Working Memory Training in Patients with Mild Cognitive Impairment
NCT06734286
Recruiting
The purpose of this study is to test whether a special memory training program, called CogMed, can help people with early memory problems. The Investigators want to see if this training improves memory and also helps reduce stress. The Investigators also want to see if CogMed results in changes to a blood biomarker called p-Tau 217, which possibly indicate Alzheimer's disease (AD).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
12/12/2024
Locations: Barrow Neurological Institute, Division of Alzheimer's Disease, Phoenix, Arizona
Conditions: Mild Cognitive Impairment (MCI)
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Natural History, Diagnosis, and Outcomes for Leukodystrophies
NCT03639285
Recruiting
The goals of this protocol is to diagnose, care for, and understand the clinical histories and outcomes of people with leukodystrophies.
Gender:
ALL
Ages:
All
Trial Updated:
12/12/2024
Locations: Primary Children's Hospital, Salt Lake City, Utah
Conditions: Leukodystrophy
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68Ga-PSMA-Dual-Contrast PET/MRI or PET/CT for Early Detection of Liver Cancer
NCT04762888
Recruiting
This phase II trial studies how well 68Ga-PSMA PET/MRI or PET/CT works in early detection of liver cancer. 68Gallium-PSMA is a radioactive tracer designed to circulate through the body and attach itself to the prostate- specific membrane antigen (PSMA) protein on liver cancer cells. Magnetic resonance imaging (MRI) is a scan that uses magnetic and radio waves to produce detailed structural information of the organs, tissues, and structures within the body. Positron emission tomography (PET) is a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Hepatocellular Carcinoma
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A Mobile Health Intervention Among Hispanics
NCT05389332
Recruiting
Hypothesis: More than 80% of the participants (n=40) will complete the intervention at three month (intervention completion) and the six month follow-up (retention rate as feasibility). More than 70% of the participants will report high overall study satisfaction (acceptability) with the intervention and study. This pre-pilot will inform intervention and procedural refinements for the pilot. Hypothesis: Participants who receive the intervention (n=57) will report more skin cancer-related preve... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
12/12/2024
Locations: Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Conditions: Cancer of Skin
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Eating to Adjust the Timing System
NCT05800990
Recruiting
The goal of this clinical trial is to test the effects of dietary composition on the rhythms of food intake, appetite regulation, and rhythms of energy expenditure. Participants will: complete 2 field-based dietary interventions be provided with standard meals record daily food intake in a real-time manner complete 2 inpatient stays be provided with standard meals have frequent blood draws provide urine, saliva, and stool samples
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
12/12/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Dietary Intervention
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Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults
NCT06044571
Recruiting
This study seeks to answer the fundamental questions of which initial, first-line weight loss intervention should be offered to older adults with obesity and multiple chronic conditions and how to address the high non-response rates observed with most conventional strategies. A sequential, multiple assignment, randomized trial (SMART) design will permit the evaluation of treatment combinations that maximize weight loss and will provide data on constructing a future tailored, adaptive interventio... Read More
Gender:
ALL
Ages:
Between 65 years and 85 years
Trial Updated:
12/12/2024
Locations: UNC Center for Aging and Health, Chapel Hill, North Carolina
Conditions: Obesity, Multiple Chronic Conditions
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Risk of Recurrent CeAD After Pregnancy
NCT06258109
Recruiting
Primary objective: To determine whether pregnancy increases the risk of recurrent CeAD and delayed stroke in women with prior CeAD based on long-term data. Methods: Multicentric, observational case-control study based on pooled individual patient data from several stroke centers. Primary endpoint: Primary composite outcome measure includes the following outcomes: (i) occurrence of recurrent CeAD, (ii) occurrence of ischemic or hemorrhagic stroke, (iii) death.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: University of Utah, Salt Lake City, Utah +11 locations
Conditions: Cervical Artery Dissection, Pregnancy Complications
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Evaluation of Sonelokimab in Patients with Active Psoriatic Arthritis and Anti-TNFα Inadequate Response
NCT06641089
Recruiting
This is a study to confirm the clinical efficacy and safety of sonelokimab compared with placebo in the treatment of adults with active psoriatic arthritis who have had a previous inadequate response or intolerance to anti-tumor necrosis factor (TNF)α therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Clinical Site, Scottsdale, Arizona +8 locations
Conditions: Arthritis, Psoriatic
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Personalized Approach to Promote Healthy Aging
NCT06734468
Recruiting
The goal of this clinical trial study is to evaluate the impact of a personalized lifestyle intervention on improving healthspan. The primary questions of interest are whether the personalized intervention will result in improvements in muscle function, immune function, and cognitive function in adults aged 50-85 years. Participants will complete baseline assessments, receive an individualized intervention plan for approximately 3 months, and then complete post-intervention assessments. The inte... Read More
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
12/12/2024
Locations: Wexford Innovation Center, Phoenix, Arizona +1 locations
Conditions: Aging, Aging, Healthy
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Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia
NCT03817502
Recruiting
The purpose of this study is to evaluate the efficacy and safety of cariprazine in the treatment of schizophrenia in the adolescent population.
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
12/12/2024
Locations: ProScience Research Group, Culver City, California +56 locations
Conditions: Schizophrenia
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The Role of the Time of Day in the Effects of Exercise on Memory in Heathy Young Adults
NCT04861818
Recruiting
Cumulative evidence indicates that a single bout of exercise has beneficial impacts on memory in young adults. From a physiological perspective, acute exercise leads to changes of heart rate variability (HRV), which is associated with memory retrieval process. From a psychological perspective, acute exercise increases the arousal level and thus facilitates cognitive processing including memory storage and retrieval. Such HRV- and/or arousal-based effects of exercise on memory could be differed b... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
12/12/2024
Locations: UNC Greensboro, Greensboro, North Carolina
Conditions: Aerobic Exercise, Cognitive Change
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Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT)
NCT05536349
Recruiting
To learn if the combination of pirtobrutinib (also called LOXO-305), venetoclax, and obinutuzumab is safe and effective when given to patients with chronic lymphocytic leukemia (CLL) or Richter transformation (RT) who have not previously received treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Leukemia
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