MDMA Plus Exposure Therapy for PTSD
NCT05746572
Recruiting
Posttraumatic stress disorder (PTSD) is a debilitating disorder. While effective treatments exist, some patients fail to receive the full benefits. Alternative treatment approaches are needed. 3,4-methylenedioxymethamphetamine (MDMA) is a medicine associated with feelings of closeness and love for others, empathy, insightfulness, and feelings of peace or well-being. Recent research combining one or two doses of MDMA with psychotherapy has shown improvements in PTSD symptoms. For the present stu... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
06/03/2025
Locations: Emory Brain Health Center, Atlanta, Georgia
Conditions: PTSD
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TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II
NCT05848687
Recruiting
The purpose of this study is to improve upon the TINI study treatment. The study will test the ability of a type of immunotherapy called blinatumomab to clear persistent leukemia. Blinatumomab targets CD19 which is located on the leukemia cells outer membrane.
Gender:
ALL
Ages:
1 year and below
Trial Updated:
06/03/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +24 locations
Conditions: Lymphoblastic Leukemia
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Phase 2 Placebo-Controlled Study to Assess the Safety and Efficacy of ESK-001 in Active Systemic Lupus Erythematosus
NCT05966480
Recruiting
The purpose of this study is to assess the clinical efficacy, safety, PK, and PD of multiple dose levels of ESK-001 compared with placebo in adult patients with SLE.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/03/2025
Locations: Investigator Site #1046, Anniston, Alabama +175 locations
Conditions: SLE
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Exercise to Boost Response to Checkpoint Blockade Immunotherapy
NCT06008977
Recruiting
The purpose of this pilot study will be to provide i) information on feasibility implementing an exercise intervention trial among patients with cutaneous cancers, including melanoma, squamous cell carcinoma (cuSCC), and Merkel cell carcinoma, scheduled to receive checkpoint blockade immunotherapy, and ii) preliminary data on the impact of a day-of-therapy exercise intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: AdventHealth Translational Research Institute, Orlando, Florida
Conditions: Cutaneous Melanoma, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma
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A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy
NCT06112743
Recruiting
The purpose of this study is to evaluate the mavacamten impact on myocardial structure with cardiac magnetic resonance imaging (CMR) in adult participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) \[New York Heart Association (NYHA) Functional Class II or III\].
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: Cedars Sinai Medical Center - 1207 San Vicente Blvd, Los Angeles, California +88 locations
Conditions: Cardiomyopathy, Hypertrophic
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EnCoRe MoMS: Engaging Communities to Reduce Morbidity From Maternal Sepsis
NCT06145724
Recruiting
Sepsis is the second leading cause of maternal death in the U.S. For racial and ethnic minoritized birthing people, especially those who are Black, living in poverty, and from underserved communities, labor and postpartum are particularly vulnerable risk periods. The goal of this multi-center, multidisciplinary study is to evaluate a maternal sepsis safety bundle.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: NYC Health + Hospitals/Lincoln, Bronx, New York +3 locations
Conditions: Maternal Sepsis, Infections
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Ultra-Low Field (ULF) Point-of-Care (POC) MRI System for Brain Morphology and Pathology
NCT06203626
Recruiting
Background: Magnetic resonance imaging (MRI) is a tool for getting pictures of the tissues and organs inside the body. MRI can help diagnose many injuries and diseases. But not all patients are equally likely to receive MRIs. Factors such as race or ethnicity, distance to imaging centers, mobility, and a lower income can limit some people s access to MRIs. A new ultra-low field (ULF) type of MRI, which can be used on a vehicle, may help take imaging scans to more people. But researchers need to... Read More
Gender:
ALL
Ages:
Between 3 years and 99 years
Trial Updated:
06/03/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Nervous System Diseases (C10 Unique ID D009422)
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Refining Treatment Options for Trichomonas Vaginalis Infection: A Comparative Analysis of Metronidazole and Secnidazole
NCT06261840
Recruiting
This is a multi-centered, randomized, open-label, parallel, phase IV clinical trial comparing the effectiveness and cost-effectiveness of oral multi-dose metronidazole (MTZ) and oral single-dose secnidazole (SEC) for the treatment of Trichomonas vaginalis in both women and men.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: University of Alabama at Birmingham [UAB] Gynecology Clinics, Birmingham, Alabama +3 locations
Conditions: Trichomonas Vaginitis, Bacterial Vaginitis
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Global Prospective, Observational Cohort of Adult Patients With Primary Sclerosing Cholangitis (WIND-PSC Study)
NCT06297993
Recruiting
Develop an appropriate real-world data comparator cohort to support the design, execution, and serve as an external control for interventional clinical trials in PSC.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/03/2025
Locations: UC Davis, Sacramento, California +9 locations
Conditions: PSC
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Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
NCT06344130
Recruiting
Background: Glioblastoma (GBM) is a cancer of the brain. Current survival rates for people with GBM are poor; survival ranges from 5.2 months to 39 months. Most tumors come back within months or years after treatment, and when they do, they are worse: Overall survival drops to less than 10 months. No standard treatment exists for people whose GBM has returned after radiation therapy. Objective: To find a safe schedule for using radiation to treat GBM tumors that returned after initial radiati... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
06/03/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Astrocytoma, Glioma, Recurrent Glioblastoma
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The Role of Vitamin K on Knee Osteoarthritis Outcomes
NCT06385275
Recruiting
The appropriate form and dosing of vitamin K to benefit relevant outcomes in knee osteoarthritis (OA) are not known. In intervention studies for conditions other than knee OA (e.g., prevention of cardiovascular disease), the most commonly used forms and doses include phylloquinone (vitamin K1; 1000µg or 500µg daily) or menaquinone-7 (MK-7 or vitamin K2; 300µg daily). However, whether these doses are adequate to increase vitamin K to levels that ameliorate risk of adverse OA outcomes is not known... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
06/03/2025
Locations: Boston Medical Center, Rheumatology Clinic, Boston, Massachusetts
Conditions: Osteo Arthritis Knee
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Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine
NCT06417775
Recruiting
A migraine is a moderate to severe headache typically on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms. Menstrual migraine (MM) is defined as migraine attacks that occur within the perimenstrual period (PMP) in at least 2 out of 3 menstrual cycles. The PMP is from 2 days before the onset of menstrual bleeding to 2 days after. This study will assess how safe and effective ubrogepant i... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: Central Research Associates /ID# 260161, Birmingham, Alabama +92 locations
Conditions: Migraine
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