Safety Study for Prospective Assessment of Pregnancy Outcomes in Patients Treated With Tildrakizumab
NCT03992729
Recruiting
This study will utilize a prospective, observational, exposure cohort design to examine pregnancy and infant outcomes in women and infants who are exposed to tildrakizumab during pregnancy to treat an approved indication. The pregnancy registry cohort study will be conducted by the Organization of Teratology Information Specialists (OTIS), which is a network of university and health department based information centers serving pregnant women and healthcare providers throughout North America. Th... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
04/04/2025
Locations: Christina Chambers, San Diego, California
Conditions: Pregnancy Related
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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NCT04124120
Recruiting
The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grfating (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and cerebrovascular events in women undergoing coronary artery bypass grfating (CABG). The investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocar... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California +140 locations
Conditions: Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting
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Family Mental Health Family Navigator Project (FMHN)
NCT04822636
Recruiting
This study will focus on developing and testing a family-based mental health navigator intervention, the Family Mental Health Navigator (FMHN), to evaluate whether the intervention combined with mHealth is preliminary efficacious in improving mental health service initiation and engagement for publicly-insured youth.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
04/04/2025
Locations: UCSF Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Mental Health
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Biomarker Profiling in Individuals at Risk for Prion Disease
NCT05124392
Recruiting
We are doing this research to identify biomarkers in individuals who are at-risk for familial prion disease. We hope to use these biomarkers to predict timing of disease onset in pre-symptomatic individuals and to guide the direction of future clinical trials.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/04/2025
Locations: Alzheimer's Clinical and Translational Research Unit, Charlestown, Massachusetts
Conditions: CJD (Creutzfeldt Jakob Disease), Prion Diseases, GSS, FFI, Familial Fatal Insomnia
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Cardiac MRI-guided Deferiprone Therapy for Acute Myocardial Infarction Patients
NCT05604131
Recruiting
The objective of this randomized, controlled pilot study is to determine the efficacy of Deferiprone to reduce the amount of free iron inside the hemorrhagic zone of myocardial infarction among hemorrhagic myocardial infarction patients.
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
04/04/2025
Locations: Krannert Cardiovascular Research Center, Indianapolis, Indiana
Conditions: Acute Myocardial Infarction Type 1
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A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living With HIV and on Suppressive Antiretroviral Therapy
NCT05612178
Recruiting
Background: Antiretroviral therapy (ART) can suppress HIV to undetectable levels in people, but the virus rebounds quickly if the drug treatment is stopped; this is because HIV can remain dormant in a pool of blood cells called the persistent viral reservoir (PVR). Yet lifelong ART is expensive and can lead to serious side effects over the long term. Some drugs may be more effective at reducing the PVR. Objective: To see if 2 study drugs (3BNC117-LS and 10-1074-LS) are safe and if they can lo... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/04/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland +1 locations
Conditions: HIV-1
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Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure
NCT05822141
Recruiting
This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/04/2025
Locations: Human Perfromance Lab, Indiana University, Bloomington, Indiana
Conditions: Cold Exposure
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Emgality for Migraine in Breastmilk
NCT06085144
Recruiting
The goal of this project is to evaluate galcanezumab transfer into maternal breastmilk, and to evaluate infant (growth, development, constipation, colic, infections) and maternal (headache) outcomes for dyads in which the mother was treated with galcanezumab and to compare outcomes for infants who were or were not breastfed after maternal treatment. In this prospective observational study, the study team proposes to prospectively collect serial milk samples from 30 adult women who are treated w... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/04/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Migraine
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A Study of Niacin Regulation
NCT06175403
Recruiting
Adults who gain most of their excess weight in the abdominal area typically do not respond to things that "turn off" fat cells the same way as lean people. The researchers are trying to understand why fat tissue responds differently in people with different body types.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/04/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Excessive Weight Gain
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Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases
NCT06300463
Recruiting
The goal of this clinical trial is to to learn about different combinations of immunotherapy in patients with colorectal cancer whose cancer has spread to their liver and are planning to have surgery to remove tumor metastases from their liver. The main questions it aims to answer are: * whether these combinations of immunotherapy change the tumor microenvironment in the liver * whether these combinations of immunotherapy are safe and effective when used in colorectal cancer with liver metastas... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, New York
Conditions: Colorectal Cancer Metastatic, Liver Metastases, Colorectal Cancer
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Reducing Obesity Using Social Ties Program
NCT06335810
Recruiting
This trial aims to test the feasibility and acceptability of addressing interpersonal barriers to weight-related behavior change. Specifically, the study will test if, by including up to two friends, family members, or co-workers in a lifestyle intervention for weight loss, the person enrolled in the study loses more weight than someone whose friends, family members, or co-workers were not invited to participate.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Obesity
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Study of WAL0921 in Patients With Glomerular Kidney Diseases
NCT06466135
Recruiting
This is an adaptive prospective, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of WAL0921 in subjects with glomerular kidney disease and proteinuria, including diabetic nephropathy and rare glomerular kidney diseases (primary focal segmental glomerulosclerosis \[FSGS\], treatment-resistant minimal change disease \[TR MCD\], primary immunoglobulin A nephropathy \[IgAN\], and primary membranous nephropathy... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/04/2025
Locations: Colorado Kidney and Vascular Care, Denver, Colorado +8 locations
Conditions: Diabetic Nephropathies, Primary Focal Segmental Glomerulosclerosis, Minimal Change Disease, Primary Immunoglobulin A Nephropathy, Primary Membranous Nephropathy
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