Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera
NCT06093672
Recruiting
The goal of this clinical trial is to compare the efficacy and safety of givinostat to hydroxyurea in Jak2V617F-positive high risk polycythemia vera patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +75 locations
Conditions: Polycythemia Vera
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Study of Safety and Efficacy of RGT-61159 in Adults with Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)
NCT06462183
Recruiting
Phase 1 study to evaluate safety, tolerability and anti-tumor activity of RGT-61159 in patients with ACC or CRC
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +9 locations
Conditions: Adenoid Cystic Carcinoma, Colorectal Cancer
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Incentive Spirometry to Improve Outcomes in Lung Cancer Patients Undergoing Concurrent Chemotherapy and Radiation Therapy
NCT06688422
Recruiting
The goal of this clinical trial is to learn if using an incentive spirometer can reduce lung problems in people with advanced lung cancer who are receiving chemotherapy and radiation therapy. The main questions the study aims to answer are: Does using an incentive spirometer lower the chances of developing lung inflammation (pneumonitis)? Does it improve overall survival and quality of life? Participants will: Use an incentive spirometer, a device that helps with deep breathing, 10 times ever... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: MD Anderson Cancer Center at Cooper, Camden, New Jersey
Conditions: Lung Cancer, Pneumonitis, Radiation-Induced Lung Injury, Immunotherapy-Induced Pneumonitis, Non-Small-Cell Lung Cancer (NSCLC)
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Testing a Self-management Intervention in HIV+ Asian Pacific Americans
NCT04353739
Recruiting
HIV infection rates are on a rapid rise within Asian Pacific Americans (APA) communities, with 80% of new infects being men. The purpose of this study is to adapt and evaluate the feasibility of a 4-session, 4-week family-informed self-management intervention protocol to promote health among APA men with HIV (APAMHIV). Family-informed self-management is a promising intervention to assist APAMHIV in securing family support and promoting health, and hence help address HIV epidemics in this underst... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
12/05/2024
Locations: APAIT, Los Angeles, California +1 locations
Conditions: Self-management
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Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study PART 2
NCT05267340
Recruiting
The primary objective will be to study changes in putamen connectivity and depression severity in depressed teens with meditation training. H1: Putamen node strength will increase in the training group compared to the active controls. H2: This increase in node strength will correlate with practice amount recorded by participants. H3: There will be a significant reduction in self-rated depression symptoms following the training as measured by the Reynolds Adolescent Depression Scale (RADS-2), com... Read More
Gender:
ALL
Ages:
Between 14 years and 18 years
Trial Updated:
12/05/2024
Locations: UCSF, San Francisco, California
Conditions: Depression Mild, Depression Moderate, Depression, Teen
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A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
NCT05791201
Recruiting
The purpose of the study is to evaluate the safety, tolerability, and efficacy of VX-264 in participants with type 1 diabetes (T1D).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2024
Locations: UHealth Diabetes Research Institute, Miami, Florida +15 locations
Conditions: Type 1 Diabetes
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Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures
NCT06113211
Recruiting
An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control. However, given the harmful side effect profile and opioid epidemic in the United States, it is advantageous to use alternate forms of analgesia. Multimodal pain control captures the effectiveness of different analgesic modalities and maximizes analgesia while minimizing side effects. The theory... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/05/2024
Locations: Henry Ford Hospital System, Detroit, Michigan
Conditions: Opioid Use, Fractures, Bone, Trauma
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Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma
NCT06508463
Recruiting
This phase I trial studies the best dose and side effects of recombinant vesicular stomatitis virus (VSV) carrying the human (h) sodium iodide symporter (NIS) and Interferon (IFN) beta (β) genes (VSV-hIFNβ-NIS) in combination with ipilimumab and cemiplimab in patients with T-cell lymphoma. A virus, called VSV-hIFNβ-NIS, which has been changed in a certain way, may be able to kill cancer cells without damaging normal cells. Immunotherapy with ipilmumab and cemiplimab may induce changes in body's... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +1 locations
Conditions: Peripheral T Cell Lymphoma, Relapsed Peripheral T-Cell Lymphoma, Peripheral T-Cell Lymphoma, Not Otherwise Specified, Anaplastic Large Cell Lymphoma, Mycosis Fungoides, Relapsed Anaplastic Large Cell Lymphoma, Relapsed Mycosis Fungoides
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Comparing Stainless Steel Crowns with Prefabricated Resin Crowns in Primary Molar Teeth
NCT06713330
Recruiting
The main reason for this research study is to learn more about a new flexible white dental crown (BioFLX) by comparing it to an existing flexible metal crown (Stainless Steel Crown). It is of interest to see if this new white crown is clinically equivalent to the existing silver crown that is mainly used in pediatric dentistry. A potential participant for this study would have cavities that require a crown, a type of filling that covers the entire tooth, and recommended dental work be done under... Read More
Gender:
ALL
Ages:
Between 2 years and 5 years
Trial Updated:
12/05/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Dental Caries
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Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
NCT01940757
Recruiting
An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious. The proposed model consists of vaccinating healthy, hookworm-naïve adults with a candidate hookworm vaccine, followed by challenging them with the investigational product, Necator americanus Larval Inoculum to assess the effect of vaccination on infection. The first proposed study will be a feasib... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
12/05/2024
Locations: George Washington University Medical Faculty Associates, Washington, District of Columbia
Conditions: Hookworm Infection
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Capillary Endoscopy Aspiration Catheter
NCT04418258
Recruiting
The small intestine is an understudied frontier of microbiome research. While aspiration during endoscopy is considered the gold standard to assess small bowel bacteria, the tools for sterile retrieval are primitive and poorly validated. Endoscopic aspiration is time-consuming and prone to contamination. Inspired by plants' ability to draw water by capillary action, a novel multi-capillary sterile system was designed which is a modified version of the conventional aspiration catheter. The purp... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
12/05/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Microbiota, SIBO
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Adjunctive Motivational Alcohol Intervention to Prevent IPV
NCT05287711
Recruiting
This is a study to provide much-needed experimental data on the efficacy of a brief alcohol Motivational Enhancement Therapy (MET) pre-group intervention for Veterans receiving group treatment for IPV perpetration. The investigators will compare those assigned to receive this 2-session MET intervention to those receiving a 2-session Alcohol Education (AE) intervention or a 2-session standard treatment as usual (TAU) telephone monitoring intervention. The investigators will examine whether MET le... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts +2 locations
Conditions: Alcohol Use and Intimate Partner Violence
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