Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension
NCT06492291
Recruiting
This is an extension study to evaluate the longer-term safety and efficacy of enlicitide decanoate in adults with hypercholesterolemia who completed either study MK-0616-013 (NCT05952856), study MK-0616-017 (NCT05952869), or study MK-0616-018 (NCT06450366).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2025
Locations: Alliance for Multispecialty Research, LLC ( Site 0027), Daphne, Alabama +221 locations
Conditions: Hypercholesterolemia
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Solutions to the Challenges of Conduction System Pacing
NCT07009834
Recruiting
Conduction system pacing is a new way of stimulating the heart using pacemaker wires. Traditional pacemakers stimulate the heart muscle which causes disordered heart beats: the walls of the heart move at different times. This wears down the heart over time. Conduction system pacemakers stimulate the heart's electrical system directly producing natural heart beats that are much less disordered. Unfortunately, these pacemakers can only be implanted by a small group of experts at specialised centr... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
07/09/2025
Locations: Imperial College Healthcare Trust; Hammersmith Hospital, London, Not set
Conditions: Conduction System Pacing, Pacing Therapy
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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer
NCT06764875
Recruiting
This is a Phase Ⅲ, randomized, open-label, Sponsor-blinded, 3-arm, global, multicenter study assessing the efficacy and safety of rilvegostomig in combination with fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab, chemotherapy, and pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma participants whose tumors express PD L1 CPS ≥ 1. Rilvegostomig in combination with trastuzumab and chemotherapy will be evaluated in a separate arm (Arm C) to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2025
Locations: Research Site, Anchorage, Alaska +264 locations
Conditions: HER2-positive Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
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Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age
NCT05422222
Recruiting
The purpose of this study is to evaluate the pharmacokinetics, safety, tolerability and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants with at least 1 triple combination responsive (TCR) mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
Gender:
ALL
Ages:
Between 1 year and 11 years
Trial Updated:
07/09/2025
Locations: Children's Hospital of Orange County, Orange, California +37 locations
Conditions: Cystic Fibrosis
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Exploring How Viral Infections Affect People With Chronic Lung Disease
NCT06625944
Recruiting
Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volun... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2025
Locations: Royal Brompton Hospital, London, Not set
Conditions: Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation, COPD (Chronic Obstructive Pulmonary Disease), Respiratory Infection Virus
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Effects of Milk-based Drinks on Gut Microbiome, Sleep and Cardiometabolic Markers
NCT07071181
Recruiting
The purpose of this study is to evaluate the effects of kefir on gastrointestinal health, sleep quality, and biochemical parameters in adults who have sleep problems. Further measurements of cognitive function, arterial stiffness and blood pressure will also be assessed. The following questions will be addressed during the study: 1. What effect does repeated ingestion of kefir have on the gut microbiome and can this positively influence sleep performance (quality and duration) in adults with s... Read More
Gender:
ALL
Ages:
Between 40 years and 70 years
Trial Updated:
07/09/2025
Locations: University of Leeds, Leeds, West Yorkshire +1 locations
Conditions: Sleep, Cardiovascular Diseases, Gut Microbiome, Cognitive Function and Mood, LDL Cholesterol
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A Phase III, Randomised Study of Adjuvant Dato-DXd in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, in Participants With Stage I Adenocarcinoma NSCLC Who Are ctDNA-positive or Have High-risk Pathological Features
NCT06564844
Recruiting
This is a Phase III, randomised, open-label, multicentre, global study assessing the efficacy and safety of adjuvant Dato-DXd in combination with rilvegostomig compared with SoC, after complete surgical resection (R0) in participants with Stage I adenocarcinoma NSCLC who are ctDNA-positive, as determined by the Sponsor-designated ctDNA assay, or have at least one high-risk pathological feature.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2025
Locations: Research Site, Gilbert, Arizona +220 locations
Conditions: Non-small Cell Lung Cancer
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A Comparison of CoolStick With Ethyl Chloride for the Assessment of Light Touch
NCT06596486
Recruiting
The main aim of this study is to compare CoolStick to ethyl chloride spray for the assessment of light touch following neuraxial anaesthesia for caesarean delivery. Coolstick and ethyl chloride will also be compared for the assessment of cold sensation. Participants will also be asked whether they experienced any intraoperative pain.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/08/2025
Locations: Newham University Hospital, London, Not set +2 locations
Conditions: Anesthesia
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Abertay Tea for Cardiovascular Health During Menopause
NCT07070635
Recruiting
The regular consumption of seaweed, as observed in Japan, is associated to a reduced cardiovascular risk and prolonged life expectancy. Interventional studies have shown that brown seaweed consumption can reduce blood pressure, improve glycaemic control and lipoprotein profiles, although this varies with population, dose, duration and the type of seaweed. Brown seaweed appears the most promising to improve cardiovascular risk, due to the presence of specific antioxidants (polyphenols called phlo... Read More
Gender:
FEMALE
Ages:
Between 45 years and 74 years
Trial Updated:
07/08/2025
Locations: Abertay University, Dundee, Not set
Conditions: Cardiovascular Risk Factor, Vascular Function
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The Mental Cost and Burden of Listening
NCT06951815
Recruiting
This randomised controlled trial aims to test the effect of hearing adjustment using hearing aids, on the ease and effectiveness of communication such as listening effort, fatigue, and sentence recognition in noise, in addition to wellbeing and sleep; and to reveal the role of cognitive resources and sleep efficiency in this relationship.
Gender:
ALL
Ages:
Between 60 years and 99 years
Trial Updated:
07/08/2025
Locations: Manchester Centre for Audiology and Deafness, Manchester, Not set
Conditions: Quality of Life (QOL), Communication Barriers, Cognitive Performance, Fatigue, Mental
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Post-market Prospective Clinical Study of Nagor Perle Mammary Implants
NCT06013514
Recruiting
Patients can undergo breast implant surgery for multiple reasons; cosmetic and reconstructive being the primary indications. In order to confidently state safety and due to strict regulation on medical devices it is important to maintain a record of safety and performance with all medical implants. This study is designed to collect data on a new generation of smooth mammary implants to assess the long term performance and safety data on this type of gel-filled mammary breast implant. The two m... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
07/08/2025
Locations: NHS Manchester, Manchester, Not set
Conditions: Breast Reconstruction, Breast Reconstruction Following Mastectomy, Breast Revision, Breast Augmentation, Breast Reconstruction With Silicone Implants, Breast Reconstruction After Mastectomy, Breast Reconstruction Surgery, Breast Implants
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A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)
NCT06660394
Recruiting
This (DEEp SEA Study) is a double-blind, randomized, placebo-controlled, multicenter study to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children and adults with DS. The study consists of 3 main phases: Screening, Titration period, and Maintenance period, followed by a Taper period and Follow-Up. Participants will be randomized to LP352 or placebo. The total duration of the study will be approximately 24 months.
Gender:
ALL
Ages:
Between 2 years and 65 years
Trial Updated:
07/08/2025
Locations: Site Number - USA19, Little Rock, Arkansas +91 locations
Conditions: Dravet Syndrome
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