Swift Outpatient Alternatives for Rapid Stabilization
NCT05996172
Recruiting
The goal of this clinical trial is to improve the effective outpatient management of acute youth suicide risk by optimizing intervention components to build an efficient, evidence-based intervention that is responsive to the needs of, and coordinated with, providers in primary care settings. The main questions are: 1. What is the strongest combination of SOARS components associated with reduction in youth suicidal thoughts and behavior (STB)? 2. Do age and STB history moderate the impact of the... Read More
Gender:
ALL
Ages:
Between 13 years and 21 years
Trial Updated:
03/24/2025
Locations: Seattle Children's, Seattle, Washington
Conditions: Suicidal Ideation, Suicide Attempt
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Wheelchair User Physical Activity Training Intervention to Enhance Cardiometabolic Health
NCT06013046
Recruiting
The goal of the study is to improve cardiometabolic health outcomes for wheelchair users and identify strategies for achieving sufficient physical activity intensity during bouts of structured physical activity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Washington University School of Medicine, St. Louis, Missouri
Conditions: Physical Disability
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Targeting Endoplasmic Reticulum Stress in Human Hypertension
NCT06025630
Recruiting
There is strong evidence suggesting that endoplasmic reticulum stress contributes to neurogenic and vascular hypertension in various animal models, however this has never been explored in humans. Therefore, this project will fill this gap by performing a single-blind, placebo-controlled trial in humans with hypertension.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/24/2025
Locations: University of North Texas Health Science Center, Fort Worth, Texas
Conditions: Hypertension
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Evaluation of Abemaciclib and Radiation Therapy Before Surgery for the Treatment of High-Risk Adipocytic Retroperitoneal Sarcoma
NCT06025747
Recruiting
This phase I trial tests the safety, side effects, and best dose of abemaciclib and how well it works with radiation therapy before surgery in treating patients with high-risk adipocytic retroperitoneal sarcoma. Abemaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving abemaciclib together with radiation therapy before surgery may shrink tumors in patients with hig... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington
Conditions: Retroperitoneal Sarcoma
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Microendoscopic EI Sensing for Real-time Intraoperative Surgical Margin Assessment
NCT06039085
Recruiting
This research will study a custom device developed to detect if any prostate cancer tissue is left behind when the prostate is removed. This device is called an Electrical Impedance Imaging (EII) probe.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Prostate Cancer
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Repurposing Valsartan May Protect Against Pulmonary Hypertension
NCT06053580
Recruiting
This is a Phase 2, single-center, randomized placebo controlled trial of valsartan (an angiotensin receptor blocker) in adults with pulmonary arterial hypertension. The study will evaluate the safety and clinical efficacy of a 24-week course of valsartan.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/24/2025
Locations: University of Washington Medical Center, Seattle, Washington
Conditions: Pulmonary Arterial Hypertension, Right Heart Failure, Right Ventricular Dysfunction, Pulmonary Vascular Disorder
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Propranolol in Primary Progressive Aphasia
NCT06066710
Recruiting
The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure. This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/24/2025
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Aphasia, Primary Progressive
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Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
NCT06077292
Recruiting
The goal of this interventional study is to determine the impact of high potency THC product use on cognitive function of young adults aged 21-25. The main question it aims to answer is: will cannabis users who switch to less potent THC products demonstrate improved cognitive function compared to baseline? Other questions this study aims to answer include: * Can researchers accurately assess THC consumption among frequent cannabis users? * Can researchers effectively incentivize cannabis user... Read More
Gender:
ALL
Ages:
Between 21 years and 25 years
Trial Updated:
03/24/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Cannabis Use, THC, Marijuana Use, Cognitive Impairment, THC Vaping
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Cerebellar Deep Brain Stimulation for Movement Disorders in Cerebral Palsy in Children and Young Adults
NCT06122675
Recruiting
The purpose of this study is to test the safety of placing Deep Brain Stimulators (DBS) in a part of the brain called the cerebellum and using electrical stimulation of that part of the brain to treat movement symptoms related to cerebral palsy. Ten children and young adults with dyskinetic cerebral palsy will be implanted with a Medtronic Percept Primary Cell Neurostimulator. We will pilot videotaped automated movement recognition techniques and formal gait analysis, as well as collect and char... Read More
Gender:
ALL
Ages:
Between 7 years and 25 years
Trial Updated:
03/24/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Dyskinetic Cerebral Palsy, Dystonic Cerebral Palsy
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Study of RMC-6291 in Combination with RMC-6236 in Participants with Advanced KRAS G12C Mutant Solid Tumors
NCT06128551
Recruiting
This study is to evaluate the safety, tolerability, and PK profiles of RMC-6291 and RMC-6236 in adults with KRAS G12C-mutated solid tumors.
Gender:
ALL
Ages:
Between 18 years and 125 years
Trial Updated:
03/24/2025
Locations: City of Hope, Duarte, California +53 locations
Conditions: Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer, Pancreatic Ductal Adenocarcinoma
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Fisetin to Improve Vascular Function in Older Adults
NCT06133634
Recruiting
This is a pilot clinical trial to test the efficacy of intermittent treatment with the flavonoid compound fisetin for improving vascular endothelial function and reducing aortic stiffness in older adults. This trial will also determine the potential mechanisms by which fisetin may improve vascular function, including by decreasing mitochondrial oxidative stress, cellular senescence and senescence-associated secretory phenotype (SASP) factors in circulation. Lastly, safety, tolerability and adher... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/24/2025
Locations: University of Colorado Boulder, Boulder, Colorado
Conditions: Aging, Endothelial Dysfunction, Arterial Stiffness
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Remote Monitoring with Health-Coaching to Improve Quality of Life in Older Patients with Multiple Myeloma
NCT06145581
Recruiting
This clinical trial tests the effectiveness of a home-based mindfulness physical activity program with remote monitoring combined with structured telephone-based health coaching to decrease fatigue and improve quality of life in older patients with multiple myeloma (MM). Studies have shown that MM patients have the highest symptom burden among all blood cancers, with older patients experiencing more symptoms and problems, such as fatigue and decreased quality of life, compared to younger patient... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/24/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Multiple Myeloma
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