Measurable Residual Disease-Guided Post-Transplant Elranatamab Maintenance
NCT06483100
Recruiting
This study evaluates an individualized approach combining highly active maintenance treatment with elranatamab with peripheral blood-based clonotypic measurable residual disease (MRD) testing in patients with newly diagnosed multiple myeloma. The overall goal is to generate efficacy data for a personalized maintenance approach using bone marrow-based MRD testing (clonoSEQ) to guide post-autologous hematopoietic cell transplant (AHCT) maintenance with elranatamab for this patient population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Multiple Myeloma
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The ENCIRCLE Trial
NCT04153292
Recruiting
This study will establish the safety and effectiveness of the SAPIEN M3 System in subjects with symptomatic, at least 3+ mitral regurgitation (MR) for whom commercially available surgical or transcatheter treatment options are deemed unsuitable. Following completion of enrollment, subjects will be eligible for enrollment in the continued access phase of the trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Heart Center Hospital, Huntsville, Alabama +67 locations
Conditions: Mitral Regurgitation, Mitral Valve Insufficiency
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Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
NCT05094271
Recruiting
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to the progression of Alzheimer's disease.
Gender:
ALL
Ages:
Between 65 years and 85 years
Trial Updated:
12/20/2024
Locations: UCSD Sleep Research, La Jolla, California
Conditions: OSA, Sleep Apnea, Obstructive Sleep Apnea, Alzheimer Disease
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iAmHealthy Parents First: A Televideo Parent and Child Obesity Program for Rural Families
NCT05612971
Recruiting
The purpose of this study is to assess whether providing a parent-only group program before providing a parent and child group program works better than the parent and child group program alone.
Gender:
ALL
Ages:
6 years and above
Trial Updated:
12/20/2024
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Weight Loss, Pediatric Obesity
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VOICES Socials for Older Veterans With Depression
NCT06145334
Recruiting
VOICES Veterans Socials (VS) support Veterans in the community through weekly social groups. Veterans socials have the potential to improve social functioning, mental health symptoms, and create lasting social support. This project aims to evaluate and improve Veterans Socials to help older Veterans with depression by adapting materials, interviewing VS attendees, and collecting questionnaires. The goal is to improve the program based on the results for future use and research.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
12/20/2024
Locations: VA Bedford HealthCare System, Bedford, MA, Bedford, Massachusetts
Conditions: Depression, Loneliness, Isolation
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Bioenergetic Effect of Pioglitazone in CLD-PH
NCT06336798
Recruiting
The goal of this clinical trial is to learn about the safety and efficacy of Pioglitazone in people with Pulmonary Hypertension (PH) due to Chronic Lung Disease (CLD). The main question it aims to answer is: • Whether pioglitazone affects mitochondrial oxygen utilization in patients with PH due to CLD. Participants will be asked to take pioglitazone or placebo once daily for 28 days followed by a washout period of 2 weeks followed by 28 days of the other study drug (participants randomized to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Emory Healthcare System, Atlanta, Georgia
Conditions: Pulmonary Hypertension, Pulmonary Hypertension Due to Lung Diseases
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Perioperative Fostamatinib With Gemcitabine and Nab-paclitaxel in Resectable Pancreatic Cancer
NCT06639724
Recruiting
This is a Phase 1b trial evaluating the combination of Fostamatinib, a Syk kinase inhibitor currently FDA-approved for chronic idiopathic thrombocytopenia purpura (ITP), with the standard of care chemotherapy agents gemcitabine and nab-paclitaxel, for the perioperative treatment of resectable non metastatic pancreatic ductal adenocarcinoma (PDAC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: University of California, San Diego Moores Cancer Center, La Jolla, California
Conditions: Pancreatic Ductal Adenocarcinoma (PDAC)
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AMNIOX CORD Study - Radical Prostatectomy With and Without Cryopreserved Umbilical Cord Allograft
NCT04263025
Recruiting
This study aims at evaluating if placement of CLARIX® CORD 1K during robotic prostatectomy decreases the time to achieve complete erectile and urinary function after the surgery. As part of the study, the patient will be asked to answer various questions after the surgery regarding sexual and urinary function.
Gender:
MALE
Ages:
Between 30 years and 70 years
Trial Updated:
12/20/2024
Locations: Hackensack University Medical Center, Hackensack, New Jersey
Conditions: Prostate Cancer
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Preventing Cognitive Decline by Reducing BP Target Trial
NCT05106036
Recruiting
The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and demen... Read More
Gender:
ALL
Ages:
70 years and above
Trial Updated:
12/20/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Cognitive Decline, Blood Pressure, Hypertension
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Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Adults With an Opioid Use Disorder (EXPO; R33 Phase)
NCT05688410
Recruiting
This work will involve conducting a randomized trial that will evaluate preliminary efficacy of "assisted" rate cycling, voluntary rate cycling and psychotherapy for pain individually and in combination as adjunctive treatments on cravings (primary outcome) in adults with an opioid use disorder. The investigators will also evaluate the effects of "assisted" rate cycling, voluntary rate cycling and I-STOP on secondary outcomes including depression, anxiety and sleep.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/20/2024
Locations: University of Colorado at Denver, Denver, Colorado +1 locations
Conditions: Opioid Use Disorder, Pain
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Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India
NCT06168019
Recruiting
This study will be conducted as a prospective cohort study, enrolling all eligible women in their first trimester of pregnancy during a baseline visit during week 6-13 of pregnancy at Government Medical College Hospital, Nagpur. The Hospital provides primary, secondary, and tertiary care and the obstetric department delivers about 10,000 babies a year. The hypothesis is that co-infection of other respiratory viruses (ORV), particularly COVID-19 and Influenza increases the risk of adverse pregnan... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
12/20/2024
Locations: Boston University School of Public Health, Global Health, Boston, Massachusetts +1 locations
Conditions: Influenza, COVID-19, SARS-COV-2 Infection, Other Respiratory Viruses, Perinatal Morbidity, Infant Morbidity
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Project AWARE 2.0 to Improve Awareness, Willingness and Ability for Research and Enrollment in Clinical Research
NCT06343220
Recruiting
The Project AWARE 2.0 Survey is intended to gain knowledge about the feelings, attitudes, and beliefs of HD family members, care partners and others affected by HD towards the way drug trials and observational studies are communicated and conducted.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Huntington Study Group, Rochester, New York
Conditions: Huntington Disease
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