All Clinical Trials in United Kingdom

A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine

NCT06241313

Recruiting

A migraine attack is a moderate or severe headache that usually occurs on one side of the head and is often accompanied by throbbing, sensitivity to light, sensitivity to sound, nausea, or other symptoms. The main goal of the study is to see if atogepant is effective, safe, and well-tolerated in treating migraine attacks quickly. Atogepant is a medicine currently approved for the preventive treatment of migraine in adults and has been shown to be effective and well tolerated when taken daily to... Read More

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

07/11/2025

Locations: Universitair Ziekenhuis Antwerpen /ID# 257582, Edegem, Antwerpen +147 locations

Universitair Ziekenhuis Antwerpen /ID# 257582, Edegem, Antwerpen

Universitair Ziekenhuis Brussel /ID# 257584, Jette, Bruxelles-Capitale

Jessa Ziekenhuis /ID# 257578, Hasselt, Limburg

AZ Sint-Jan Brugge /ID# 257585, Brugge, Not set

AZ Groeninge /ID# 257586, Kortrijk, Not set

CHR de la Citadelle /ID# 257587, Liege, Not set

H.-Hartziekenhuis Lier /ID# 257577, Lier, Not set

Cabinet Prive Dr Sava /ID# 257581, Saint-Nicolas, Not set

The first affiliated hospital of bengbu medical college /ID# 258758, Bengbu, Anhui

Beijing Friendship Hospital /ID# 258830, Beijing, Beijing

Xuanwu Hospital Capital Medical University /ID# 258510, Beijing, Beijing

Peking University Third Hospital /ID# 259573, Beijing, Beijing

Chinese PLA General Hospital /ID# 257540, Beijing, Beijing

Peking University First Hospital /ID# 258672, Xicheng District, Beijing

Fujian Medical University Union Hospital /ID# 259575, Fuzhou, Fujian

The First Affiliated Hospital of Xiamen University /ID# 259576, Xiamen, Fujian

Lanzhou University Second Hospital /ID# 259667, Lanzhou, Gansu

Guangzhou First People's Hospital /ID# 258656, Guangzhou, Guangdong

The Second Affiliated Hospital of Guangzhou Medical University /ID# 258638, Guangzhou, Guangdong

The University Of Hong Kong - Shenzhen Hospital /ID# 258462, Shenzhen, Guangdong

The Affiliated Hospital of Guizhou Medical University /ID# 259536, Guiyang, Guizhou

Hainan General Hospital /ID# 259548, Haikou, Hainan

Hebei General Hospital /ID# 258583, Shijiazhuang, Hebei

Zhengzhou People's Hospital /ID# 258670, Zhengzhou, Henan

The Second Xiangya Hospital of Central South University /ID# 260623, Changsha, Hunan

The Third Xiangya Hospital of Central South University /ID# 258787, Changsha, Hunan

Zhuzhou Central Hospital /ID# 260076, Zhuzhou, Hunan

The Second Affiliated Hospital of Nanjing Medical University /ID# 258648, Nanjing, Jiangsu

The Second Affiliated Hospital of Soochow University /ID# 259551, Suzhou, Jiangsu

The First Affiliated Hospital of Soochow University /ID# 258783, Suzhou, Jiangsu

Jiangxi Pingxiang People's Hospital /ID# 258652, Pingxiang, Jiangxi

The First Hospital of Jilin University /ID# 259585, Changchun, Jilin

The Second hospital of Jilin university /ID# 258556, Changchun, Jilin

General Hospital of Northern Theater Command /ID# 259556, Shenyang, Liaoning

Shaanxi Provincial People'S Hospital /ID# 259529, XI An, Shaanxi

Second Hospital of Shanxi Medical University /ID# 259669, Taiyuan, Shanxi

West China Hospital, Sichuan University /ID# 258664, Chengdu, Sichuan

Tianjin Medical University General Hospital /ID# 259513, Tianjin, Tianjin

Tianjin People's Hospital /ID# 258625, Tianjin, Tianjin

The second affiliated hospital of Zhejiang University school of medicine /ID# 258860, Hangzhou, Zhejiang

The First Affiliated Hospital of Wenzhou Medical University /ID# 258939, Wenzhou, Zhejiang

Baotou Central Hospital /ID# 258786, Baotou, Not set

The first people's Hospital Affiliated to Shanghai Jiaotong University /ID# 259554, Shanghai, Not set

CCR Ostrava, s.r.o. /ID# 257743, Ostrava, Ostrava-mesto

Fakultni Nemocnice Ostrava /ID# 259023, Ostrava, Ostrava-mesto

Praglandia /ID# 257667, Prague, Praha 5

NeuroHK s.r.o. /ID# 257671, Hradec Kralove, Not set

Clintrial s.r.o. /ID# 257663, Prague 10, Not set

FORBELI s.r.o. /ID# 259019, Prague, Not set

DADO MEDICAL s.r.o. /ID# 257672, Praha, Not set

Axon Clinical, s.r.o. /ID# 259024, Praha, Not set

Fakultni Thomayerova nemocnice /ID# 259021, Praha, Not set

INEP medical s.r.o. /ID# 257669, Praha, Not set

Vestra Clinics s.r.o. /ID# 259022, Rychnov nad Kneznou, Not set

Neuropraxis Muenchen Sued /ID# 258077, Unterhaching, Bayern

Kopfschmerzzentrum - Frankfurt /ID# 258019, Frankfurt am Main, Hessen

Studienzentrum Nord-West /ID# 258024, Westerstede, Niedersachsen

Universitaetsklinikum Duesseldorf /ID# 258078, Düsseldorf, Nordrhein-Westfalen

Ambenet Hausarztpraxis /ID# 258075, Leipzig, Sachsen

Schmerzklinik Kiel /ID# 258005, Kiel, Schleswig-Holstein

Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 258076, Berlin, Not set

Universitaetsklinikum Essen /ID# 258023, Essen, Not set

Vitos Orthopaedische Klinik Kassel gemeinnuetzige GmbH /ID# 258008, Kassel, Not set

Velocity Clinical Research /ID# 258020, Wiesbaden, Not set

Jávorszky Ödön Kórház /ID# 258969, Vác, Pest

Cortex Study Center /ID# 259032, Budapest, Not set

Semmelweis Egyetem /ID# 258546, Budapest, Not set

Semmelweis Egyetem /ID# 258800, Budapest, Not set

UNO Medical Trials /ID# 259186, Budapest, Not set

S-Medicon Kft /ID# 258547, Budapest, Not set

Istituto Neurologico Mediterraneo Neuromed /ID# 258593, Pozzilli, Isernia

ASL 1 Abruzzo - Ospedale SS. Filippo and Nicola /ID# 258590, Avezzano, L Aquila

IRCCS Ospedale San Raffaele /ID# 258592, Milan, Milano

Istituto Auxologico Italiano - Irccs /ID# 258623, Milan, Milano

A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 258591, Torino, Piemonte

Univ. of Bologna-IRCCS-Istituto delle Scienze Neurologiche /ID# 261089, Bologna, Not set

ASST degli Spedali Civili di Brescia /ID# 258594, Brescia, Not set

ICOT Istituto Marco Pasquali /ID# 258621, Latina, Not set

Fondazione Mondino Istituto Neurologico Nazionale a Carattere Scientifico IRCCS /ID# 258589, Pavia, Not set

Fondazione Policlinico Universitario Campus Bio-Medico /ID# 258588, Roma, Not set

Ospedale San Paolo - ASL2 /ID# 258622, Savona, Not set

Tokyo Dental College Ichikawa General Hospital /ID# 259570, Ichikawa-shi, Chiba

Ikeda Neurosurgical Clinic /ID# 259085, Kasuga-shi, Fukuoka

Higashi Sapporo Neurology And Neurosurgery Clinic /ID# 262708, Sapporo-shi, Hokkaido

Umenotsuji Clinic /ID# 258717, Kochi-shi, Kochi

Sendai Headache and Neurology Clinic Medical Corporation /ID# 258862, Sendai-shi, Miyagi

Tominaga Clinic /ID# 258553, Osaka-shi, Osaka

Usuda Clinic Of Internal Medicine /ID# 260422, Setagaya-ku, Tokyo

Tokyo Headache Clinic /ID# 258534, Shibuya-ku, Tokyo

Nagaseki Headache Clinic /ID# 259214, Kai, Yamanashi

DOI Internal Medicine-Neurology Clinic /ID# 259009, Hiroshima, Not set

Tatsuoka Neurology Clinic /ID# 258771, Kyoto, Not set

Hallym University Dongtan Sacred Heart Hospital /ID# 257999, Hwaseong, Gyeonggido

Chonnam National University Hospital /ID# 259154, Gwangju-si, Jeonranamdo

Nowon Eulji Medical Center, Eulji University /ID# 258000, Seoul, Seoul Teugbyeolsi

Seoul National University Hospital /ID# 258002, Seoul, Seoul Teugbyeolsi

Kangbuk Samsung Hospital /ID# 258001, Seoul, Seoul Teugbyeolsi

Yonsei University Health System Severance Hospital /ID# 257998, Seoul, Not set

Vitamed Galaj i Cichomski Sp.j. /ID# 258278, Bydgoszcz, Kujawsko-pomorskie

Athleticomed Sp. z o.o /ID# 258253, Bydgoszcz, Kujawsko-pomorskie

Indywidualna Praktyka Lekarska dr hab. med. Anna Szczepanska-Szerej /ID# 258281, Lublin, Lubelskie

Linden Sp. z o.o. sp.k. /ID# 258283, Krakow, Malopolskie

Instytut Zdrowia Dr Boczarska Jedynak /ID# 258248, Oświęcim, Malopolskie

Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 258250, Gdansk, Pomorskie

Silmedic Sp. z o.o. /ID# 258249, Katowice, Slaskie

Solumed Centrum Medyczne /ID# 258288, Poznan, Wielkopolskie

Clinical Research Center Sp. z.o.o. Medic-R sp. k /ID# 258268, Poznan, Wielkopolskie

MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak /ID# 258287, Wroclaw, Not set

Unidade Local de Saude do Alto Ave, EPE /ID# 257986, Guimaraes, Braga

Unidade Local de Saude de Almada-Seixal, EPE /ID# 257987, Almada, Setubal

Hospital da Luz Lisboa /ID# 257983, Lisboa, Not set

Unidade Local de Saude de Santa Maria, EPE /ID# 257989, Lisboa, Not set

Unidade Local de Saude de Santo Antonio, E.P.E. /ID# 258140, Porto, Not set

Unidade Local de Saude da Arrabida, EPE /ID# 258139, Setubal, Not set

University Hospital Bratislava - Hospital ak. L. Derera /ID# 257947, Bratislava, Bratislavsky Kraj

Neurologicka a algeziologicka ambulancia, SANERA /ID# 259176, Prešov, Presovsky Kraj

Liptovska nemocnica s poliklinikou MUDr. Ivana Stodolu Liptovsky Mikulas /ID# 258315, Liptovsky Mikulas, Zilinsky Kraj

MUDr. Beata Dupejova neurologicka ambulancia s.r.o. /ID# 257901, Banska Bystrica, Not set

Univerzitna nemocnica - Nemocnica svateho Michala a.s. /ID# 257909, Bratislava, Not set

Poliklinika Bezrucova (Cliniq s.r.o.) /ID# 257961, Bratislava, Not set

Hospital Universitario Marques de Valdecilla /ID# 257658, Santander, Cantabria

Clinica Universidad de Navarra - Pamplona /ID# 257656, Pamplona, Navarra

Hospital Universitario Vall d'Hebron /ID# 257652, Barcelona, Not set

Hospital Universitario La Paz /ID# 257654, Madrid, Not set

Hospital Universitario Virgen del Rocio /ID# 257657, Sevilla, Not set

Hospital Universitario y Politecnico La Fe /ID# 257655, Valencia, Not set

Hospital Clinico Universitario de Valladolid /ID# 257653, Valladolid, Not set

Hospital Clinico Universitario Lozano Blesa /ID# 257661, Zaragoza, Not set

Skaneuro Privatmottagning /ID# 258833, Lund, Skane Lan

Karolinska Universitetssjukhuset - Huddinge /ID# 258837, Huddinge, Stockholms Lan

Neurology Clinic /ID# 258835, Stockholm, Stockholms Lan

CTC EbbePark Linkoping /ID# 261170, Linköping, Not set

Optimuskliniken /ID# 258834, Upplands Vasby, Not set

Kuang-Tien General Hospital /ID# 258063, Taichung City, Taichung

Taipei Veterans General Hospital /ID# 258062, Taipei City, Taipei

China Medical University Hospital /ID# 258417, Taichung, Not set

Tri-Service General Hospital /ID# 258064, Taipei City, Not set

Linkou Chang Gung Memorial Hospital /ID# 259171, Taoyuan City, Not set

North Coast Medical Ltd - Newquay Health Centre /ID# 260019, Newquay, Cornwall

The Adam Practice /ID# 258190, Poole, Dorset

Queen Elizabeth University Hospital - NHS Greater Glasgow and Clyde /ID# 259384, Glasgow, Lanarkshire

Re:Cognition Health Birmingham /ID# 258186, Birmingham, Not set

Re:Cognition Health Bristol /ID# 258187, Bristol, Not set

Royal Primary Care Ashgate /ID# 258923, Derbyshire, Not set

Re:Cognition Health - Guildford /ID# 258188, Guildford, Not set

St Pancras Clinical Research /ID# 258183, London, Not set

The University of Nottingham Health Service /ID# 259380, Nottingham, Not set

Primary Care Sheffield /ID# 259448, Sheffield, Not set

Conditions: Migraine

Learn More ›

A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

NCT05646381

Recruiting

The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.

Gender:

ALL

Ages:

Between 50 years and 80 years

Trial Updated:

07/11/2025

Locations: Heart Center Research Llc, Huntsville, Alabama +113 locations

Heart Center Research Llc, Huntsville, Alabama

Cardiovascular Res Found, Beverly Hills, California

National Heart Institute, Beverly Hills, California

Foothill Cardiology, Covina, California

Valley Clinical Trials, Northridge, California

University Of California San Diego, San Diego, California

UC San Francisco Medical Center, San Francisco, California

Stanford University Medical Center, Stanford, California

Excel Medical Clinical Trials LLC, Boca Raton, Florida

Inpatient Research Clinical LLC, Miami Lakes, Florida

Advanced Research for Health Improvement LLC, Naples, Florida

Midwest Heart and Vascular Spec, Overland Park, Kansas

Tufts Medical Center, Boston, Massachusetts

Massachusetts General Hospital, Boston, Massachusetts

Brigham and Womens Hosp Harvard Med School, Boston, Massachusetts

Henry Ford Hospital, Detroit, Michigan

AA Medical Research Center, Flint, Michigan

William Beaumont Hospital, Royal Oak, Michigan

Minneapolis Heart Institute, Minneapolis, Minnesota

University Of Minnesota, Minneapolis, Minnesota

Overlook Medical Center, Summit, New Jersey

New York Presbyterian Hospital, New York, New York

Icahn School of Med at Mt Sinai, New York, New York

Strong Memorial Hospital, Rochester, New York

Wake Forest University Baptist Medical Center, Winston Salem, North Carolina

Lindner Ctr At The Christ Hosp, Cincinnati, Ohio

Ohio State University, Columbus, Ohio

Perelman School of Medicine, Philadelphia, Pennsylvania

Orion Medical, Houston, Texas

Virginia Heart, Falls Church, Virginia

Carient Heart and Vascular, Manassas, Virginia

Novartis Investigative Site, Innsbruck, Tyrol

Novartis Investigative Site, Linz, Not set

Novartis Investigative Site, Wien, Not set

Novartis Investigative Site, Aalst, Not set

Novartis Investigative Site, Genk, Not set

Novartis Investigative Site, Kortrijk, Not set

Novartis Investigative Site, Roeselare, Not set

Novartis Investigative Site, Yvoir, Not set

Novartis Investigative Site, Cambridge, Ontario

Novartis Investigative Site, North York, Ontario

Novartis Investigative Site, Ottawa, Ontario

Novartis Investigative Site, Montreal, Quebec

Novartis Investigative Site, Sainte Foy, Quebec

Novartis Investigative Site, Hradec Kralove, Not set

Novartis Investigative Site, Jaromer budova Polikliniky, Not set

Novartis Investigative Site, Prague 4, Not set

Novartis Investigative Site, Praha, Not set

Novartis Investigative Site, Esbjerg, Not set

Novartis Investigative Site, Hvidovre, Not set

Novartis Investigative Site, Roskilde, Not set

Novartis Investigative Site, Viborg, Not set

Novartis Investigative Site, Paris, Not set

Novartis Investigative Site, Pessac, Not set

Novartis Investigative Site, Poitiers, Not set

Novartis Investigative Site, Rennes, Not set

Novartis Investigative Site, Frankfurt Am Main, Hessen

Novartis Investigative Site, Dresden, Sachsen

Novartis Investigative Site, Berlin, Not set

Novartis Investigative Site, Essen, Not set

Novartis Investigative Site, Hamburg, Not set

Novartis Investigative Site, Lueneburg, Not set

Novartis Investigative Site, Muenchen, Not set

Novartis Investigative Site, Muenster, Not set

Novartis Investigative Site, Oldenburg, Not set

Novartis Investigative Site, Beer-Sheva, Not set

Novartis Investigative Site, Haifa, Not set

Novartis Investigative Site, Jerusalem, Not set

Novartis Investigative Site, Nahariya, Not set

Novartis Investigative Site, Petach Tikva, Not set

Novartis Investigative Site, Ramat Gan, Not set

Novartis Investigative Site, Ancona, AN

Novartis Investigative Site, Bergamo, BG

Novartis Investigative Site, Bologna, BO

Novartis Investigative Site, Brescia, BS

Novartis Investigative Site, Caserta, CE

Novartis Investigative Site, Cona, FE

Novartis Investigative Site, Pozzilli, IS

Novartis Investigative Site, Milano, MI

Novartis Investigative Site, Padova, PD

Novartis Investigative Site, Pordenone, Not set

Novartis Investigative Site, Amsterdam, Not set

Novartis Investigative Site, Rotterdam, Not set

Novartis Investigative Site, Braga, Not set

Novartis Investigative Site, Coimbra, Not set

Novartis Investigative Site, Vila Nova De Gaia, Not set

Novartis Investigative Site, Salamanca, Castilla Y Leon

Novartis Investigative Site, Caceres, Extremadura

Novartis Investigative Site, Madrid, Not set

Novartis Investigative Site, Valencia, Not set

Novartis Investigative Site, Basel, Not set

Novartis Investigative Site, Geneve 14, Not set

Novartis Investigative Site, Lausanne, Not set

Novartis Investigative Site, Lugano, Not set

Novartis Investigative Site, Zuerich, Not set

Novartis Investigative Site, Edinburgh, Not set

Novartis Investigative Site, Leicester, Not set

Novartis Investigative Site, Liverpool, Not set

Novartis Investigative Site, Londonderry, Not set

Novartis Investigative Site, London, Not set

Novartis Investigative Site, Middlesbrough, Not set

Novartis Investigative Site, Tyne and Wear, Not set

Conditions: Aortic Stenosis

Learn More ›

A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, and to Explore the Effect of Food After Multiple Doses of Selected Prototypes in Healthy Adult Participants

NCT07063342

Recruiting

The purpose of this study is to evaluate novel KarX and KarT prototypes versus the KarXT and KarX-EC reference following single doses, and to explore the effect of food after multiple doses of selected prototypes in healthy adult participants.

Gender:

ALL

Ages:

Between 18 years and 55 years

Trial Updated:

07/11/2025

Locations: Quotient Sciences, Nottingham, Nottinghamshire

Conditions: Healthy Volunteers

Learn More ›

AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer.

NCT02102165

Recruiting

This program initially aims to recruit 1300 breast cancer patients from a large number of hospitals across Europe. Eligible patients are those who are 18 or older, either female or male, and who have not received more than 1 type of treatment from the time metastases were discovered, metastasi(e)s has just been diagnosed or their disease has come back (disease relapse). Biopsy samples from both the primary and metastatic (or relapsed) tumor will be collected for central analyses, together with b... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/11/2025

Locations: Institut Jules Bordet, Brussels, Not set +51 locations

Institut Jules Bordet, Brussels, Not set

Cliniques Universitaires St-Luc, Brussels, Not set

Grand Hopital Charleroi, Charleroi, Not set

UZ Leuven, Leuven, Not set

CHU de Liège, Liège, Not set

Clinique et Maternité Sainte-Elisabeth (CMSE - Namur), Namur, Not set

Kliniken Essen-Mitte, Klinik für Senologie/ Brustzentrum, Essen, Not set

Frauenkliniken Maistrasse-Innenstadt und Großhadern, München, Not set

Landspitali, Reykjavík, Not set

Ospedale degli Infermi - S.O.C.Oncologia, Biella, Not set

Ospedale di Bolzano - Oncologia Medica, Bolzano, Not set

Ospedale Ramazzini di Carpi, Carpi, Not set

IRCCS AOU San Martino-IST, Genova, Not set

ULSS 21 Legnago, Legnago, Not set

Istituto Europeo di Oncologia, Milano, Not set

UOC Oncologia Medica - AOU Parma, Parma, Not set

Fondazione Salvatore Maugeri, Pavia, Not set

IRCCS Az Ospedaliera S.Maria Nuova, Reggio Emilia, Not set

Centre Hospitalier, Luxembourg, Not set

Champalimaud Foundation, Lisboa, Not set

Complexo Hospitalario Universitario A Coruña, A Coruña, Not set

Hospital del Mar, Barcelona, Not set

Dr Rosell Oncology Institute, Quirón Dexeus University Hospital, Barcelona, Not set

Hospital Vall d'Hebron, Barcelona, Not set

Consorcio Hospitalario Provincial de Castellón, Castellón De La Plana, Not set

Hospital San Pedro de Alcantara, Cáceres, Not set

Hospital Universitari Arnau de Vilanova, Lleida, Not set

MD Anderson Cancer Center, Madrid, Not set

Hospital Clínico San Carlos, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Centro Integral Oncológico Clara Campa, Madrid, Not set

Hospital Universitario Virgen del Rocio, Sevilla, Not set

Instituto Valenciano de Oncología, Valencia, Not set

Hospital Clinico Universitario de Valencia, Valencia, Not set

Hospital General Universitario de Valencia, Valencia, Not set

Sahlgrenska University Hospital, Gothenburg, Not set

Ryhov County Hospital, Jönköping, Not set

Kantonsspital Baden, Baden, Not set

Inselspital Bern, Bern, Not set

Kantonsspital Graubuenden, Chur, Not set

Luzerner Kantonsspital, Division of Medical Oncology, Lucerne, Not set

Queen Elizabeth Hospital - University Hospitals Birmingham NHS Foundation Trust, Birmingham, Not set

University Hospitals Bristol NHS Foundation Trust, Bristol, Not set

Velindre NHS Trust, Cardiff, Not set

NHS Tayside, Ninewells Hospital, Dundee, Not set

Edinburgh Cancer Centre - Western General Hospital, Edinburgh, Not set

Beatson West of Scotland Cancer Centre, Glasgow, Not set

Christie NHS Foundation Trust, Manchester, Not set

Nottingham University Hospital NHS Trust, Nottingham, Not set

Singleton Hospital - ABM University Health Board, Swansea, Not set

Royal Cornwall Hospital - Royal Cornwall Hospitals NHS Trust, Truro, Not set

Yeovil District Hospital NHS Foundation Trust, Yeovil, Not set

Conditions: Metastatic Breast Cancer

Learn More ›

Valved Graft PMCF Study

NCT04754217

Recruiting

Multicenter, global, prospective, non-randomized, interventional, post-market trial. All subjects enrolled will receive an Abbott Valved Graft device.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/11/2025

Locations: University Hospital - Univ. of Alabama at Birmingham (UAB), Birmingham, Alabama +24 locations

University Hospital - Univ. of Alabama at Birmingham (UAB), Birmingham, Alabama

University of Michigan, Ann Arbor, Michigan

Mission Health & Hospitals, Asheville, North Carolina

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Klinik Floridsdorf, Vienna, Not set

Rigshospitalet, Copenhagen, Not set

CHU de Besancon - Jean Minjoz, Besançon, Not set

CHRU Lille, Lille, Not set

Groupe Hospitalier Bichat - Claude Bernard, Paris, Not set

Herz-und Diabetes Zentrum NRW, Bad Oeynhausen, Not set

Deutsches Herzzentrum Berlin, Berlin, Not set

Klinikum Links der Weser, Bremen, Not set

Medizinische Hochschule Hannover, Hannover, Not set

Onassis Cardiac Surgery Center, Athens, Not set

Policlinico S.Orsola-Malpighi, Bologna, Not set

Ospedale San Raffaele, Milan, Not set

Policlinico San Donato, San Donato Milanese, Not set

Wojewodzki Szpital Zespolony w Kielcach, Kielce, Not set

Krakowski Szpital Specjalistyczny im. Jana Pawla II, Krakow, Not set

The Cardinal Stefan Wyszynski Institute of Cardiology, Warsaw, Not set

Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi, Łódź, Not set

Hospital Universitario del Vinalopó, Elche, Not set

Hospital Universitario Son Espases, Palma De Mallorca, Not set

James Cook University Hospital, Middlesbrough, Not set

Conditions: Aortic Valve Disease, Ascending Aorta Abnormality, Aortic Dissection

Learn More ›

Longitudinal Early-onset Alzheimer's Disease Study Protocol

NCT03507257

Recruiting

The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical, cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EOnonAD) participants, and (3) cognitively normal (CN) control participants.

Gender:

ALL

Ages:

Between 40 years and 64 years

Trial Updated:

07/11/2025

Locations: Banner Sun Health Research Institute, Sun City, Arizona +22 locations

Conditions: Early Onset Alzheimer Disease, Alzheimer Disease, Mild Cognitive Impairment

Learn More ›

Integrated Molecular and Clinical Profiling to Improve Disease Characterization and Outcome Prediction in Nodal Marginal Zone Lymphoma

NCT05700149

Recruiting

International retrospective observational cohort study aimed to describe a molecular classification for NMZL.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/11/2025

Locations: University of Miami, Miami, Florida +35 locations

University of Miami, Miami, Florida

Weill Cornell Medical, New York, New York

Hematology Center after Prof. Yeolyan, Yerevan, Not set

University Hospital Centre Zagreb, Zagreb, Not set

AO SS Antonio e Biagio e C. Arrigo, Alessandria, AL

Istituto Tumori "Giovanni Paolo II" I.R.C.C.S., Bari, BA

ASST Papa Giovanni XXIII, Bergamo, BG

ASST degli Spedali Civili di Brescia, Brescia, BS

AOU Policlinico Vittorio Emanuele, Presidio Ferrarotto, Catania, CT

Azienda Ospedaliero Universitaria di Ferrara, Cona, FE

Azienda Ospedaliera Universitaria Careggi, Florence, FI

Azienda Ospedaliera Papardo, Messina, ME

IRCCS Ospedale San Raffaele, Milan, MI

IEO Istituto Europeo di Oncologia, Milan, MI

ASST Grande Ospedale Metropolitano Niguarda, Milan, MI

Azienda Sanitaria Locale di Pescara, Pescara, PE

Centro di Riferimento Oncologico, Aviano, PN

Fondazione IRCCS Policlinico San Matteo, Pavia, PV

AUSL IRCCS di Reggio Emilia, Arcispedale S. Maria Nuova, Reggio Emilia, RE

Fondazione PTV - Policlinico Tor Vergata, Rom, RM

Sapienza University - AOU Policlinico Umberto I, Rom, RM

Fondazione Policlinico Univeristario A. Gemelli, IRCCS, Università Cattolica S. Cuore, Rom, RM

ASST dei Sette Laghi - Ospedale di Circolo di Varese, Varese, VA

IRCCS - Azienda Ospedaliero-Universitaria di Bologna, Bologna, Not set

Azienda Ospedaliera Universitaria Federico II, Napoli, Not set

AOU Maggiore della Carità, Novara, Not set

Chonnam National University Hwasun Hospital, Hwasun-gun, Not set

Portuguese Institute of Oncology, Lisboa, Not set

University Hospital Basel, Basel, Not set

Oncology Institute of Southern Switzerland and Institute of Oncology Research, Bellinzona, Not set

Hôpitaux Universitaires Genevois, Genève, Not set

Kantonsspital St. Gallen, St. Gallen, Not set

University Hospital Zurich, Zürich, Not set

Leicester Royal Infirmary, Leicester, Not set

Norfolk and Norwich University Hospital, Norwich, Not set

Oxford University Hospitals, Oxford, Not set

Conditions: Nodal Marginal Zone Lymphoma

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Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia

NCT06584357

Recruiting

Bio-Hermes-002 is a 120-day cross-sectional study that will result in a blood, CSF, retinal, digital, MRI, and PET brain imaging biomarker database that can be used to determine the primary objective. Digital biomarkers and blood-based biomarkers will be tested to determine whether a meaningful relationship exists between biomarkers alone or in combination with tau or amyloid brain pathology identified through PET images.

Gender:

ALL

Ages:

Between 60 years and 90 years

Trial Updated:

07/11/2025

Locations: JEM Research Institute, Atlantis, Florida +22 locations

Conditions: Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease, Early Onset, Memory Loss, Memory Disorders, Memory Impairment

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Study of Novel Treatment Combinations in Patients With Lung Cancer

NCT05633667

Recruiting

The goal of this platform clinical trial is to test how well novel treatment combinations work in participants with lung cancer. Substudy-01 will compare the different novel combinations versus standard of care in participants with metastatic (cancer that has spread) non-small-cell lung cancer (NSCLC) who have not been treated before. Substudy-02 will compare the different novel combination versus standard of care in participants with cancer that has progressed after receiving previous treatment... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/11/2025

Locations: Arizona Oncology Associates,Substudy-01, Tucson, Arizona +87 locations

Arizona Oncology Associates,Substudy-01, Tucson, Arizona

Arizona Oncology Associates,Substudy-02, Tucson, Arizona

Rocky Mountain Cancer Center,Substudy-01, Denver, Colorado

Rocky Mountain Cancer Center,Substudy-02, Denver, Colorado

Fort Wayne Medical Oncology and Hematology, Inc.,Substudy-03, Fort Wayne, Indiana

Baptist Health Lexington,Substudy-03, Lexington, Kentucky

Washington University School of Medicine - Siteman Cancer Center,Substudy-01, Saint Louis, Missouri

Washington University School of Medicine - Siteman Cancer Center,Substudy-02, Saint Louis, Missouri

Washington University School of Medicine - Siteman Cancer Center,Substudy-03, Saint Louis, Missouri

Washington University School of Medicine - Siteman Cancer Center, Saint Louis, Missouri

Oncology Hematology Care Clinical Trials, LLC,Substudy-01, Cincinnati, Ohio

Oncology Hematology Care Clinical Trials, LLC,Substudy-02, Cincinnati, Ohio

Oncology Associates of Oregon, PC,Substudy-01, Eugene, Oregon

Oncology Associates of Oregon, PC,Substudy-02, Eugene, Oregon

Texas Oncology - Central South,Substudy-01, Austin, Texas

Texas Oncology - Central South,Substudy-02, Austin, Texas

US Oncology Investigational Products Center (IPC),Substudy-01, Fairfax, Virginia

US Oncology Investigational Products Center (IPC),Substudy-02, Fairfax, Virginia

Fred Hutchinson Cancer Center,Substudy-01, Seattle, Washington

Fred Hutchinson Cancer Center,Substudy-02, Seattle, Washington

Centro Gaúcho Integrado de Oncologia Hematologia, Ensino e Pesquisa Ltda./Hospital Mãe de Deus,Substudy-03, Porto Alegre, Not set

Hospital Mae de Deus, Porto Alegre, Not set

Hospital Sao Lucas da PUC Rio Grande do Sul,Substudy-03, Porto Alegre, Not set

Fundação Antonio Prudente/A.C. Camargo Cancer Center,Substudy-03, São Paulo, Not set

Real e Benemérita Associação Portuguesa de Beneficência/Hospital Beneficência Portuguesa de São Paulo (Hospital BP),Substudy-03, São Paulo, Not set

Queen Mary Hospital,Substudy-01, Hong Kong, Not set

Queen Mary Hospital,Substudy-02, Hong Kong, Not set

Queen Elizabeth Hospital,Substudy-01, Hong Kong, Not set

Queen Elizabeth Hospital,Substudy-02, Hong Kong, Not set

Prince of Wales Hospital,Substudy-01, New Territories, Not set

Prince of Wales Hospital,Substudy-02, New Territories, Not set

Rambam Health Care Campus,Substudy-01, Haifa, Not set

Rambam Health Care Campus,Substudy-02, Haifa, Not set

Rambam Health Care Campus,Substudy-03, Haifa, Not set

Shaare Zedek Medical Center,Substudy-01, Jerusalem, Not set

Shaare Zedek Medical Center,Substudy-02, Jerusalem, Not set

Shaare Zedek Medical Center,Substudy-03, Jerusalem, Not set

Hadassah University Medical Center,Substudy-03, Jerusalem, Not set

Rabin Medical Center,Substudy-03, Petah Tiqva, Not set

Tel Aviv Sourasky Medical Center,Substudy-01, Tel Aviv-Yafo, Not set

Tel Aviv Sourasky Medical Center,Substudy-02, Tel Aviv-Yafo, Not set

Tel-Aviv Sourasky Medical Center,Substudy-03, Tel Aviv-Yafo, Not set

Chungbuk National University Hospital,Substudy-01, Cheongju-si, Not set

Chungbuk National University Hospital,Substudy-02, Cheongju-si, Not set

National Cancer Center,Substudy-01, Goyang, Not set

National Cancer Center,Substudy-02, Goyang, Not set

National Cancer Center,Substudy-03, Goyang, Not set

Chonnam National University Hwasun Hospital,Substudy-01, Gwangju, Not set

Chonnam National University Hwasun Hospital,Substudy-03, Gwangju, Not set

Seoul National University Bundang Hospital,Substudy-01, Gyeonggi-do, Not set

Seoul National University Bundang Hospital,Substudy-03, Gyeonggi-do, Not set

Kosin University Gospel Hospital,Substudy-01, Seo-gu, Not set

Kosin University Gospel Hospital,Substudy-03, Seo-gu, Not set

Severance Hospital, Yonsei University Health System,Substudy-03, Seoul, Not set

Asan Medical Center,Substudy-02, Seoul, Not set

Asan Medical Center,Substudy-03, Seoul, Not set

Asan Medical Centre,Substudy-01, Seoul, Not set

Samsung Medical Center,Substudy-01, Seoul, Not set

Samsung Medical Center,Substudy-02, Seoul, Not set

Samsung Medical Center,Substudy-03, Seoul, Not set

Severance Hospital, Yonsei University Health System,Substudy-01, Seoul, Not set

Severance Hospital, Yonsei University Health System,Substudy-02, Seoul, Not set

Seoul National University,Substudy-01, Seoul, Not set

Seoul National University,Substudy-02, Seoul, Not set

Korea University Guro Hospital,Substudy-01, Seoul, Not set

Korea University Guro Hospital,Substudy-03, Seoul, Not set

Changhua Christian Hospital,Substudy-01, Changhua City, Not set

Changhua Christian Hospital,Substudy-02, Changhua City, Not set

Changhua Christian Hospital,Substudy-03, Changhua City, Not set

Kaohsiung Medical University Chung-Ho Memorial Hospital,Substudy-01, Kaohsiung City, Not set

Kaohsiung Medical University Chung-Ho Memorial Hospital,Substudy-02, Kaohsiung City, Not set

Kaohsiung Medical University Chung-Ho Memorial Hospital,Substudy-03, Kaohsiung City, Not set

Kaohsiung Chang Gung Memorial Hospital,Substudy-01, Kaohsiung, Not set

Kaohsiung Chang Gung Memorial Hospital,Substudy-02, Kaohsiung, Not set

Kaohsiung Chang Gung Memorial Hospital,Substudy-03, Kaohsiung, Not set

National Taiwan University Hospital,Substudy-01, Taipei City, Not set

National Taiwan University Hospital,Substudy-02, Taipei City, Not set

Memorial Ankara Hospital,Substudy-03, Ankara, Not set

Dicle University Medical Faculty,Substudy-03, Diyarbakir, Not set

Necmettin Erbakan Universitesi,Substudy-03, Meram Konya, Not set

Gazi University Medical Faculty,Substudy-03, Yenimahalle, Not set

Birmingham Heartlands Hospital,Substudy-03, Birmingham, Not set

University Hospitals Birmingham NHS Trust,Substudy-01, Birmingham, Not set

University Hospitals Birmingham NHS Trust,Substudy-02, Birmingham, Not set

St James University Hospital,,Substudy-01, Leeds, Not set

St. Bartholomew's Hospital,Substudy-01, London, Not set

St. Bartholomew's Hospital,Substudy-02, London, Not set

St. Bartholomew's Hospital,Substudy-03, London, Not set

Conditions: Lung Cancer, Advanced or Metastatic Non-Small-Cell Lung Cancer, Resectable Non-Small-Cell Lung Cancer

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Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms

NCT04279847

Recruiting

The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of INCB057643 as monotherapy or combination with ruxolitinib for participants with myelofibrosis (MF) and other myeloid neoplasms.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/10/2025

Locations: University of Alabama At Birmingham, Birmingham, Alabama +51 locations

University of Alabama At Birmingham, Birmingham, Alabama

University of Colorado Cancer Center, Aurora, Colorado

University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida

Emory University-Winship Cancer Institute, Atlanta, Georgia

University of Iowa Hospital and Clinics, Iowa City, Iowa

Washington University School of Medicine, Saint Louis, Missouri

Rutgers Cancer Institute of Nj, New Brunswick, New Jersey

Roswell Park Cancer Institute, Buffalo, New York

Nyu Langone Health - Long Island Hospital, Mineola, New York

Nyu Langone Laura and Isaac Perlmutter Cancer Center, New York, New York

Weill Medical College of Cornell University, New York, New York

University of North Carolina At Chapel Hill, Chapel Hill, North Carolina

University of Cincinnati Cancer Institute, Cincinnati, Ohio

Ohio State University, Columbus, Ohio

Oregon Health and Science University, Portland, Oregon

Texas Oncology-Baylor Sammons Cancer Center, Dallas, Texas

Md Anderson Cancer Center, Houston, Texas

Oncology Consultants, Houston, Texas

Huntsman Cancer Institute At University of Utah, Salt Lake City, Utah

Fred Hutchinson Cancer Center, Seattle, Washington

Medical College of Wisconsin, Milwaukee, Wisconsin

Princess Margaret Cancer Center, Toronto, Ontario

McGill University Jewish General Hospital, Montreal, Quebec

St Paul'S Hospital, Vancouver, Not set

Peking Union Medical College Hospital, Beijing, Not set

Nanfang Hospital_Southern Medical University, Guangzhou, Not set

The First Affiliated Hospital, Zhejiang University School of Medicine (Fahzu), Hangzhou, Not set

Henan Cancer Hostipal, Zhengzhou, Not set

Helsinki University Central Hospital, Helsinki, Not set

Aou Policlinico S. Orsola-Malpighi, Bologna, Not set

Azienda Ospedaliero-Universitaria Careggi (Aouc), Firenze, Not set

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori, Meldola, Not set

Fondazione Irccs Ca Granda Ospedale Maggiore, Milan, Not set

Azienda Ospedaliero Universitaria San Luigi Gonzaga Di Orbassano, Orbassano, Not set

Azienda Policlinico Umberto 1 Universita Sapienza Di Roma, Rome, Not set

Centro Ricerche Cliniche Di Verona, Verona, Not set

Fujita Health University Hospital, Aichi, Not set

Chiba University Hospital, Chiba, Not set

National Cancer Center Hospital East, Chiba, Not set

University of Yamanashi Hospital, Chuo, Not set

Kyushu University Hospital, Fukuoka, Not set

Kumamoto Shinto General Hospital, Kumamoto, Not set

Radboud University Nijmegen Medical Center, Nijmegen, Not set

Hospital Universitari Germans Trias I Pujol, Badalona, Not set

Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario Virgen de La Arrixaca, Murcia, Not set

Hospital Clinico Universitario de Salamanca, Salamanca, Not set

United Lincolnshire Hospitals, Boston, Not set

Lincoln County Hospital, Lincoln, Not set

The Christie Nhs Foundation Trust Uk, Manchester, Not set

University of Oxford, Oxford, Not set

Conditions: Relapsed or Refractory Primary Myelofibrosis, Secondary Myelofibrosis (Post-Polycythemia Vera Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis), Myelofibrosis, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome, Myeloproliferative Neoplasm, ET (Essential Thrombocythemia)

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A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)

NCT06355531

Recruiting

PROSPER trial is a trial to assess the efficacy of FNP-223 in slowing disease progression in participants with PSP as measured by the PSP Rating Scale (PSPRS) over 52 weeks and to assess the safety and tolerability of FNP-223 for 52 weeks in participants with PSP.

Gender:

ALL

Ages:

Between 50 years and 80 years

Trial Updated:

07/10/2025

Locations: The Neurology Center of Southern California - Carlsbad, Carlsbad, California +43 locations

The Neurology Center of Southern California - Carlsbad, Carlsbad, California

UCSF Weill Institute for Neurosciences, San Francisco, California

Rocky Mountain Movement Disorders Center, Denver, Colorado

University of Miami Miller School of Medicine, Miami, Florida

Augusta University, Augusta, Georgia

Massachusetts General Hospital, Boston, Massachusetts

Quest Research Institute, Farmington Hills, Michigan

Robert & John M. Bendheim Parkinson and Movement Disorders Center at Mount Sinai, New York, New York

Columbia University Irving Medical Center, New York, New York

Duke Neurology, Durham, North Carolina

Vanderbilt University Medical Center, Nashville, Tennessee

Central Texas Neurology Consultants, Round Rock, Texas

Groupe Hospitalier Pellegrin, Bordeaux, Not set

Hôpital de la Timone, Marseille, Not set

L'Hôpital Universitaire Carémeau, Nîmes, Not set

Hôpital Universitaire Pitié Salpêtrière, Paris, Not set

Hôpital Pierre-Paul Riquet, Toulouse, Not set

Neurologisches Fachkrankenhaus für Bewegungsstörungen/Parkinson, Beelitz, Not set

Universitätsklinikum Düsseldorf, Düsseldorf, Not set

Universitätsklinikum Leipzig, Leipzig, Not set

Ludwig-Maximilians-Universität München (LMU), Munich, Not set

Pécsi Tudományegyetem Általános Orvostudományi Kar, Pécs, Not set

IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Not set

Azienda Ospedale Università di Padova, Padova, Not set

Azienda Ospedaliero-Universitaria Pisana, Pisa, Not set

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - San Raffaele Pisana, Roma, Not set

Azienda Ospedaliera Universitaria San Giovanni di Dio Ruggi d'Aragona, Salerno, Not set

Neurologia Śląska Centrum Medyczne, Katowice, Not set

Mazowiecki Szpital Bródnowski w Warszawie, Warsaw, Not set

Hospital de Braga, Braga, Not set

Campus Neurológico Senior - Torres Vedras, Torres Vedras, Not set

Complejo Hospitalario Universitario A Coruña, A Coruña, Not set

Hospital Germans Trias i Pujol, Badalona, Not set

Hospital Universitario Cruces, Barakaldo, Not set

Hospital Clínic de Barcelona, Barcelona, Not set

Hospital Universitario Ramón y Cajal, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario de Navarra, Pamplona, Not set

Hospital Universitario Virgen del Rocío, Sevilla, Not set

Hospital Universitari i Politècnic La Fe, Valencia, Not set

University of Cambridge, Cambridge, Not set

University College London Hospitals, London, Not set

Newcastle Upon Tyne Hospitals, Newcastle, Not set

University Hospital Southampton, Southampton, Not set

Conditions: Progressive Supranuclear Palsy

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A Prospective Long-term Observational Study in Patients With Monoclonal Gammopathy of Undetermined Significance

NCT05539079

Recruiting

Multiple Myeloma (MM) is a rare blood cancer affecting over 5000 people a year in the UK. All cases of myeloma start with a condition called monoclonal gammopathy of undetermined significance (MGUS). MGUS occurs in approximately 3.2% of people aged 50 and over. Only a small proportion of these people - around 1% each year - will develop myeloma. Most people with MGUS have no symptoms, but a small number of people will suffer complications. This group are referred to as having monoclonal gammopathy of clinical significance (MGCS). People with myeloma frequently experience long delays in diagnosis; the delays are longer than for any other cancer. Although we know that MGUS leads to myeloma, most cases of MGUS are only found 'incidentally' when the person is having blood tests for something else. And the people who have MGUS do not have consistent testing or follow up. This situation means that 80 - 90% of people who are diagnosed with myeloma did not have an earlier MGUS diagnosis. Earlier diagnosis of myeloma might be possible with better understanding MGUS and how it should be monitored. The SECURE study will help with this. It will help confirm the rate at which people with MGUS progress to a diagnosis of myeloma. It will further understanding of screening, diagnosis, and monitoring patterns of people with MGUS and MGCS in the UK. The study aims to find out more about the role of family history and demographic factors in the development of MGUS. It will also find out more about the psychological impact of an MGUS diagnosis and individual quality of life. Patients with MGUS will be identified by their clinical care team and invited to participate in the SECURE study. Participants will be required to answer surveys and questionnaires annually for a period of 5 years or until their disease changes. The study will recruit participants from 20 NHS sites in the UK. Some will be asked to provide blood samples. SECURE is funded by Cancer Research UK (CRUK) and the National Institute for Health Research (NIHR). Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/10/2025

Locations: Secure Study, Oxford, Oxfordshire

Conditions: MGUS

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