The state of Virginia currently has 16 active clinical trials seeking participants for Alzheimer's Disease research studies. These trials are conducted in various cities, including Richmond, Charlottesville, Norfolk and Fairfax.
The Use of Memantine for Prevention of Alzheimer's Disease
NCT05063851
Recruiting
As the US population ages, the prevalence of dementia is increasing, and Alzheimer's Disease (AD) is the most prevalent one. Solving the Alzheimer's Disease (AD) epidemic is likely to require preventive therapy beginning many years before symptoms are expected to be evident in at-risk individuals. AD is caused by the dysfunction, loss of synapses, and eventual neuronal death, which may occur up to 25 years before clinical symptoms appear. This study, based off of pre-clinical data, seeks to asse... Read More
Gender:
All
Ages:
Between 50 years and 65 years
Trial Updated:
11/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Alzheimer Disease
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Optina Diagnostics' Cerebral ß-Amyloid Status (CAS) Test
NCT05107882
Recruiting
This observational, cross-sectional study is designed to validate a novel diagnostic test for the detection of phenotypic changes in the retina that correlate with likely PET amyloid status (negative or positive), to aid in the evaluation of adult patients with cognitive impairment who are being evaluated for Alzheimer's disease and other causes of cognitive decline. The CAS test is an adjunct to other diagnostic evaluations, and is indicated for use with the Optina Diagnostics' MHRC (K200254).
Gender:
All
Ages:
Between 50 years and 90 years
Trial Updated:
07/07/2023
Locations: East Virginia Medical School (EVMS), Norfolk, Virginia
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Mild Dementia
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The Role of the Locus Coeruleus in Age-related Distractibility
NCT05574634
Recruiting
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coe... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
06/02/2023
Locations: Virginia Polytechnic Institute and State University, Blacksburg, Virginia
Conditions: Aging, Alzheimer Disease
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Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer's Disease
NCT04436081
Recruiting
This is a randomized, double-blinded, placebo-controlled, crossover trial that aims to 1) determine the efficacy of THC-free cannabidiol (CBD oil) in reducing the severity of agitation among participants and 2) determine whether THC-free CBD oil can reduce the burden on caregivers and increase the participants' quality of life.
Gender:
All
Ages:
Between 50 years and 90 years
Trial Updated:
02/15/2023
Locations: Eastern Virginia Medical School, Norfolk, Virginia
Conditions: Alzheimer Disease, Dementia, Major Neurocognitive Disorder With Aggressive Behavior
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