There are currently 587 clinical trials in Richmond, Virginia looking for participants to engage in research studies. Trials are conducted at various facilities, including Virginia Commonwealth University, Virginia Commonwealth University/Massey Cancer Center, GSK Investigational Site and Virginia Cancer Institute. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
NCT03435796
Recruiting
This is a prospective study for the long-term follow-up (LTFU) of safety and efficacy for all pediatric and adult participants exposed to Gene-modified (GM) T cell therapy participating in a previous Celgene sponsored or Celgene alliance partner sponsored study. Participants who received at least one GM T cell infusion will be asked to enroll in this LTFU protocol upon either premature discontinuation from, or completion of the prior parent treatment protocol.
Gender:
All
Ages:
All
Trial Updated:
05/20/2024
Locations: Local Institution - 01023, Richmond, Virginia
Conditions: Neoplasms
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AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
NCT06137118
Recruiting
This is a Phase 1/2, global multicentre, open-label, single-arm, dose escalation and dose optimisation study of AZD0486 to evaluate the safety, tolerability, and efficacy of AZD0486 monotherapy in participants with R/R B ALL who have received ≥ 2 prior lines of therapies. The study will consist of 3 parts. Part A monotherapy dose escalation. Part B dose optimisation. Part C Dose expansion at the recommended phase 2 dose (RP2D)
Gender:
All
Ages:
Between 12 years and 80 years
Trial Updated:
05/20/2024
Locations: Research Site, Richmond, Virginia
Conditions: B-cell Acute Lymphoblastic Leukemia (B-ALL)
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Preventing Firearm Violence in Youth: A Hospital-based Prevention Strategy
NCT05078164
Recruiting
The goal of the study is to understand if hospital-based violence interventions are effective for reducing youth violence among violently injured youth. This study will allow researchers to learn more about the intervention's effectiveness. The researchers also want to understand if the violence intervention impacts other behaviors, such as firearm use, drug use, aggression, risky behaviors, and rates of violent re-injury.
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
05/20/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Violence in Adolescence
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A Phase 2/3 Study in Adult and Pediatric Participants With SCD
NCT05431088
Recruiting
The purpose of this study is to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of osivelotor.
Gender:
All
Ages:
Between 6 months and 65 years
Trial Updated:
05/20/2024
Locations: Clinical Research Services Unit - Virginia Commonwealth University Medical Center, Richmond, Virginia +1 locations
Conditions: Sickle Cell Disease
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A Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Chemotherapy in Unresectable or Metastatic Cholangiocarcinoma
NCT03656536
Recruiting
The purpose of this study is to evaluate the efficacy and safety of pemigatinib versus gemcitabine plus cisplatin chemotherapy in first-line treatment of participants with unresectable or metastatic cholangiocarcinoma with FGFR2 rearrangement.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/20/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Unresectable Cholangiocarcinoma, Metastatic Cholangiocarcinoma
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Vitamin D Supplementation on Reported Rates of Taxane-Induced Neuropathy
NCT05259527
Recruiting
This is a two-arm randomized clinical trial in which 80 participants with Vitamin D deficiency and scheduled to begin taxane-based chemotherapy will be randomized to either: 1) prescribed vitamin D replacement or 2) standard of care.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/17/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Neuropathic Pain
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A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
NCT03423628
Recruiting
This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is being given to patients. This study will test safety, tolerability and PK (how the drug is absorbed, distributed and eliminated) of ascending doses of AZD1390 in combination with distinct regimens of radiation therapy
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
05/17/2024
Locations: Research Site, Richmond, Virginia
Conditions: Recurrent Glioblastoma Multiforme, Primary Glioblastoma Multiforme, Brain Neoplasms, Malignant, Leptomeningeal Disease (LMD)
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Decreasing Long-term Opioid Use in Cancer Survivors
NCT05067556
Recruiting
This is a feasibility pilot trial assessing a behavioral intervention for chronic pain among disease-free cancer survivors to decrease long-term opioid dependence.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/17/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Pain, Chronic Pain, Cancer Pain, Survivorship
Register for Updates
Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults With Cancer
NCT05958316
Recruiting
Determine the effects of the Computerized Symptom Assessment Tool (C-SCAT) versus usual care on the primary outcomes of self-efficacy for symptom management and symptom self-management behaviors
Gender:
All
Ages:
Between 15 years and 29 years
Trial Updated:
05/17/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Symptoms and Signs, Cancer, Childhood Cancer
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A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
NCT04607421
Recruiting
The purpose of this study is to evaluate two study medicines (encorafenib plus cetuximab) taken alone or together with standard chemotherapy for the potential treatment of colorectal cancer that: has spread to other parts of the body (metastatic); has a certain type of abnormal gene called "BRAF"; and has not received prior treatment. Participants in this study will receive one of the following study treatments: Encorafenib plus cetuximab: These participants will receive encorafenib by mouth... Read More
Gender:
All
Ages:
16 years and above
Trial Updated:
05/16/2024
Locations: VCU Health - Adult Outpatient Pavilion (AOP) Investigational Drug Services, Richmond, Virginia +3 locations
Conditions: Neoplasms
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AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (DMD)
NCT05693142
Recruiting
RGX-202 is a gene therapy designed to deliver a transgene for a novel microdystrophin that includes functional elements of naturally-occurring dystrophin including the C-Terminal (CT) domain. This is a multicenter, open-label dose evaluation clinical study to assess the safety, tolerability and clinical efficacy of a one-time intravenous (IV) dose of RGX-202 in participants with Duchenne.
Gender:
Male
Ages:
Between 4 years and 11 years
Trial Updated:
05/16/2024
Locations: Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia
Conditions: Duchenne Muscular Dystrophy
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Models of Primary Osteoporosis Screening in Male Veterans
NCT04079868
Recruiting
Models of Osteoporosis Screening in Male Veterans aims to test 1 distinct care model of primary osteoporosis screening in men within the VA healthcare setting. All care models deliver VA recommended osteoporosis screening and treatment to high-risk Veterans by appropriate Durham VA clinical staff. The MOPS project will evaluate patient, provider and facility outcomes to determine the effectiveness of each intervention.
Gender:
All
Ages:
All
Trial Updated:
05/15/2024
Locations: Hunter Holmes McGuire VA Medical Center, Richmond, VA, Richmond, Virginia
Conditions: Osteoporosis, Osteopenia, Osteoporotic Fracture
Register for Updates