Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
NCT04328337
Recruiting
The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS). The secondary premises are that this reduction is driven by elevated non esterified fatty acids which act to turn on specific si... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
03/28/2025
Locations: Biomedical Research Imaging Center Marsico Hall (UNC), Chapel Hill, North Carolina +1 locations
Conditions: Obesity
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COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study
NCT04391816
Recruiting
Background: The SARS-CoV-2 virus has caused a pandemic infection called COVID-19. It is a global threat to people, communities, and health systems. Researchers are concerned about the mental health effects of the pandemic. They want to learn more about how it is affecting people s alcohol use and problems, and how it may continue to affect them over time. Objective: To study the impact of the COVID-19 pandemic on alcohol use and consequences in individuals across the spectrum of alcohol use a... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/28/2025
Locations: NIAAA Section on Human Psychopharmacology, Bethesda, Maryland
Conditions: Alcohol Drinking, Alcohol-Related Disorders, Pandemic, Psychological Stress
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Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence
NCT04582903
Recruiting
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The global outbreak of COVID-19 is a major public health problem. COVID-19 causes a wide range of symptoms. These symptoms range from mild breathing problems to life-threatening problems or death. Some people have no symptoms. This study aims to learn how acute and late immune responses to COVID-19 lead to different outcomes. The immune system is the body s defense against germs,... Read More
Gender:
ALL
Ages:
Between 1 day and 99 years
Trial Updated:
03/28/2025
Locations: Niaid/Lcim, Rockville, Maryland
Conditions: COVID-19 Infection
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TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors
NCT04969315
Recruiting
The goal of this clinical trial is to evaluate TT-10, TT-4 and TT-10 + TT-4, (Dual Blockade) in participants with advanced selected solid tumors, who have failed or are not eligible for standard of care. The main questions it aims to answer are: 1. To evaluate the safety and tolerability of TT-10, TT-4 and TT-10 + TT-4, (Dual Blockade) 2. To determine the maximum tolerated dose or the recommended phase 2 dose of TT-10, TT-4 and TT-10 + TT-4, (Dual Blockade) 3. To obtain a preliminary estimate o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: USC Norris Comprehensive Cancer Center, Los Angeles, California +2 locations
Conditions: Renal Cell Cancer, Castrate Resistant Prostate Cancer, Non Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Colorectal Cancer (CRC), Endometrial Cancer, Ovarian Cancer
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A Study of DSP-5336 in Relapsed/Refractory AML/ ALL With or Without MLL Rearrangement or NPM1 Mutation
NCT04988555
Recruiting
A phase 1/2 dose escalation / dose expansion study of Enzomenib (DSP-5336) in adult patients with acute leukemia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: Hoag Family Cancer Center, Newport Beach, California +91 locations
Conditions: Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Acute
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Cannabidiol for Reduction of Brain Neuroinflammation
NCT05066308
Recruiting
This study will investigate whether cannabidiol (CBD), the primary centrally and peripherally active non-intoxicating compound in the cannabis plant, exerts anti-neuroinflammatory effects in patients with chronic low back pain (cLBP) with or without mild-to-moderate depression.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/28/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Back Pain, Depressive Symptoms
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Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction
NCT05093959
Recruiting
Met-PEF will be a randomized, double-blind, placebo-controlled trial to examine the effects of 20 weeks of 1500 mg/day of metformin on physical function, quality of life (QOL), microbiome diversity, leaky gut, and systemic inflammation in patients with 80 older patients with heart failure with preserved ejection fraction (HFpEF).
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/28/2025
Locations: Atrium Health Sanger Heart and Vascular Clinic Institute, Charlotte, North Carolina +1 locations
Conditions: Heart Failure With Preserved Ejection Fraction
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Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
NCT05095207
Recruiting
This is an open label multicenter, Phase IB/II Study of Abemaciclib in Combination with Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/28/2025
Locations: Mount Sinai Beth Israel, New York, New York +2 locations
Conditions: Breast Cancer, Metastasis
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Non-invasive BCI-controlled Assistive Devices
NCT05183152
Recruiting
Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement without actually performing it. Brain-computer interfaces (BCIs) can decode SMRs to control assistive devices and promote functional recovery. Despite rapid advancements in non-invasive BCI systems ba... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/28/2025
Locations: The University of Texas at Austin, Austin, Texas
Conditions: Motor Disorders, Healthy, Spinal Cord Injuries, Muscular Diseases, Motor Neuron Disease, Stroke, Traumatic Brain Injury, Movement Disorders, Multiple Sclerosis
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Bilateral TAP and RS Blocks Using Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy
NCT05224089
Recruiting
This study will be a single center, prospective triple blinded randomized controlled study, comparing the use of liposomal bupivacaine (Exparel) to regular bupivacaine with adjuncts in bilateral mid-abdominal transverse abdominis plane (TAP) blocks for patients undergoing laparoscopic colectomy procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: Hartford Hospital, Hartford, Connecticut
Conditions: Bowel Disease
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Impact of Parental Emotion Regulation on the Treatment of ADHD
NCT05299814
Recruiting
Aim: To examine if parental emotion regulation (ER) moderates the response to parent training interventions. H1: Reduced parental ER capacity will predict diminished efficacy for behavioral parent training to improve negative parenting behavior (NPB) and behavior problems in offspring with ADHD. H2: Increased parental emotional reactivity will predict diminished efficacy for behavioral parent training to improve negative parenting behavior (NPB) and behavior problems in offspring with ADHD.
Gender:
ALL
Ages:
Between 5 years and 12 years
Trial Updated:
03/28/2025
Locations: Penn State Health Dept of Psychiatry, Hershey, Pennsylvania
Conditions: ADHD
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Fulvestrant+Abemaciclib With Run-In of Fulvestrant in Er-Positive, Her2-Negative Metastatic Breast Cancer
NCT05305924
Recruiting
The study will investigate if CDK4/6 inhibitor holiday will reset the cell cycle process to respond to the combination of fulvestrant and abemaciclib, and this approach may represent an effective therapeutic strategy to manage such patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: Houston Methodist Cancer Center, Houston, Texas
Conditions: ER-Positive Breast Cancer, HER2-negative Breast Cancer
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