MR-US Image Fusion Targeted Biopsy for Single-cell Prostate Cancer Research
Recruiting
The investigators hypothesize that this single-cell analysis can be used to evaluate prostate needle-core biopsies prospectively even in non-homogenous samples by providing profiles of proteomic and phenotypic signatures. These profiles will in turn enable better predictions of the malignant progression of prostate cancers in the settings of current clinical practice.
Gender:
MALE
Ages:
Between 18 years and 80 years
Trial Updated:
05/06/2025
Locations: Yale University, New Haven, Connecticut
Conditions: Prostate Cancer
An Observational Research Study to Uncover Subtypes of Cancer Cachexia
Recruiting
This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable). Patients with these cancer types are at risk for developing cancer cachexia (CC), which is defined as weight loss, muscle loss, and fat loss due to cancer. CC has been associated with reduced physical performance, impaired quality of life, and poorer survival. Many... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Mercy Hospital Fort Smith, Ft. Smith, Arkansas +194 locations
Conditions: Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Advanced Pancreatic Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Unresectable Colorectal Carcinoma, Unresectable Lung Non-Small Cell Carcinoma, Unresectable Pancreatic Adenocarcinoma
The Use of Residual De-identified Specimens and/or Samples From Patients for Clinical Research
Recruiting
Acquire residual human specimens and/or samples from patient samples which were sent for testing at LabPMM, LLC for Clinical Research
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: LabPMM, San Diego, California
Conditions: Hematologic Diseases
A First-in-human Research Study on How NNC0662-0419 Works in People Living With Overweight or Obesity
Recruiting
This study is testing a new study medicine which may be used to treat people living with overweight or obesity. The purpose of the study is to see if the new study medicine is safe, how it works in human body and what human body does to the study medicine. Participants will either get the study medicine NNC0662-0419 or placebo (a "dummy" medicine without any active ingredients) given by study staff as an injection under participants skin. Which treatment participants will get is decided by chanc... Read More
Gender:
ALL
Ages:
Between 19 years and 55 years
Trial Updated:
05/02/2025
Locations: Celerion, Lincoln, Lincoln, Nebraska
Conditions: Overweight, Obesity
An Observational Research Study for Cancer Patients on Immune Checkpoint Inhibitors, DiRECT Study
Recruiting
This study compares treatment outcomes between patients of African American/Black (AA) ancestry and European American/White (EA) ancestry currently receiving immune checkpoint inhibitor treatment. Collecting samples of blood and saliva and health and treatment information from racially diverse patients receiving immune checkpoint inhibitor treatment over time may help doctors better understand health care disparities among all cancer patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro, Arkansas +258 locations
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science
Recruiting
The goal of this study is to identify genes that convey susceptibility to congenital diaphragmatic hernia in humans. The identification of such genes, and examination of their structure and function, will enable a delineation of molecular pathogenesis and, ultimately, prevention or treatment of congenital diaphragmatic hernia. There are many different possible modes of inheritance for congenital anomalies, including autosomal dominant, autosomal recessive, and multifactorial. Multi-factorial inh... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/30/2025
Locations: Rush Hospital, Chicago, Illinois +13 locations
Conditions: Congenital Diaphragmatic Hernia
NearWave Optical Molecular Monitoring
Recruiting
The purpose of this study is to assess the feasibility of the NearWave optical molecular monitoring system for monitoring therapy progression and predicting pathologic complete response (pCR) of breast cancer patients undergoing neoadjuvant chemotherapy (NAC).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Indiana University Simon Comprehensive Cancer Center, Indianapolis, Indiana
Conditions: Breast Cancer, HER2-positive Breast Cancer, TNBC - Triple-Negative Breast Cancer, HER2-negative Breast Cancer, Invasive Breast Carcinoma
Heart Attack Research Program: Platelet Sub-Study (HARP)
Recruiting
This prospective observational cohort study, will investigate the platelet phenotype, platelet genetic composition, and role of platelets as effector cells in women and men with myocardial infarction (MINOCA or MI-CAD) and controls. This study, which will take place at NYU and Bellevue Medical Center, and participating external sites. May have concurrent enrollment with the HARP Main Imaging (NCT02914483). Additionally, a sex, group of age and race matched disease controls 'CATH-NOCA' composed o... Read More
Gender:
FEMALE
Ages:
Between 21 years and 99 years
Trial Updated:
04/28/2025
Locations: NYU Langone Medical Center, New York, New York
Conditions: Myocardial Infarction
Heart Attack Research Program- Imaging Study
Recruiting
The HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in patients with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every 6 months, for a maximum of 10 years.
Gender:
ALL
Ages:
Between 21 years and 99 years
Trial Updated:
04/28/2025
Locations: University of Alabama-Birmingham, Birmingham, Alabama +18 locations
Conditions: Myocardial Infarction
Amish/Mennonite Research Contact Registry
Recruiting
The purpose of this registry is to find members of the Plain Community who are interested in participating in future medical research studies. Having a registry makes it easier to contact and offer study participation to individuals who are appropriate for a new research study based on their own and their family medical history. Studies will focus on increasing knowledge about disorders affecting those who are Amish and Mennonite.
Gender:
ALL
Ages:
All
Trial Updated:
04/28/2025
Locations: Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: All
An Investigation to Validate Speech Perception Assessment for Adult Cochlear Recipients Using a Mobile Research App
Recruiting
The study is a feasibility, prospective, repeated-measures, multi-country, multi-centre, study of the Mobile Research App to measure and validate speech perception endpoints in adult cochlear implant recipients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/27/2025
Locations: Denver Research and Technology Labs, Lone Tree, Colorado +3 locations
Conditions: Hearing Loss
Pulmonary Hemodynamics During Exercise - Research Network
Recruiting
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of Arizona, Banner University Medical Center, Phoenix, Arizona +31 locations
Conditions: Pulmonary Circulation Diseases