Post-market Study of the Biodesign Hernia Graft
NCT04294446
Recruiting
The purpose of this study is to collect data on the performance of the Biodesign® Hernia Graft when used to reinforce soft tissues during ventral hernia repair.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee +2 locations
Conditions: Ventral Hernia
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Improving Spinal Cord Stimulation With ECAPS
NCT04938245
Recruiting
The purpose of this study will be to investigate the optimization of spinal cord stimulation with ECAPs in patients with spinal cord implants.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
12/12/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Chronic Pain
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A SkeleTal Muscle Recovery Intervention with Dietary Protein in Heart Failure
NCT05627440
Recruiting
Severe skeletal wasting and catabolic weight loss are highly common among patients with heart failure with reduced ejection fraction (HFrEF). This prospective randomized controlled trial will compare changes in the muscle mass in the arms and the legs (appendicular lean mass) in patients with HFrEF randomized between 3 groups of no, low- or high-dose protein supplementation. The dietary protein supplementation will be Ensure(R) products manufactured by Abbott Nutrition. The Investigators hypothe... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
12/12/2024
Locations: Tufts Medical Center, Boston, Massachusetts +1 locations
Conditions: Heart Failure, Muscle Atrophy
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Measuring Acute Drug Demand in Humans
NCT05829655
Recruiting
This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/12/2024
Locations: Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Opioid Use Disorder, Opioid Dependence
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NS-050/NCNP-03 in Boys With DMD (Meteor50)
NCT06053814
Recruiting
This is a Phase 1/2 study of Multiple-Ascending Dose (MAD) levels for 12 weeks of treatment followed by 24 weeks of open-label treatment with a selected dose of NS-050/NCNP-03 administered once weekly to ambulant boys with DMD, who have a DMD exon deletion amenable to exon 50 skipping.
Gender:
MALE
Ages:
Between 4 years and 14 years
Trial Updated:
12/12/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California +10 locations
Conditions: Duchenne Muscular Dystrophy
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Assessing the Maternal Outcome Monitoring Systems
NCT06415942
Recruiting
Pregnancy-related death is a growing public health issues, which are of particular concern to minority groups, including African-Americans and Spanish-speaking Latinas. Our proposal aims to improve a patient's ability to detect warning signs of pregnancy related death and seek medical care.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: NewYork-Presbyterian Columbia University Irving Medical Center, New York, New York +1 locations
Conditions: Maternal Death, Maternal Complication of Pregnancy
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Self-Determination Theory-informed Occupational Therapy Program to Increase Physical Activity Among Survivors of Breast Cancer
NCT06671730
Recruiting
We will evaluate a novel 8-week telehealth-delivered occupational therapy (OT) program among breast cancer survivors that seeks to promote engagement in aerobic physical activity (PA) and muscle strengthening exercise (MSE). The telehealth-based delivery of this OT program circumvents some barriers to OT access and participation (e.g., time burden; distance to OT clinic) among breast cancer survivors- particularly important for Oklahoma given that 33% of residents live in rural areas. Additional... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: University of Oklahoma Health Sciences, Oklahoma City, Oklahoma
Conditions: Breast Cancer Survivor
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A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma
NCT06736613
Recruiting
The purpose of this study is to find out how many people with B-cell lymphoma who are at high risk for central nervous system/CNS relapse test positive for cerebral spinal fluid/CSF ctDNA but test negative for CNS involvement using standard tests. The study will also look at how often CNS relapse happens in people with and without detected CSF ctDNA.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Stage III High Grade B-Cell Lymphoma, Stage IV High Grade B-Cell Lymphoma, DLBCL - Diffuse Large B Cell Lymphoma, Intravascular Large B-Cell Lymphoma, Diffuse Large B Cell Lymphoma of Breast, Diffuse Large B Cell Lymphoma of Testis, HIV-associated Diffuse Large B Cell Lymphoma, Double Expressor DLBCL
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International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry
NCT04496687
Recruiting
The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD. The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its re... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Cedars Sinai, Los Angeles, California +30 locations
Conditions: Spontaneous Coronary Artery Dissection
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Trial of Cemiplimab, or Cemip-Chemo Followed by Biomarker-guided Treatment for Pts w/HPV H&N Ca
NCT04988074
Recruiting
To determine if it is feasible to use neoadjuvant immunotherapy (or immunotherapy plus chemotherapy) to reduce treatment intensity and improve long-term quality of life while maintaining very high cure rates.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: HPV-Related Squamous Cell Carcinoma
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Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years
NCT05643534
Recruiting
This is a randomized, double-blind, placebo-controlled study to assess the efficacy, safety and tolerability of tenapanor (25 mg and 50 mg) in pediatric patients (≥12 and \<18 years old) with IBS-C when administered twice daily (BID) for 12 consecutive weeks.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
12/12/2024
Locations: G & L Research, LLC, Foley, Alabama +32 locations
Conditions: Irritable Bowel Syndrome With Constipation (IBS-C)
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FOG-001 in Locally Advanced or Metastatic Solid Tumors
NCT05919264
Recruiting
The goal of this clinical trial is to determine if FOG-001 is safe and effective in participants with locally advanced or metastatic cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Honor Health, Scottsdale, Arizona +8 locations
Conditions: Cancer, Colorectal Cancer, Solid Tumor, Locally Advanced Solid Tumor, Metastatic Cancer, WNT Pathway, β-catenin, Beta-catenin, Adenomatous Polyposis Coli, APC, HCC, Desmoid, Microsatellite Stable Colorectal Cancer, Metastatic Castration-resistant Prostate Cancer, FAP, Endometrial Carcinoma, Prostate Cancer, Microsatellite Instability-High Colorectal Cancer, CTNNB1, Adamantinomatous Craniopharyngioma
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