Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury
NCT05233111
Recruiting
This study will examine the use brief prolonged exposure (Brief PE) therapy compared to standard clinical care to reduce posttraumatic distress among people who have had a spinal cord injury and are receiving rehabilitation in an inpatient setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/15/2022
Locations: Baylor Institute for Rehabilitation, Dallas, Texas
Conditions: Spinal Cord Injuries, PTSD, Post-Traumatic Stress Disorder
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PPROM Registry (Preterm Premature Rupture of Membranes)
NCT02997345
Recruiting
Preterm Premature Rupture of Membranes (PPROM) before 37 weeks of pregnancy is responsible for 40% of preterm births in the United States. The PPROM Registry aims to identify possible causes of PPROM, evaluate trends in expectant management, measure maternal and fetal care, and to review short term and long term outcomes of affected pregnancies and births.
Gender:
FEMALE
Ages:
Between 14 years and 55 years
Trial Updated:
02/14/2022
Locations: Www.Aapprom.Org/the-Registry, Denver, Colorado
Conditions: Fetal Membranes, Premature Rupture, Preterm Premature Rupture of the Membranes, Oligohydramnios, Premature Birth
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Health and Resilience Projects: Foundations
NCT05253235
Recruiting
The Health and Resilience Project (HARP): Foundations is investigating the efficacy of the Strong African American Families (SAAF) intervention in promoting the health and well being of African American adolescents. Youth age 10-13 and their primary caregivers are randomly assigned to receive SAAF or to a control group. Participants complete baseline and follow-up measures regarding vulnerability to substance use based on a neuroimmune model of stress coping.
Gender:
ALL
Ages:
Between 10 years and 13 years
Trial Updated:
02/14/2022
Locations: Center for Family Research, Athens, Georgia
Conditions: Substance Use
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SIESTA for Acute Stroke Rehabilitation
NCT04536623
Recruiting
The SIESTA-Rehabilitation protocol combines two sleep-promoting interventions, (1) empowering nurses to reduce unnecessary disruptions and (2) a systematic protocol to screen, diagnose, and treat sleep-disordered breathing, to determine its impact on relevant sleep and rehabilitation outcomes in the acute inpatient stroke rehabilitation setting compared to the standard of care. Our primary outcome is change in Quality Indicator (QI) score, a measure that has replaced the Functional Independence... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/03/2022
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Sleep-Disordered Breathing
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Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis
NCT04716803
Recruiting
The purpose of this study is to investigate the safety and effectiveness of bone marrow aspirate concentrate (BMAC) in patients with moderate to severe osteoarthritis of the knee. BMAC provides a rich source of mesenchymal stem cells (MSCs) and is a stem cell-based therapy that has been reported to preserve or improve the structure of joints. The Angel System is the device used in this study to concentrate bone marrow from the patient and is intended to separate a mixture of blood and bone marro... Read More
Gender:
ALL
Ages:
Between 45 years and 75 years
Trial Updated:
01/24/2022
Locations: University of California San Diego Koman Outpatient Pavilion, La Jolla, California
Conditions: Osteo Arthritis Knee
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Pilot Study: KeraStat® Gel for Topical Delivery of Morphine for Management of Non-Healing, Painful Open Wounds and Ulcers
NCT05217160
Recruiting
This study is intended to provide information from subjects who currently have painful, chronically open wounds and assess the pain reduction capacity of KeraStat® Gel with Morphine. In gathering data from subjects who have baseline pain from their chronically open wounds, the investigators can then evaluate the capacity of KeraStat® Gel plus Morphine in reducing the subjects daily pain levels, pain associated with dressing changes, and pain medication consumption.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/19/2022
Locations: South Texas Aesthetic and Reconstructive Surgery, San Antonio, Texas
Conditions: Wound of Skin, Burns
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Qualification for Cone-Optogenetics
NCT05218928
Recruiting
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Gender:
All
Ages:
All
Trial Updated:
01/19/2022
Locations: University of California San Francisco, Department of Ophthalmology, San Francisco, California +8 locations
Conditions: Retinal Dystrophies
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Clinical and Radiographic Outcomes of TLIF w/3D Printed Cellular Implant
NCT05023733
Recruiting
This study is designed to evaluate clinical outcomes and spine fusion rates for patients undergoing transforaminal lumbar interbody fusion using the CONDUIT 3D printed titanium TLIF cage.
Gender:
ALL
Ages:
Between 35 years and 80 years
Trial Updated:
01/14/2022
Locations: Hartford Healthcare Bone and Joint Institute, Hartford, Connecticut
Conditions: Foraminal Stenosis, Degenerative Disc Disease, Lumbar Spondylolisthesis, Lumbar Spinal Stenosis
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Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT05211856
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Fountain Valley, California +277 locations
Conditions: Chronic Lymphocytic Leukemia
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Advancing Dignity, Health, and Optimism in Connection With Long Acting Injectables
NCT05208541
Recruiting
ADHOC-LA is an observational study of people living with HIV who either are taking, or have taken, a long-acting injectable therapy to manage their HIV. Data from this study will be used to research the ways in which HIV impacts the lives of these patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2022
Locations: Mazonson & Santas Inc, Menlo Park, California
Conditions: HIV
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A Prospective Biomarker Study in Active SPMS Subjects Treated With Cladribine Tablets
NCT04550455
Recruiting
The purpose of this study is to explore the concept that biomarker sensitivity will detect activity in Multiple Sclerosis (MS) subjects and allow appropriate change in treatment to prevent dysfunction.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
01/12/2022
Locations: Multiple Sclerosis Center of Northeastern New York, P.C., Latham, New York
Conditions: Multiple Sclerosis
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ACute Uncomplicated Type b Aortic Dissection: Endovascular Repair vs. Best Medical Therapy
NCT02622542
Recruiting
The purpose of the study is to conduct a randomized controlled trial comparing best medical therapy (BMT) alone to BMT with thoracic endovascular aortic repair (BMT+TEVAR) for uncomplicated acute type B aortic dissection.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/11/2022
Locations: Department of Cardiothoracic and Vascular Surgery and Memorial Hermann Heart and Vascular Institute - Texas Medical Center, Houston, Texas +1 locations
Conditions: Distal Aortic Dissection, Dissection, Aortic Acute, Acute Type B Aortic Dissection (Uncomplicated)
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