Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease
NCT03082755
Recruiting
Nighttime agitation in persons with Alzheimer's disease causes patient suffering, distresses caregivers, and often results in prescriptions for harmful antipsychotics. Effective treatments are lacking because of limited knowledge of the etiology of nighttime agitation. The investigators propose a clinical trial to better elucidate whether a sleep disorder, restless legs syndrome, may be a mechanism for nighttime agitation, and if treatment with gabapentin enacarbil (Horizant®) reduces nighttime... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/16/2022
Locations: The University of Texas at Austin, Austin, Texas
Conditions: Alzheimer Disease
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CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
NCT04688190
Recruiting
This multinational, investigator-initiated, retrospective study aims to investigate outcomes of patients, who underwent transcatheter mitral valve implantation (TMVI), in comparison to those screened for TMVI but deemed ineligible, who subsequently underwent interventional mitral valve edge-to-edge repair, mitral valve surgery or medical/conservative therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2022
Locations: Cedars-Sinai Medical Center, Los Angeles, Los Angeles, California +25 locations
Conditions: Mitral Regurgitation
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Pilot Study to Evaluate the Long-term Chronic Care of Patients Who Could or do Utilize an Osseointegrated Device (OID)
NCT04899037
Recruiting
The primary objective of the study is to evaluate OID hearing intervention on cognition among patients who could vs. do utilize an OID. We will also evaluate the long-term effects of OID use on secondary outcomes measures (hearing performance, quality-of-life, social interaction, communication, physical functioning, etc)
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/16/2022
Locations: Department of USF Health Otolaryngology; Auditory Rehabilitation & Clinical Trials Lab, Tampa, Florida
Conditions: Hearing Loss, Conductive, Hearing Loss, Mixed, Deafness, Unilateral
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Neuroimaging Memories of Fear and Safety in the Human Brain
NCT04975009
Recruiting
The purpose of this research is to use functional magnetic resonance imaging (fMRI) to investigate how the brain forms associations between neutral and negative stimuli. The ultimate goal is to understand the neural systems involved in regulating negative emotional responses to fearful stimuli.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
05/16/2022
Locations: The University of Texas at Austin, Austin, Texas +1 locations
Conditions: Fear Anxiety, PTSD
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Mycobacterial Lung Diseases in Virginia: Sequencing and Clinical Determinants of Relapse and Outcome
NCT05277857
Recruiting
Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2022
Locations: University of Virginia, Division of Infectious Disease, Charlottesville, Virginia
Conditions: Nontuberculous Mycobacterial Lung Disease
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The Emergency Department Longitudinal Integrated Care
NCT05327166
Recruiting
Collaborative care is a comprehensive patient-centered model of healthcare delivery targeting behavioral health or substance use that stems from the chronic disease management framework. The intervention being tested ('Emergency Department Longitudinal Integrated Care' or ED LINC) derives from the collaborative care model and has demonstrated feasibility in previous studies. This study expands on the model to test the effectiveness of the ED-LINC intervention when compared with usual care. The... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2022
Locations: Harborview Medical Center, Seattle, Washington
Conditions: Opioid Use Disorder
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Delayed Blood Stem Transplantation in HLA Matched Kidney Transplant Recipients to Eliminate Immunosuppressive Drugs.
NCT03591302
Recruiting
The study will determine whether patients with functioning Human Leukocyte Antigen (HLA) matched kidney transplants for at least one year and who want to discontinue immunosuppressive drugs can be treated with Total Lymphoid Irradiation (TLI) and rabbit Anti-Thymocyte Globulin (rATG) and an HLA matched donor hematopoietic progenitor cell infusion such that their drugs are successfully withdrawn while maintaining normal renal function.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2022
Locations: Stanford University Medical Center, Palo Alto, California
Conditions: Immune Tolerance
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KRT-232 in Combination With TL-895 for the Treatment of R/R MF and KRT-232 for the Treatment of JAKi Intolerant MF
NCT04640532
Recruiting
This study evaluates KRT-232 in Combination With TL-895 for the Treatment of Relapsed or Refractory Myelofibrosis and KRT-232 for the Treatment of JAK Inhibitor Intolerant Myelofibrosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2022
Locations: University of Alabama at Birmingham School of Medicine, Division of Hematology and Oncology, Birmingham, Alabama +36 locations
Conditions: Myelofibrosis, Post-PV MF, Post-ET Myelofibrosis, Primary Myelofibrosis
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The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections
NCT04708171
Recruiting
The study is designed as an international, multicenter prospective cohort study. Patients with presumed glioblastoma (GBM) in- or near eloquent areas on diagnostic MRI will be selected by neurosurgeons. Patients will be treated following one of three study arms: 1) a craniotomy where the resection boundaries for motor or language functions will be identified by the "awake" mapping technique (awake craniotomy, AC); 2) a craniotomy where the resection boundaries for motor functions will be identif... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
05/05/2022
Locations: University of California, San Francisco, San Francisco, California +7 locations
Conditions: Glioblastoma
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Study of KRT-232 or TL-895 in Janus Associated Kinase Inhibitor Treatment-Naïve Myelofibrosis
NCT04878003
Recruiting
This study evaluates either KRT-232 or TL-895 in treatment naïve patients with myelofibrosis (MF) The study will be conducted in 2 stages. Stage 1 will evaluate safety, tolerability, and efficacy of either KRT-232 (Arm 1) or TL-895 (Arm 2) in treatment naïve patients. Stage 2 will expand enrollment in Arm 1 and/or Arm 2 if expansion criteria is met.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2022
Locations: Innovative Clinical Research Institute, Glendale, California +28 locations
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV-MF), Post-Essential Thrombocythemia Myelofibrosis (Post-ET-MF)
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Gait Analysis of a Lateral-Pivot Design Total Knee Replacement
NCT04275362
Recruiting
Previous motion analysis studies have demonstrated excellent ability to distinguish subtle differences in gait between normal subjects and those suffering from arthritis. With proper techniques and analysis differences between osteoarthritis patient groups can be distinguished. Previous research has indicated that subjects who received a single-radius design total knee replacement have superior gait performance that those who received a multi-radius design total knee replacement. The DJO Global... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/04/2022
Locations: MORE Foundation, Phoenix, Arizona
Conditions: Knee Osteoarthritis
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Optical Coherence Tomography of the Saphenous Vein Graft
NCT05129228
Recruiting
OCTOCAB is a prospective, randomized (1:1), single-center trial. The purpose of this study is to determine whether intravascular optical coherence tomography (OCT) guided saphenous vein grafting in coronary artery bypass surgery will reduce the rate of early vein graft failure (VGF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/04/2022
Locations: St Francis Hospital, Roslyn, New York
Conditions: Coronary Bypass Graft Stenosis
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