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A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.
Recruiting
The purpose of this study is to measure the efficacy and safety of baxdrostat/dapagliflozin in participants ≥ 18 years of age with CKD and HTN.
This study consists of a screening, a 4-week dapagliflozin run-in period for participants naïve to SGLT2i at baseline; a 24-month double-blind period in which participants will receive either baxdrostat/dapagliflozin or dapagliflozin; and a 6-week open-label period in which all participants will discontinue baxdrostat/placebo and receive dapagliflozin a... Read More
The purpose of this study is to measure the efficacy and safety of baxdrostat/dapagliflozin in participants ≥ 18 years of age with CKD and HTN.
This study consists of a screening, a 4-week dapagliflozin run-in period for participants naïve to SGLT2i at baseline; a 24-month double-blind period in which participants will receive either baxdrostat/dapagliflozin or dapagliflozin; and a 6-week open-label period in which all participants will discontinue baxdrostat/placebo and receive dapagliflozin alone.
Site visits will take place at 2-, 4-, 8-, and 16- weeks following randomisation. Thereafter visits will occur approximately every 4 months, until the 24-month visit at which time baxdrostat/placebo will be discontinued. Participants will continue open-label dapagliflozin for another 6-weeks (approximately), where reassessment of GFR will occur for the primary efficacy endpoint.
In the event of premature discontinuation of blinded study intervention, participants will continue in the study and receive open-label dapagliflozin monotherapy, unless the participant meets dapagliflozin specific discontinuation criteria, in which case all study interventions will be discontinued. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
08/05/2025
Locations: Research Site, Fairhope, Alabama +623 locations
Research Site, Fairhope, Alabama
Research Site, Phoenix, Arizona
Research Site, Surprise, Arizona
Research Site, Tucson, Arizona
Research Site, Searcy, Arkansas
Research Site, Beverly Hills, California
Research Site, Canyon Country, California
Research Site, Fremont, California
Research Site, Fullerton, California
Research Site, Huntington Park, California
Research Site, Lincoln, California
Research Site, Los Alamitos, California
Research Site, San Francisco, California
Research Site, Stanford, California
Research Site, Tarzana, California
Research Site, Torrance, California
Research Site, Arvada, Colorado
Research Site, Denver, Colorado
Research Site, New Britain, Connecticut
Research Site, Boca Raton, Florida
Research Site, Boynton Beach, Florida
Research Site, Coral Gables, Florida
Research Site, Edgewater, Florida
Research Site, Fort Lauderdale, Florida
Research Site, Hialeah, Florida
Research Site, Hollywood, Florida
Research Site, Jacksonville, Florida
Research Site, Lake City, Florida
Research Site, Lake Worth, Florida
Research Site, Melbourne, Florida
Research Site, Miami Lakes, Florida
Research Site, Miami, Florida
Research Site, New Port Richey, Florida
Research Site, Ocoee, Florida
Research Site, Orlando, Florida
Research Site, Orlando, Florida
Research Site, Port Charlotte, Florida
Research Site, Port Orange, Florida
Research Site, Riverview, Florida
Research Site, Winter Haven, Florida
Research Site, Atlanta, Georgia
Research Site, Conyers, Georgia
Research Site, Macon, Georgia
Research Site, Peachtree Corners, Georgia
Research Site, Honolulu, Hawaii
Research Site, Champaign, Illinois
Research Site, Chicago, Illinois
Research Site, Hazel Crest, Illinois
Research Site, Huntley, Illinois
Research Site, Rockford, Illinois
Research Site, Evansville, Indiana
Research Site, Fort Wayne, Indiana
Research Site, Hutchinson, Kansas
Research Site, Wichita, Kansas
Research Site, Lexington, Kentucky
Research Site, Bethesda, Maryland
Research Site, Lanham, Maryland
Research Site, Boston, Massachusetts
Research Site, Boston, Massachusetts
Research Site, New Bedford, Massachusetts
Research Site, Plymouth, Massachusetts
Research Site, Detroit, Michigan
Research Site, Pontiac, Michigan
Research Site, Saint Joseph, Michigan
Research Site, Columbia, Missouri
Research Site, Kansas City, Missouri
Research Site, Kansas City, Missouri
Research Site, Kansas City, Missouri
Research Site, Saint Louis, Missouri
Research Site, Saint Peters, Missouri
Research Site, Eatontown, New Jersey
Research Site, Binghamton, New York
Research Site, Buffalo, New York
Research Site, Manhasset, New York
Research Site, Middletown, New York
Research Site, New York, New York
Research Site, Niagara Falls, New York
Research Site, Orchard Park, New York
Research Site, Rockville Centre, New York
Research Site, Greenville, North Carolina
Research Site, Jacksonville, North Carolina
Research Site, New Bern, North Carolina
Research Site, Statesville, North Carolina
Research Site, Wilmington, North Carolina
Research Site, Wilmington, North Carolina
Research Site, Columbus, Ohio
Research Site, Columbus, Ohio
Research Site, Maumee, Ohio
Research Site, Roseburg, Oregon
Research Site, Chester, Pennsylvania
Research Site, Langhorne, Pennsylvania
Research Site, Uniontown, Pennsylvania
Research Site, East Providence, Rhode Island
Research Site, East Providence, Rhode Island
Research Site, Providence, Rhode Island
Research Site, Charleston, South Carolina
Research Site, Columbia, South Carolina
Research Site, Sioux Falls, South Dakota
Research Site, Chattanooga, Tennessee
Research Site, Kingsport, Tennessee
Research Site, Memphis, Tennessee
Research Site, Memphis, Tennessee
Research Site, Arlington, Texas
Research Site, Austin, Texas
Research Site, Austin, Texas
Research Site, Dallas, Texas
Research Site, Dallas, Texas
Research Site, Dallas, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Humble, Texas
Research Site, Lewisville, Texas
Research Site, Lufkin, Texas
Research Site, Odessa, Texas
Research Site, Pasadena, Texas
Research Site, San Antonio, Texas
Research Site, San Antonio, Texas
Research Site, Salt Lake City, Utah
Research Site, Salt Lake City, Utah
Research Site, Burlington, Vermont
Research Site, Arlington, Virginia
Research Site, Manassas, Virginia
Research Site, Newport News, Virginia
Research Site, Richmond, Virginia
Research Site, Salem, Virginia
Research Site, Woodbridge, Virginia
Research Site, Buenos Aires, Not set
Research Site, Caba, Not set
Research Site, Caba, Not set
Research Site, Ciudad Autonoma de Bs As, Not set
Research Site, Ciudad de Buenos Aires, Not set
Research Site, Cordoba, Not set
Research Site, La Plata, Not set
Research Site, Lanus, Not set
Research Site, Mar del Plata, Not set
Research Site, Mar del Plata, Not set
Research Site, Mendoza, Not set
Research Site, San Nicolás, Not set
Research Site, Birtinya, Not set
Research Site, Clayton, Not set
Research Site, Darlinghurst, Not set
Research Site, Gosford, Not set
Research Site, Kogarah, Not set
Research Site, Parkville, Not set
Research Site, Perth, Not set
Research Site, Perth, Not set
Research Site, St Leonards, Not set
Research Site, Wollongong, Not set
Research Site, Aalst, Not set
Research Site, Bonheiden, Not set
Research Site, Brussel, Not set
Research Site, Gent, Not set
Research Site, Ieper, Not set
Research Site, Kortrijk, Not set
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Research Site, Liege, Not set
Research Site, Liège, Not set
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Research Site, Campina Grande do Sul, Not set
Research Site, Campinas, Not set
Research Site, Campinas, Not set
Research Site, Curitiba, Not set
Research Site, Curitiba, Not set
Research Site, Fortaleza, Not set
Research Site, Joinville, Not set
Research Site, Maringá, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, São José do Rio Preto, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Dupnitsa, Not set
Research Site, Gotse Delchev, Not set
Research Site, Kozloduy, Not set
Research Site, Lom, Not set
Research Site, Pleven, Not set
Research Site, Plovdiv, Not set
Research Site, Plovdiv, Not set
Research Site, Plovdiv, Not set
Research Site, Sandanski, Not set
Research Site, Sliven, Not set
Research Site, Stara Zagora, Not set
Research Site, Veliko Tarnovo, Not set
Research Site, Yambol, Not set
Research Site, Yambol, Not set
Research Site, Edmonton, Alberta
Research Site, Surrey, British Columbia
Research Site, Vancouver, British Columbia
Research Site, Vancouver, British Columbia
Research Site, Winnipeg, Manitoba
Research Site, Halifax, Nova Scotia
Research Site, Sydney, Nova Scotia
Research Site, Brampton, Ontario
Research Site, Concord, Ontario
Research Site, London, Ontario
Research Site, Oshawa, Ontario
Research Site, Stoney Creek, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Waterloo, Ontario
Research Site, Laval, Quebec
Research Site, Montréal, Quebec
Research Site, Montréal, Quebec
Research Site, Sherbrooke, Quebec
Research Site, Quebec, Not set
Research Site, Saint John, Not set
Research Site, Araucania, Not set
Research Site, Santiago, Not set
Research Site, Valdivia, Not set
Research Site, Victoria, Not set
Research Site, Viña del Mar, Not set
Research Site, Baotou, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
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Research Site, Chengdu, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Dongguan, Not set
Research Site, Foshan, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guiyang, Not set
Research Site, Haikou, Not set
Research Site, Hangzhou, Not set
Research Site, Hengyang, Not set
Research Site, Huai'an, Not set
Research Site, Lanzhou, Not set
Research Site, Nanchang, Not set
Research Site, Nanjing, Not set
Research Site, Ningbo, Not set
Research Site, Panjin, Not set
Research Site, Pingxiang, Not set
Research Site, Sanya, Not set
Research Site, Shanghai, Not set
Research Site, Shenyang, Not set
Research Site, Shenzhen, Not set
Research Site, Urumqi, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Wuxi, Not set
Research Site, Xiamen, Not set
Research Site, Xian, Not set
Research Site, Yantai, Not set
Research Site, Yinchuan, Not set
Research Site, Zhengzhou, Not set
Research Site, Frýdek-Místek, Not set
Research Site, Jilemnice, Not set
Research Site, Krnov, Not set
Research Site, Nachod, Not set
Research Site, Olomouc, Not set
Research Site, Police nad Metují, Not set
Research Site, Praha 10, Not set
Research Site, Praha 6, Not set
Research Site, Praha, Not set
Research Site, Trebic, Not set
Research Site, Uherske Hradiste, Not set
Research Site, Aalborg, Not set
Research Site, Aarhus N, Not set
Research Site, Aarhus, Not set
Research Site, Copenhagen E, Not set
Research Site, Esbjerg, Not set
Research Site, Herlev, Not set
Research Site, Herning, Not set
Research Site, Holbæk, Not set
Research Site, Odense, Not set
Research Site, Amiens Cedex 1, Not set
Research Site, Annonay Cedex, Not set
Research Site, Bois-Guillaume, Not set
Research Site, Bordeaux, Not set
Research Site, Boulogne Billancourt Cedex, Not set
Research Site, Brest Cedex, Not set
Research Site, Clermont-Ferrand, Not set
Research Site, La Roche Sur Yon, Not set
Research Site, Le Puy-en-Velay, Not set
Research Site, Lille, Not set
Research Site, Marseille, Not set
Research Site, Montpellier, Not set
Research Site, Nimes, Not set
Research Site, Paris, Not set
Research Site, Paris, Not set
Research Site, Paris, Not set
Research Site, Poitiers, Not set
Research Site, Pontoise, Not set
Research Site, Quimper, Not set
Research Site, Sarcelles, Not set
Research Site, Toulouse, Not set
Research Site, Tours, Not set
Research Site, Valenciennes, Not set
Research Site, Vandoeuvre-Les-Nancy, Not set
Research Site, Aachen, Not set
Research Site, Amberg, Not set
Research Site, Bad Oeynhausen, Not set
Research Site, Berlin, Not set
Research Site, Berlin, Not set
Research Site, Berlin, Not set
Research Site, Berlin, Not set
Research Site, Bochum, Not set
Research Site, Dresden, Not set
Research Site, Essen, Not set
Research Site, Falkensee, Not set
Research Site, Hamburg, Not set
Research Site, Herne, Not set
Research Site, Kaiserslautern, Not set
Research Site, Leipzig, Not set
Research Site, Mainz, Not set
Research Site, Mannheim, Not set
Research Site, München, Not set
Research Site, Münster, Not set
Research Site, Nürnberg, Not set
Research Site, Oldenburg, Not set
Research Site, Reinfeld (Holstein), Not set
Research Site, Schwerin, Not set
Research Site, Ulm, Not set
Research Site, Völklingen, Not set
Research Site, Wiesbaden, Not set
Research Site, Witten, Not set
Research Site, Alexandroupolis, Not set
Research Site, Athens, Not set
Research Site, Heraclion, Not set
Research Site, Ioannina, Not set
Research Site, Patras, Not set
Research Site, Thessaloniki, Not set
Research Site, Thessaloniki, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Békéscsaba, Not set
Research Site, Dunaújváros, Not set
Research Site, Kecskemét, Not set
Research Site, Nyíregyháza, Not set
Research Site, Nyíregyháza, Not set
Research Site, Nyíregyháza, Not set
Research Site, Pécs, Not set
Research Site, Pécs, Not set
Research Site, Siófok, Not set
Research Site, Szeged, Not set
Research Site, Székesfehérvár, Not set
Research Site, Ahmedabad, Not set
Research Site, Bangalore, Not set
Research Site, Belagavi, Not set
Research Site, Calicut, Not set
Research Site, Chennai, Not set
Research Site, Coimbatore, Not set
Research Site, Dehradun, Not set
Research Site, Hyderabad, Not set
Research Site, Hyderabad, Not set
Research Site, Jodhpur, Not set
Research Site, Kolkata, Not set
Research Site, Madurai, Not set
Research Site, New Delhi, Not set
Research Site, New Delhi, Not set
Research Site, Pune, Not set
Research Site, Vijayawada, Not set
Research Site, Ashkelon, Not set
Research Site, Haifa, Not set
Research Site, Jerusalem, Not set
Research Site, Kfar Saba, Not set
Research Site, Petah Tikva, Not set
Research Site, Ramat Gan, Not set
Research Site, Rehovot, Not set
Research Site, Tel Aviv, Not set
Research Site, Bologna, Not set
Research Site, Catanzaro, Not set
Research Site, Chiavari, Not set
Research Site, Desio, Not set
Research Site, Milano, Not set
Research Site, Napoli, Not set
Research Site, Parma, Not set
Research Site, Rozzano, Not set
Research Site, San Giovanni Rotondo, Not set
Research Site, Torino, Not set
Research Site, Chuo-ku, Not set
Research Site, Chuo-ku, Not set
Research Site, Chuo-ku, Not set
Research Site, Daito-shi, Not set
Research Site, Fujisawa-shi, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Hiroshima, Not set
Research Site, Ina-shi, Not set
Research Site, Kamakura-shi, Not set
Research Site, Kamakura-shi, Not set
Research Site, Kasugai-shi, Not set
Research Site, Kawaguchi, Not set
Research Site, Kofu-shi, Not set
Research Site, Kumagaya-shi, Not set
Research Site, Kurume-shi, Not set
Research Site, Kyoto-shi, Not set
Research Site, Marugame-shi, Not set
Research Site, Matsuyama-city, Not set
Research Site, Nagoya-shi, Not set
Research Site, Naka, Not set
Research Site, Nishinomiya-Shi, Not set
Research Site, Obihiro-shi, Not set
Research Site, Oita-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osaka, Not set
Research Site, Sakai-shi, Not set
Research Site, Sapporo, Not set
Research Site, Sendai-shi, Not set
Research Site, Shinjyuku-ku, Not set
Research Site, Shizuoka-shi, Not set
Research Site, Takatsuki-shi, Not set
Research Site, Toride-shi, Not set
Research Site, Toyota-Shi, Not set
Research Site, Tsu-shi, Not set
Research Site, Tsu-shi, Not set
Research Site, Ueda-shi, Not set
Research Site, Urayasu, Not set
Research Site, Yaizu-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Ansan-si, Not set
Research Site, Anyang-si, Not set
Research Site, Busan, Not set
Research Site, Cheonan-si, Not set
Research Site, Daejeon, Not set
Research Site, Goyang-si, Not set
Research Site, Gwangju, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Uijeongbu, Not set
Research Site, Wonju-si, Not set
Research Site, Yangsan-si, Not set
Research Site, Klang, Not set
Research Site, Kota Kinabalu, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuantan, Not set
Research Site, Seremban, Not set
Research Site, Taiping, Not set
Research Site, Alkmaar, Not set
Research Site, Almere, Not set
Research Site, Amersfoort, Not set
Research Site, Dordrecht, Not set
Research Site, Hardenberg, Not set
Research Site, Harderwijk, Not set
Research Site, Hilversum, Not set
Research Site, Roosendaal, Not set
Research Site, Tilburg, Not set
Research Site, Utrecht, Not set
Research Site, Arequipa, Not set
Research Site, Chorrillos, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, LIma, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Piura, Not set
Research Site, Cebu City, Not set
Research Site, Davao City, Not set
Research Site, Iloilo City, Not set
Research Site, Laguna, Not set
Research Site, Manila, Not set
Research Site, Quezon City, Not set
Research Site, Quezon City, Not set
Research Site, San Fernando, Not set
Research Site, Chrzanów, Not set
Research Site, Gdynia, Not set
Research Site, Krakow, Not set
Research Site, Kraków, Not set
Research Site, Kraków, Not set
Research Site, Kraków, Not set
Research Site, Kraków, Not set
Research Site, Lodz, Not set
Research Site, Lublin, Not set
Research Site, Olsztyn, Not set
Research Site, Poznań, Not set
Research Site, Poznań, Not set
Research Site, Ruda Śląska, Not set
Research Site, Rzeszów, Not set
Research Site, Szczecin, Not set
Research Site, Tczew, Not set
Research Site, Warszawa, Not set
Research Site, Wrocław, Not set
Research Site, Wrocław, Not set
Research Site, Wrocław, Not set
Research Site, Łódź, Not set
Research Site, Łódź, Not set
Research Site, Łódź, Not set
Research Site, Łódź, Not set
Research Site, Żywiec, Not set
Research Site, Bucharest, Not set
Research Site, Bucharest, Not set
Research Site, Bucharest, Not set
Research Site, Bucuresti, Not set
Research Site, Cluj-Napoca, Not set
Research Site, Iasi, Not set
Research Site, Oradea, Not set
Research Site, Targu Mures, Not set
Research Site, Timisoara, Not set
Research Site, Dammam, Not set
Research Site, Riyadh, Not set
Research Site, Riyadh, Not set
Research Site, Riyadh, Not set
Research Site, Riyadh, Not set
Research Site, Belgrade, Not set
Research Site, Belgrade, Not set
Research Site, Kragujevac, Not set
Research Site, Nis, Not set
Research Site, Novi Sad, Not set
Research Site, Banska Bystrica, Not set
Research Site, Dolný Kubín, Not set
Research Site, Košice, Not set
Research Site, Lucenec, Not set
Research Site, Martin, Not set
Research Site, Myjava, Not set
Research Site, Nitra, Not set
Research Site, Nitra, Not set
Research Site, Presov, Not set
Research Site, Puchov, Not set
Research Site, Rožňava, Not set
Research Site, Trnava, Not set
Research Site, Zilina, Not set
Research Site, Benoni, Not set
Research Site, Bloemfontein, Not set
Research Site, Cape Town, Not set
Research Site, Cape Town, Not set
Research Site, Durban, Not set
Research Site, Lenasia, Not set
Research Site, Midrand, Not set
Research Site, Newton, Not set
Research Site, Parow, Not set
Research Site, Stanger, Not set
Research Site, A Coruña, Not set
Research Site, Almeria, Not set
Research Site, Badalona, Not set
Research Site, L' Hospitalet De Llobregat, Not set
Research Site, Lugo, Not set
Research Site, Madrid, Not set
Research Site, Málaga, Not set
Research Site, Málaga, Not set
Research Site, Palma deMallorca, Not set
Research Site, Pamplona, Not set
Research Site, Sevilla, Not set
Research Site, Valencia, Not set
Research Site, Danderyd, Not set
Research Site, Gävle, Not set
Research Site, Göteborg, Not set
Research Site, Linkoping, Not set
Research Site, Rättvik, Not set
Research Site, Stockholm, Not set
Research Site, Uppsala, Not set
Research Site, Varberg, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, New Taipei, Not set
Research Site, Taichung City, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Taipei City, Not set
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Research Site, Taipei, Not set
Research Site, Taoyuan, Not set
Research Site, Yung Kang City, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Chiang Mai, Not set
Research Site, Hat Yai, Not set
Research Site, Muang, Not set
Research Site, Phutthamonthon, Not set
Research Site, Ratchathewi, Not set
Research Site, Ubonratchathani, Not set
Research Site, Adana, Not set
Research Site, Adapazarı, Not set
Research Site, Afyonkarahisar, Not set
Research Site, Ankara, Not set
Research Site, Antalya, Not set
Research Site, Bursa, Not set
Research Site, Istanbul, Not set
Research Site, Kahramanmaras, Not set
Research Site, Kayseri, Not set
Research Site, Kocaeli, Not set
Research Site, Chernivtsі, Not set
Research Site, Ivano-Frankivsk, Not set
Research Site, Kyiv, Not set
Research Site, Kyiv, Not set
Research Site, Kyiv, Not set
Research Site, Kyiv, Not set
Research Site, Kyiv, Not set
Research Site, Ternopil, Not set
Research Site, Ternopil, Not set
Research Site, Uzhhorod, Not set
Research Site, Vinnytsia, Not set
Research Site, Vinnytsia, Not set
Research Site, Vinnytsia, Not set
Research Site, Vinnytsya, Not set
Research Site, Bristol, Not set
Research Site, Cambridge, Not set
Research Site, Dundee, Not set
Research Site, Glasgow, Not set
Research Site, Harrow, Not set
Research Site, Hounslow, Not set
Research Site, Leicester, Not set
Research Site, Liverpool, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Newcastle-Under-Lyme, Not set
Research Site, Nottingham, Not set
Research Site, Wolverhampton, Not set
Research Site, Bien Hoa, Not set
Research Site, Can Tho, Not set
Research Site, Can Tho, Not set
Research Site, Da Nang, Not set
Research Site, Ha Noi, Not set
Research Site, Hai Phong, Not set
Research Site, Ho Chi Minh, Not set
Research Site, Ho Chi Minh, Not set
Research Site, Hochiminh city, Not set
Conditions: Chronic Kidney Disease and Hypertension
A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)
Recruiting
The purpose of this Phase 3 study is to evaluate if BRd prolongs progression free survival (PFS) and/or improves minimal residual disease (MRD) negative status compared with DRd in participants with TI-NDMM.
The purpose of this Phase 3 study is to evaluate if BRd prolongs progression free survival (PFS) and/or improves minimal residual disease (MRD) negative status compared with DRd in participants with TI-NDMM. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: GSK Investigational Site, Mobile, Alabama +76 locations
GSK Investigational Site, Mobile, Alabama
GSK Investigational Site, Kingwood, Texas
GSK Investigational Site, Capital Federal, Not set
GSK Investigational Site, Ciudad Autonoma de Buenos Aire, Not set
GSK Investigational Site, COrdoba, Not set
GSK Investigational Site, Rosario, Not set
GSK Investigational Site, Viedma, Not set
GSK Investigational Site, Gosford NSW, New South Wales
GSK Investigational Site, Box Hill, Victoria
GSK Investigational Site, Fitzroy, Not set
GSK Investigational Site, Brugge, Not set
GSK Investigational Site, Bruxelles, Not set
GSK Investigational Site, Gent, Not set
GSK Investigational Site, Hornu, Not set
GSK Investigational Site, Roeselare, Not set
GSK Investigational Site, Beijing, Not set
GSK Investigational Site, Guangzhou, Not set
GSK Investigational Site, Nanchang, Not set
GSK Investigational Site, Nanchang, Not set
GSK Investigational Site, Shanghia, Not set
GSK Investigational Site, Shenzhen, Not set
GSK Investigational Site, Tianjin, Not set
GSK Investigational Site, Wenzhou, Not set
GSK Investigational Site, Ostrava, Not set
GSK Investigational Site, Bobigny cedex, Not set
GSK Investigational Site, Nantes, Not set
GSK Investigational Site, Villejuif cedex, Not set
GSK Investigational Site, Alexandroupolis, Not set
GSK Investigational Site, Athens, Not set
GSK Investigational Site, Athens, Not set
GSK Investigational Site, Athens, Not set
GSK Investigational Site, Patra, Not set
GSK Investigational Site, Thessaloniki, Not set
GSK Investigational Site, Dublin 9, Not set
GSK Investigational Site, Waterford, Not set
GSK Investigational Site, Ancona, Not set
GSK Investigational Site, Meldola FC, Not set
GSK Investigational Site, Roma, Not set
GSK Investigational Site, Aichi, Not set
GSK Investigational Site, Ehime, Not set
GSK Investigational Site, Ehime, Not set
GSK Investigational Site, Fukuoka, Not set
GSK Investigational Site, Fukushima, Not set
GSK Investigational Site, Gunma, Not set
GSK Investigational Site, Hyogo, Not set
GSK Investigational Site, Hyogo, Not set
GSK Investigational Site, Ibaraki, Not set
GSK Investigational Site, Ishikawa, Not set
GSK Investigational Site, Iwate, Not set
GSK Investigational Site, Kanagawa, Not set
GSK Investigational Site, Miyagi, Not set
GSK Investigational Site, Nara, Not set
GSK Investigational Site, Sapporo, Not set
GSK Investigational Site, Suita, Not set
GSK Investigational Site, Tokyo, Not set
GSK Investigational Site, Yamagata, Not set
GSK Investigational Site, Hwasun, Not set
GSK Investigational Site, Jeonju, Not set
GSK Investigational Site, Seoul, Not set
GSK Investigational Site, Seoul, Not set
GSK Investigational Site, Seoul, Not set
GSK Investigational Site, Seoul, Not set
GSK Investigational Site, Seoul, Not set
GSK Investigational Site, Ulsan, Not set
GSK Investigational Site, Lublin, Not set
GSK Investigational Site, Badalona, Not set
GSK Investigational Site, Gijon, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Malaga, Not set
GSK Investigational Site, Murcia, Not set
GSK Investigational Site, Salamanca, Not set
GSK Investigational Site, Santander, Not set
GSK Investigational Site, Valladolid, Not set
GSK Investigational Site, Kaohsiung, Not set
GSK Investigational Site, Plymouth, Not set
Conditions: Multiple Myeloma, Newly Diagnosed Multiple Myeloma
A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis.
Recruiting
The ASPIRE trial is a 52 week randomized, double-blind, placebo-controlled, parallel-group, multicenter trial in which the efficacy, safety, and pharmacokinetics of orally administered buloxibutid, either on top of stable IPF therapy or as monotherapy, are assessed in participants with IPF.
Trial website: www.aspire-ipf.com
The ASPIRE trial is a 52 week randomized, double-blind, placebo-controlled, parallel-group, multicenter trial in which the efficacy, safety, and pharmacokinetics of orally administered buloxibutid, either on top of stable IPF therapy or as monotherapy, are assessed in participants with IPF.
Trial website: www.aspire-ipf.com Read Less
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/05/2025
Locations: UAB Hospital, School of Medicine/Lung Health Center, Birmingham, Alabama +101 locations
UAB Hospital, School of Medicine/Lung Health Center, Birmingham, Alabama
Keck Medicine of University of Southern California, Los Angeles, California
Paradigm Clinical Research Centers, Inc., Redding, California
UC Davis Health System, Sacramento, California
UC San Diego Medical Center - Hillcrest, San Diego, California
Paradigm Clinical Research, San Diego, California
National Jewish Medical and Research Center, Denver, Colorado
University of Florida Health (UF Health), Gainesville, Florida
Clinical Research Specialists, Kissimmee, Florida
Emory Saint Joseph's Hospital, Atlanta, Georgia
Endeavor Health - Evanston Hospital, Evanston, Illinois
University of Kansas Medical Center, Kansas City, Kansas
Massachusetts General Hospital, Pulmonary & Critical Care Medicine, Boston, Massachusetts
William Beaumont Hospital - Royal Oak, Royal Oak, Michigan
Renown Regional Medical Center, Reno, Nevada
University of New Mexico, Health Sciences Center, Albuquerque, New Mexico
Stony Brook University, Stony Brook, New York
Southeastern Research Center, Winston-Salem, North Carolina
Cleveland Clinic - Cleveland, Department of Pulmonary Medicine, Cleveland, Ohio
Oregon Clinic, Pulmonary, Critical Care & Sleep Medicine East, Portland, Oregon
Temple University Hospital, Philadelphia, Pennsylvania
Low Country Lung and Critical Care, North Charleston, South Carolina
Baylor Scott & White Research Institute, Dallas, Texas
University of Utah, Health Sciences Center, Salt Lake City, Utah
University of Wisconsin Clinical Science Center, Madison, Wisconsin
Research Institute of Respiratory Diseases, San Miguel De Tucumán, Tucuman
CEMER Medical Center for Respiratory Diseases, Buenos Aires, Not set
IMER Respiratory Medicine Institute, Córdoba, Not set
Breathe Comprehensive Clinical Health, Godoy Cruz, Not set
Emphysema Foundation, Pneumology, Mar Del Plata, Not set
Vistalba Health Center, Mendoza, Not set
Flinders Medical Centre, Adelaide, Not set
The Prince Charles Hospital, Brisbane, Not set
Concord Repatriation General Hospital, Department of Respiratory Medicine, Concord, Not set
St Vincent's Hospital, Sydney Ltd., Darlinghurst, Not set
Townsville University Hospital, Douglas, Not set
Austin Hospital, Heidelberg, Not set
Royal Prince Alfred Hospital, Sydney, Not set
The Queen Elizabeth Hospital, Woodville, Not set
Kepler University Hospital GmbH, Department of Pulmonology, Linz, Upper Austria
Salzburg Regional Hospital, Department of Pneumology/Respiratory Medicine, Salzburg, Not set
Hospital Penzing, Department of Respiratory and lung diseases, Vienna, Not set
Erasme Hospital, Brussels, Not set
University Hospitals Saint-Luc, Brussels, Not set
University Hospital Center Sart-Tilman, Liège, Not set
UCL Mont-Godinne University Hospitals, Yvoir, Not set
Kelowna Respiratory & Allergy Clinic, Kelowna, British Columbia
Laval Hospital, Laval, Quebec
Pierre-Le Gardeur, Terrebonne, Quebec
Diex Research Trois-Riviere Inc., Trois-Rivieres, Quebec
University Hospital Freiburg, Freiburg, Baden-Wuerttemberg
University Hospital Heidelberg, Clinic of Thoracic Medicine Heidelberg GmbH, Heidelberg, Baden-Wuerttemberg
University Hospital Tuebingen, Tuebingen, Baden-Wuerttemberg
Immenhausen Lung Hospital, Immenhausen, Hesse
Hannover Medical School, Center for Internal Medicine, Hannover, Lower Saxony
RuhrlandClinic - Lung Center, Essen, North Rhine-Westphalia
Vivantes Hospital Neukoelln, Berlin, Not set
University General Hospital of Heraklion, Pneumonology Clinic, Heraklion, Crete
"Sotiria" Chest Diseases Hospital of Athens, Athens, Not set
General Hospital of Chest Diseases "Sotiria" 5th Pulmonology Department, Athens, Not set
University General Hospital "Attikon", 2nd Pulmonary Department, Athens, Not set
University General Hospital of Ioannina, Ioánnina, Not set
University General Hospital of Patras, Patras, Not set
General Hospital of Thessaloniki "G. Papanikolaou", University Department of Pulmonology, Thessaloniki, Not set
IRCCS Policlinic Hospital San Martino, Genoa, Liguria
University Hospital - Ospedali Riuniti Umberto I - GM Lancisi - G Salesi of Ancona, Ancona, Not set
Local Healthcare Company Papa Giovanni XXIII (ASST Papa Giovanni XXIII), Bergamo, Not set
San Gerardo of Tintori IRCCS Foundation, Monza, Not set
Foundation PTV - Polyclinic Tor Vergata, Roma, Not set
University Hospital City of Health and Science of Turin - Hospital Molinette, Turin, Not set
Soon Chun Hyang Central Medical Center, Bucheon-si, Not set
The Catholic University Of Korea Bucheon St. Mary's Hospital, Bucheon-si, Not set
InJe University Busan Paik Hospital, Busan, Not set
InJe University Haeundae Paik Hospital, Busan, Not set
Hanyang University - Myongji Hospital, Goyang-si, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Soon Chun Hyang University Hospital Seoul, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
National Institute of Respiratory Diseases Ismael Cosio Villegas (INER), Mexico City, Distrito Federal
Dr. Jose Eleuterio Gonzalez Monterrey University Hospital, Monterrey, Nuevo Leon
Integral Health Medical Unit, San Nicolás De Los Garza, Nuevo Leon
Oaxaca Site Management Organization S.C - (Osmo), Oaxaca, Not set
MICS Medical Centre Bydgoszcz, Bydgoszcz, Not set
VITAMED Galaj i Cichomski General Partnership, Bydgoszcz, Not set
Twoja Przychodnia Medical Centre of Nowa Sol, Nowa Sól, Not set
Allergology- Pulmunology Outpatient Clinic Alergopneuma, Pulmonology Outpatient Clinic, Świdnik, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Far Eastern Memorial Hospital, New Taipei City, Not set
China Medical University Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Queen Elizabeth Hospital Birmingham, Birmingham, Not set
Royal Devon and Exeter Hospital, Exeter, Not set
Guy's Hospital, London, Not set
Royal Brompton Hospital, London, Not set
Wythenshawe Hospital, Manchester, Not set
Oxford University Hospitals NHS Trust, Oxford, Not set
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment
Recruiting
This study is open to adults 18 years and older with advanced or metastatic non-small cell lung cancer. People can join the study if they have tumours with HER2 mutations and have not yet received any systemic therapy including chemotherapy for advanced or metastatic lung cancer. The purpose of this study is to find out whether a medicine called zongertinib (BI 1810631) can slow down the worsening of advanced non-small cell lung cancer better than the standard treatment available. Zongertinib ma... Read More
This study is open to adults 18 years and older with advanced or metastatic non-small cell lung cancer. People can join the study if they have tumours with HER2 mutations and have not yet received any systemic therapy including chemotherapy for advanced or metastatic lung cancer. The purpose of this study is to find out whether a medicine called zongertinib (BI 1810631) can slow down the worsening of advanced non-small cell lung cancer better than the standard treatment available. Zongertinib may slow cancer cell growth by inhibiting HER2. This would prolong cancer re-occurrence and increase survival. Current standard treatment is pembrolizumab plus platinum-pemetrexed chemotherapy.
Participants are put into 2 groups by chance. One group receives zongertinib at regular times throughout the study and the other group receives infusions of pembrolizumab, pemetrexed and cisplatin or carboplatin (pembrolizumab plus platinum-pemetrexed chemotherapy) into a vein.
Participants may be in the study up to a maximum of 70 months. During this time, they visit the study site about every 3 weeks for study procedures. The doctors regularly check the size of the tumour with a CT or MRI scan, at the beginning of the study and every 6 weeks. After 18 months they check the tumour size every 12 weeks. Doctors regularly check whether the cancer has spread to other parts of the body. The doctors also regularly check participants' health and take note of any unwanted effects. The time it takes for the cancer to worsen is compared between the 2 groups to see whether the treatment works. The participants also fill in questionnaires about their symptoms and quality of life. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Clearview Cancer Institute, Huntsville, Alabama +169 locations
Clearview Cancer Institute, Huntsville, Alabama
Mohtaseb Cancer Center and Blood Disorders, LLC, Bullhead City, Arizona
Precision NextGen Oncology, Beverly Hills, California
ClinRé 001-022 (Premier Cancer Care and Infusion Center), Fresno, California
OPN Healthcare, Inc., Glendale, California
Scripps Green Hospital, La Jolla, California
Valkyrie Clinical Trials, Los Angeles, California
Sharp Memorial Hospital, San Diego, California
St. Louis Cancer Care, LLP, Bridgeton, Missouri
Oncology Hematology Associates, Springfield, Missouri
Cancer Care Specialists, Reno, Nevada
Montefiore Medical Center, Bronx, New York
Northwell Health, Lake Success, New York
Regional Medical Oncology Center, Wilson, North Carolina
Gabrail Cancer Center, Canton, Ohio
Carolina Blood and Cancer Care Associates, PA, Rock Hill, South Carolina
SCRI Oncology Partners, Nashville, Tennessee
Huntsman Cancer Institute, Salt Lake City, Utah
Virginia Cancer Specialists, PC, Fairfax, Virginia
Swedish Cancer Institute, Edmonds, Washington
Swedish Cancer Institute, Issaquah, Washington
Swedish Cancer Institute, Seattle, Washington
Clinica Adventista Belgrano, Caba, Not set
Instituto Medico Especializado Alexander Fleming, Ciudad Autónoma de Bs As, Not set
Instituto Oncologico de Cordoba, Córdoba, Not set
Centro Oncologico Riojano Integral (CORI), La Rioja, Not set
Instituto Médico de la Fundación Estudios Clínicos, Rosario, Not set
Clinicas Viedma S.A., Viedma, Not set
Prince of Wales Hospital-Randwick-66496, Randwick, New South Wales
Royal North Shore Hospital-St Leonards-20807, St Leonards, New South Wales
Princess Alexandra Hospital, Woolloongabba, Queensland
Austin Health, Heidelberg, Victoria
St John of God Subiaco Hospital, Subiaco, Western Australia
Krems University Hospital, Krems an der Donau, Not set
Clinic Floridsdorf, Vienna, Not set
Brussels - HOSP Jules Bordet, Anderlecht, Not set
UNIV UZ Gent, Gent, Not set
UZ Leuven, Leuven, Not set
Associacao Dr. Bartholomeu Tacchini, Bento Goncalves, Not set
Hospital do Cancer de Londrina, Londrina, Not set
Hospital Sao Lucas da PUCRS, Porto Alegre, Not set
OncoClinicas Rio de Janeiro, Rio de Janeiro, Not set
CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia, Santo André, Not set
ICESP - Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Not set
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set
Princess Margaret Cancer Centre, Toronto, Ontario
Bradford Hill- Centro de Investigación Clínica, Recoleta, Not set
Cancer Hospital of Chinese Academy of Medical Science, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
West China Hospital of Sichuan University, Chengdu, Not set
Fujian Cancer Hospital, Fuzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
The First Affiliated Hospital, Zhejiang University, Hangzhou, Not set
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Zhongshan Hospital Affiliated to Fudan University, Shanghai, Not set
Taizhou Hospital of Zhejiang Province, Taizhou, Not set
The First Affiliated Hospital of Wenzhou Med College, Wenzhou, Not set
Wuhan Union Hospital, Wuhan, Not set
First Affiliated Hospital of Xiamen University, Xiamen, Not set
Henan Cancer Hospital, Zhengzhou, Not set
HOP Louis Pradel, Bron, Not set
CTR Leon Berard, Lyon, Not set
HOP Nord, Marseille, Not set
HOP Tenon, Paris, Not set
INS Curie, Paris, Not set
HOP Pontchaillou, Rennes, Not set
HOP Civil, Strasbourg, Not set
INS Claudius Regaud IUCT-Oncopole, Toulouse, Not set
INS Gustave Roussy, Villejuif, Not set
Universitätsklinikum Augsburg, Augsburg, Not set
Gemeinschaftskrankenhaus Havelhöhe gGmbH, Berlin, Not set
Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Justus-Liebig Universität Gießen, Gießen, Not set
Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg, Heidelberg, Not set
Universitätsklinikum Köln (AöR), Köln, Not set
Pius-Hospital, Oldenburg, Oldenburg, Not set
Universitätsklinikum Tübingen, Tübingen, Not set
Queen Elizabeth Hospital-Hong Kong-51727, Hong Kong, Not set
Princess Margaret Hospital, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Koranyi National Institute For Pulmonolgy, Budapest, Not set
National Institute of Oncology, Budapest, Not set
Deszk Hospital of Chest Diseases, Deszk, Not set
Pulmonology Institute of Veszprem County, Farkasgyepu, Farkasgyepu, Not set
Fejer County Saint George University Teaching Hospital, Szekesfehervar, Not set
Rambam Medical Center, Haifa, Not set
Meir Medical Center, Kfar-Saba, Not set
Rabin Medical Center Beilinson, Petach Tikva, Not set
Sourasky Medical Center, Tel Aviv, Not set
Istituto Tumori Giovanni Paolo II, Bari, Not set
Istituto Di Candiolo, Candiolo (TO), Not set
AOU Policlinico G. Rodolico San Marco, Catania, Not set
Istituto Nazionale IRCCS Tumori Fondazione Pascale, Napoli, Not set
Azienda Ospedaliera Unversitaria di Parma, Parma, Not set
AOU Policlinico Umberto I, Roma, Not set
A. O. Ospedale Circolo Fond. Macchi, Varese, Not set
Aichi Cancer Center Hospital, Aichi, Nagoya, Not set
Hirosaki University Hospital, Aomori, Hirosaki, Not set
National Cancer Center Hospital East, Chiba, Kashiwa, Not set
Shikoku Cancer Center, Ehime, Matsuyama, Not set
Kyushu University Hospital, Fukuoka, Fukuoka, Not set
Hakodate Goryoukaku Hospital, Hokkaido, Hakodate, Not set
Hokkaido Cancer Center, Hokkaido, Sapporo, Not set
Kanazawa University Hospital, Ishikawa, Kanazawa, Not set
St. Marianna University Hospital, Kanagawa, Kawasaki, Not set
Kanagawa Cancer Center, Kanagawa, Yokohama, Not set
University Hospital Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Not set
Tohoku University Hospital, Miyagi, Sendai, Not set
Okayama University Hospital, Okayama, Okayama, Not set
Osaka International Cancer Institute, Osaka, Osaka, Not set
Shizuoka Cancer Center, Shizuoka, Sunto-gun, Not set
Juntendo University Hospital, Tokyo, Bunkyo-ku, Not set
Komagome Hospital, Tokyo, Bunkyo-ku, Not set
National Cancer Center Hospital, Tokyo, Chuo-ku, Not set
Japanese Foundation for Cancer Research, Tokyo, Koto-ku, Not set
Wakayama Medical University Hospital, Wakayama, Wakayama, Not set
Chungbuk National University Hospital, Cheongiu, Not set
National Cancer Center, Goyang, Not set
Gachon University Gil Medical Center, Incheon, Not set
Kangbuk Samsung Hospital, Seoul, Not set
Severance Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, St.Vincent's Hospital, Suwon, Not set
Health Pharma Professional Research S.A. de C.V., Ciudad de Mexico, Not set
Centro Oncologico Personalizado, Mexico, Not set
Instituto Nacional de Cancerologia, Mexico, Not set
FAICIC S de RL de C.V., Veracruz, Not set
Nederlands Kanker Instituut - Antoni van Leeuwenhoek Amsterdam (METC AVL), Amsterdam, Not set
Maastricht University, Maastricht, Not set
Vestre Viken HF, Drammen Sykehus, Drammen, Not set
Oslo Universitetssykehus HF, Radiumhospitalet, Oslo, Not set
Polish Mother's Memorial Hospital - Research Institute, Lodz, Not set
Greater Poland Center of Pulmonology and Thoracic Surgery, Poznan, Not set
MED POLONIA SP Z O O, Clinical Trials Department,Poznan, Poznan, Not set
Oncology Center-Maria Sklodowska-Curie Institute, Warsaw, Not set
Hospital CUF Tejo, Lisboa, Not set
Centro Hospitalar Lisboa Norte Hospital Pulido Valente, Lisboa, Not set
Hospital CUF Porto, Porto, Not set
Pan American Center for Oncology Trials, LLC, Rio Piedras, Not set
National University Hospital-Singapore-22806, Singapore, Not set
National Cancer Centre Singapore, Singapore, Not set
Hospital A Coruña, A Coruña, Not set
Hospital General Universitario de Alicante, Alicante, Not set
Hospital Santa Creu i Sant Pau, Barcelona, Not set
Hospital Vall d'Hebron, Barcelona, Not set
Hospital de Basurto, Bilbao, Not set
Hospital Duran i Reynals, L'Hospitalet de Llobregat, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Ramón y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital La Paz, Madrid, Not set
Hospital Regional Universitario de Málaga, Málaga, Not set
Hospital Virgen del Rocío, Sevilla, Not set
Hospital Clínico de Valencia, Valencia, Not set
Sahlgrenska Universitetsjukhuset, Göteborg, Not set
Karolinska Universitetssjukhuset Solna, Stockholm, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Chung Shan Medical University Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
National Taiwan University Cancer Center, Taipei, Not set
Chang Gung Memorial Hospital(Linkou), Taoyuan, Not set
Western General Hospital, Edinburgh, Not set
Leicester Royal Infirmary, Leicester, Not set
Guy's Hospital, London, Not set
The Royal Marsden Hospital, Chelsea, London, Not set
The Royal Marsden Hospital, Sutton, Sutton, Not set
Conditions: Lung Cancer, Non-squamous, Non-small Cell
A Study to See Iftolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old withAutosomal Recessive Polycystic Kidney Disease (ARPKD)
Recruiting
To evaluate the safety of tolvaptan in pediatric subjects with ARPKD
To evaluate the safety of tolvaptan in pediatric subjects with ARPKD Read Less
Gender:
ALL
Ages:
Between 28 days and 18 years
Trial Updated:
08/05/2025
Locations: Children's National Medical Center, Washington, District of Columbia +22 locations
Children's National Medical Center, Washington, District of Columbia
Emory University Hospital, Atlanta, Georgia
Northwestern University Feinberg School of Medicine - Ann & Robert H. Lurie Children's Hospital of Chicago - Neonatology, Chicago, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Children's Hospital - New Orleans, New Orleans, Louisiana
Johns Hopkins Pediatric Specialty Clinic, Baltimore, Maryland
C.S. Mott Children's Hospital, Ann Arbor, Michigan
Mayo Clinic - Rochester, Rochester, Minnesota
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Cleveland Clinic, Cleveland, Ohio
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Primary Children's Hospital, Salt Lake City, Utah
Université Catholique De Louvain And Cliniques St Luc, Brussels, Brussels Capital Region
Universitair Ziekenhuis Gent, Gent, Oost-Vlaanderen
UZ Leuven, Leuven, Vlaams Brabant
Universitätsklinikum Köln, Cologne, Nordrhein-Westfalen
Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Mazowieckie
Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa, Bialystok, Not set
Universitat de Barcelona - Hospital Sant Joan de Deu Barcelona (HSJDB), Esplugues De Llobregat, Barcelona
Hospital Universitari Parc Tauli, Sabadell, Barcelona
Hospital Universitari Vall D Hebron, Barcelona, Not set
Hospital Universitario Virgen del Rocío Avenida Manuel Siurot, Sevilla, Not set
Great Ormond Street Hospital for Children NHS Trust, London, Not set
Conditions: Autosomal Recessive Polycystic Kidney (ARPKD)
Open-Label Extension of EryDex Study IEDAT-04-2022
Recruiting
This is an international, multi-center, prospective, open-label, non-comparative study to provide EryDex treatment to ataxia telangiectasia (A-T) patients who complete the IEDAT-04-2022 trial on the neurological effects of EryDex on subjects with ataxia telangiectasia (NEAT trial).
This is an international, multi-center, prospective, open-label, non-comparative study to provide EryDex treatment to ataxia telangiectasia (A-T) patients who complete the IEDAT-04-2022 trial on the neurological effects of EryDex on subjects with ataxia telangiectasia (NEAT trial). Read Less
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/04/2025
Locations: University of California Los Angeles (UCLA), Ataxia Center and HD Center of excellence, Los Angeles, California +20 locations
University of California Los Angeles (UCLA), Ataxia Center and HD Center of excellence, Los Angeles, California
The Johns Hopkins Hospital, Division of pediatric allergy and immunology, Baltimore, Maryland
Biotrial Inc., Newark, New Jersey
Cincinnati Children's Hospital, Division of neurology, Cincinnati, Ohio
UT Health Houston, Department of pediatrics, division of child & adolescent neurology, Houston, Texas
Copenhagen University Hospital, Rigshospitalet, Department of Pediatric Neurology, Copenhagen, Not set
Tübingen University Hospital, Division Translational Genomics of Neurodegenerative Diseases, Tübingen, Bade-Würtenberg
IKF Pneumologie GmbH & Co. KG; Institut für klinische Forschung Pneumologie Clinical Research Center Respiratory Diseases, Frankfurt, Hesse
University Hospital Frankfurt, Pediatric and Adolescent Clinic, Frankfurt, Not set
Spedali Civili di Brescia, Pediatric immunology department, Brescia, Not set
Policlinico Umberto I, La sapienza University, Department of neurosciences and menthal health, Roma, Not set
Oslo University Hospital, Rikshospitalet, Division of Pediatric and Adolescent Medicine, Norwegian National Unit for Newborn Screening, Oslo, Not set
MedPolonia sp zoo, Poznań, Not set
Instytut "Pomnik-Centrum Zdrowia Dziecka", Immunology clinic, Warsaw, Not set
Hospital Universitari Vall d'Hebron, Department of pediatric neurology, Barcelona, Not set
Hospital Universitario La Paz, Department of pediatric neurology, Madrid, Not set
University Children's Hospital Zürich - Eleonore Foundation, Zürich, Not set
University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set
St George's University Hospitals NHS Foundation Trust, Centre for Neonatal and Paediatric Infection, London, Not set
Great Ormond Street Hospital for Children, Zayed Centre for Research, London, Not set
Nottingham Children's Hospital, Queen's Medical Center, Children's neurology, Nottingham, Not set
Conditions: Ataxia Telangiectasia
A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II)
Recruiting
This is a Phase 2/3, multiregional, two-arm, double-blind, randomized, active (standard-of-care)-controlled study of the efficacy and safety of tividenofusp alfa (DNL310), an investigational central nervous system (CNS)-penetrant enzyme-replacement therapy (ERT) for mucopolysaccharidosis type II (MPS II).
Participants may also qualify to enter an open-label treatment phase with DNL310 or idursulfase based on pre-specified criteria.
This is a Phase 2/3, multiregional, two-arm, double-blind, randomized, active (standard-of-care)-controlled study of the efficacy and safety of tividenofusp alfa (DNL310), an investigational central nervous system (CNS)-penetrant enzyme-replacement therapy (ERT) for mucopolysaccharidosis type II (MPS II).
Participants may also qualify to enter an open-label treatment phase with DNL310 or idursulfase based on pre-specified criteria. Read Less
Gender:
ALL
Ages:
Between 2 years and 25 years
Trial Updated:
08/04/2025
Locations: UCSF Benioff Children's Hospital Oakland, Oakland, California +31 locations
UCSF Benioff Children's Hospital Oakland, Oakland, California
Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois
Hackensack University Medical Center, Hackensack, New Jersey
UNC Children's Research Institute, Chapel Hill, North Carolina
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
The University of Texas Medical School at Houston, Houston, Texas
University of Utah, PPDS, Salt Lake City, Utah
Sanatorio Mater Dei, Buenos Aires, Not set
Women's and Children's Hospital, North Adelaide, Not set
Universitair Ziekenhuis Brussel, Jette, Brussels
UZ Antwerpen, Antwerpen, Not set
Hospital de Clínicas de Porto Alegre (HCPA) - PPDS, Porto Alegre, Not set
Instituto Fernandes Figueira, Rio De Janeiro, Not set
University of Alberta - Faculty of Medicine & Dentistry, Edmonton, Alberta
Hospital for Sick Children, Toronto, Ontario
McGill University Health Center, Montreal, Quebec
Vseobecna Fakultni Nemocnice V Praze, Praha, Not set
Hôpital Jeanne de Flandre, Lille, Not set
Medizinische Universität Lausitz - Carl Thiem, Cottbus, Not set
SphinCS, Hochheim, Not set
Azienda Sanitaria Universitaria Friuli Centrale - PO Universitario Santa Maria della Misericordia, Udine, Not set
Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, Not set
Hospital Universitario Vall d'Hebron, Barcelona, Not set
Hospital Infantil Universitario Niño Jesus, Madrid, Not set
Drottning Silvias Barn Och Ungdomssjukhus, Göteborg, Not set
Cukurova University Medical Faculty Balcali Hospital, Adana, Not set
Gazi Universitesi Tip Fakultesi, Çankaya, Not set
Birmingham Women's and Children's NHS Foundation Trust, Birmingham, Not set
Royal Free Hospital, London, Not set
Great Ormond Street Hospital for Children, London, Not set
Salford Royal Hospital, Salford, Not set
Conditions: Mucopolysaccharidosis II
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis
Recruiting
This is a 2-part (phase 2b/3) prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1 (phase 2b) is a dose-finding study for CSL300 vs placebo. Part 2 (phase 3) aims to assess the efficacy of CSL300 on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis.
This is a 2-part (phase 2b/3) prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1 (phase 2b) is a dose-finding study for CSL300 vs placebo. Part 2 (phase 3) aims to assess the efficacy of CSL300 on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: 84000149 - Nephrology Consultants, LLC, Huntsville, Alabama +345 locations
84000149 - Nephrology Consultants, LLC, Huntsville, Alabama
84000340 - DaVita Clinical Research Montgomery, Montgomery, Alabama
84000552 - AKDHC Medical, Glendale, Arizona
84000178 - Kidney Disease Medical Group, Glendale, Arizona
84000231 - AKDHC Medical, Phoenix, Arizona
84000286 - AKDHC Medical, Tucson, Arizona
84000145 - National Institute of Clinical Research, Bakersfield, California
84000151 - National Institute of Clinical Research, Bakersfield, California
84000277 - Amicis Research Center, Beverly Hills, California
84000241 - California Institute of Renal Research, Chula Vista, California
84000462 - Davita Fullerton Dialysis Center, Fullerton, California
84000574 - National Institute of Clinical Research, Inc., Fullerton, California
84000464 - St. Jude Medical Center, Garden Grove, California
84000573 - National Institute of Clinical Research, Inc., Garden Grove, California
84000152 - National Institute of Clinical Research, Garden Grove, California
84000531 - Sherman Medical Group, Inc, Glendale, California
84000230 - Kidney Disease Medical Group, Glendale, California
84000379 - Renal Consultants Medical Group, Granada Hills, California
84000631 - Balboa Research, La Jolla, California
84000221 - California Institute of Renal Research, La Mesa, California
84000235 - California Institute of Renal Research, La Mesa, California
84000198 - Southern California Medical Research Center, La Palma, California
84000467 - Southern California Medical Research Center, La Palma, California
84000329 - Academic Medical Research Institute, Los Angeles, California
84000439 - National Institute of Clinical Research, Inc., Los Angeles, California
84000158 - DaVita Carabello Dialysis Center, Los Angeles, California
84000175 - Renal Medical Associates/NARI, Lynwood, California
84000279 - Amicis Research Center, Northridge, California
84000533 - FORMAT Medical Research, Oxnard, California
84000331 - Van Buren Dialysis Center, Riverside, California
84000228 - National Nephrology Alliance Research - Riverside, Riverside, California
84000492 - Central Coast Nephrology Medical Corp, Salinas, California
84000238 - California Institute of Renal Research, San Diego, California
84000143 - California Institute of Renal Research, San Diego, California
84000330 - North America Research Institute, San Dimas, California
84000341 - North America Research Institute, San Dimas, California
84000281 - Satellite Healthcare, San Jose, California
84000440 - Nephrology Educational Services, Tarzana, California
84000536 - Valiance Clinical Research, Tarzana, California
84000278 - Amicis Research Center, Vacaville, California
84000323 - National Institute of Clinical Research, Inc, Victorville, California
84000174 - DaVita Vista Del Sol Dialysis, Victorville, California
84000589 - Western Nephrology, Arvada, Colorado
84000454 - Kidney Associates of Colorado, P.C., Denver, Colorado
84000223 - Colorado Kidney Care, Denver, Colorado
84000176 - Greater Hartford Nephrology, LLC, Bloomfield, Connecticut
84000173 - Nephrology and Hypertension Associates PC, Middlebury, Connecticut
84000494 - Nephrology Associates (Delaware), Newark, Delaware
84000441 - Boca Raton Regional - Research Physicians Network Alliance, Boca Raton, Florida
84000779 - Nova Clinical Research, LLC, Bradenton, Florida
84000661 - Access Research Institute, Brooksville, Florida
84000193 - Horizon Research Group LLC, Coral Gables, Florida
84000443 - South Florida Nephrology Group, PA, Coral Springs, Florida
84000597 - Family First Medical Research Center, Hialeah Gardens, Florida
84000650 - Advanced Medical Research Group, Hollywood, Florida
84000406 - Elixia Pines, Hollywood, Florida
84000140 -South Florida Research Institute, Lauderdale Lakes, Florida
84000599 - South Florida Research Organization LLC, Medley, Florida
84000527 - Floridian Clinical Research, Miami Lakes, Florida
84000495 - Total Research Group, LLC, Miami, Florida
84000663 - Iconic Clinical Research Center, Miami, Florida
84000362 - Kidney and Hypertension Specialists of Miami, Miami, Florida
84000182 - Nephrology Associates of South Miami, Miami, Florida
84000400 - Elixia Central Florida, Orlando, Florida
84000139 - Genesis Clinical Research, Tampa, Florida
84000532 - Florida Kidney Specialists, Temple Terrace, Florida
84000426 - Florida Premier Research Institute, Winter Park, Florida
84000366 - Southwest Georgia Nephrology Clinic, Albany, Georgia
84000326 - Coastal Medical Research, LLC, Brunswick, Georgia
84000157 - Renal Associates LLC, Columbus, Georgia
84000327 - American Clinical Trials, Douglasville, Georgia
84000582 - Georgia Nephrology, Lawrenceville, Georgia
84000194 - Atekha Nephrology Clinic LLC, Statesboro, Georgia
84000528 - NANI Research, Fort Wayne, Indiana
84000453 - Nephrology Physician's LLC, Mishawaka, Indiana
84000534 - Dunes Clinical Research LLC, Sioux City, Iowa
84000374 - Kansas Nephrology Physicians, PA, Wichita, Kansas
84000554 - Nephrology Associates of Kentuckiana, PSC, Louisville, Kentucky
84000550 - Renal Associates of Baton Rouge, Baton Rouge, Louisiana
84000220 - Massachusetts General Hospital, Boston, Massachusetts
84000465 - Paragon Health, Inc, Kalamazoo, Michigan
84000408 - Michigan Kidney Consultants, PC, Pontiac, Michigan
84000171 - St. Clair Nephrology Research, Roseville, Michigan
84000237 - Center for Advanced Kidney Research, PLC, Saint Clair Shores, Michigan
84000146 - DCR Edina, Minneapolis, Minnesota
84000338 - DCR Edina, Minneapolis, Minnesota
84000225 - Southwest Mississippi Nephrology PLLC, Brookhaven, Mississippi
84000153 - Nephrology Associates, PC, Columbus, Mississippi
84000144 - Nephrology and Hypertension Associates Ltd, Tupelo, Mississippi
84000147 - Clinical Research Consultants, Kansas City, Missouri
84000377 - DCI-Rockhill, Kansas City, Missouri
84000328 - GSR Enterprises, Inc., Lincoln, Nebraska
84000222 - Great Plains Health - Nephrology, North Platte, Nebraska
84000420 - DaVita Clinical Research - Henderson, Henderson, Nevada
84000337 - Kidney Specialists of Southern Nevada, Las Vegas, Nevada
84000148 - Sierra Nevada Specialty Care, Reno, Nevada
84000141 - Seacoast Kidney and Hypertension Specialists, Portsmouth, New Hampshire
84000436 - Hypertension & Nephrology Association, Eatontown, New Jersey
84000452 - New Jersey Kidney Care, Jersey City, New Jersey
84000155 - DaVita Clinic Research Bronx, Bronx, New York
84000276 - Albert Einstein College of Medicine - Montefiore Medical Center, Bronx, New York
84000184 - Mattoo & Bhat Medical Associates, P.C., College Point, New York
84000393 - NYU Langone Hospital - Long Island, Mineola, New York
84000191 - Metrolina Nephrology Associates, PA, Charlotte, North Carolina
84000150 - Durham Nephrology Associates, PA, Durham, North Carolina
84000232 - East Carolina University, Greenville, North Carolina
84000410 - North Carolina Nephrology, PA, Raleigh, North Carolina
84000548 - HNC Dialysis, Ltd., Columbus, Ohio
84000234 - Northeast Clinical Research Center, LLC, Bethlehem, Pennsylvania
84000192 - Columbia Nephrology, Columbia, South Carolina
84000367 - Dialysis Clinic, Inc., Spartanburg, South Carolina
84000229 - DaVita Clinical Research, Spartanburg, South Carolina
84000547 - Southeast Renal Research Institute, Chattanooga, Tennessee
84000361 - Dialysis Clinic Inc - University Nephology, Knoxville, Tennessee
84000180 - Knoxville Kidney Center PLLC, Knoxville, Tennessee
84000451 - Cussimanio Research Group LLC, Austin, Texas
84000438 - Research Management, Inc., Austin, Texas
84000549 - MW Clinical Research Center, Beaumont, Texas
84000457 - US Renal Care, Dallas, Texas
84000354 - Davita Clinical Research, El Paso, Texas
84000421 - DaVita Clinical Research - Horizon, El Paso, Texas
84000458 - Fort Worth Renal Group, Fort Worth, Texas
84000649 - Clinical Research Strategies, Houston, Texas
84000350 - DaVita Clinical Research, Houston, Texas
84000498 - DaVita Clinical Research, Houston, Texas
84000598 - Aqua Research Institute, Houston, Texas
84000450 - Houston Medical Research Institute, LLC, Houston, Texas
84000360 - Clinical Research Strategies, Inc., Houston, Texas
84000196 - Southwest Houston Research, Houston, Texas
84000634 - Prime Clinical Research, Inc., Mansfield, Texas
84000373 - Gamma Medical Research, Inc., McAllen, Texas
84000324 - National Institute of Clinical Research, Inc., San Antonio, Texas
84000351 - DaVita Clinical Research, San Antonio, Texas
84000419 - Davita Clinical Research, San Antonio, Texas
84000553 - DCR-San Antonio Stone Oak, San Antonio, Texas
84000339 - DaVita Clinical Research North Houston, Shenandoah, Texas
84000660 - Medrasa Clinical Research, Sherman, Texas
84000551 - Renal Research of Montgomery County, The Woodlands, Texas
84000535 - DCR-Norfolk Great Bridge, Chesapeake, Virginia
84000424 - Nephrology Associates of Northern Virginia Inc, Fairfax, Virginia
84000138 - Peninsula Kidney Associates, Hampton, Virginia
84000156 - Tidewater Kidney Specialists, Norfolk, Virginia
84000336 - Nephrology and Hypertension Associates, Bluefield, West Virginia
03600023 - Royal North Shore Hospital (RNSH), Saint Leonards, New South Wales
03600017 - Concord Repatriation General Hospital, Sydney, New South Wales
03600037 - Cairns Hospital, Cairns, Queensland
03600021 - Sunshine Coast University Private Hospital, Nambour, Queensland
03600014 - Princess Alexandra Hospital, Woolloongabba, Queensland
03600013 - Monash Medical Centre, Clayton, Victoria
03600011 - Sunshine Hospital, St Albans, Victoria
03600011 - Sunshine Hospital, St Albans, Victoria
03600056 - Wide Bay Hospital and Health Service, Bundaberg, Not set
03600050 - Fiona Stanley Hospital, Murdoch, Not set
03600021 - Sunshine Coast University Private Hospital, Nambour, Not set
03600020 - Gold Coast University Hospital, Southport, Not set
03600038 - Fraser Coast Renal Service, Hervey Bay Hospital, Urraween, Not set
03600012 - Westmead Hospital, Westmead, Not set
03600048 - Wollongong Renal Unit, Wollongong, Not set
05600011 - Onze-Lieve-Vrouwziekenhuis VZW, Aalst, Not set
05600011 - Onze-Lieve-Vrouwziekenhuis VZW, Aalst, Not set
05600005 - Imelda Ziekenhuis, Bonheiden, Not set
05600004 - AZ Sint-Lucas, Gent, Not set
05600013 - Centre Hospitalier Universitaire de Tivoli, La Louvière, Not set
05600012 - Universitair Ziekenhuis Leuven, Leuven, Not set
05600003 - CHR de la Citadelle, Liège, Not set
05600003 - CHR de la Citadelle, Liège, Not set
05600018 - AZ Delta (H.-Hartziekenhuis Roeselare-Menen vzw (HHRM)) - Campus Rumbeke, Roeselare, Not set
05600014 - VITAZ, Department Nierziekten & Dialyse, Sint-Niklaas, Not set
10000002 - Multiprofile Hospital for Active Treatment- Sveti Nikolay Chudotvoretz - LOM EOOD, Lom, Not set
10000009 - University Multiprofile Hospital for Active Treatment Sveti Georgi EAD, Plovdiv, Not set
10000007 - UMHAT Plovdiv, Plovdiv, Not set
10000001 - Medical Center - Smolyan OOD, Smolyan, Not set
10000005 - Dialysis Center VIA DIAL OOD, Stara Zagora, Not set
10000008 - UMHAT Prof. Dr. Stoyan Kirkovich, Stara Zagora, Not set
12400008 - University of Alberta Hospital, Edmonton, Alberta
12400008 - University of Alberta Hospital, Edmonton, Alberta
12400021 - Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia
12400026 - St. Josephs Healthcare Hamilton, Hamilton, Ontario
12400009 - Kingston Health Sciences Centre, Kingston, Ontario
12400030 - London Health Sciences Centre - University Hospital, London, Ontario
12400024 - Lakeridge Health Oshawa, Oshawa, Ontario
12400023 - McGill University Health Centre, Montreal, Quebec
12400015 - Hôpital du Sacré-Cœur-de-Montréal, Montréal, Quebec
12400014 - Maisonneuve-Rosemont Hospital, Montréal, Not set
12400031 - CHUM - Centre hospitalier de l'Universite de Montreal, Montréal, Not set
12400048 - Ciussse-Chus, Sherbrooke, Not set
12400032 - St. Michaels Hospital, Toronto, Not set
12400016 - St Paul Hospital, Vancouver, Not set
12400027 - Seven Oaks Hospital, Winnipeg, Not set
15600014 - Peking University First Hospital, Beijing, Not set
15600036 - Beijing Tsinghua Chang Gung Hospital, Beijing, Not set
15600033 - Anhui Medical University-The Second Hospital, Hefei City, Not set
15600019 - Gansu Provincial People's Hospital, Lanzhou City, Not set
15600045 - Nanchang University - The First Affiliated Hospital, Nanchang, Not set
15600052 - The People's Hospital Guangxi Zhuang of Autonomous Region, Nanning, Not set
15600035 - Southern Medical University - Jiangxi Pingxiang People's Hospital, Pingxiang City, Not set
15600030 - Shanghai First People's Hospital, Shanghai Shi, Not set
15600034 - Shanghai Jiao Tong University School of Medicine (SJTUSM)-Renji Hospital, Shanghai, Not set
15600049 - Shijiazhuang People's Hospital, Shijiazhuang Shi, Not set
15600038 - Second Hospital of Shanxi Medical University, Taiyuan City, Not set
15600044 - Tianjin People's Hospital, Tianjin, Not set
15600037 - Huazhong University of Science and Technology - Tongji Medical College - The Central Hospital of Wuhan (Wuhan Second Hospital), Wuhan City, Not set
15600015 - Wuxi People's Hospital, Wuxi City, Not set
15600018 - Zhongshan Hospital Xiamen University, Xiamen City, Not set
15600040 - Yan'an University Xianyang Hospital, Xianyang City, Not set
15600029 - Xinxiang City First People's Hospital, Xinxiang City, Not set
15600022 - Northern Jiangsu People's Hospital, Yangzhou City, Not set
15600025 - Yibin Second People's Hospital, Yibin Shi, Not set
15600026 - Affiliated Hospital of Jiangsu University, Zhenjiang City, Not set
20800009 - Aalborg Universitetshospital, Aalborg, Not set
20800010 - Herlev Hospital, Herlev, Not set
20800008 - Gødstrup Hospital, Herning, Not set
20800011 - Trail Nation: Nordsjællands Hospital, Hillerød, Not set
25000011 - CHU Amiens - Nephrology Dialysi Transplantation Department, Amiens, Not set
25000014 - CHU de Saint-Étienne - Hôpital Nord, Aura, Not set
25000027 - Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital de la Cavale Blanche, Brest, Not set
25000013 - CHU de Caen, Caen, Not set
25000026 - Hopital Prive La Louviere, Lille, Not set
25000033 - CHU de Limoges, Limoges Cedex, Not set
25000018 - Centre Hospitalier Universitaire Montpellier - Hôpital Lapeyronie, Montpellier, Not set
25000020 - CHU de Nimes - Hopital Universitaire Caremeau, Nîmes, Not set
25000028 - Hopital Pitie-Salpetriere, Paris, Not set
25000025 - AURA Paris - Plaisance, Paris, Not set
25000019 - Centre Hospitalier Universitaire (CHU) de Reims - Hopital Maison Blanche, Reims, Not set
25000016 - AURA St Quen Dialysis centre, Saint-Ouen, Not set
25000029 - Hôpitaux Universitaires de Strasbourg - Hôpital Civil, Strasbourg, Not set
25000012 - CHU Rangueil, Toulouse, Not set
27600047 - Charite-Universitatsmedizin Berlin, Berlin, Not set
27600041 - Nierenzentrum Bad König, Hessen, Not set
27600039 - Westpfalz Klinikum GmbH, Kaiserslautern, Not set
27600022 - UKSH - Universitatsklinik Schleswig-Holstein, Kiel, Not set
27600021 - Kuratorium fuer Dialyse und Nierentransplantation e.V. - KfH-Nierenzentrum - St. Georg, Leipzig, Not set
27600040 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Not set
27600020 - Nephrologisches Zentrum Villingen-Schwenningen, Villingen-Schwenningen, Not set
27600020 - Nephrologisches Zentrum Villingen-Schwenningen, Villingen-Schwenningen, Not set
30000015 - University Hospital of Alexandroupolis, Alexandroupolis, Not set
30000012 - University General Hospital of Heraklion, Crete, Not set
30000004 - University General Hospital of Ioannina, Ioánnina, Not set
30000002 - General Hospital of Ioannina G. Hatzikosta, Ioánnina, Not set
30000014 - Nephrological Clinic University Hospital, University of Thessaly, Larissa, Not set
30000013 - General Hospital of Ptolemaida, Ptolemaḯda, Not set
30000008 - University Hospital of Patras, Rio, Not set
30000005 - Aristotle University, Hippokration, Thessaloniki, Not set
30000003 - AHEPA Univ. Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloníki, Not set
30000006 - General Hospital of Thessaloniki, Agios Pavlos, Thessaloníki, Not set
30000009 - Papageorgiou General Hospital of Thessaloniki, Thessaloníki, Not set
30000011 - Nephrology Department G. Papanikolaou General Hospital, Thessaloníki, Not set
30000016 - General Hospital of Arta, Árta, Not set
34800012 - B. Braun Avitum - 14. Dialízisközpont Kistarcs, Kistarcsa, Not set
37600008 - Carmel Medical Center, Haifa, Not set
37600012 - Edith Wolfson Medical Center, H̱olon, Not set
37600010 - Rabin Medical Center, Petah Tikva, Not set
37600011 - Chaim Sheba Medical Center (Sheba Tel-Hashomer Medical Center ), Ramat Gan, Not set
37600009 - Ichilov Hospital-Tel-Aviv Sourasky Medical Center, Tel Aviv, Not set
37600002 - Medical Research & Development Fund for Health Services, PORIYA Hospital, Tiberias, Not set
37600013 - Ziv Medical Center, Zefat, Not set
38000025 - ASST degli Spedali Civili di Brescia, Brescia, Not set
38000031 - Azienda Ospedaliera Sant'Anna e San Sebastiano di Caserta, Caserta, Not set
38000034 - AOU Policlinico G Rodolico - San Marco - Presidio Ospedaliero ospedale San Marco, Catania, Not set
38000061 - Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant'Anna, Ferrara, Not set
38000074 - Ospedale Santa Maria Annunziata, Florence, Not set
38000027 - A. O. -Universitaria Ospedali Riuniti di Foggia Farmacia Osp, Foggia, Not set
38000063 - Vito Fazzi Hospital in Lecce, Lecce, Not set
38000024 - ASST di Lecco - Presidio Ospedaliero A. Manzoni di Lecco, Lecco, Not set
38000029 - Università degli Studi di Messina, Messina, Not set
38000023 - IRCCS Ospedale San Raffaele, Milano, Not set
38000069 - Ospedale Maggiore di Novara, Novara, Not set
38000019 - ICS Maugeri S.p.A. SB; Università di Pavia; Fondazione Salvatore Maugeri IRCCS, Pavia, Not set
38000026 - University of Verona, Peschiera Del Garda, Not set
38000064 - AUSL Piacenza Hospital-Unit Nephrology Dialysis, Dept of Medicine, Piacenza, Not set
38000032 - Ospedale Santo Stefan, Prato, Not set
38000060 - Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria, Not set
38000067 - Rimini Hospital, Rimini, Not set
38000016 - Ospedale Casa Sollievo della Sofferenza (CSS), San Giovanni Rotondo, Not set
38000020 - Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona, Not set
39200053 - Daiyukai Daiichi Hospital, Ichinomiya-shi, Aichi
39200044 - Juntendo University Urayasu Hospital, Urayasu-shi, Chiba-ken
39200046 - Steel Memorial Yawata Hospital, Kitakyushu-shi, Fukuoka
39200048 - Maebashi Hirosegawa Clinic, Maebashi-shi, Gunma
39200049 - Joumou Ohashi Clinic, Maebashi-shi, Gunma
39200045 - Teine Urological Clinic, Sapporo-shi, Hokkaido
39200054 - Omi freai Hospital, Kusatsu-shi, Shiga
39200027 - Tokyo Womens Med University, Shinjuku-Ku, Tokyo
39200042 - Matsunami General Hospital, Hashima-gun, Not set
39200041 - Ishikiriseiki Hospital, Higashiosaka-shi, Not set
39200055 - Miki Internal Medicine Urology Clinic, Hokkaido, Not set
39200033 - Tokyo Medical University Ibaraki Medical Center, Inashiki-gun, Not set
39200043 - Ueyama Hospital, Kagoshima-shi, Not set
39200038 - St. Mary's Hospital, Kurume-shi, Not set
39200021 - Kurume University Hospital, Kurume, Not set
39200028 - Rakuwakai Otowa Kinen Hospital, Kyoto-Shi, Not set
39200037 - Nagaoka Red-Cross Hospital, Nagaoka-Shi, Not set
39200035 - Daido Hospital, Nagoya-shi, Not set
39200020 - Chubu Rosai Hospital, Nagoya, Not set
39200026 - Omihachiman Community Medical Center - Kidney Center, Omihachiman, Not set
39200032 - Oguranaika Jin Cinic, Oyama-shi, Not set
39200029 - Ibaraki Seinan Medical Center Hospital, Sakaimachi, Not set
39200031 - Kurosawa Hospital, Takasaki-Shi, Not set
39200034 - Kikuchi Medical Clinic, Tsukuba-shi, Not set
39200030 - St.Hill Hospital, Ube-shi, Not set
39200051 - Bosei Kannai Clinic, Yokohama-shi, Not set
39200036 - Sanin Rosai Hospital, Yonago-shi, Not set
41000002 - SMG - SNU Boramae Medical Center, Ilsan-gu, Seoul
41000006 - Hallym University Sacred Heart Hospital, Anyang-si, Not set
41000004 - Keimyung University Dongsan Medical Center, Daegu, Not set
41000001 - Gangnam Severance Hospital, Gangnam-gu, Not set
41000009 - National Health Insurance Service - Ilsan Hospital, Goyang-si, Not set
41000010 - Hanyang University Guri Hospital, Guri-si, Not set
41000008 - Konkuk University Medical Center, Gwangju, Not set
41000005 - Seoul National University Hospital, Seoul, Not set
41000012 - Severance Hospital, Yonsei University, Seoul, Not set
41000007 - Yonsei University - Wonju Severance Christian Hospital, Wonju-si, Not set
57800004 - Vestre Viken HF - Drammen Sykehus (Sykehuset Buskerud), Drammen, Not set
61600011 - Powiatowy Szpital Specjalistyczny w Stalowej Woli, Stalowa Wola, Not set
61600025 - DaVita Stacja Dializ, Warszawa, Not set
62000011 - Unidade Local de Saúde de Braga, E. P. E., Braga, Not set
62000010 - Unidade Local de Saúde de Loures -Odivelas, E. P. E., Loures, Not set
62000009 - Unidade Local de Saúde de São José, E. P. E., Oeiras, Not set
62000005 - Unidade Local de Saúde de Santo António, E. P. E., Porto, Not set
62000007 - Unidade Local de Saúde do Estuário do Tejo, E. P. E., Vila Franca De Xira, Not set
64200014 - SC International Healthcare Systems SA - IHS Sf. Ioan Dialysis Center, Bucharest, Not set
64200024 - Fundeni Clinical Institute, Bucuresti, Not set
64200016 - Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta (Emergency Clinic Hospital Constanta), Constanta, Not set
64200026 - Spitalul Clinic -Dr. C.I. Parhon - Iasi, Iasi, Not set
64200005 - Spital Judetean de Urgenta Satu Mare, Satu Mare, Not set
70300002 - LC-REN s.r.o., Lučenec, Not set
72400011 - Universidad de Alcala (UAH), Guadalajara, Not set
72400007 - Hospital Universitari Arnau de Vilanova, Lleida, Not set
72400031 - Hospital Clinico Universitario - Valencia, Valencia, Not set
75200001 - Uppsala Universitet - Akademiska Sjukhuset, Uppsala, Not set
82600041 - University Hospitals Birmingham NHS Foundation Trust - Birmingham Heartlands Hospital (BHH), Birmingham, Not set
82600027 - Bradford Teaching Hospitals NHS Foundation Trust, Bradford, Not set
82600023 - University Hospital Coventry and Warwickshire, Coventry, Not set
82600060 - University Hospitals of Derby and Burton NHS Foundation Trust - Royal Derby Hospital, Derby, Not set
82600022 - Dorset County Hospital NHS Foundation Trust - Dorset County Hospital (DCH), Dorchester, Not set
82600024 - Royal Liverpool University Hospital, Liverpool, Not set
82600028 - Altnagelvin Area Hospital, Londonderry, Not set
82600026 - William Harvey Research Institute ; Barts Health NHS Trust - The Royal London Hospital, London, Not set
82600026 - William Harvey Research Institute ; Barts Health NHS Trust - The Royal London Hospital, London, Not set
82600032 - King´s College NHS Trust, London, Not set
82600034 - St George's University Hospitals NHS Foundation Trust - St G, London, Not set
82600042 - Hammersmith Hospital Imperial College Healthcare NHS Trust -Hammersmith Hospital - West London Renal and Transplant Centre, London, Not set
82600029 - Northern Care Alliance NHS Foundation Trust - Salford Royal NHS Foundation Trust-Salford Care Organisation, Salford, Not set
82600039 - The Shrewsbury and Telford Hospital NHS Trust (SaTH) - Royal Shrewsbury Hospital, Shrewsbury, Not set
82600025 - Royal Stoke University Hospital, Stoke-on-Trent, Not set
82600049 - The Royal Wolverhampton NHS Trust - New Cross Hospital, Wolverhampton, Not set
Conditions: Atherosclerotic Cardiovascular Disease, End Stage Kidney Disease, Atherosclerotic Cardiovascular Disease in Patients With ESKD
A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Recruiting
B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). This study will assess how safe and effective epcoritamab plus lenalidomide (E-Len) is compared to rituximab plus gemcitabine and oxaliplatin (R-GemOx) )in treating adult participants with relapsed or refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL). Adverse events and change in disease condition will be assessed.
Epcoritamab is an investigational drug being... Read More
B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). This study will assess how safe and effective epcoritamab plus lenalidomide (E-Len) is compared to rituximab plus gemcitabine and oxaliplatin (R-GemOx) )in treating adult participants with relapsed or refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL). Adverse events and change in disease condition will be assessed.
Epcoritamab is an investigational drug being developed for the treatment of DLBCL. Study doctors put the participants in 1 of 3 groups, called treatment arms. Each group receives a different treatment. Around 360 adult participants with R/R DLBCL will be enrolled in approximately 165 sites across the world.
Participants in arm A will receive subcutaneous (SC) injections of epcoritamab plus oral lenalidomide capsules (E-Len) for up to 12 cycles (each cycle is 28 days). Participants in arm B will receive intravenously (IV) infused R-GemOx for up to 4 cycles (each cycle is 28 days). Participants in arm C will receive SC injections of epcoritamab for up to 12 cycles (each cycle is 28 days).
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: City of Hope National Medical Center /ID# 273338, Duarte, California +152 locations
City of Hope National Medical Center /ID# 273338, Duarte, California
Valkyrie Clinical Trials /ID# 269935, Los Angeles, California
Lutheran Medical Center- Cancer Centers of Colorado /ID# 265823, Golden, Colorado
City Of Hope Cancer Center - Atlanta /ID# 273092, Newnan, Georgia
City of Hope, Chicago /ID# 274430, Zion, Illinois
Northwest Cancer Center - Dyer Clinic /ID# 269787, Dyer, Indiana
Cancer Center of Kansas - Wichita /ID# 270117, Wichita, Kansas
University of Kentucky Chandler Medical Center /ID# 242087, Lexington, Kentucky
University of Maryland, Baltimore /ID# 242216, Baltimore, Maryland
Henry Ford Hospital /ID# 266446, Detroit, Michigan
Gulfport Memorial Hospital /ID# 268104, Gulfport, Mississippi
New York Medical College /ID# 265799, Valhalla, New York
East Carolina University - Brody School of Medicine /ID# 242227, Greenville, North Carolina
Thompson Cancer Survival Ctr /ID# 242149, Knoxville, Tennessee
Community Cancer Trials Of Utah /ID# 271715, Ogden, Utah
Utah Cancer Specialists - Salt Lake City /ID# 268603, Salt Lake City, Utah
Veterans Affairs Medical Center - Salt Lake City /ID# 265329, Salt Lake City, Utah
Canberra Hospital /ID# 265312, Garran, Australian Capital Territory
Royal Prince Alfred Hospital /ID# 263242, Sydney, New South Wales
Wollongong Hospital /ID# 244646, Wollongong, New South Wales
Toowoomba Hospital /ID# 263243, Toowoomba, Queensland
Monash Health - Monash Medical Centre /ID# 262783, Clayton, Victoria
Royal Perth Hospital /ID# 243790, Perth, Western Australia
Universitair Ziekenhuis Brussel /ID# 242574, Jette, Bruxelles-Capitale
Centre Hospitalier Epicura - site d'Hornu /ID# 265148, Boussu, Hainaut
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 242565, Yvoir, Namur
Universitair Ziekenhuis Leuven /ID# 246671, Leuven, Vlaams-Brabant
AZ-Delta /ID# 264740, Roeselare, West-Vlaanderen
UMHAT Sveti Georgi /ID# 242905, Plovdiv, Not set
UMHAT Sveti Ivan Rilski /ID# 242389, Sofia, Not set
SHAT Hematologic Diseases /ID# 242708, Sofia, Not set
UMHAT Multiprofile Hospital for Active Treatment Sveta Marina /ID# 262761, Varna, Not set
CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 262751, Montreal, Quebec
Peking University Third Hospital /ID# 242941, Beijing, Beijing
Fujian Province Cancer Hospital /ID# 265075, Fuzhou, Fujian
The First Affiliated Hospital of Xiamen /ID# 264305, Xiamen, Fujian
Sun Yat-Sen University Cancer Center /ID# 242712, Guangzhou, Guangdong
Guangdong Provincial People's Hospital /ID# 242942, Guangzhou, Guangdong
The Second Hospital of Hebei Medical University /ID# 242944, Shijiazhuang, Hebei
Harbin Medical University Cancer Hospital /Id# 242961, Harbin, Heilongjiang
Henan Cancer Hospital /ID# 242700, Zhengzhou, Henan
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 242702, Wuhan, Hubei
Hubei Cancer Hospital /ID# 242963, Wuhan, Hubei
The First Affiliated Hospital of Soochow University /ID# 242939, Suzhou, Jiangsu
The First Affiliated Hospital of Nanchang University /ID# 242703, Nanchang, Jiangxi
Jiangxi Provincial Cancer Hospital /ID# 242968, Nanchang, Jiangxi
The First Hospital of Jilin University /ID# 242940, Changchun, Jilin
The First Hospital of China Medical University /ID# 242701, Shenyang, Liaoning
Shandong Cancer Hospital /ID# 264036, Jinan, Shandong
Shanghai Tongji Hospital /ID# 263952, Shanghai, Shanghai
Tianjin Cancer Hospital /ID# 243940, Tianjin, Tianjin
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 243139, Tianjin, Tianjin
The Affiliated Cancer Hospital of Xinjiang Medical University /ID# 242966, Urumqi, Xinjiang
Yunnan Province Cancer Hospital /ID# 264057, Kunming, Yunnan
The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 242960, Hangzhou, Zhejiang
The second affiliated hospital of Zhejiang University school of medicine /ID# 243137, Hangzhou, Zhejiang
Zhejiang Cancer hospital /ID# 242711, Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University /ID# 263951, Wenzhou, Zhejiang
Klinicka bolnica Merkur /ID# 262619, Zagreb, Grad Zagreb
Klinicki bolnicki centar Sestre milosrdnice /ID# 262620, Zagreb, Grad Zagreb
Klinicki bolnicki centar Zagreb /ID# 262617, Zagreb, Grad Zagreb
Klinicki bolnicki centar Osijek /ID# 262621, Osijek, Osjecko-baranjska Zupanija
Klinički Bolnički Centar Rijeka /ID# 266004, Rijeka, Primorsko-goranska Zupanija
Klinicki Bolnicki Centar (KBC) Split /ID# 262618, Split, Splitsko-dalmatinska Zupanija
Fakultní nemocnice Hradec Králové - Sokolská /ID# 264071, Hradec Králové, Hradec Kralove
Institut de cancérologie Strasbourg Europe (ICANS) /ID# 264068, Strasbourg, Bas-Rhin
CHU de CAEN - Hopital de la Cote de Nacre /ID# 243075, Caen, Calvados
CHRU Tours - Hopital Bretonneau /ID# 244580, Tours CEDEX 9, Indre-et-Loire
Centre Hospitalier D'Avignon /ID# 243072, Avignon, Provence-Alpes-Cote-d Azur
Centre Hospitalier de la Cote Basque /ID# 243065, Bayonne, Pyrenees-Atlantiques
CHU Poitiers - La miletrie /ID# 243074, Poitiers, Vienne
Hopital Saint Vincent de Paul /ID# 243070, Lille Cedex, Not set
General Hospital of Athens Laiko /ID# 262809, Athens, Attiki
University General Hospital Attikon /ID# 242041, Athens, Attiki
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 242039, Athens, Not set
General University Hospital of Thessaloniki AXEPA /ID# 242038, Thessaloniki, Not set
Theageneio Anticancer Hospital /ID# 242036, Thessaloniki, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 262924, Pecs, Baranya
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 262901, Gyor, Gyor-Moson-Sopron
Debreceni Egyetem-Klinikai Kozpont /ID# 242451, Debrecen, Hajdu-Bihar
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 242468, Nyiregyhaza, Szabolcs-Szatmar-Bereg
Semmelweis Egyetem /ID# 242455, Budapest, Not set
Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet /ID# 262923, Budapest, Not set
Orszagos Onkologiai Intezet /ID# 242457, Budapest, Not set
Fujita Health University Hospital /ID# 265968, Toyoake, Aichi
National Hospital Organization Shikoku Cancer Center /ID# 265977, Matsuyama, Ehime
Kyushu University Hospital /ID# 267624, Fukuoka-shi, Fukuoka
Fukushima Medical University Hospital /ID# 264667, Fukushima-shi, Fukushima
Sapporo Medical University Hospital /ID# 264928, Sapporo, Hokkaido
Kagoshima University Hospital /ID# 248259, Kagoshima-shi, Kagoshima
Tokai University Hospital /ID# 265433, Isehara, Kanagawa
Kansai Medical University Hirakata Hospital /ID# 266018, Hirakata-shi, Osaka
Kindai University Hospital /ID# 265474, Osaka sayama-shi, Osaka
Saitama Cancer Center /ID# 265277, Kitaadachi-gun, Saitama
University of Yamanashi Hospital /ID# 264671, Chuo-shi, Yamanashi
Inje University - Busan Paik Hospital /ID# 262842, Busan, Busan Gwang Yeogsi
Dong-A University Medical Center /ID# 262841, Busan, Busan Gwang Yeogsi
Seoul National University Bundang Hospital /ID# 242405, Seongnam-si, Gyeonggido
Keimyung University Dongsan Hospital /ID# 262840, Daegu, Gyeongsangbugdo
Jeonbuk National University Hospital /ID# 242958, Jeonju, Jeonrabugdo
Chonnam National University Hwasun Hospital /ID# 262843, Hwasun-gun, Jeonranamdo
Seoul National University Hospital /ID# 242407, Seoul, Seoul Teugbyeolsi
Asan Medical Center /ID# 242409, Seoul, Seoul Teugbyeolsi
Samsung Medical Center /ID# 242408, Seoul, Seoul Teugbyeolsi
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 242406, Seoul, Seoul Teugbyeolsi
Ulsan University Hospital /ID# 242956, Ulsan, Ulsan Gwang Yeogsi
Centro De Investigación Clinica Chapultepec /ID# 243959, Mexico City, Ciudad De Mexico
Centro de Quimioterapia E Investigacion Sas de Cv /Id# 263293, Jalisco, Not set
Medisch Centrum Leeuwarden /ID# 245501, Leeuwarden, Friesland
Jeroen Bosch Ziekenhuis, locatie 's-Hertogenbosch /ID# 265204, 's-Hertogenbosch, Noord-Brabant
OLVG - Locatie Oost /ID# 263355, Amsterdam, Noord-Holland
St. Antonius Ziekenhuis /ID# 245197, Nieuwegein, Utrecht
Albert Schweitzer Ziekenhuis, locatie Dordwijk /ID# 263361, Dordrecht, Zuid-Holland
North Shore Hospital /ID# 266060, Auckland, Not set
Wellington Hospital /ID# 265966, Wellington, Not set
Pratia MCM Krakow /ID# 262882, Krakow, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 263314, Warsaw, Mazowieckie
Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 242436, Kielce, Swietokrzyskie
Aidport sp z o.o. /ID# 262766, Poznan, Wielkopolskie
Hospital da Luz /ID# 262965, Lisbon, Lisboa
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE /ID# 262961, Porto, Not set
Unidade Local de Saude Sao Joao, EPE /ID# 262962, Porto, Not set
Fundeni Clinical Institute /ID# 266734, Bucharest, Bucuresti
Institutul Oncologic Prof Dr. Ion Chiricuta Cluj Napoca /ID# 243753, Cluj-Napoca, Cluj
Institutul Regional de Oncologie /ID# 244367, Jassi, Iasi
Spitalul Clinic Coltea /ID# 243694, Bucharest, Not set
Clinical Hospital Center Zvezdara /ID# 263059, Belgrade, Beograd
Institute for Oncology and Radiology of Serbia /ID# 263055, Belgrade, Beograd
University Clinical Center Serbia /ID# 263057, Belgrade, Beograd
Clinical Hospital Center - Bežanijska Kosa /ID# 263053, Belgrade, Beograd
University Clinical Center Nis /ID# 263701, Niš, Nisavski Okrug
Institute for Oncology of Vojvodina /ID# 263052, Sremska Kamenica, Vojvodina
University Clinical Center Vojvodina /ID# 264138, Novi Sad, Not set
National Cancer Centre Singapore /ID# 267015, Singapore, Central Singapore
National University Hospital /ID# 264016, Singapore, Not set
Tan Tock Seng Hospital /ID# 266061, Singapore, Not set
Wits Clinical Research /ID# 264656, Johannesburg, Gauteng
Alberts Cellular Therapy /ID# 262720, Pretoria, Gauteng
Constantiaberg Haematology /ID# 273041, Cape Town, Western Cape
Haemalife Inc. /ID# 262719, Kuilsrivier, Western Cape
National Taiwan University Hospital /ID# 243300, Taipei City, Taipei
China Medical University Hospital /ID# 242931, Taichung, Not set
Taichung Veterans General Hospital /ID# 242937, Taichung, Not set
National Cheng Kung University Hospital /ID# 243301, Tainan, Not set
Ankara Universitesi Fakultesi /ID# 242410, Ankara, Not set
Adnan Menderes University /ID# 242418, Aydin, Not set
Trakya University Medical Facu /ID# 242419, Edirne, Istanbul, Not set
Ege University Medical Faculty /ID# 242417, Izmir, Not set
Ondokuz mayis University Facul /ID# 242412, Samsun, Not set
Karadeniz Technical University Farabi Hospital /ID# 264694, Trabzon, Not set
Istanbul Florence Nightingale Hospital /ID# 271544, Şişli, Not set
Nottingham City Hospital /ID# 265129, Nottingham, Nottinghamshire
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 242923, Newcastle upon Tyne, Not set
Conditions: Diffuse Large B-Cell Lymphoma
Comparison of EVAR and ESAR for Infrarenal Aortic Aneurysms With a Wide Proximal Neck
Recruiting
The HERCULES trial is a Randomized controlled clinical trial designed to prospectively compare endosuture aneurysm repair (ESAR) to standard endovascular aneurysm repair (EVAR) clinical outcomes in treatment of infrarenal abdominal aortic aneurysm (AAA) in subjects having wide proximal aortic neck diameters (≥ 28mm and ≤ 32mm).
The HERCULES trial is a Randomized controlled clinical trial designed to prospectively compare endosuture aneurysm repair (ESAR) to standard endovascular aneurysm repair (EVAR) clinical outcomes in treatment of infrarenal abdominal aortic aneurysm (AAA) in subjects having wide proximal aortic neck diameters (≥ 28mm and ≤ 32mm). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Washington Regional Medical Center, Washington, Arkansas +26 locations
Washington Regional Medical Center, Washington, Arkansas
Mt Sinai Med Ctr, Miami Beach, Florida
Loyola, Maywood, Illinois
Beaumont University Hospital, Royal Oak, Michigan
Alina Health, Minneapolis, Minnesota
University of Missouri, Columbia, Missouri
Barnes-Jewish Hospital, Saint Louis, Missouri
Robert Wood Johnson University Medical Center, New Brunswick, New Jersey
Sisters of Charity hospital, Buffalo, New York
Stony Brook University Medical Center, Stony Brook, New York
NC Heart& Vascular, Raleigh, North Carolina
Promedica Toledo Hospital, Toledo, Ohio
Ballad Health/Holston Valley, Kingsport, Tennessee
Virginia Commonwealth University (VCU), Richmond, Virginia
HCL Lyon, Lyon, Not set
Saint Joseph Marseille, Marseille, Not set
Les Franciscaines, Nîmes, Not set
Osp. S.Orsola Malpighi - Bologna, Bologna, Not set
Rijnstate hospital, Arnhem, Not set
Catharina Ziekenhuis, Eindhoven, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital Ramon Y Cajal, Madrid, Not set
EHC-Hôpital de Morges, Morges, Not set
Queen Elizabeth University Hospital, Glasgow, Glasgow, Not set
Leeds General Infirmary, Leeds, Not set
St. George's Hospital, London, Not set
St. Mary's Hospital, London, Not set
Conditions: Aortic Aneurysm, Abdominal
Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
Recruiting
Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome of excessive immune activation. Secondary hemophagocytic lymphohistiocytosis (sHLH) is the most common form of this disease and is typically associated with several other clinical conditions (eg, malignancy associated HLH (mHLH), infection, or autoimmune disease). ELA026 is a fully human immunoglobulin G1 (IgG1) signal regulatory protein (SIRP)-directed monoclonal antibody designed to deplete the myeloid and T... Read More
Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome of excessive immune activation. Secondary hemophagocytic lymphohistiocytosis (sHLH) is the most common form of this disease and is typically associated with several other clinical conditions (eg, malignancy associated HLH (mHLH), infection, or autoimmune disease). ELA026 is a fully human immunoglobulin G1 (IgG1) signal regulatory protein (SIRP)-directed monoclonal antibody designed to deplete the myeloid and T cells driving the inflammation. The purpose of this study is to assess the safety, efficacy pharmacokinetics and pharmacodynamics of ELA026 in participants with sHLH. Read Less
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/04/2025
Locations: University of Alabama at Birmingham School of Medicine, Birmingham, Alabama +19 locations
University of Alabama at Birmingham School of Medicine, Birmingham, Alabama
Phoenix Children's Hospital, Phoenix, Arizona
University of California, Los Angeles, Los Angeles, California
MedStar Georgetown, Washington, District of Columbia
Johns Hopkins All Children's Hospital, St. Petersburg, Florida
Columbia University, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Thomas Jefferson University, Philadelphia, Pennsylvania
MD Anderson, Houston, Texas
Texas Children's Hospital, Houston, Texas
Medizinische Universität Innsbruck, Innsbruck, Not set
Medical University of Vienna, Vienna, Not set
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Not set
Bambino Gesu' Roma, Roma, Not set
Amsterdam UMC, Amsterdam, Not set
Erasmus UMC, Rotterdam, Not set
Hospital 12 de Octubre, Madrid, Madrid, Not set
Hospital Ramon y Cajal, Madrid, Not set
Hospital La Fe Valencia, Valencia, Not set
University College London Hospitals, London, Not set
Conditions: Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
Personalized Long-term Human Albumin Treatment in Patients With Decompensated Cirrhosis and Ascites
Recruiting
The goal of this clinical biomarker validation trial is to test the effect of a predictive biomarker panel to human albumin infusions in patients with liver cirrhosis and ascites. The main questions it aims to answer are:
* If the predictive biomarker panel can identify patients who are likely to benefit from regular human albumin infusions
* If the predictive biomarker panel can lower the number-needed-to-treat of regular human albumin infusions in patients with liver cirrhosis and ascites
Th... Read More
The goal of this clinical biomarker validation trial is to test the effect of a predictive biomarker panel to human albumin infusions in patients with liver cirrhosis and ascites. The main questions it aims to answer are:
* If the predictive biomarker panel can identify patients who are likely to benefit from regular human albumin infusions
* If the predictive biomarker panel can lower the number-needed-to-treat of regular human albumin infusions in patients with liver cirrhosis and ascites
The predictive biomarker panel will stratify patients into either a high- or low-expected effect of human albumin infusions. Hereafter are participants randomized into treatment arms.
Participants in the active treatment arm will receive regular human albumin infusions during a course of 6 months. Infusions will occur every 10th day for the duration of the study.
Researchers will compare 20% human albumin infusions with regular 0.9% sodium chloride to identify the effects on the number of liver-related events. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Katholieke Universiteit Leuven, Leuven, Not set +11 locations
Katholieke Universiteit Leuven, Leuven, Not set
Herlev Hospital, Herlev, Not set
Odense University Hospital, Odense, Not set
Charité - Universitätsmedizin Berlin, Berlin, Not set
Universitätsklinikum Jena, Jena, Not set
Universitätsklinikum Münster, Münster, Not set
Debreceni Egyetem, Debrecen, Not set
Academisch Ziekenhuis Leiden, Leiden, Not set
Alrijne Ziekenhuis Leiden, Leiderdorp, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Hospital Del Mar, Barcelona, Not set
King's College Hospital, London, Not set
Conditions: Decompensated Cirrhosis and Ascites
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