Road (Regulatory and Lab Supplies), San Diego, California
Kaiser Permanente Zion Medical Center, San Diego, California
UCSF Cancer Center MZ Phlebotomy, San Francisco, California
UCSF Mount Zion Phlebotomy, San Francisco, California
UCSF Parnassus Phlebotomy, San Francisco, California
UCSF Investigational Drugs Pharmacy, San Francisco, California
University of California, San Francisco | HDFCCC - Hematopoietic Malignancies, San Francisco, California
University of California, San Francisco, San Francisco, California
Kaiser Permanente San Marcos Medical Offices, San Marcos, California
UCLA Hematology/Oncology - Santa Monica, Santa Monica, California
Kaiser Permanente Woodland Hills Medical Center, Woodland Hills, California
Medstar Washington Hospital Center, Washington, District of Columbia
Florida Cancer Specialists, Bonita Springs, Florida
Florida Cancer Specialists, Bradenton, Florida
Florida Cancer Specialists, Bradenton, Florida
Florida Cancer Specialists, Cape Coral, Florida
Florida Cancer Specialists, Daytona Beach, Florida
Florida Cancer Specialists, Fleming Island, Florida
Florida Cancer Specialists, Fort Myers, Florida
Florida Cancer Specialists, Fort Myers, Florida
Florida Cancer Specialists, Naples, Florida
Florida Cancer Specialists, Port Charlotte, Florida
Florida Cancer Specialists, Sarasota, Florida
Florida Cancer Specialists, Sarasota, Florida
Florida Cancer Specialists, Stuart, Florida
Florida Cancer Specialists, Tallahassee, Florida
Moffitt Cancer Center McKinley Hospital, Tampa, Florida
Florida Cancer Specialists, Venice, Florida
Florida Cancer Specialists, Venice, Florida
Florida Cancer Specialists, Vero Beach, Florida
Florida Cancer Specialists, Wellington, Florida
Florida Cancer Specialists, West Palm Beach, Florida
Northwest Georgia Oncology Centers, a Service of Tanner Medical Center Villa Rica, Carrollton, Georgia
West Georgia Infusion Center, a Service of Tanner Medical Center Villa Rica, Carrollton, Georgia
Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Cartersville, Georgia
Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Douglasville, Georgia
Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Hiram, Georgia
WellStar Paulding Hospital, Hiram, Georgia
Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Marietta, Georgia
Northwest Georgia Oncology Centers, Marietta, Georgia
UChicago Medicine - River East, Chicago, Illinois
University of Chicago Medical Center, Chicago, Illinois
Accellacare - Deerfield, Deerfield, Illinois
UChicago Medicine at Ingalls - Flossmoor, Flossmoor, Illinois
UChicago Medicine Ingalls Memorial, Harvey, Illinois
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox, Illinois
The University of Chicago Medicine Center for Advanced Care Orland Park, Orland Park, Illinois
UChicago Medicine at Ingalls - Tinley Park, Tinley Park, Illinois
UMass Memorial Medical Center, Worcester, Massachusetts
University of Massachusetts Chan Medical School, Worcester, Massachusetts
Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Karmanos Cancer Institute Weisberg Cancer Treatment Center, Farmington Hills, Michigan
Cancer & Hematology Centers of Western Michigan, PC, Grand Rapids, Michigan
Cancer & Hematology Centers of Western Michigan, PC- Kit Storage, Grand Rapids, Michigan
Cancer & Hematology Centers of Western Michigan, PC, Holland, Michigan
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan
Cancer & Hematology Centers of Western Michigan, PC, Norton Shores, Michigan
MSK Basking Ridge, Basking Ridge, New Jersey
MSK Monmouth, Middletown, New Jersey
MSK Bergen, Montvale, New Jersey
MSK Wesrchester, Harrison, New York
Northwell Health, Lake Success, New York
Memorial Sloan Kattering Cancer Centre- Investigational Drug Service Pharmacy, Long Island City, New York
Ship study drug to: Mount Sinai Hospital- Pharmacy Dept, New York, New York
Evelyn H. Lauder Breast and Imaging Centre (BAIC), New York, New York
Memorial Sloan Kettering Cancer Center - Main Campus, New York, New York
Sidney Kimmel Centre for Prostate and Urological Cancer, New York, New York
SUNY Upstate Medical University, Syracuse, New York
MSK nassau, Uniondale, New York
UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
UNC Lineberger Comprehensive Cancer Center / University of North Carolina, Chapel Hill, North Carolina
Carolinas Medical Center (biopsy only), Charlotte, North Carolina
Carolinas Medical Center Investigational Drug Services, Charlotte, North Carolina
Levine Cancer Institute, Charlotte, North Carolina
Atrium Health Mercy (biopsy only), Charlotte, North Carolina
Atrium Health Pineville (biopsy only), Charlotte, North Carolina
Atrium Health University City (biopsy only), Charlotte, North Carolina
Levine Cancer Institute University, Charlotte, North Carolina
Levine Cancer Institute - Ballantyne, Charlotte, North Carolina
Atrium Health Cabarrus (biopsy only), Concord, North Carolina
Levine Cancer Institute Concord, Concord, North Carolina
Atrium Health Union (biopsy only), Monroe, North Carolina
University Hospitals Cleveland Medical Center, Cleveland, Ohio
James Cancer Hospital & Solove Research Institute, Columbus, Ohio
Ohio State University Hospital, Columbus, Ohio
Ohio State University, Columbus, Ohio
OSU Wexner Medical Center & James Cancer Hospital, Columbus, Ohio
OU Health Stephenson Cancer Center, Oklahoma City, Oklahoma
OU Medical Center, Oklahoma City, Oklahoma
University of Tennessee Medical Center, Knoxville, Tennessee
Baylor Scott and White Research Institute, Dallas, Texas
The University of Texas MD Anderson Cancer Center, Houston, Texas
Baylor Scott & White Medical Center - Temple, Temple, Texas
Huntsman Cancer Institute at The University of Utah, Salt Lake City, Utah
Inova Schar Cancer Institute, Fairfax, Virginia
Harborview Medical Center, Seattle, Washington
Fred Hutchinson Cancer Center, Seattle, Washington
University of Washington Medical Center, Seattle, Washington
Froedtert Hospital/Medical College of Wisconsin, Milwaukee, Wisconsin
Clinica Viedma, Viedma, RÍO Negro
Fundacion Cenit, Caba, Not set
Centro Medico Austral, Caba, Not set
Centro Oncologico Korben, Caba, Not set
Hospital Aleman, Ciudad autonoma de Buenos Aires, Not set
Instituto Medico Especializado Alexander Fleming, Ciudad Autonoma de Buenos Aires, Not set
Hospital Sirio Libanes - Buenos Aires, Ciudad Autonoma de Buenos Aires, Not set
Instituto Oncologico de Cordoba, Cordoba, Not set
GenesisCare - North Shore, St Leonards, New South Wales
Macquarie University, Sydney, New South Wales
Mater Cancer Care Centre, Mater Misericordiae Limited, South Brisbane, Queensland
Peninsula & South Eastern Haematology and Oncology Group, Frankston, Victoria
Lyell McEwin Hospital, Elizabeth Vale, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
AZ Maria Middelares, Gent, Not set
CHU UCL Namur-Site de Saint Elisabeth, Namur, Not set
Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta
BC Cancer - Vancouver Fairmont Medical Building, Vancouver, British Columbia
BC Cancer - Vancouver, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Jewish General Hospital, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke, Fleurimont, Not set
Oncovida SA, Santiago, Providencia
Pontificia Universidad Catolica de Chile, Santiago, Providencia
IC La Serena Research SpA, La Serena, Not set
Rambam Health Care Campus, Haifa, Not set
Rabin medical Center, Petach Tikva, Not set
Sheba Medical Center, Ramat Gan, Not set
The Chaim Sheba Medical Center, Ramat-Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
Ospedale San Raffaele, Milano, Lombardy
Centro di Riferimento Oncologico Di Aviano, Aviano, Pordenone
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Rome
Azienda Ospedaliero Universitaria Pisana, Pisa, Toscana
IRCCS Ospedale San Raffaele, U.O. Farmacia Studi Clinici, Milan, Not set
IOV-Istituto Oncologico Veneto IRCCS-U.O. Oncologia Medica 1-SC Farmacia, Padova, Not set
Azienda Ospedaliero Universitaria Pisana, Pisa, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Not set
Azienda Ospedaliera S. Maria di Terni, Terni, Not set
S.C. Farmacia Interna, Terni, Not set
National Cancer Center Hospital East, Kashiwa-shi, Chiba
Sapporo Medical University Hospital, Sapporo-shi, Hokkaido
Osaka University Hospital, Suita-shi, Osaka
Tokushima University Hospital, Tokushima-Shi, Tokushima
The Cancer Institute Hospital of JFCR, Koto-ku, Tokyo
Osaka Prefectural Hospital Organization - Osaka International Cancer Institute, Osaka, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Andaluca
Hospital Universitari Parc Tauli Sabadell, Sabadell, Barcelona
Hospital Universitari Vall d'Hebrón, Barcelona, Not set
MD Anderson Cancer Center - Madrid, Madrid, Not set
MD Anderson Cancer Center Madrid, Madrid, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Not set
Beatson West of Scotland Cancer Centre, Glasgow, Scotland
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Not set
Barts Health NHS Trust, St Bartholomew's Hospital, London, Not set
Guy's Hospital, London, Not set
Charing Cross Hospital, London, Not set
The Christie NHS Foundation Trust - Christie Hospital, Manchester, Not set
The Christie NHS Foundation Trust, Manchester, Not set
The Clatterbridge Cancer Centre NHS Foundation Trust, The Clatterbridge Cancer Centre - Wirral, Merseyside, Not set
Conditions: Urothelial Carcinoma
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